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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models?			Type	Book Chapter
	Year	2014	Publication	G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology	Abbreviated Journal
	Volume	796	Issue	3	Pages	159-181
	Keywords	β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
	Abstract	Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
	Address
	Corporate Author				Thesis
	Publisher	Springer Netherlands	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0065-2598	ISBN	978-94-007-7422-3	Medium
	Area		Expedition		Conference
	Notes	IAM; 600.075			Approved	no
	Call Number	IAM @ iam @ RGG2014			Serial	2197
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	Author	Debora Gil; Agnes Borras; Sergio Vera; Miguel Angel Gonzalez Ballester
	Title	A Validation Benchmark for Assessment of Medial Surface Quality for Medical Applications			Type	Conference Article
	Year	2013	Publication	9th International Conference on Computer Vision Systems	Abbreviated Journal
	Volume	7963	Issue		Pages	334-343
	Keywords	Medial Surfaces; Shape Representation; Medical Applications; Performance Evaluation
	Abstract	Confident use of medial surfaces in medical decision support systems requires evaluating their quality for detecting pathological deformations and describing anatomical volumes. Validation in the medical imaging field is a challenging task mainly due to the difficulties for getting consensual ground truth. In this paper we propose a validation benchmark for assessing medial surfaces in the context of medical applications. Our benchmark includes a home-made database of synthetic medial surfaces and volumes and specific scores for evaluating surface accuracy, its stability against volume deformations and its capabilities for accurate reconstruction of anatomical volumes.
	Address	Sant Petersburg; Russia; July 2013
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-39401-0	Medium
	Area		Expedition		Conference	ICVS
	Notes	IAM; 600.044; 600.060			Approved	no
	Call Number	Admin @ si @ GBV2013			Serial	2300
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	Author	Ferran Poveda; Debora Gil;Enric Marti
	Title	Multi-resolution DT-MRI cardiac tractography			Type	Conference Article
	Year	2012	Publication	Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges	Abbreviated Journal
	Volume	7746	Issue		Pages	270-277
	Keywords
	Abstract	Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture.
	Address	Nice, France
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-36960-5	Medium
	Area		Expedition		Conference	STACOM
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ PGM2012			Serial	1986
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	Author	Debora Gil;Agnes Borras;Ruth Aris;Mariano Vazquez;Pierre Lafortune; Guillame Houzeaux
	Title	What a difference in biomechanics cardiac fiber makes			Type	Conference Article
	Year	2012	Publication	Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges	Abbreviated Journal
	Volume	7746	Issue		Pages	253-260
	Keywords
	Abstract	Computational simulations of the heart are a powerful tool for a comprehensive understanding of cardiac function and its intrinsic relationship with its muscular architecture. Cardiac biomechanical models require a vector field representing the orientation of cardiac fibers. A wrong orientation of the fibers can lead to a non-realistic simulation of the heart functionality. In this paper we explore the impact of the fiber information on the simulated biomechanics of cardiac muscular anatomy. We have used the John Hopkins database to perform a biomechanical simulation using both a synthetic benchmark fiber distribution and the data obtained experimentally from DTI. Results illustrate how differences in fiber orientation affect heart deformation along cardiac cycle.
	Address	Nice, France
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-36960-5	Medium
	Area		Expedition		Conference	STACOM
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ GBA2012			Serial	1987
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	Author	Patricia Marquez;Debora Gil;Aura Hernandez-Sabate
	Title	A Complete Confidence Framework for Optical Flow			Type	Conference Article
	Year	2012	Publication	12th European Conference on Computer Vision – Workshops and Demonstrations	Abbreviated Journal
	Volume	7584	Issue	2	Pages	124-133
	Keywords	Optical flow, confidence measures, sparsification plots, error prediction plots
	Abstract	Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.
	Address
	Corporate Author				Thesis
	Publisher	Springer-Verlag	Place of Publication	Florence, Italy, October 7-13, 2012	Editor	Andrea Fusiello, Vittorio Murino ,Rita Cucchiara
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-3-642-33867-0	Medium
	Area		Expedition		Conference	ECCVW
	Notes	IAM;ADAS;			Approved	no
	Call Number	IAM @ iam @ MGH2012b			Serial	1991
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	Author	Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate
	Title	Error Analysis for Lucas-Kanade Based Schemes			Type	Conference Article
	Year	2012	Publication	9th International Conference on Image Analysis and Recognition	Abbreviated Journal
	Volume	7324	Issue	I	Pages	184-191
	Keywords	Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance
	Abstract	Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures.
	Address	Aveiro, Portugal
	Corporate Author				Thesis
	Publisher	Springer-Verlag Berlin Heidelberg	Place of Publication		Editor
	Language	english	Summary Language		Original Title
	Series Editor	Campilho, Aurélio and Kamel, Mohamed	Series Title	Lecture Notes in Computer Science	Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-31294-6	Medium
	Area		Expedition		Conference	ICIAR
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ MGH2012a			Serial	1899
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	Author	Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru; Miguel Angel Gonzalez Ballester
	Title	Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs			Type	Book Chapter
	Year	2012	Publication	Workshop on Computational and Clinical Applications in Abdominal Imaging	Abbreviated Journal
	Volume	7029	Issue		Pages	223–230
	Keywords	medial manifolds, abdomen.
	Abstract	Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.
	Address	Toronto; Canada;
	Corporate Author				Thesis
	Publisher	Springer Link	Place of Publication	Berlin	Editor	H. Yoshida et al
	Language	English	Summary Language	English	Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-28556-1	Medium
	Area		Expedition		Conference	ABDI
	Notes	IAM;MV			Approved	no
	Call Number	IAM @ iam @ VGB2012			Serial	1834
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	Author	Jaume Garcia; Debora Gil; Aura Hernandez-Sabate
	Title	Endowing Canonical Geometries to Cardiac Structures			Type	Book Chapter
	Year	2010	Publication	Statistical Atlases And Computational Models Of The Heart	Abbreviated Journal
	Volume	6364	Issue		Pages	124-133
	Keywords
	Abstract	International conference on Cardiac electrophysiological simulation challenge In this paper, we show that canonical (shape-based) geometries can be endowed to cardiac structures using tubular coordinates defined over their medial axis. We give an analytic formulation of these geometries by means of B-Splines. Since B-Splines present vector space structure PCA can be applied to their control points and statistical models relating boundaries and the interior of the anatomical structures can be derived. We demonstrate the applicability in two cardiac structures, the 3D Left Ventricular volume, and the 2D Left-Right ventricle set in 2D Short Axis view.
	Address
	Corporate Author				Thesis
	Publisher	Springer Berlin / Heidelberg	Place of Publication		Editor	Camara, O.; Pop, M.; Rhode, K.; Sermesant, M.; Smith, N.; Young, A.
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ GGH2010b			Serial	1515
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	Author	Debora Gil; Aura Hernandez-Sabate; Mireia Burnat; Steven Jansen; Jordi Martinez-Vilalta
	Title	Structure-Preserving Smoothing of Biomedical Images			Type	Conference Article
	Year	2009	Publication	13th International Conference on Computer Analysis of Images and Patterns	Abbreviated Journal
	Volume	5702	Issue		Pages	427-434
	Keywords	non-linear smoothing; differential geometry; anatomical structures segmentation; cardiac magnetic resonance; computerized tomography.
	Abstract	Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images.
	Address	Münster, Germany
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-642-03766-5	Medium
	Area		Expedition		Conference	CAIP
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ GHB2009			Serial	1527
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	Author	Debora Gil; Oriol Rodriguez-Leon; Petia Radeva; Aura Hernandez-Sabate
	Title	Assessing Artery Motion Compensation in IVUS			Type	Book Chapter
	Year	2007	Publication	Computer Analysis Of Images And Patterns	Abbreviated Journal	LNCS
	Volume	4673	Issue		Pages	213-220
	Keywords	validation standards; quality measures; IVUS motion compensation; conservation laws; Fourier development
	Abstract	Cardiac dynamics suppression is a main issue for visual improvement and computation of tissue mechanical properties in IntraVascular UltraSound (IVUS). Although in recent times several motion compensation techniques have arisen, there is a lack of objective evaluation of motion reduction in in vivo pullbacks. We consider that the assessment protocol deserves special attention for the sake of a clinical applicability as reliable as possible. Our work focuses on defining a quality measure and a validation protocol assessing IVUS motion compensation. On the grounds of continuum mechanics laws we introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases.
	Address
	Corporate Author				Thesis
	Publisher	Springerlink	Place of Publication	Heidelberg	Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-3-540-74271-5	Medium
	Area		Expedition		Conference
	Notes	IAM;MILAB			Approved	no
	Call Number	IAM @ iam @ GRR2007			Serial	1540
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	Author	Antoni Gurgui; Debora Gil; Enric Marti; Vicente Grau
	Title	Left-Ventricle Basal Region Constrained Parametric Mapping to Unitary Domain			Type	Conference Article
	Year	2016	Publication	7th International Workshop on Statistical Atlases & Computational Modelling of the Heart	Abbreviated Journal
	Volume	10124	Issue		Pages	163-171
	Keywords	Laplacian; Constrained maps; Parameterization; Basal ring
	Abstract	Due to its complex geometry, the basal ring is often omitted when putting different heart geometries into correspondence. In this paper, we present the first results on a new mapping of the left ventricle basal rings onto a normalized coordinate system using a fold-over free approach to the solution to the Laplacian. To guarantee correspondences between different basal rings, we imposed some internal constrained positions at anatomical landmarks in the normalized coordinate system. To prevent internal fold-overs, constraints are handled by cutting the volume into regions defined by anatomical features and mapping each piece of the volume separately. Initial results presented in this paper indicate that our method is able to handle internal constrains without introducing fold-overs and thus guarantees one-to-one mappings between different basal ring geometries.
	Address	Athens; October 2016
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference	STACOM
	Notes	IAM;			Approved	no
	Call Number	Admin @ si @ GGM2016			Serial	2884
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	Author	Debora Gil; F. Javier Sanchez; Gloria Fernandez Esparrach; Jorge Bernal
	Title	3D Stable Spatio-temporal Polyp Localization in Colonoscopy Videos			Type	Book Chapter
	Year	2015	Publication	Computer-Assisted and Robotic Endoscopy. Revised selected papers of Second International Workshop, CARE 2015, Held in Conjunction with MICCAI 2015	Abbreviated Journal
	Volume	9515	Issue		Pages	140-152
	Keywords	Colonoscopy, Polyp Detection, Polyp Localization, Region Extraction, Watersheds
	Abstract	Computational intelligent systems could reduce polyp miss rate in colonoscopy for colon cancer diagnosis and, thus, increase the efficiency of the procedure. One of the main problems of existing polyp localization methods is a lack of spatio-temporal stability in their response. We propose to explore the response of a given polyp localization across temporal windows in order to select those image regions presenting the highest stable spatio-temporal response. Spatio-temporal stability is achieved by extracting 3D watershed regions on the temporal window. Stability in localization response is statistically determined by analysis of the variance of the output of the localization method inside each 3D region. We have explored the benefits of considering spatio-temporal stability in two different tasks: polyp localization and polyp detection. Experimental results indicate an average improvement of 21:5% in polyp localization and 43:78% in polyp detection.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference	CARE
	Notes	IAM; MV; 600.075			Approved	no
	Call Number	Admin @ si @ GSF2015			Serial	2733
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	Author	Hanne Kause; Aura Hernandez-Sabate; Patricia Marquez; Andrea Fuster; Luc Florack; Hans van Assen; Debora Gil
	Title	Confidence Measures for Assessing the HARP Algorithm in Tagged Magnetic Resonance Imaging			Type	Book Chapter
	Year	2015	Publication	Statistical Atlases and Computational Models of the Heart. Revised selected papers of Imaging and Modelling Challenges 6th International Workshop, STACOM 2015, Held in Conjunction with MICCAI 2015	Abbreviated Journal
	Volume	9534	Issue		Pages	69-79
	Keywords
	Abstract	Cardiac deformation and changes therein have been linked to pathologies. Both can be extracted in detail from tagged Magnetic Resonance Imaging (tMRI) using harmonic phase (HARP) images. Although point tracking algorithms have shown to have high accuracies on HARP images, these vary with position. Detecting and discarding areas with unreliable results is crucial for use in clinical support systems. This paper assesses the capability of two confidence measures (CMs), based on energy and image structure, for detecting locations with reduced accuracy in motion tracking results. These CMs were tested on a database of simulated tMRI images containing the most common artifacts that may affect tracking accuracy. CM performance is assessed based on its capability for HARP tracking error bounding and compared in terms of significant differences detected using a multi comparison analysis of variance that takes into account the most influential factors on HARP tracking performance. Results showed that the CM based on image structure was better suited to detect unreliable optical flow vectors. In addition, it was shown that CMs can be used to detect optical flow vectors with large errors in order to improve the optical flow obtained with the HARP tracking algorithm.
	Address	Munich; Germany; January 2015
	Corporate Author				Thesis
	Publisher	Springer International Publishing	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-319-28711-9	Medium
	Area		Expedition		Conference	STACOM
	Notes	ADAS; IAM; 600.075; 600.076; 600.060; 601.145			Approved	no
	Call Number	Admin @ si @ KHM2015			Serial	2734
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	Author	Patricia Marquez; H. Kause; A. Fuster; Aura Hernandez-Sabate; L. Florack; Debora Gil; Hans van Assen
	Title	Factors Affecting Optical Flow Performance in Tagging Magnetic Resonance Imaging			Type	Conference Article
	Year	2014	Publication	17th International Conference on Medical Image Computing and Computer Assisted Intervention	Abbreviated Journal
	Volume	8896	Issue		Pages	231-238
	Keywords	Optical flow; Performance Evaluation; Synthetic Database; ANOVA; Tagging Magnetic Resonance Imaging
	Abstract	Changes in cardiac deformation patterns are correlated with cardiac pathologies. Deformation can be extracted from tagging Magnetic Resonance Imaging (tMRI) using Optical Flow (OF) techniques. For applications of OF in a clinical setting it is important to assess to what extent the performance of a particular OF method is stable across dierent clinical acquisition artifacts. This paper presents a statistical validation framework, based on ANOVA, to assess the motion and appearance factors that have the largest in uence on OF accuracy drop. In order to validate this framework, we created a database of simulated tMRI data including the most common artifacts of MRI and test three dierent OF methods, including HARP.
	Address	Boston; USA; September 2014
	Corporate Author				Thesis
	Publisher	Springer International Publishing	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-319-14677-5	Medium
	Area		Expedition		Conference	STACOM
	Notes	IAM; ADAS; 600.060; 601.145; 600.076; 600.075			Approved	no
	Call Number	Admin @ si @ MKF2014			Serial	2495
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	Author	Jorge Bernal; Debora Gil; Carles Sanchez; F. Javier Sanchez
	Title	Discarding Non Informative Regions for Efficient Colonoscopy Image Analysis			Type	Conference Article
	Year	2014	Publication	1st MICCAI Workshop on Computer-Assisted and Robotic Endoscopy	Abbreviated Journal
	Volume	8899	Issue		Pages	1-10
	Keywords	Image Segmentation; Polyps, Colonoscopy; Valley Information; Energy Maps
	Abstract	In this paper we present a novel polyp region segmentation method for colonoscopy videos. Our method uses valley information associated to polyp boundaries in order to provide an initial segmentation. This first segmentation is refined to eliminate boundary discontinuities caused by image artifacts or other elements of the scene. Experimental results over a publicly annotated database show that our method outperforms both general and specific segmentation methods by providing more accurate regions rich in polyp content. We also prove how image preprocessing is needed to improve final polyp region segmentation.
	Address	Boston; USA; September 2014
	Corporate Author				Thesis
	Publisher	Springer International Publishing	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN	0302-9743	ISBN	978-3-319-13409-3	Medium
	Area		Expedition		Conference	CARE
	Notes	MV; IAM; 600.044; 600.047; 600.060; 600.075			Approved	no
	Call Number	Admin @ si @ BGS2014b			Serial	2503
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