Abstract: The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.

Abstract: The recognition of continuous natural gestures is a complex and challenging problem due to the multi-modal nature of involved visual cues (e.g. fingers and lips movements, subtle facial expressions, body pose, etc.), as well as technical limitations such as spatial and temporal resolution and unreliable
depth cues. In order to promote the research advance on this field, we organized a challenge on multi-modal gesture recognition. We made available a large video database of 13; 858 gestures from a lexicon of 20 Italian gesture categories recorded with a KinectTM camera, providing the audio, skeletal model, user mask, RGB and depth images. The focus of the challenge was on user independent multiple gesture learning. There are no resting positions and the gestures are performed in continuous sequences lasting 1-2 minutes, containing between 8 and 20 gesture instances in each sequence. As a result, the dataset contains around 1:720:800 frames. In addition to the 20 main gesture categories, ‘distracter’ gestures are included, meaning that additional audio
and gestures out of the vocabulary are included. The final evaluation of the challenge was defined in terms of the Levenshtein edit distance, where the goal was to indicate the real order of gestures within the sequence. 54 international teams participated in the challenge, and outstanding results
were obtained by the first ranked participants.

Abstract: The Wireless Capsule Endoscopy (WCE) technology allows the visualization of the whole small intestine tract. Since the capsule is freely moving, mainly by the means of peristalsis, the data acquired during the study gives a lot of information about the intestinal motility. However, due to: (1) huge amount of frames, (2) complex intestinal scene appearance and (3) intestinal dynamics that make difficult the visualization of the small intestine physiological phenomena, the analysis of the WCE data requires computer-aided systems to speed up the analysis. In this paper, we propose an efficient algorithm for building a novel representation of the WCE video data, optimal for motility analysis and inspection. The algorithm transforms the 3D video data into 2D longitudinal view by choosing the most informative, from the intestinal motility point of view, part of each frame. This step maximizes the lumen visibility in its longitudinal extension. The task of finding “the best longitudinal view” has been defined as a cost function optimization problem which global minimum is obtained by using Dynamic Programming. Validation on both synthetic data and WCE data shows that the adaptive longitudinal view is a good alternative to the traditional motility analysis done by video analysis. The proposed novel data representation a new, holistic insight into the small intestine motility, allowing to easily define and analyze motility events that are difficult to spot by analyzing WCE video. Moreover, the visual inspection of small intestine motility is 4 times faster then by means of video skimming of the WCE.

Abstract: This book contains the papers presented at the Eighth CVC Workshop on Computer Vision Trends and Challenges (CVCR&D'2013). The workshop was held at the Computer Vision Center (Universitat Autònoma de Barcelona), the October 25th, 2013. The CVC workshops provide an excellent opportunity for young researchers and project engineers to share new ideas and knowledge about the progress of their work, and also, to discuss about challenges and future perspectives. In addition, the workshop is the welcome event for new people that recently have joined the institute.
The program of CVCR&D is organized in a single-track single-day workshop. It comprises several sessions dedicated to specific topics. For each session, a doctor working on the topic introduces the general research lines. The PhD students expose their specific research. A poster session will be held for open questions. Session topics cover the current research lines and development projects of the CVC: Medical Imaging, Medical Imaging, Color & Texture Analysis, Object Recognition, Image Sequence Evaluation, Advanced Driver Assistance Systems, Machine Vision, Document Analysis, Pattern Recognition and Applications. We want to thank all paper authors and Program Committee members. Their contribution shows that the CVC has a dynamic, active, and promising scientific community.
We hope you all enjoy this Eighth workshop and we are looking forward to meeting you and new people next year in the Ninth CVCR&D.

Abstract: This paper addresses the problem of generating possible object locations for use in object recognition. We introduce selective search which combines the strength of both an exhaustive search and segmentation. Like segmentation, we use the image structure to guide our sampling process. Like exhaustive search, we aim to capture all possible object locations. Instead of a single technique to generate possible object locations, we diversify our search and use a variety of complementary image partitionings to deal with as many image conditions as possible. Our selective search results in a small set of data-driven, class-independent, high quality locations, yielding 99 % recall and a Mean Average Best Overlap of 0.879 at 10,097 locations. The reduced number of locations compared to an exhaustive search enables the use of stronger machine learning techniques and stronger appearance models for object recognition. In this paper we show that our selective search enables the use of the powerful Bag-of-Words model for recognition. The selective search software is made publicly available (Software: http://disi.unitn.it/~uijlings/SelectiveSearch.html).

Abstract: This paper deals with a subgraph matching problem in Region Adjacency Graph (RAG) applied to symbol spotting in graphical documents. RAG is a very important, efficient and natural way of representing graphical information with a graph but this is limited to cases where the information is well defined with perfectly delineated regions. What if the information we are interested in is not confined within well defined regions? This paper addresses this particular problem and solves it by defining near convex grouping of oriented line segments which results in near convex regions. Pure convexity imposes hard constraints and can not handle all the cases efficiently. Hence to solve this problem we have defined a new type of convexity of regions, which allows convex regions to have concavity to some extend. We call this kind of regions Near Convex Regions (NCRs). These NCRs are then used to create the Near Convex Region Adjacency Graph (NCRAG) and with this representation we have formulated the problem of symbol spotting in graphical documents as a subgraph matching problem. For subgraph matching we have used the Approximate Edit Distance Algorithm (AEDA) on the neighborhood string, which starts working after finding a key node in the input or target graph and iteratively identifies similar nodes of the query graph in the neighborhood of the key node. The experiments are performed on artificial, real and distorted datasets.

Abstract: This paper describes an approach to human action recognition based on a probabilistic optimization model of body parts using hidden Markov model (HMM). Our method is able to distinguish between similar actions by only considering the body parts having major contribution to the actions, for example, legs for walking, jogging and running; arms for boxing, waving and clapping. We apply HMMs to model the stochastic movement of the body parts for action recognition. The HMM construction uses an ensemble of body-part detectors, followed by grouping of part detections, to perform human identification. Three example-based body-part detectors are trained to detect three components of the human body: the head, legs and arms. These detectors cope with viewpoint changes and self-occlusions through the use of ten sub-classifiers that detect body parts over a specific range of viewpoints. Each sub-classifier is a support vector machine trained on features selected for the discriminative power for each particular part/viewpoint combination. Grouping of these detections is performed using a simple geometric constraint model that yields a viewpoint-invariant human detector. We test our approach on three publicly available action datasets: the KTH dataset, Weizmann dataset and HumanEva dataset. Our results illustrate that with a simple and compact representation we can achieve robust recognition of human actions comparable to the most complex, state-of-the-art methods.