Abstract: Brightness induction is the modulation of the perceived intensity of an area by the luminance of surrounding areas. From a purely computational perspective, we built a low-level computational model (CIWaM) of early sensory processing based on multi-resolution wavelets with the aim of replicating brightness and colour (Otazu et al., 2010, Journal of Vision, 10(12):5) induction effects. Furthermore, we successfully used the CIWaM architecture to define a computational saliency model (Murray et al, 2011, CVPR, 433-440; Vanrell et al, submitted to AVA/BMVA'12). From a biological perspective, neurophysiological evidence suggests that perceived brightness information may be explicitly represented in V1. In this work we investigate possible neural mechanisms that offer a plausible explanation for such effects. To this end, we consider the model by Z.Li (Li, 1999, Network:Comput. Neural Syst., 10, 187-212) which is based on biological data and focuses on the part of V1 responsible for contextual influences, namely, layer 2-3 pyramidal cells, interneurons, and horizontal intracortical connections. This model has proven to account for phenomena such as visual saliency, which share with brightness induction the relevant effect of contextual influences (the ones modelled by CIWaM). In the proposed model, the input to the network is derived from a complete multiscale and multiorientation wavelet decomposition taken from the computational model (CIWaM).
This model successfully accounts for well known pyschophysical effects (among them: the White's and modied White's effects, the Todorovic, Chevreul, achromatic ring patterns, and grating induction effects) for static contexts and also for brigthness induction in dynamic contexts defined by modulating the luminance of surrounding areas. From a methodological point of view, we conclude that the results obtained by the computational model (CIWaM) are compatible with the ones obtained by the neurodynamical model proposed here.

Abstract: We present a fully automatic diagnostic imaging test for Attention-Deficit/Hyperactivity Disorder diagnosis assistance based on previously found evidences of caudate nucleus volumetric abnormalities. The proposed method consists of different steps: a new automatic method for external and internal segmentation of caudate based on Machine Learning methodologies; the definition of a set of new volume relation features, 3D Dissociated Dipoles, used for caudate representation and classification. We separately validate the contributions using real data from a pediatric population and show precise internal caudate segmentation and discrimination power of the diagnostic test, showing significant performance improvements in comparison to other state-of-the-art methods.

Abstract: In this thesis we tackle the problem of automatic characterization of human coronary vessel in Intravascular Ultrasound (IVUS) image modality. The basis for the whole characterization process is machine learning applied to multi-class problems. In all the presented approaches, the Error-Correcting Output Codes (ECOC) framework is used as central element for the design of multi-class classifiers.
Two main topics are tackled in this thesis. First, the automatic detection of the vessel borders is presented. For this purpose, a novel context-aware classifier for multi-class classification of the vessel morphology is presented, namely ECOC-DRF. Based on ECOC-DRF, the lumen border and the media-adventitia border in IVUS are robustly detected by means of a novel holistic approach, achieving an error comparable with inter-observer variability and with state of the art methods.
The two vessel borders define the atheroma area of the vessel. In this area, tissue characterization is required. For this purpose, we present a framework for automatic plaque characterization by processing both texture in IVUS images and spectral information in raw Radio Frequency data. Furthermore, a novel method for fusing in-vivo and in-vitro IVUS data for plaque characterization is presented, namely pSFFS. The method demonstrates to effectively fuse data generating a classifier that improves the tissue characterization in both in-vitro and in-vivo datasets.
A novel method for automatic video summarization in IVUS sequences is also presented. The method aims to detect the key frames of the sequence, i.e., the frames representative of morphological changes. This novel method represents the basis for video summarization in IVUS as well as the markers for the partition of the vessel into morphological and clinically interesting events.
Finally, multi-class learning based on ECOC is applied to lung tissue characterization in Computed Tomography. The novel proposed approach, based on supervised and unsupervised learning, achieves accurate tissue classification on a large and heterogeneous dataset.

Abstract: Biometric information has become a technology complementary to cryptography, allowing to conveniently manage cryptographic data. Two important needs are ful lled: rst of all, making such data always readily available, and additionally, making its legitimate owner easily identi able. In this work we propose a signature system which integrates face recognition biometrics with and identity-based signature scheme, so the user's face e ectively becomes his public key and system ID. Thus, other users may verify messages using photos of the claimed sender, providing a reasonable trade-o between system security and usability, as well as a much more straightforward public key authenticity and distribution process.

Abstract: Today, robust learners trained in a real supervised machine learning application should count with a rich collection of positive and negative examples. Although in many applications, it is not difficult to obtain huge amount of data, labeling those data can be a very expensive process, especially when dealing with data of high variability and complexity. A good example of such cases are data from medical imaging applications where annotating anomalies like tumors, polyps, atherosclerotic plaque or informative frames in wireless endoscopy need highly trained experts. Building a representative set of training data from medical videos (e.g. Wireless Capsule Endoscopy) means that thousands of frames to be labeled by an expert. It is quite normal that data in new videos come different and thus are not represented by the training set. In this paper, we review the main approaches on active learning and illustrate how active learning can help to reduce expert effort in constructing the training sets. We show that applying active learning criteria, the number of human interventions can be significantly reduced. The proposed system allows the annotation of informative/non-informative frames of Wireless Capsule Endoscopy video containing more than 30000 frames each one with less than 100 expert ”clicks”.