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C. Butakoff; Simone Balocco; F.M. Sukno; C. Hoogendoorn; C. Tobon-Gomez; G. Avegliano; A.F. Frangi |
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Title |
Left-ventricular Epi- and Endocardium Extraction from 3D Ultrasound Images Using an Automatically Constructed 3D ASM |
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Journal Article |
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Year |
2016 |
Publication |
Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization |
Abbreviated Journal |
CMBBE |
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4 |
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5 |
Pages |
265-280 |
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Keywords |
ASM; cardiac segmentation; statistical model; shape model; 3D ultrasound; cardiac segmentation |
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Abstract |
In this paper, we propose an automatic method for constructing an active shape model (ASM) to segment the complete cardiac left ventricle in 3D ultrasound (3DUS) images, which avoids costly manual landmarking. The automatic construction of the ASM has already been addressed in the literature; however, the direct application of these methods to 3DUS is hampered by a high level of noise and artefacts. Therefore, we propose to construct the ASM by fusing the multidetector computed tomography data, to learn the shape, with the artificially generated 3DUS, in order to learn the neighbourhood of the boundaries. Our artificial images were generated by two approaches: a faster one that does not take into account the geometry of the transducer, and a more comprehensive one, implemented in Field II toolbox. The segmentation accuracy of our ASM was evaluated on 20 patients with left-ventricular asynchrony, demonstrating plausibility of the approach. |
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2168-1163 |
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MILAB |
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Admin @ si @ BBS2016 |
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2449 |
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Author |
Jean-Pascal Jacob; Mariella Dimiccoli; Lionel Moisan |
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Title |
Active skeleton for bacteria modeling |
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Journal Article |
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2016 |
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Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization |
Abbreviated Journal |
CMBBE |
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5 |
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4 |
Pages |
274-286 |
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Bacteria modelling; medial axis; active contours; active skeleton; shape contraints |
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The investigation of spatio-temporal dynamics of bacterial cells and their molecular components requires automated image analysis tools to track cell shape properties and molecular component locations inside the cells. In the study of bacteria aging, the molecular components of interest are protein aggregates accumulated near bacteria boundaries. This particular location makes very ambiguous the correspondence between aggregates and cells, since computing accurately bacteria boundaries in phase-contrast time-lapse imaging is a challenging task. This paper proposes an active skeleton formulation for bacteria modeling which provides several advantages: an easy computation of shape properties (perimeter, length, thickness, orientation), an improved boundary accuracy in noisy images, and a natural bacteria-centered coordinate system that permits the intrinsic location of molecular components inside the cell. Starting from an initial skeleton estimate, the medial axis of the bacterium is obtained by minimizing an energy function which incorporates bacteria shape constraints. Experimental results on biological images and comparative evaluation of the performances validate the proposed approach for modeling cigar-shaped bacteria like Escherichia coli. The Image-J plugin of the proposed method can be found online at this http URL |
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MILAB |
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Admin @ si @ JDM2016 |
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2711 |
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Author |
Jean-Pascal Jacob; Mariella Dimiccoli; L. Moisan |
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Title |
Active skeleton for bacteria modelling |
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Journal Article |
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2017 |
Publication |
Computer Methods in Biomechanics and Biomedical Engineering: Imaging and Visualization |
Abbreviated Journal |
CMBBE |
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5 |
Issue |
4 |
Pages |
274-286 |
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The investigation of spatio-temporal dynamics of bacterial cells and their molecular components requires automated image analysis tools to track cell shape properties and molecular component locations inside the cells. In the study of bacteria aging, the molecular components of interest are protein aggregates accumulated near bacteria boundaries. This particular location makes very ambiguous the correspondence between aggregates and cells, since computing accurately bacteria boundaries in phase-contrast time-lapse imaging is a challenging task. This paper proposes an active skeleton formulation for bacteria modelling which provides several advantages: an easy computation of shape properties (perimeter, length, thickness and orientation), an improved boundary accuracy in noisy images and a natural bacteria-centred coordinate system that permits the intrinsic location of molecular components inside the cell. Starting from an initial skeleton estimate, the medial axis of the bacterium is obtained by minimising an energy function which incorporates bacteria shape constraints. Experimental results on biological images and comparative evaluation of the performances validate the proposed approach for modelling cigar-shaped bacteria like Escherichia coli. The Image-J plugin of the proposed method can be found online at http://fluobactracker.inrialpes.fr. |
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Taylor & Francis Group |
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MILAB; |
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Admin @ si @JDM2017 |
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2784 |
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Simone Balocco; Carlo Gatta; Francesco Ciompi; A. Wahle; Petia Radeva; S. Carlier; G. Unal; E. Sanidas; J. Mauri; X. Carillo; T. Kovarnik; C. Wang; H. Chen; T. P. Exarchos; D. I. Fotiadis; F. Destrempes; G. Cloutier; Oriol Pujol; Marina Alberti; E. G. Mendizabal-Ruiz; M. Rivera; T. Aksoy; R. W. Downe; I. A. Kakadiaris |
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Title |
Standardized evaluation methodology and reference database for evaluating IVUS image segmentation |
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Journal Article |
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Year |
2014 |
Publication |
Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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Volume |
38 |
Issue |
2 |
Pages |
70-90 |
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Keywords |
IVUS (intravascular ultrasound); Evaluation framework; Algorithm comparison; Image segmentation |
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This paper describes an evaluation framework that allows a standardized and quantitative comparison of IVUS lumen and media segmentation algorithms. This framework has been introduced at the MICCAI 2011 Computing and Visualization for (Intra)Vascular Imaging (CVII) workshop, comparing the results of eight teams that participated.
We describe the available data-base comprising of multi-center, multi-vendor and multi-frequency IVUS datasets, their acquisition, the creation of the reference standard and the evaluation measures. The approaches address segmentation of the lumen, the media, or both borders; semi- or fully-automatic operation; and 2-D vs. 3-D methodology. Three performance measures for quantitative analysis have
been proposed. The results of the evaluation indicate that segmentation of the vessel lumen and media is possible with an accuracy that is comparable to manual annotation when semi-automatic methods are used, as well as encouraging results can be obtained also in case of fully-automatic segmentation. The analysis performed in this paper also highlights the challenges in IVUS segmentation that remains to be
solved. |
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MILAB; LAMP; HuPBA; 600.046; 600.063; 600.079 |
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no |
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Admin @ si @ BGC2013 |
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2314 |
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Author |
Laura Igual; Joan Carles Soliva; Sergio Escalera; Roger Gimeno; Oscar Vilarroya; Petia Radeva |
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Title |
Automatic Brain Caudate Nuclei Segmentation and Classification in Diagnostic of Attention-Deficit/Hyperactivity Disorder |
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Journal Article |
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Year |
2012 |
Publication |
Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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Volume |
36 |
Issue |
8 |
Pages |
591-600 |
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Keywords |
Automatic caudate segmentation; Attention-Deficit/Hyperactivity Disorder; Diagnostic test; Machine learning; Decision stumps; Dissociated dipoles |
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We present a fully automatic diagnostic imaging test for Attention-Deficit/Hyperactivity Disorder diagnosis assistance based on previously found evidences of caudate nucleus volumetric abnormalities. The proposed method consists of different steps: a new automatic method for external and internal segmentation of caudate based on Machine Learning methodologies; the definition of a set of new volume relation features, 3D Dissociated Dipoles, used for caudate representation and classification. We separately validate the contributions using real data from a pediatric population and show precise internal caudate segmentation and discrimination power of the diagnostic test, showing significant performance improvements in comparison to other state-of-the-art methods. |
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OR; HuPBA; MILAB |
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no |
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Admin @ si @ ISE2012 |
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2143 |
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Author |
Michal Drozdzal; Santiago Segui; Carolina Malagelada; Fernando Azpiroz; Petia Radeva |
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Title |
Adaptable image cuts for motility inspection using WCE |
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Journal Article |
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2013 |
Publication |
Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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37 |
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1 |
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72-80 |
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Abstract |
The Wireless Capsule Endoscopy (WCE) technology allows the visualization of the whole small intestine tract. Since the capsule is freely moving, mainly by the means of peristalsis, the data acquired during the study gives a lot of information about the intestinal motility. However, due to: (1) huge amount of frames, (2) complex intestinal scene appearance and (3) intestinal dynamics that make difficult the visualization of the small intestine physiological phenomena, the analysis of the WCE data requires computer-aided systems to speed up the analysis. In this paper, we propose an efficient algorithm for building a novel representation of the WCE video data, optimal for motility analysis and inspection. The algorithm transforms the 3D video data into 2D longitudinal view by choosing the most informative, from the intestinal motility point of view, part of each frame. This step maximizes the lumen visibility in its longitudinal extension. The task of finding “the best longitudinal view” has been defined as a cost function optimization problem which global minimum is obtained by using Dynamic Programming. Validation on both synthetic data and WCE data shows that the adaptive longitudinal view is a good alternative to the traditional motility analysis done by video analysis. The proposed novel data representation a new, holistic insight into the small intestine motility, allowing to easily define and analyze motility events that are difficult to spot by analyzing WCE video. Moreover, the visual inspection of small intestine motility is 4 times faster then by means of video skimming of the WCE. |
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MILAB; OR; 600.046; 605.203 |
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Admin @ si @ DSM2012 |
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2151 |
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Author |
Simeon Petkov; Xavier Carrillo; Petia Radeva; Carlo Gatta |
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Title |
Diaphragm border detection in coronary X-ray angiographies: New method and applications |
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Journal Article |
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2014 |
Publication |
Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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Volume |
38 |
Issue |
4 |
Pages |
296-305 |
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X-ray angiography is widely used in cardiac disease diagnosis during or prior to intravascular interventions. The diaphragm motion and the heart beating induce gray-level changes, which are one of the main obstacles in quantitative analysis of myocardial perfusion. In this paper we focus on detecting the diaphragm border in both single images or whole X-ray angiography sequences. We show that the proposed method outperforms state of the art approaches. We extend a previous publicly available data set, adding new ground truth data. We also compose another set of more challenging images, thus having two separate data sets of increasing difficulty. Finally, we show three applications of our method: (1) a strategy to reduce false positives in vessel enhanced images; (2) a digital diaphragm removal algorithm; (3) an improvement in Myocardial Blush Grade semi-automatic estimation. |
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MILAB; LAMP; 600.079 |
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no |
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Admin @ si @ PCR2014 |
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2468 |
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Author |
Jorge Bernal; F. Javier Sanchez; Gloria Fernandez Esparrach; Debora Gil; Cristina Rodriguez de Miguel; Fernando Vilariño |
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Title |
WM-DOVA Maps for Accurate Polyp Highlighting in Colonoscopy: Validation vs. Saliency Maps from Physicians |
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Journal Article |
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2015 |
Publication |
Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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43 |
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99-111 |
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Keywords |
Polyp localization; Energy Maps; Colonoscopy; Saliency; Valley detection |
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We introduce in this paper a novel polyp localization method for colonoscopy videos. Our method is based on a model of appearance for polyps which defines polyp boundaries in terms of valley information. We propose the integration of valley information in a robust way fostering complete, concave and continuous boundaries typically associated to polyps. This integration is done by using a window of radial sectors which accumulate valley information to create WMDOVA1 energy maps related with the likelihood of polyp presence. We perform a double validation of our maps, which include the introduction of two new databases, including the first, up to our knowledge, fully annotated database with clinical metadata associated. First we assess that the highest value corresponds with the location of the polyp in the image. Second, we show that WM-DOVA energy maps can be comparable with saliency maps obtained from physicians' fixations obtained via an eye-tracker. Finally, we prove that our method outperforms state-of-the-art computational saliency results. Our method shows good performance, particularly for small polyps which are reported to be the main sources of polyp miss-rate, which indicates the potential applicability of our method in clinical practice. |
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0895-6111 |
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MV; IAM; 600.047; 600.060; 600.075;SIAI |
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Admin @ si @ BSF2015 |
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2609 |
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P. Canals; Simone Balocco; O. Diaz; J. Li; A. Garcia Tornel; M. Olive Gadea; M. Ribo |
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A fully automatic method for vascular tortuosity feature extraction in the supra-aortic region: unraveling possibilities in stroke treatment planning |
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Journal Article |
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2023 |
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Computerized Medical Imaging and Graphics |
Abbreviated Journal |
CMIG |
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Volume |
104 |
Issue |
102170 |
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Artificial intelligence; Deep learning; Stroke; Thrombectomy; Vascular feature extraction; Vascular tortuosity |
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Abstract |
Vascular tortuosity of supra-aortic vessels is widely considered one of the main reasons for failure and delays in endovascular treatment of large vessel occlusion in patients with acute ischemic stroke. Characterization of tortuosity is a challenging task due to the lack of objective, robust and effective analysis tools. We present a fully automatic method for arterial segmentation, vessel labelling and tortuosity feature extraction applied to the supra-aortic region. A sample of 566 computed tomography angiography scans from acute ischemic stroke patients (aged 74.8 ± 12.9, 51.0% females) were used for training, validation and testing of a segmentation module based on a U-Net architecture (162 cases) and a vessel labelling module powered by a graph U-Net (566 cases). Successively, 30 cases were processed for testing of a tortuosity feature extraction module. Measurements obtained through automatic processing were compared to manual annotations from two observers for a thorough validation of the method. The proposed feature extraction method presented similar performance to the inter-rater variability observed in the measurement of 33 geometrical and morphological features of the arterial anatomy in the supra-aortic region. This system will contribute to the development of more complex models to advance the treatment of stroke by adding immediate automation, objectivity, repeatability and robustness to the vascular tortuosity characterization of patients. |
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MILAB |
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Admin @ si @ CBD2023 |
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4005 |
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Tadashi Araki; Nobutaka Ikeda; Nilanjan Dey; Sayan Chakraborty; Luca Saba; Dinesh Kumar; Elisa Cuadrado Godia; Xiaoyi Jiang; Ajay Gupta; Petia Radeva; John R. Laird; Andrew Nicolaides; Jasjit S. Suri |
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A comparative approach of four different image registration techniques for quantitative assessment of coronary artery calcium lesions using intravascular ultrasound |
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2015 |
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Computer Methods and Programs in Biomedicine |
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CMPB |
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118 |
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2 |
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158-172 |
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MILAB |
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Admin @ si @ AID2015 |
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2640 |
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Sumit K. Banchhor; Tadashi Araki; Narendra D. Londhe; Nobutaka Ikeda; Petia Radeva; Ayman El-Baz; Luca Saba; Andrew Nicolaides; Shoaib Shafique; John R. Laird; Jasjit S. Suri |
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Five multiresolution-based calcium volume measurement techniques from coronary IVUS videos: A comparative approach |
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Journal Article |
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2016 |
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Computer Methods and Programs in Biomedicine |
Abbreviated Journal |
CMPB |
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134 |
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237-258 |
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BACKGROUND AND OBJECTIVE:
Fast intravascular ultrasound (IVUS) video processing is required for calcium volume computation during the planning phase of percutaneous coronary interventional (PCI) procedures. Nonlinear multiresolution techniques are generally applied to improve the processing time by down-sampling the video frames.
METHODS:
This paper presents four different segmentation methods for calcium volume measurement, namely Threshold-based, Fuzzy c-Means (FCM), K-means, and Hidden Markov Random Field (HMRF) embedded with five different kinds of multiresolution techniques (bilinear, bicubic, wavelet, Lanczos, and Gaussian pyramid). This leads to 20 different kinds of combinations. IVUS image data sets consisting of 38,760 IVUS frames taken from 19 patients were collected using 40 MHz IVUS catheter (Atlantis® SR Pro, Boston Scientific®, pullback speed of 0.5 mm/sec.). The performance of these 20 systems is compared with and without multiresolution using the following metrics: (a) computational time; (b) calcium volume; (c) image quality degradation ratio; and (d) quality assessment ratio.
RESULTS:
Among the four segmentation methods embedded with five kinds of multiresolution techniques, FCM segmentation combined with wavelet-based multiresolution gave the best performance. FCM and wavelet experienced the highest percentage mean improvement in computational time of 77.15% and 74.07%, respectively. Wavelet interpolation experiences the highest mean precision-of-merit (PoM) of 94.06 ± 3.64% and 81.34 ± 16.29% as compared to other multiresolution techniques for volume level and frame level respectively. Wavelet multiresolution technique also experiences the highest Jaccard Index and Dice Similarity of 0.7 and 0.8, respectively. Multiresolution is a nonlinear operation which introduces bias and thus degrades the image. The proposed system also provides a bias correction approach to enrich the system, giving a better mean calcium volume similarity for all the multiresolution-based segmentation methods. After including the bias correction, bicubic interpolation gives the largest increase in mean calcium volume similarity of 4.13% compared to the rest of the multiresolution techniques. The system is automated and can be adapted in clinical settings.
CONCLUSIONS:
We demonstrated the time improvement in calcium volume computation without compromising the quality of IVUS image. Among the 20 different combinations of multiresolution with calcium volume segmentation methods, the FCM embedded with wavelet-based multiresolution gave the best performance. |
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MILAB; |
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Admin @ si @ BAL2016 |
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2830 |
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Giuseppe Pezzano; Vicent Ribas Ripoll; Petia Radeva |
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Title |
CoLe-CNN: Context-learning convolutional neural network with adaptive loss function for lung nodule segmentation |
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Journal Article |
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2021 |
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Computer Methods and Programs in Biomedicine |
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CMPB |
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198 |
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105792 |
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Background and objective:An accurate segmentation of lung nodules in computed tomography images is a crucial step for the physical characterization of the tumour. Being often completely manually accomplished, nodule segmentation turns to be a tedious and time-consuming procedure and this represents a high obstacle in clinical practice. In this paper, we propose a novel Convolutional Neural Network for nodule segmentation that combines a light and efficient architecture with innovative loss function and segmentation strategy. Methods:In contrast to most of the standard end-to-end architectures for nodule segmentation, our network learns the context of the nodules by producing two masks representing all the background and secondary-important elements in the Computed Tomography scan. The nodule is detected by subtracting the context from the original scan image. Additionally, we introduce an asymmetric loss function that automatically compensates for potential errors in the nodule annotations. We trained and tested our Neural Network on the public LIDC-IDRI database, compared it with the state of the art and run a pseudo-Turing test between four radiologists and the network. Results:The results proved that the behaviour of the algorithm is very near to the human performance and its segmentation masks are almost indistinguishable from the ones made by the radiologists. Our method clearly outperforms the state of the art on CT nodule segmentation in terms of F1 score and IoU of and respectively. Conclusions: The main structure of the network ensures all the properties of the UNet architecture, while the Multi Convolutional Layers give a more accurate pattern recognition. The newly adopted solutions also increase the details on the border of the nodule, even under the noisiest conditions. This method can be applied now for single CT slice nodule segmentation and it represents a starting point for the future development of a fully automatic 3D segmentation software. |
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MILAB; no proj |
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no |
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Admin @ si @ PRR2021 |
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3530 |
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Juan Borrego-Carazo; Carles Sanchez; David Castells; Jordi Carrabina; Debora Gil |
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BronchoPose: an analysis of data and model configuration for vision-based bronchoscopy pose estimation |
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2023 |
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Computer Methods and Programs in Biomedicine |
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CMPB |
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228 |
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107241 |
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Videobronchoscopy guiding; Deep learning; Architecture optimization; Datasets; Standardized evaluation framework; Pose estimation |
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Vision-based bronchoscopy (VB) models require the registration of the virtual lung model with the frames from the video bronchoscopy to provide effective guidance during the biopsy. The registration can be achieved by either tracking the position and orientation of the bronchoscopy camera or by calibrating its deviation from the pose (position and orientation) simulated in the virtual lung model. Recent advances in neural networks and temporal image processing have provided new opportunities for guided bronchoscopy. However, such progress has been hindered by the lack of comparative experimental conditions.
In the present paper, we share a novel synthetic dataset allowing for a fair comparison of methods. Moreover, this paper investigates several neural network architectures for the learning of temporal information at different levels of subject personalization. In order to improve orientation measurement, we also present a standardized comparison framework and a novel metric for camera orientation learning. Results on the dataset show that the proposed metric and architectures, as well as the standardized conditions, provide notable improvements to current state-of-the-art camera pose estimation in video bronchoscopy. |
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Elsevier |
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IAM; |
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no |
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Admin @ si @ BSC2023 |
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3702 |
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Debora Gil; David Roche; Agnes Borras; Jesus Giraldo |
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Terminating Evolutionary Algorithms at their Steady State |
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2015 |
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Computational Optimization and Applications |
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COA |
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61 |
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2 |
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489-515 |
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Evolutionary algorithms; Termination condition; Steady state; Differential evolution |
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Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications. |
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Springer US |
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0926-6003 |
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IAM; 600.044; 605.203; 600.060; 600.075 |
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no |
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Admin @ si @ GRB2015 |
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2560 |
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Antonio Clavelli; Dimosthenis Karatzas; Josep Llados; Mario Ferraro; Giuseppe Boccignone |
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Modelling task-dependent eye guidance to objects in pictures |
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2014 |
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Cognitive Computation |
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CoCom |
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6 |
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3 |
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558-584 |
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Visual attention; Gaze guidance; Value; Payoff; Stochastic fixation prediction |
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5Y Impact Factor: 1.14 / 3rd (Computer Science, Artificial Intelligence)
We introduce a model of attentional eye guidance based on the rationale that the deployment of gaze is to be considered in the context of a general action-perception loop relying on two strictly intertwined processes: sensory processing, depending on current gaze position, identifies sources of information that are most valuable under the given task; motor processing links such information with the oculomotor act by sampling the next gaze position and thus performing the gaze shift. In such a framework, the choice of where to look next is task-dependent and oriented to classes of objects embedded within pictures of complex scenes. The dependence on task is taken into account by exploiting the value and the payoff of gazing at certain image patches or proto-objects that provide a sparse representation of the scene objects. The different levels of the action-perception loop are represented in probabilistic form and eventually give rise to a stochastic process that generates the gaze sequence. This way the model also accounts for statistical properties of gaze shifts such as individual scan path variability. Results of the simulations are compared either with experimental data derived from publicly available datasets and from our own experiments. |
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Springer US |
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1866-9956 |
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DAG; 600.056; 600.045; 605.203; 601.212; 600.077 |
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Admin @ si @ CKL2014 |
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2419 |
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