Abstract: Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results.

Abstract: Dimensionality reduction is key to alleviate machine learning artifacts in clinical applications with Small Sample Size (SSS) unbalanced datasets. Existing methods rely on either the probabilistic distribution of training data or the discriminant power of the reduced space, disregarding the impact of repeatability and uncertainty in features.In the present study is proposed the use of reproducibility of radiomics features to select features with high inter-class correlation coefficient (ICC). The reproducibility includes the variability introduced in the image acquisition, like medical scans acquisition parameters and convolution kernels, that affects intensity-based features and tumor annotations made by physicians, that influences morphological descriptors of the lesion.For the reproducibility of radiomics features three studies were conducted on cases collected at Vall Hebron Oncology Institute (VHIO) on responders to oncology treatment. The studies focused on the variability due to the convolution kernel, image acquisition parameters, and the inter-observer lesion identification. The features selected were those features with a ICC higher than 0.7 in the three studies.The selected features based on reproducibility were evaluated for lesion malignancy classification using a different database. Results show better performance compared to several state-of-the-art methods including Principal Component Analysis (PCA), Kernel Discriminant Analysis via QR decomposition (KDAQR), LASSO, and an own built Convolutional Neural Network.

Abstract: Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images.

Abstract: Accurate symbol recognition in graphic documents needs an accurate representation of the symbols to be recognized. If structural approaches are used for recognition, symbols have to be described in terms of their shape, using structural relationships among extracted features. Unlike statistical pattern recognition, in structural methods, symbols are usually manually defined from expertise knowledge, and not automatically infered from sample images. In this work we explain one approach to learn from examples a representative structural description of a symbol, thus providing better information about shape variability. The description of a symbol is based on a probabilistic model. It consists of a set of lines described by the mean and the variance of line parameters, respectively providing information about the model of the symbol, and its shape variability. The representation of each image in the sample set as a set of lines is achieved using deformable template matching.

Abstract: A hatched area is characterized by a set of parallel straight lines placed at regular intervals. In this paper, a Hough-based schema is introduced to recognize hatched areas in technical documents from attributed graph structures representing the document once it has been vectorized. Defining a Hough-based transform from a graph instead of the raster image allows to drastically reduce the processing time and, second, to obtain more reliable results because straight lines have already been detected in the vectorization step. A second advantage of the proposed method is that no assumptions must be made a priori about the slope and frequency of hatching patterns, but they are computed in run time for each hatched area.