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Author |
Debora Gil; Jaume Garcia; Manuel Vazquez; Ruth Aris; Guillaume Houzeaux |
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Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
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Year |
2008 |
Publication |
8th World Congress on Computational Mechanichs (WCCM8)/5th European Congress on Computational Methods in Applied Sciences and Engineering (ECCOMAS 2008) |
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Keywords |
Left Ventricle; Electromechanical Models; Image Processing; Magnetic Resonance. |
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Abstract |
Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality . In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp. We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment. The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted. The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venezia (Italia) |
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B-31470-08 |
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IAM @ iam @ GGV2008c |
Serial |
1521 |
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Author |
Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil |
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Title |
A medial map capturing the essential geometry of organs |
Type |
Conference Article |
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Year |
2012 |
Publication |
ISBI Workshop on Open Source Medical Image Analysis software |
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Pages |
1691 - 1694 |
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Keywords |
Medial Surface Representation, Volume Reconstruction,Geometry , Image reconstruction , Liver , Manifolds , Shape , Surface morphology , Surface reconstruction |
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Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Accurate computation of one pixel wide medial surfaces is mandatory. Those surfaces must represent faithfully the geometry of the volume. Although morphological methods produce excellent results in 2D, their complexity and quality drops across dimensions, due to a more complex description of pixel neighborhoods. This paper introduces a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. Our experiments show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume |
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Barcelona,Spain |
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IEEE |
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ISSN |
1945-7928 |
ISBN |
978-1-4577-1857-1 |
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ISBI |
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IAM @ iam @ VGG2012a |
Serial |
1989 |
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Author |
Jaume Garcia; Albert Andaluz; Debora Gil; Francesc Carreras |
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Title |
Decoupled External Forces in a Predictor-Corrector Segmentation Scheme for LV Contours in Tagged MR Images |
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Conference Article |
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2010 |
Publication |
32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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4805-4808 |
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Computation of functional regional scores requires proper identification of LV contours. On one hand, manual segmentation is robust, but it is time consuming and requires high expertise. On the other hand, the tag pattern in TMR sequences is a problem for automatic segmentation of LV boundaries. We propose a segmentation method based on a predictorcorrector (Active Contours – Shape Models) scheme. Special stress is put in the definition of the AC external forces. First, we introduce a semantic description of the LV that discriminates myocardial tissue by using texture and motion descriptors. Second, in order to ensure convergence regardless of the initial contour, the external energy is decoupled according to the orientation of the edges in the image potential. We have validated the model in terms of error in segmented contours and accuracy of regional clinical scores. |
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Buenos Aires (Argentina) |
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IEEE EMB |
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ISSN |
1557-170X |
ISBN |
978-1-4244-4123-5 |
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EMBC |
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Call Number |
IAM @ iam @ GAG2010 |
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1514 |
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Author |
Debora Gil; Aura Hernandez-Sabate; Mireia Burnat; Steven Jansen; Jordi Martinez-Vilalta |
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Title |
Structure-Preserving Smoothing of Biomedical Images |
Type |
Conference Article |
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Year |
2009 |
Publication |
13th International Conference on Computer Analysis of Images and Patterns |
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Volume |
5702 |
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Pages |
427-434 |
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Keywords |
non-linear smoothing; differential geometry; anatomical structures segmentation; cardiac magnetic resonance; computerized tomography. |
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Abstract |
Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images. |
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Münster, Germany |
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Springer Berlin Heidelberg |
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LNCS |
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0302-9743 |
ISBN |
978-3-642-03766-5 |
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CAIP |
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Call Number |
IAM @ iam @ GHB2009 |
Serial |
1527 |
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Author |
Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate |
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Title |
Error Analysis for Lucas-Kanade Based Schemes |
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Conference Article |
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Year |
2012 |
Publication |
9th International Conference on Image Analysis and Recognition |
Abbreviated Journal |
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Volume |
7324 |
Issue |
I |
Pages |
184-191 |
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Keywords |
Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance |
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Abstract |
Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures. |
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Aveiro, Portugal |
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Springer-Verlag Berlin Heidelberg |
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english |
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Campilho, Aurélio and Kamel, Mohamed |
Series Title |
Lecture Notes in Computer Science |
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LNCS |
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0302-9743 |
ISBN |
978-3-642-31294-6 |
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ICIAR |
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IAM @ iam @ MGH2012a |
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1899 |
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Author |
Debora Gil; Agnes Borras; Sergio Vera; Miguel Angel Gonzalez Ballester |
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Title |
A Validation Benchmark for Assessment of Medial Surface Quality for Medical Applications |
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Conference Article |
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Year |
2013 |
Publication |
9th International Conference on Computer Vision Systems |
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7963 |
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334-343 |
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Keywords |
Medial Surfaces; Shape Representation; Medical Applications; Performance Evaluation |
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Confident use of medial surfaces in medical decision support systems requires evaluating their quality for detecting pathological deformations and describing anatomical volumes. Validation in the medical imaging field is a challenging task mainly due to the difficulties for getting consensual ground truth. In this paper we propose a validation benchmark for assessing medial surfaces in the context of medical applications. Our benchmark includes a home-made database of synthetic medial surfaces and volumes and specific scores for evaluating surface accuracy, its stability against volume deformations and its capabilities for accurate reconstruction of anatomical volumes. |
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Sant Petersburg; Russia; July 2013 |
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Springer Berlin Heidelberg |
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LNCS |
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0302-9743 |
ISBN |
978-3-642-39401-0 |
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ICVS |
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IAM; 600.044; 600.060 |
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Admin @ si @ GBV2013 |
Serial |
2300 |
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Author |
Ferran Poveda; Debora Gil;Enric Marti |
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Title |
Multi-resolution DT-MRI cardiac tractography |
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Conference Article |
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2012 |
Publication |
Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges |
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7746 |
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270-277 |
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Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture. |
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Nice, France |
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Springer Berlin Heidelberg |
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LNCS |
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0302-9743 |
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978-3-642-36960-5 |
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STACOM |
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IAM |
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IAM @ iam @ PGM2012 |
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1986 |
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Author |
Debora Gil;Agnes Borras;Ruth Aris;Mariano Vazquez;Pierre Lafortune; Guillame Houzeaux |
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Title |
What a difference in biomechanics cardiac fiber makes |
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Conference Article |
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2012 |
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Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges |
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7746 |
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253-260 |
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Computational simulations of the heart are a powerful tool for a comprehensive understanding of cardiac function and its intrinsic relationship with its muscular architecture. Cardiac biomechanical models require a vector field representing the orientation of cardiac fibers. A wrong orientation of the fibers can lead to a
non-realistic simulation of the heart functionality. In this paper we explore the impact of the fiber information on the simulated biomechanics of cardiac muscular anatomy. We have used the John Hopkins database to perform a biomechanical simulation using both a synthetic benchmark fiber distribution and the data obtained experimentally from DTI. Results illustrate how differences in fiber orientation affect heart deformation along cardiac cycle. |
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Nice, France |
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Springer Berlin Heidelberg |
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0302-9743 |
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978-3-642-36960-5 |
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STACOM |
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IAM |
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IAM @ iam @ GBA2012 |
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1987 |
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Author |
Patricia Marquez; Debora Gil; Aura Hernandez-Sabate; Daniel Kondermann |
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Title |
When Is A Confidence Measure Good Enough? |
Type |
Conference Article |
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Year |
2013 |
Publication |
9th International Conference on Computer Vision Systems |
Abbreviated Journal |
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7963 |
Issue |
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Pages |
344-353 |
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Keywords |
Optical flow, confidence measure, performance evaluation |
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Abstract |
Confidence estimation has recently become a hot topic in image processing and computer vision.Yet, several definitions exist of the term “confidence” which are sometimes used interchangeably. This is a position paper, in which we aim to give an overview on existing definitions,
thereby clarifying the meaning of the used terms to facilitate further research in this field. Based on these clarifications, we develop a theory to compare confidence measures with respect to their quality. |
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St Petersburg; Russia; July 2013 |
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Springer Link |
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LNCS |
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0302-9743 |
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978-3-642-39401-0 |
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ICVS |
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IAM;ADAS; 600.044; 600.057; 600.060; 601.145 |
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IAM @ iam @ MGH2013a |
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2218 |
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Author |
Patricia Marquez; H. Kause; A. Fuster; Aura Hernandez-Sabate; L. Florack; Debora Gil; Hans van Assen |
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Title |
Factors Affecting Optical Flow Performance in Tagging Magnetic Resonance Imaging |
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Conference Article |
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2014 |
Publication |
17th International Conference on Medical Image Computing and Computer Assisted Intervention |
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8896 |
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231-238 |
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Optical flow; Performance Evaluation; Synthetic Database; ANOVA; Tagging Magnetic Resonance Imaging |
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Changes in cardiac deformation patterns are correlated with cardiac pathologies. Deformation can be extracted from tagging Magnetic Resonance Imaging (tMRI) using Optical Flow (OF) techniques. For applications of OF in a clinical setting it is important to assess to what extent the performance of a particular OF method is stable across di erent clinical acquisition artifacts. This paper presents a statistical validation framework, based on ANOVA, to assess the motion and appearance factors that have the largest in uence on OF accuracy drop.
In order to validate this framework, we created a database of simulated tMRI data including the most common artifacts of MRI and test three di erent OF methods, including HARP. |
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Boston; USA; September 2014 |
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Springer International Publishing |
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LNCS |
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0302-9743 |
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978-3-319-14677-5 |
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IAM; ADAS; 600.060; 601.145; 600.076; 600.075 |
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Admin @ si @ MKF2014 |
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2495 |
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