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Author |
Alberto Hidalgo; Ferran Poveda; Enric Marti;Debora Gil;Albert Andaluz; Francesc Carreras; Manuel Ballester |
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Title |
Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography |
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Journal Article |
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Year |
2012 |
Publication |
European Radiology |
Abbreviated Journal |
ECR |
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Volume |
3 |
Issue |
1 |
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361-362 |
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Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model. |
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Viena, Austria |
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Springer Link |
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1869-4101 |
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IAM |
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no |
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IAM @ iam @ HPM2012 |
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1858 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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2013 |
Publication |
Drug Discovery Today |
Abbreviated Journal |
DDT |
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18 |
Issue |
7-8 |
Pages |
365-371 |
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The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
Serial |
2190 |
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Author |
Enric Marti; Debora Gil; Carme Julia |
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Una experiencia de PBL en la docencia de la asignatura de Graficos por Computador en Ingenieria Informatica |
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Miscellaneous |
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2006 |
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IV Contreso Internacional de Docencia Universitaria e Innovacion |
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1 |
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375 |
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Barcelona (Spain) |
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IAM;ADAS; |
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IAM @ iam @ MGJ2006b |
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931 |
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Author |
Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities |
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Journal Article |
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Year |
2017 |
Publication |
Medical Image Analysis |
Abbreviated Journal |
MIA |
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35 |
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390-402 |
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Keywords |
Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points |
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Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies. |
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Elsevier B.V. |
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IAM; 600.060; 600.096; 600.075; 600.145 |
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Admin @ si @ GVB2017 |
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2775 |
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Author |
Santi Puch; Irina Sanchez; Aura Hernandez-Sabate; Gemma Piella; Vesna Prckovska |
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Title |
Global Planar Convolutions for Improved Context Aggregation in Brain Tumor Segmentation |
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Conference Article |
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2018 |
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International MICCAI Brainlesion Workshop |
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11384 |
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393-405 |
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Brain tumors; 3D fully-convolutional CNN; Magnetic resonance imaging; Global planar convolution |
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In this work, we introduce the Global Planar Convolution module as a building-block for fully-convolutional networks that aggregates global information and, therefore, enhances the context perception capabilities of segmentation networks in the context of brain tumor segmentation. We implement two baseline architectures (3D UNet and a residual version of 3D UNet, ResUNet) and present a novel architecture based on these two architectures, ContextNet, that includes the proposed Global Planar Convolution module. We show that the addition of such module eliminates the need of building networks with several representation levels, which tend to be over-parametrized and to showcase slow rates of convergence. Furthermore, we provide a visual demonstration of the behavior of GPC modules via visualization of intermediate representations. We finally participate in the 2018 edition of the BraTS challenge with our best performing models, that are based on ContextNet, and report the evaluation scores on the validation and the test sets of the challenge. |
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MICCAIW |
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ADAS; 600.118;IAM |
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no |
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Admin @ si @ PSH2018 |
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3251 |
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Author |
Marta Ligero; Guillermo Torres; Carles Sanchez; Katerine Diaz; Raquel Perez; Debora Gil |
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Title |
Selection of Radiomics Features based on their Reproducibility |
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Conference Article |
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2019 |
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41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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403-408 |
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Dimensionality reduction is key to alleviate machine learning artifacts in clinical applications with Small Sample Size (SSS) unbalanced datasets. Existing methods rely on either the probabilistic distribution of training data or the discriminant power of the reduced space, disregarding the impact of repeatability and uncertainty in features.In the present study is proposed the use of reproducibility of radiomics features to select features with high inter-class correlation coefficient (ICC). The reproducibility includes the variability introduced in the image acquisition, like medical scans acquisition parameters and convolution kernels, that affects intensity-based features and tumor annotations made by physicians, that influences morphological descriptors of the lesion.For the reproducibility of radiomics features three studies were conducted on cases collected at Vall Hebron Oncology Institute (VHIO) on responders to oncology treatment. The studies focused on the variability due to the convolution kernel, image acquisition parameters, and the inter-observer lesion identification. The features selected were those features with a ICC higher than 0.7 in the three studies.The selected features based on reproducibility were evaluated for lesion malignancy classification using a different database. Results show better performance compared to several state-of-the-art methods including Principal Component Analysis (PCA), Kernel Discriminant Analysis via QR decomposition (KDAQR), LASSO, and an own built Convolutional Neural Network. |
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Berlin; Alemanya; July 2019 |
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EMBC |
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IAM; 600.139; 600.145 |
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no |
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Admin @ si @ LTS2019 |
Serial |
3358 |
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Author |
Francesco Brughi; Debora Gil; Llorenç Badiella; Eva Jove Casabella; Oriol Ramos Terrades |
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Title |
Exploring the impact of inter-query variability on the performance of retrieval systems |
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Conference Article |
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2014 |
Publication |
11th International Conference on Image Analysis and Recognition |
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8814 |
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413–420 |
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This paper introduces a framework for evaluating the performance of information retrieval systems. Current evaluation metrics provide an average score that does not consider performance variability across the query set. In this manner, conclusions lack of any statistical significance, yielding poor inference to cases outside the query set and possibly unfair comparisons. We propose to apply statistical methods in order to obtain a more informative measure for problems in which different query classes can be identified. In this context, we assess the performance variability on two levels: overall variability across the whole query set and specific query class-related variability. To this end, we estimate confidence bands for precision-recall curves, and we apply ANOVA in order to assess the significance of the performance across different query classes. |
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Algarve; Portugal; October 2014 |
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Springer International Publishing |
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0302-9743 |
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978-3-319-11757-7 |
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ICIAR |
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IAM; DAG; 600.060; 600.061; 600.077; 600.075 |
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Admin @ si @ BGB2014 |
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2559 |
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Author |
Debora Gil; Aura Hernandez-Sabate; Mireia Burnat; Steven Jansen; Jordi Martinez-Vilalta |
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Title |
Structure-Preserving Smoothing of Biomedical Images |
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Conference Article |
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2009 |
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13th International Conference on Computer Analysis of Images and Patterns |
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5702 |
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427-434 |
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non-linear smoothing; differential geometry; anatomical structures segmentation; cardiac magnetic resonance; computerized tomography. |
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Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images. |
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Münster, Germany |
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Springer Berlin Heidelberg |
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0302-9743 |
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978-3-642-03766-5 |
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CAIP |
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IAM |
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IAM @ iam @ GHB2009 |
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1527 |
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Author |
Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate |
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Title |
Local Analysis of Confidence Measures for Optical Flow Quality Evaluation |
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Conference Article |
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2014 |
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9th International Conference on Computer Vision Theory and Applications |
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3 |
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450-457 |
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Optical Flow; Confidence Measure; Performance Evaluation. |
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Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance. |
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Lisboa; January 2014 |
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VISAPP |
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IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 |
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Admin @ si @ MGM2014 |
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2432 |
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Author |
Ernest Valveny; Enric Marti |
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Learning of structural descriptions of graphic symbols using deformable template matching |
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2001 |
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Proc. Sixth Int Document Analysis and Recognition Conf |
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455-459 |
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Accurate symbol recognition in graphic documents needs an accurate representation of the symbols to be recognized. If structural approaches are used for recognition, symbols have to be described in terms of their shape, using structural relationships among extracted features. Unlike statistical pattern recognition, in structural methods, symbols are usually manually defined from expertise knowledge, and not automatically infered from sample images. In this work we explain one approach to learn from examples a representative structural description of a symbol, thus providing better information about shape variability. The description of a symbol is based on a probabilistic model. It consists of a set of lines described by the mean and the variance of line parameters, respectively providing information about the model of the symbol, and its shape variability. The representation of each image in the sample set as a set of lines is achieved using deformable template matching. |
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DAG;IAM; |
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IAM @ iam @ VMA2001 |
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1654 |
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