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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Assessing agonist efficacy in an uncertain Em world |
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Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
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79 |
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The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Fairmont Banff Springs, Banff, Alberta, Canada |
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Keystone Symposia |
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Keystone Symposia |
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A. Christopoulus and M. Bouvier |
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english |
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english |
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Keystone Symposia |
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KSMCB |
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IAM |
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IAM @ iam @ RGG2012 |
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1855 |
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Author |
Aura Hernandez-Sabate; Debora Gil; Petia Radeva; E.N.Nofrerias |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Anisotropic processing of image structures for adventitia detection in intravascular ultrasound images |
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Conference Article |
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Year |
2004 |
Publication |
Proc. Computers in Cardiology |
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Volume |
31 |
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229-232 |
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The adventitia layer appears as a weak edge in IVUS images with a non-uniform grey level, which difficulties its detection. In order to enhance edges, we apply an anisotropic filter that homogenizes the grey level along the image significant structures (ridges, valleys and edges). A standard edge detector applied to the filtered image yields a set of candidate points prone to be unconnected. The final model is obtained by interpolating the former line segments along the tangent direction to the level curves of the filtered image with an anisotropic contour closing technique based on functional extension principles |
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Chicago (USA) |
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IAM; MILAB |
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IAM @ iam @ HGR2004 |
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1555 |
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Author |
Debora Gil; Petia Radeva; Fernando Vilariño |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Anisotropic Contour Completion |
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Conference Article |
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Year |
2003 |
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Proceedings of the IEEE International Conference on Image Processing |
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In this paper we introduce a novel application of the diffusion tensor for anisotropic image processing. The Anisotropic Contour Completion (ACC) we suggest consists in extending the characteristic function of the open curve by means of a degenerated diffusion tensor that prevents any diffusion in the normal direction. We show that ACC is equivalent to a dilation with a continuous elliptic structural element that takes into account the local orientation of the contours to be closed. Experiments on contours extracted from real images show that ACC produces shapes able to adapt to any curve in an active contour framework. 1. |
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Barcelona, Spain |
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0-7803-7751-6 |
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IAM;MV;MILAB;SIAI |
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IAM @ iam @ GRV2003 |
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1539 |
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Author |
Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Anatomical parameterization for volumetric meshing of the liver |
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Conference Article |
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Year |
2014 |
Publication |
SPIE – Medical Imaging |
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Volume |
9036 |
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Keywords |
Coordinate System; Anatomy Modeling; Parameterization |
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Abstract |
A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference. |
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Amsterdam; September 2014 |
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SPIE-MI |
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IAM; 600.075 |
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no |
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Call Number |
Admin @ si @ VGG2014 |
Serial |
2456 |
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Author |
Oriol Rodriguez-Leor; J. Mauri; Eduard Fernandez-Nofrerias; Vicente de Valle; E. Garcia; A. Barrios; Debora Gil; Petia Radeva |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
Analysis of the changes in angiography local grey-level values to determine myocardial perfusion |
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Conference Article |
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Year |
2006 |
Publication |
World Congress of Cardiology |
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Pages |
862 |
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Barcelona (Spain) |
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IAM;MILAB |
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no |
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IAM @ iam @ RMF2006 |
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1644 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
An inference model for analyzing termination conditions of Evolutionary Algorithms |
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Conference Article |
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Year |
2011 |
Publication |
14th Congrès Català en Intel·ligencia Artificial |
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216-225 |
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Evolutionary Computation Convergence, Termination Conditions, Statistical Inference |
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In real-world problems, it is mandatory to design a termination condition for Evolutionary Algorithms (EAs) ensuring stabilization close to the unknown optimum. Distribution-based quantities are good candidates as far as suitable parameters are used. A main limitation for application to real-world problems is that such parameters strongly depend on the topology of the objective function, as well as, the EA paradigm used.
We claim that the termination problem would be fully solved if we had a model measuring to what extent a distribution-based quantity asymptotically behaves like the solution accuracy. We present a regression-prediction model that relates any two given quantities and reports if they can be statistically swapped as termination conditions. Our framework is applied to two issues. First, exploring if the parameters involved in the computation of distribution-based quantities influence their asymptotic behavior. Second, to what extent existing distribution-based quantities can be asymptotically exchanged for the accuracy of the EA solution. |
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Lleida, Catalonia (Spain) |
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Associació Catalana Intel·ligència Artificial |
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978-1-60750-841-0 |
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CCIA |
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IAM |
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IAM @ iam @ RGG2011a |
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1677 |
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Author |
Aura Hernandez-Sabate; Monica Mitiko; Sergio Shiguemi; Debora Gil |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
A validation protocol for assessing cardiac phase retrieval in IntraVascular UltraSound |
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Conference Article |
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Year |
2010 |
Publication |
Computing in Cardiology |
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37 |
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899-902 |
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A good reliable approach to cardiac triggering is of utmost importance in obtaining accurate quantitative results of atherosclerotic plaque burden from the analysis of IntraVascular UltraSound. Although, in the last years, there has been an increase in research of methods for retrospective gating, there is no general consensus in a validation protocol. Many methods are based on quality assessment of longitudinal cuts appearance and those reporting quantitative numbers do not follow a standard protocol. Such heterogeneity in validation protocols makes faithful comparison across methods a difficult task. We propose a validation protocol based on the variability of the retrieved cardiac phase and explore the capability of several quality measures for quantifying such variability. An ideal detector, suitable for its application in clinical practice, should produce stable phases. That is, it should always sample the same cardiac cycle fraction. In this context, one should measure the variability (variance) of a candidate sampling with respect a ground truth (reference) sampling, since the variance would indicate how spread we are aiming a target. In order to quantify the deviation between the sampling and the ground truth, we have considered two quality scores reported in the literature: signed distance to the closest reference sample and distance to the right of each reference sample. We have also considered the residuals of the regression line of reference against candidate sampling. The performance of the measures has been explored on a set of synthetic samplings covering different cardiac cycle fractions and variabilities. From our simulations, we conclude that the metrics related to distances are sensitive to the shift considered while the residuals are robust against fraction and variabilities as far as one can establish a pair-wise correspondence between candidate and reference. We will further investigate the impact of false positive and negative detections in experimental data. |
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IEEE |
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0276-6547 |
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978-1-4244-7318-2 |
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CINC |
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IAM; |
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IAM @ iam @ HSM2010 |
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1551 |
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Author |
Debora Gil; Agnes Borras; Sergio Vera; Miguel Angel Gonzalez Ballester |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
A Validation Benchmark for Assessment of Medial Surface Quality for Medical Applications |
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Conference Article |
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Year |
2013 |
Publication |
9th International Conference on Computer Vision Systems |
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Volume |
7963 |
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334-343 |
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Medial Surfaces; Shape Representation; Medical Applications; Performance Evaluation |
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Confident use of medial surfaces in medical decision support systems requires evaluating their quality for detecting pathological deformations and describing anatomical volumes. Validation in the medical imaging field is a challenging task mainly due to the difficulties for getting consensual ground truth. In this paper we propose a validation benchmark for assessing medial surfaces in the context of medical applications. Our benchmark includes a home-made database of synthetic medial surfaces and volumes and specific scores for evaluating surface accuracy, its stability against volume deformations and its capabilities for accurate reconstruction of anatomical volumes. |
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Sant Petersburg; Russia; July 2013 |
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Springer Berlin Heidelberg |
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LNCS |
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0302-9743 |
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978-3-642-39401-0 |
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ICVS |
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IAM; 600.044; 600.060 |
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Admin @ si @ GBV2013 |
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2300 |
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Author |
Debora Gil; Jaume Garcia; Ruth Aris; Guillaume Houzeaux; Manuel Vazquez |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
A Riemmanian approach to cardiac fiber architecture modelling |
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Conference Article |
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2009 |
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1st International Conference on Mathematical & Computational Biomedical Engineering |
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59-62 |
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cardiac fiber architecture; diffusion tensor magnetic resonance imaging; differential (Rie- mannian) geometry. |
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There is general consensus that myocardial fiber architecture should be modelled in order to fully understand the electromechanical properties of the Left Ventricle (LV). Diffusion Tensor magnetic resonance Imaging (DTI) is the reference image modality for rapid measurement of fiber orientations by means of the tensor principal eigenvectors. In this work, we present a mathematical framework for across subject comparison of the local geometry of the LV anatomy including the fiber architecture from the statistical analysis of DTI studies. We use concepts of differential geometry for defining a parametric domain suitable for statistical analysis of a low number of samples. We use Riemannian metrics to define a consistent computation of DTI principal eigenvector modes of variation. Our framework has been applied to build an atlas of the LV fiber architecture from 7 DTI normal canine hearts. |
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Swansea (UK) |
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Nithiarasu, R.L.R.V.L. |
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CMBE |
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IAM |
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IAM @ iam @ FGA2009 |
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1520 |
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Author |
Guillermo Torres; Debora Gil; Antonio Rosell; Sonia Baeza; Carles Sanchez |
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Title ![sorted by Title field, descending order (down)](http://refbase.cvc.uab.es/img/sort_desc.gif) |
A radiomic biopsy for virtual histology of pulmonary nodules |
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Conference Article |
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2023 |
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IEEE International Symposium on Biomedical Imaging |
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Pòster |
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Cartagena de Indias; Colombia; April 2023 |
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ISBI |
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IAM |
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Admin @ si @ TGR2023b |
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3954 |
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