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Author |
Debora Gil; Aura Hernandez-Sabate; Mireia Brunat;Steven Jansen; Jordi Martinez-Vilalta |
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Title |
Structure-preserving smoothing of biomedical images |
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Journal Article |
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Year |
2011 |
Publication |
Pattern Recognition |
Abbreviated Journal |
PR |
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Volume |
44 |
Issue |
9 |
Pages |
1842-1851 |
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Keywords |
Non-linear smoothing; Differential geometry; Anatomical structures; segmentation; Cardiac magnetic resonance; Computerized tomography |
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Abstract |
Smoothing of biomedical images should preserve gray-level transitions between adjacent tissues, while restoring contours consistent with anatomical structures. Anisotropic diffusion operators are based on image appearance discontinuities (either local or contextual) and might fail at weak inter-tissue transitions. Meanwhile, the output of block-wise and morphological operations is prone to present a block structure due to the shape and size of the considered pixel neighborhood. In this contribution, we use differential geometry concepts to define a diffusion operator that restricts to image consistent level-sets. In this manner, the final state is a non-uniform intensity image presenting homogeneous inter-tissue transitions along anatomical structures, while smoothing intra-structure texture. Experiments on different types of medical images (magnetic resonance, computerized tomography) illustrate its benefit on a further process (such as segmentation) of images. |
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0031-3203 |
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IAM; ADAS |
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no |
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IAM @ iam @ GHB2011 |
Serial |
1526 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
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Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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0065-2598 |
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978-94-007-7422-3 |
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IAM; 600.075 |
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IAM @ iam @ RGG2014 |
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2197 |
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Author |
Enric Marti; Jordi Regincos;Jaime Lopez-Krahe; Juan J.Villanueva |
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Title |
Hand line drawing interpretation as three-dimensional objects |
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Journal Article |
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Year |
1993 |
Publication |
Signal Processing – Intelligent systems for signal and image understanding |
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Volume |
32 |
Issue |
1-2 |
Pages |
91-110 |
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Keywords |
Line drawing interpretation; line labelling; scene analysis; man-machine interaction; CAD input; line extraction |
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In this paper we present a technique to interpret hand line drawings as objects in a three-dimensional space. The object domain considered is based on planar surfaces with straight edges, concretely, on ansextension of Origami world to hidden lines. The line drawing represents the object under orthographic projection and it is sensed using a scanner. Our method is structured in two modules: feature extraction and feature interpretation. In the first one, image processing techniques are applied under certain tolerance margins to detect lines and junctions on the hand line drawing. Feature interpretation module is founded on line labelling techniques using a labelled junction dictionary. A labelling algorithm is here proposed. It uses relaxation techniques to reduce the number of incompatible labels with the junction dictionary so that the convergence of solutions can be accelerated. We formulate some labelling hypotheses tending to eliminate elements in two sets of labelled interpretations. That is, those which are compatible with the dictionary but do not correspond to three-dimensional objects and those which represent objects not very probable to be specified by means of a line drawing. New entities arise on the line drawing as a result of the extension of Origami world. These are defined to enunciate the assumptions of our method as well as to clarify the algorithms proposed. This technique is framed in a project aimed to implement a system to create 3D objects to improve man-machine interaction in CAD systems. |
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Elsevier North-Holland, Inc. |
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Amsterdam, The Netherlands, The Netherlands |
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0165-1684 |
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IAM;ISE; |
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no |
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IAM @ iam @ MRL1993 |
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1611 |
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Author |
Debora Gil; Petia Radeva |
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Title |
Inhibition of false landmarks |
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Journal Article |
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Year |
2006 |
Publication |
Pattern Recognition Letters |
Abbreviated Journal |
PRL |
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Volume |
27 |
Issue |
9 |
Pages |
1022-1030 |
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Corners and junctions are landmarks characterized by the lack of differentiability in the unit tangent to the image level curve. Detectors based on differential operators are not, by their own definition, the best posed as they require a higher degree of differentiability to yield a reliable response. We argue that a corner detector should be based on the degree of continuity of the tangent vector to the image level sets, work on the image domain and need no assumptions on neither the image local structure nor the particular geometry of the corner/junction. An operator measuring the degree of differentiability of the projection matrix on the image gradient fulfills the above requirements. Because using smoothing kernels leads to corner misplacement, we suggest an alternative fake response remover based on the receptive field inhibition of spurious details. The combination of both orientation discontinuity detection and noise inhibition produce our inhibition orientation energy (IOE) landmark locator. |
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Elsevier Science Inc. |
Place of Publication |
New York, NY, USA |
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0167-8655 |
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IAM;MILAB |
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no |
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Call Number |
IAM @ iam @ GiR2006 |
Serial |
1529 |
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Author |
Ernest Valveny; Enric Marti |
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Title |
A model for image generation and symbol recognition through the deformation of lineal shapes |
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Journal Article |
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Year |
2003 |
Publication |
Pattern Recognition Letters |
Abbreviated Journal |
PRL |
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Volume |
24 |
Issue |
15 |
Pages |
2857-2867 |
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We describe a general framework for the recognition of distorted images of lineal shapes, which relies on three items: a model to represent lineal shapes and their deformations, a model for the generation of distorted binary images and the combination of both models in a common probabilistic framework, where the generation of deformations is related to an internal energy, and the generation of binary images to an external energy. Then, recognition consists in the minimization of a global energy function, performed by using the EM algorithm. This general framework has been applied to the recognition of hand-drawn lineal symbols in graphic documents. |
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Elsevier Science Inc. |
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New York, NY, USA |
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0167-8655 |
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DAG; IAM |
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IAM @ iam @ VAM2003 |
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1653 |
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Author |
Oriol Pujol; Debora Gil; Petia Radeva |
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Title |
Fundamentals of Stop and Go active models |
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Journal Article |
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Year |
2005 |
Publication |
Image and Vision Computing |
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23 |
Issue |
8 |
Pages |
681-691 |
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Keywords |
Deformable models; Geodesic snakes; Region-based segmentation |
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An efficient snake formulation should conform to the idea of picking the smoothest curve among all the shapes approximating an object of interest. In current geodesic snakes, the regularizing curvature also affects the convergence stage, hindering the latter at concave regions. In the present work, we make use of characteristic functions to define a novel geodesic formulation that decouples regularity and convergence. This term decoupling endows the snake with higher adaptability to non-convex shapes. Convergence is ensured by splitting the definition of the external force into an attractive vector field and a repulsive one. In our paper, we propose to use likelihood maps as approximation of characteristic functions of object appearance. The better efficiency and accuracy of our decoupled scheme are illustrated in the particular case of feature space-based segmentation. |
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Butterworth-Heinemann |
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Newton, MA, USA |
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0262-8856 |
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IAM;MILAB;HuPBA |
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IAM @ iam @ PGR2005 |
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1629 |
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Author |
Jaume Garcia; David Rotger; Francesc Carreras; R.Leta; Petia Radeva |
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Title |
Contrast echography segmentation and tracking by trained deformable models |
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Conference Article |
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Year |
2003 |
Publication |
Proc. Computers in Cardiology |
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30 |
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173-176 |
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The objective of this work is to segment the human left ventricle myocardium (LVM) in contrast echocardiography imaging and thus track it along a cardiac cycle in order to extract quantitative data about heart function. Ultrasound images are hard to work with due to their speckle appearance. To overcome this we report the combination of active contour models (ACM) or snakes and active shape models (ASM). The ability of ACM in giving closed and smooth curves in addition to the power of the ASM in producing shapes similar to the ones learned, evoke to a robust algorithm. Meanwhile the snake is attracted towards image main features, ASM acts as a correction factor. The algorithm was tested independently on 180 frames and satisfying results were obtained: in 95% the maximum difference between automatic and experts segmentation was less than 12 pixels. |
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Centre de Visió per Computador – Dept. Informàtica, UAB Edifici O – Campus UAB, 08193 Bellater |
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0276-6547 |
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0-7803-8170-X |
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IAM;MILAB |
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IAM @ iam @ GRC2003 |
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1512 |
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Author |
Aura Hernandez-Sabate; Monica Mitiko; Sergio Shiguemi; Debora Gil |
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Title |
A validation protocol for assessing cardiac phase retrieval in IntraVascular UltraSound |
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Conference Article |
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2010 |
Publication |
Computing in Cardiology |
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37 |
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899-902 |
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A good reliable approach to cardiac triggering is of utmost importance in obtaining accurate quantitative results of atherosclerotic plaque burden from the analysis of IntraVascular UltraSound. Although, in the last years, there has been an increase in research of methods for retrospective gating, there is no general consensus in a validation protocol. Many methods are based on quality assessment of longitudinal cuts appearance and those reporting quantitative numbers do not follow a standard protocol. Such heterogeneity in validation protocols makes faithful comparison across methods a difficult task. We propose a validation protocol based on the variability of the retrieved cardiac phase and explore the capability of several quality measures for quantifying such variability. An ideal detector, suitable for its application in clinical practice, should produce stable phases. That is, it should always sample the same cardiac cycle fraction. In this context, one should measure the variability (variance) of a candidate sampling with respect a ground truth (reference) sampling, since the variance would indicate how spread we are aiming a target. In order to quantify the deviation between the sampling and the ground truth, we have considered two quality scores reported in the literature: signed distance to the closest reference sample and distance to the right of each reference sample. We have also considered the residuals of the regression line of reference against candidate sampling. The performance of the measures has been explored on a set of synthetic samplings covering different cardiac cycle fractions and variabilities. From our simulations, we conclude that the metrics related to distances are sensitive to the shift considered while the residuals are robust against fraction and variabilities as far as one can establish a pair-wise correspondence between candidate and reference. We will further investigate the impact of false positive and negative detections in experimental data. |
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IEEE |
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0276-6547 |
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978-1-4244-7318-2 |
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CINC |
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IAM; |
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IAM @ iam @ HSM2010 |
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1551 |
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Author |
Jaume Garcia; Debora Gil; Luis Badiella; Aura Hernandez-Sabate; Francesc Carreras; Sandra Pujades; Enric Marti |
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Title |
A Normalized Framework for the Design of Feature Spaces Assessing the Left Ventricular Function |
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Journal Article |
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Year |
2010 |
Publication |
IEEE Transactions on Medical Imaging |
Abbreviated Journal |
TMI |
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Volume |
29 |
Issue |
3 |
Pages |
733-745 |
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A through description of the left ventricle functionality requires combining complementary regional scores. A main limitation is the lack of multiparametric normality models oriented to the assessment of regional wall motion abnormalities (RWMA). This paper covers two main topics involved in RWMA assessment. We propose a general framework allowing the fusion and comparison across subjects of different regional scores. Our framework is used to explore which combination of regional scores (including 2-D motion and strains) is better suited for RWMA detection. Our statistical analysis indicates that for a proper (within interobserver variability) identification of RWMA, models should consider motion and extreme strains. |
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0278-0062 |
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IAM |
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IAM @ iam @ GGH2010b |
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1507 |
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Author |
Aura Hernandez-Sabate; Debora Gil;Eduard Fernandez-Nofrerias;Petia Radeva; Enric Marti |
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Title |
Approaching Artery Rigid Dynamics in IVUS |
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Journal Article |
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Year |
2009 |
Publication |
IEEE Transactions on Medical Imaging |
Abbreviated Journal |
TMI |
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28 |
Issue |
11 |
Pages |
1670-1680 |
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Fourier analysis; intravascular ultrasound (IVUS) dynamics; longitudinal motion; quality measures; tissue deformation. |
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Tissue biomechanical properties (like strain and stress) are playing an increasing role in diagnosis and long-term treatment of intravascular coronary diseases. Their assessment strongly relies on estimation of vessel wall deformation. Since intravascular ultrasound (IVUS) sequences allow visualizing vessel morphology and reflect its dynamics, this technique represents a useful tool for evaluation of tissue mechanical properties. Image misalignment introduced by vessel-catheter motion is a major artifact for a proper tracking of tissue deformation. In this work, we focus on compensating and assessing IVUS rigid in-plane motion due to heart beating. Motion parameters are computed by considering both the vessel geometry and its appearance in the image. Continuum mechanics laws serve to introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; whereas results in in vivo pullbacks show the reliability of the presented methodologies in clinical cases. |
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0278-0062 |
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IAM; MILAB |
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IAM @ iam @ HGF2009 |
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1545 |
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