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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
Type |
Book Chapter |
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Year  |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
Abbreviated Journal |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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ISSN |
0065-2598 |
ISBN |
978-94-007-7422-3 |
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IAM; 600.075 |
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no |
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Call Number |
IAM @ iam @ RGG2014 |
Serial |
2197 |
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Author |
Enric Marti; Antoni Gurgui; Debora Gil; Aura Hernandez-Sabate; Jaume Rocarias; Ferran Poveda |
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Title |
ABP on line: Seguimiento, estregas y evaluación en aprendizaje basado en proyectos |
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Miscellaneous |
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Year |
2014 |
Publication |
8th International Congress on University Teaching and Innovation |
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Address |
Tarragona; juliol 2014 |
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CIDUI |
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IAM; ADAS; 600.076; 600.063; 600.075 |
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Call Number |
Admin @ si @ MGG2014 |
Serial |
2457 |
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Author |
Francesco Brughi; Debora Gil; Llorenç Badiella; Eva Jove Casabella; Oriol Ramos Terrades |
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Title |
Exploring the impact of inter-query variability on the performance of retrieval systems |
Type |
Conference Article |
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Year |
2014 |
Publication |
11th International Conference on Image Analysis and Recognition |
Abbreviated Journal |
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Volume |
8814 |
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Pages |
413–420 |
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Abstract |
This paper introduces a framework for evaluating the performance of information retrieval systems. Current evaluation metrics provide an average score that does not consider performance variability across the query set. In this manner, conclusions lack of any statistical significance, yielding poor inference to cases outside the query set and possibly unfair comparisons. We propose to apply statistical methods in order to obtain a more informative measure for problems in which different query classes can be identified. In this context, we assess the performance variability on two levels: overall variability across the whole query set and specific query class-related variability. To this end, we estimate confidence bands for precision-recall curves, and we apply ANOVA in order to assess the significance of the performance across different query classes. |
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Algarve; Portugal; October 2014 |
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Springer International Publishing |
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0302-9743 |
ISBN |
978-3-319-11757-7 |
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ICIAR |
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IAM; DAG; 600.060; 600.061; 600.077; 600.075 |
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Admin @ si @ BGB2014 |
Serial |
2559 |
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Author |
Jorge Bernal; Debora Gil; Carles Sanchez; F. Javier Sanchez |
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Title |
Discarding Non Informative Regions for Efficient Colonoscopy Image Analysis |
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Conference Article |
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Year |
2014 |
Publication |
1st MICCAI Workshop on Computer-Assisted and Robotic Endoscopy |
Abbreviated Journal |
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Volume |
8899 |
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Pages |
1-10 |
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Keywords |
Image Segmentation; Polyps, Colonoscopy; Valley Information; Energy Maps |
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Abstract |
In this paper we present a novel polyp region segmentation method for colonoscopy videos. Our method uses valley information associated to polyp boundaries in order to provide an initial segmentation. This first segmentation is refined to eliminate boundary discontinuities caused by image artifacts or other elements of the scene. Experimental results over a publicly annotated database show that our method outperforms both general and specific segmentation methods by providing more accurate regions rich in polyp content. We also prove how image preprocessing is needed to improve final polyp region segmentation. |
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Boston; USA; September 2014 |
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Springer International Publishing |
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0302-9743 |
ISBN |
978-3-319-13409-3 |
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CARE |
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Notes |
MV; IAM; 600.044; 600.047; 600.060; 600.075 |
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Call Number |
Admin @ si @ BGS2014b |
Serial |
2503 |
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Author |
Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate |
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Title |
Local Analysis of Confidence Measures for Optical Flow Quality Evaluation |
Type |
Conference Article |
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Year |
2014 |
Publication |
9th International Conference on Computer Vision Theory and Applications |
Abbreviated Journal |
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Volume |
3 |
Issue |
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Pages |
450-457 |
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Keywords |
Optical Flow; Confidence Measure; Performance Evaluation. |
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Abstract |
Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance. |
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Address |
Lisboa; January 2014 |
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VISAPP |
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Notes |
IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 |
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no |
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Call Number |
Admin @ si @ MGM2014 |
Serial |
2432 |
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Author |
Patricia Marquez; H. Kause; A. Fuster; Aura Hernandez-Sabate; L. Florack; Debora Gil; Hans van Assen |
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Title |
Factors Affecting Optical Flow Performance in Tagging Magnetic Resonance Imaging |
Type |
Conference Article |
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Year |
2014 |
Publication |
17th International Conference on Medical Image Computing and Computer Assisted Intervention |
Abbreviated Journal |
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Volume |
8896 |
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Pages |
231-238 |
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Keywords |
Optical flow; Performance Evaluation; Synthetic Database; ANOVA; Tagging Magnetic Resonance Imaging |
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Abstract |
Changes in cardiac deformation patterns are correlated with cardiac pathologies. Deformation can be extracted from tagging Magnetic Resonance Imaging (tMRI) using Optical Flow (OF) techniques. For applications of OF in a clinical setting it is important to assess to what extent the performance of a particular OF method is stable across di erent clinical acquisition artifacts. This paper presents a statistical validation framework, based on ANOVA, to assess the motion and appearance factors that have the largest in uence on OF accuracy drop.
In order to validate this framework, we created a database of simulated tMRI data including the most common artifacts of MRI and test three di erent OF methods, including HARP. |
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Boston; USA; September 2014 |
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Springer International Publishing |
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0302-9743 |
ISBN |
978-3-319-14677-5 |
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STACOM |
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Notes |
IAM; ADAS; 600.060; 601.145; 600.076; 600.075 |
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no |
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Call Number |
Admin @ si @ MKF2014 |
Serial |
2495 |
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Author |
Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical parameterization for volumetric meshing of the liver |
Type |
Conference Article |
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Year |
2014 |
Publication |
SPIE – Medical Imaging |
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Volume |
9036 |
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Keywords |
Coordinate System; Anatomy Modeling; Parameterization |
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Abstract |
A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference. |
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Amsterdam; September 2014 |
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SPIE-MI |
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Notes |
IAM; 600.075 |
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no |
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Call Number |
Admin @ si @ VGG2014 |
Serial |
2456 |
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Author |
A. M. Here; B. C. Lopez; Debora Gil; J. J. Camarero; Jordi Martinez-Vilalta |
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Title |
A new software to analyse wood anatomical features in conifer species |
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Conference Article |
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Year |
2013 |
Publication |
International Symposium on Wood Structure in Plant Biology and Ecology |
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Abstract |
International Symposium on Wood Structure in Plant Biology and Ecology |
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Naples; Italy; March 2013 |
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WSE |
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IAM |
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no |
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Call Number |
Admin @ si @ HLG2013 |
Serial |
2303 |
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Author |
Carles Sanchez; Debora Gil; Antoni Rosell; Albert Andaluz; F. Javier Sanchez |
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Title |
Segmentation of Tracheal Rings in Videobronchoscopy combining Geometry and Appearance |
Type |
Conference Article |
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Year |
2013 |
Publication |
Proceedings of the International Conference on Computer Vision Theory and Applications |
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1 |
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153--161 |
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Video-bronchoscopy, tracheal ring segmentation, trachea geometric and appearance model |
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Abstract |
Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways and minimal invasive interventions. Tracheal procedures are ordinary interventions that require measurement of the percentage of obstructed pathway for injury (stenosis) assessment. Visual assessment of stenosis in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error. Accurate detection of tracheal rings is the basis for automated estimation of the size of stenosed trachea. Processing of videobronchoscopic images acquired at the operating room is a challenging task due to the wide range of artifacts and acquisition conditions. We present a model of the geometric-appearance of tracheal rings for its detection in videobronchoscopic videos. Experiments on sequences acquired at the operating room, show a performance close to inter-observer variability |
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Address |
Barcelona; February 2013 |
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SciTePress |
Place of Publication |
Portugal |
Editor |
Sebastiano Battiato and José Braz |
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LNCS |
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978-989-8565-47-1 |
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800 |
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VISAPP |
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IAM;MV; 600.044; 600.047; 600.060; 605.203 |
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IAM @ iam @ SGR2013 |
Serial |
2123 |
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Author |
Carles Sanchez; Jorge Bernal; Debora Gil; F. Javier Sanchez |
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Title |
On-line lumen centre detection in gastrointestinal and respiratory endoscopy |
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Conference Article |
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Year |
2013 |
Publication |
Second International Workshop Clinical Image-Based Procedures |
Abbreviated Journal |
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8361 |
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31-38 |
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Lumen centre detection; Bronchoscopy; Colonoscopy |
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We present in this paper a novel lumen centre detection for gastrointestinal and respiratory endoscopic images. The proposed method is based on the appearance and geometry of the lumen, which we defined as the darkest image region which centre is a hub of image gradients. Experimental results validated on the first public annotated gastro-respiratory database prove the reliability of the method for a wide range of images (with precision over 95 %). |
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Nagoya; Japan; September 2013 |
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Springer International Publishing |
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Editor |
Erdt, Marius and Linguraru, Marius George and Oyarzun Laura, Cristina and Shekhar, Raj and Wesarg, Stefan and González Ballester, Miguel Angel and Drechsler, Klaus |
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LNCS |
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978-3-319-05665-4 |
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800 |
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CLIP |
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MV; IAM; 600.047; 600.044; 600.060 |
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Admin @ si @ SBG2013 |
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2302 |
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