Abstract: This work addresses the detection of Helicobacter pylori a bacterium classified since 1994 as class 1 carcinogen to humans. By its highest specificity and sensitivity, the preferred diagnosis technique is the analysis of histological images with immunohistochemical staining, a process in which certain stained antibodies bind to antigens of the biological element of interest. This analysis is a time demanding task, which is currently done by an expert pathologist that visually inspects the digitized samples.
We propose to use autoencoders to learn latent patterns of healthy tissue and detect H. pylori as an anomaly in image staining. Unlike existing classification approaches, an autoencoder is able to learn patterns in an unsupervised manner (without the need of image annotations) with high performance. In particular, our model has an overall 91% of accuracy with 86\% sensitivity, 96% specificity and 0.97 AUC in the detection of H. pylori.

Abstract: Vision-based bronchoscopy (VB) models require the registration of the virtual lung model with the frames from the video bronchoscopy to provide effective guidance during the biopsy. The registration can be achieved by either tracking the position and orientation of the bronchoscopy camera or by calibrating its deviation from the pose (position and orientation) simulated in the virtual lung model. Recent advances in neural networks and temporal image processing have provided new opportunities for guided bronchoscopy. However, such progress has been hindered by the lack of comparative experimental conditions.
In the present paper, we share a novel synthetic dataset allowing for a fair comparison of methods. Moreover, this paper investigates several neural network architectures for the learning of temporal information at different levels of subject personalization. In order to improve orientation measurement, we also present a standardized comparison framework and a novel metric for camera orientation learning. Results on the dataset show that the proposed metric and architectures, as well as the standardized conditions, provide notable improvements to current state-of-the-art camera pose estimation in video bronchoscopy.

Abstract: Domain Adaptation (DA) has recently raised strong interests in the medical imaging community. While a large variety of DA techniques has been proposed for image segmentation, most of these techniques have been validated either on private datasets or on small publicly available datasets. Moreover, these datasets mostly addressed single-class problems. To tackle these limitations, the Cross-Modality Domain Adaptation (crossMoDA) challenge was organised in conjunction with the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2021). CrossMoDA is the first large and multi-class benchmark for unsupervised cross-modality DA. The challenge's goal is to segment two key brain structures involved in the follow-up and treatment planning of vestibular schwannoma (VS): the VS and the cochleas. Currently, the diagnosis and surveillance in patients with VS are performed using contrast-enhanced T1 (ceT1) MRI. However, there is growing interest in using non-contrast sequences such as high-resolution T2 (hrT2) MRI. Therefore, we created an unsupervised cross-modality segmentation benchmark. The training set provides annotated ceT1 (N=105) and unpaired non-annotated hrT2 (N=105). The aim was to automatically perform unilateral VS and bilateral cochlea segmentation on hrT2 as provided in the testing set (N=137). A total of 16 teams submitted their algorithm for the evaluation phase. The level of performance reached by the top-performing teams is strikingly high (best median Dice – VS:88.4%; Cochleas:85.7%) and close to full supervision (median Dice – VS:92.5%; Cochleas:87.7%). All top-performing methods made use of an image-to-image translation approach to transform the source-domain images into pseudo-target-domain images. A segmentation network was then trained using these generated images and the manual annotations provided for the source image.

Abstract: During recent years, there here has been a boom in terms of deep learning use for handwriting analysis and recognition. One main application for handwriting analysis is early detection and diagnosis in the health field. Unfortunately, most real case problems still suffer a scarcity of data, which makes difficult the use of deep learning-based models. To alleviate this problem, some works resort to synthetic data generation. Lately, more works are directed towards guided data synthetic generation, a generation that uses the domain and data knowledge to generate realistic data that can be useful to train deep learning models. In this work, we combine the domain knowledge about the Alzheimer’s disease for handwriting and use it for a more guided data generation. Concretely, we have explored the use of in-air movements for synthetic data generation.

Abstract: Transformer models have shown great success handling long-range interactions, making them a promising tool for modeling video. However, they lack inductive biases and scale quadratically with input length. These limitations are further exacerbated when dealing with the high dimensionality introduced by the temporal dimension. While there are surveys analyzing the advances of Transformers for vision, none focus on an in-depth analysis of video-specific designs. In this survey, we analyze the main contributions and trends of works leveraging Transformers to model video. Specifically, we delve into how videos are handled at the input level first. Then, we study the architectural changes made to deal with video more efficiently, reduce redundancy, re-introduce useful inductive biases, and capture long-term temporal dynamics. In addition, we provide an overview of different training regimes and explore effective self-supervised learning strategies for video. Finally, we conduct a performance comparison on the most common benchmark for Video Transformers (i.e., action classification), finding them to outperform 3D ConvNets even with less computational complexity.

Abstract: Multimodal learning from document data has achieved great success lately as it allows to pre-train semantically meaningful features as a prior into a learnable downstream approach. In this paper, we approach the document classification problem by learning cross-modal representations through language and vision cues, considering intra- and inter-modality relationships. Instead of merging features from different modalities into a common representation space, the proposed method exploits high-level interactions and learns relevant semantic information from effective attention flows within and across modalities. The proposed learning objective is devised between intra- and inter-modality alignment tasks, where the similarity distribution per task is computed by contracting positive sample pairs while simultaneously contrasting negative ones in the common feature representation space}. Extensive experiments on public document classification datasets demonstrate the effectiveness and the generalization capacity of our model on both low-scale and large-scale datasets.

Abstract: Existing work on DocVQA only considers single-page documents. However, in real applications documents are mostly composed of multiple pages that should be processed altogether. In this work, we propose a new multimodal hierarchical method Hi-VT5, that overcomes the limitations of current methods to process long multipage documents. In contrast to previous hierarchical methods that focus on different semantic granularity (He et al., 2021) or different subtasks (Zhou et al., 2022) used in image classification. Our method is a hierarchical transformer architecture where the encoder learns to summarize the most relevant information of every page and then, the decoder uses this summarized representation to generate the final answer, following a bottom-up approach. Moreover, due to the lack of multipage DocVQA datasets, we also introduce MP-DocVQA, an extension of SP-DocVQA where questions are posed over multipage documents instead of single pages. Through extensive experimentation, we demonstrate that Hi-VT5 is able, in a single stage, to answer the questions and provide the page that contains the answer, which can be used as a kind of explainability measure.