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David Roche, Debora Gil, & Jesus Giraldo. (2012). "Assessing agonist efficacy in an uncertain Em world " In A. Christopoulus and M. Bouvier (Ed.), 40th Keystone Symposia on mollecular and celular biology (79). Keystone Symposia.
Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
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Albert Andaluz, Francesc Carreras, Cristina Santa Marta, & Debora Gil. (2012). "Myocardial torsion estimation with Tagged-MRI in the OsiriX platform " In Wiro Niessen(Erasmus MC) and Marc Modat(UCL) (Ed.), ISBI Workshop on Open Source Medical Image Analysis software. IEEE.
Abstract: Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es
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Patricia Marquez, Debora Gil, & Aura Hernandez-Sabate. (2013). "Evaluation of the Capabilities of Confidence Measures for Assessing Optical Flow Quality " In ICCV Workshop on Computer Vision in Vehicle Technology: From Earth to Mars (pp. 624–631).
Abstract: Assessing Optical Flow (OF) quality is essential for its further use in reliable decision support systems. The absence of ground truth in such situations leads to the computation of OF Confidence Measures (CM) obtained from either input or output data. A fair comparison across the capabilities of the different CM for bounding OF error is required in order to choose the best OF-CM pair for discarding points where OF computation is not reliable. This paper presents a statistical probabilistic framework for assessing the quality of a given CM. Our quality measure is given in terms of the percentage of pixels whose OF error bound can not be determined by CM values. We also provide statistical tools for the computation of CM values that ensures a given accuracy of the flow field.
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A. M. Here, B. C. Lopez, Debora Gil, J. J. Camarero, & Jordi Martinez-Vilalta. (2013). "A new software to analyse wood anatomical features in conifer species " In International Symposium on Wood Structure in Plant Biology and Ecology.
Abstract: International Symposium on Wood Structure in Plant Biology and Ecology
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Sergio Vera, Miguel Angel Gonzalez Ballester, & Debora Gil. (2013). "Volumetric Anatomical Parameterization and Meshing for Inter-patient Liver Coordinate System Deffinition " In 16th International Conference on Medical Image Computing and Computer Assisted Intervention.
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Carles Sanchez, Jorge Bernal, Debora Gil, & F. Javier Sanchez. (2013). "On-line lumen centre detection in gastrointestinal and respiratory endoscopy " In Klaus Miguel Angel and Drechsler Stefan and González Ballester Raj and Wesarg Cristina and Shekhar Marius George and Oyarzun Laura M. and L. Erdt (Ed.), Second International Workshop Clinical Image-Based Procedures (Vol. 8361, pp. 31–38). Springer International Publishing.
Abstract: We present in this paper a novel lumen centre detection for gastrointestinal and respiratory endoscopic images. The proposed method is based on the appearance and geometry of the lumen, which we defined as the darkest image region which centre is a hub of image gradients. Experimental results validated on the first public annotated gastro-respiratory database prove the reliability of the method for a wide range of images (with precision over 95 %).
Keywords: Lumen centre detection; Bronchoscopy; Colonoscopy
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David Roche, Debora Gil, & Jesus Giraldo. (2013). "Detecting loss of diversity for an efficient termination of EAs " In 15th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing (pp. 561–566).
Abstract: Termination of Evolutionary Algorithms (EA) at its steady state so that useless iterations are not performed is a main point for its efficient application to black-box problems. Many EA algorithms evolve while there is still diversity in their population and, thus, they could be terminated by analyzing the behavior some measures of EA population diversity. This paper presents a numeric approximation to steady states that can be used to detect the moment EA population has lost its diversity for EA termination. Our condition has been applied to 3 EA paradigms based on diversity and a selection of functions
covering the properties most relevant for EA convergence.
Experiments show that our condition works regardless of the search space dimension and function landscape.
Keywords: EA termination; EA population diversity; EA steady state
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Patricia Marquez, Debora Gil, & Aura Hernandez-Sabate. (2012). "A Complete Confidence Framework for Optical Flow " In Rita Cucchiara V. M. Andrea Fusiello (Ed.), 12th European Conference on Computer Vision – Workshops and Demonstrations (Vol. 7584, pp. 124–133). Florence, Italy, October 7-13, 2012: Springer-Verlag.
Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.
Keywords: Optical flow, confidence measures, sparsification plots, error prediction plots
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Sergio Vera, Debora Gil, Agnes Borras, F. Javier Sanchez, Frederic Perez, & Marius G. Linguraru. (2011)." Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs" In In H. Yoshida et al (Ed.), Workshop on Computational and Clinical Applications in Abdominal Imaging (Vol. 7029, pp. 223–230). Springer Berlin Heidelberg.
Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.
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Carles Sanchez, Debora Gil, Antoni Rosell, Albert Andaluz, & F. Javier Sanchez. (2013). "Segmentation of Tracheal Rings in Videobronchoscopy combining Geometry and Appearance " In Sebastiano Battiato and José Braz (Ed.), Proceedings of the International Conference on Computer Vision Theory and Applications (Vol. 1, pp. 153–161). Portugal: SciTePress.
Abstract: Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways and minimal invasive interventions. Tracheal procedures are ordinary interventions that require measurement of the percentage of obstructed pathway for injury (stenosis) assessment. Visual assessment of stenosis in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error. Accurate detection of tracheal rings is the basis for automated estimation of the size of stenosed trachea. Processing of videobronchoscopic images acquired at the operating room is a challenging task due to the wide range of artifacts and acquisition conditions. We present a model of the geometric-appearance of tracheal rings for its detection in videobronchoscopic videos. Experiments on sequences acquired at the operating room, show a performance close to inter-observer variability
Keywords: Video-bronchoscopy, tracheal ring segmentation, trachea geometric and appearance model
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