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Author David Roche; Debora Gil; Jesus Giraldo edit   pdf
url  openurl
  Title Assessing agonist efficacy in an uncertain Em world Type Conference Article
  Year 2012 Publication 40th Keystone Symposia on mollecular and celular biology Abbreviated Journal  
  Volume Issue Pages 79  
  Keywords  
  Abstract The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
 
  Address Fairmont Banff Springs, Banff, Alberta, Canada  
  Corporate Author Keystone Symposia Thesis  
  Publisher Keystone Symposia Place of Publication Editor A. Christopoulus and M. Bouvier  
  Language english Summary Language english Original Title  
  Series Editor Keystone Symposia Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference KSMCB  
  Notes IAM Approved no  
  Call Number IAM @ iam @ RGG2012 Serial (up) 1855  
Permanent link to this record
 

 
Author Patricia Marquez; Debora Gil ; Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title Error Analysis for Lucas-Kanade Based Schemes Type Conference Article
  Year 2012 Publication 9th International Conference on Image Analysis and Recognition Abbreviated Journal  
  Volume 7324 Issue I Pages 184-191  
  Keywords Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance  
  Abstract Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures.  
  Address Aveiro, Portugal  
  Corporate Author Thesis  
  Publisher Springer-Verlag Berlin Heidelberg Place of Publication Editor  
  Language english Summary Language Original Title  
  Series Editor Campilho, Aurélio and Kamel, Mohamed Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-31294-6 Medium  
  Area Expedition Conference ICIAR  
  Notes IAM Approved no  
  Call Number IAM @ iam @ MGH2012a Serial (up) 1899  
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Author Albert Andaluz; Francesc Carreras; Cristina Santa Marta;Debora Gil edit   pdf
url  openurl
  Title Myocardial torsion estimation with Tagged-MRI in the OsiriX platform Type Conference Article
  Year 2012 Publication ISBI Workshop on Open Source Medical Image Analysis software Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es
 
  Address Barcelona, Spain  
  Corporate Author Thesis  
  Publisher IEEE Place of Publication Editor Wiro Niessen (Erasmus MC) and Marc Modat (UCL)  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number IAM @ iam @ ACS2012 Serial (up) 1900  
Permanent link to this record
 

 
Author Ferran Poveda; Debora Gil;Enric Marti edit   pdf
doi  isbn
openurl 
  Title Multi-resolution DT-MRI cardiac tractography Type Conference Article
  Year 2012 Publication Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges Abbreviated Journal  
  Volume 7746 Issue Pages 270-277  
  Keywords  
  Abstract Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture.  
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-36960-5 Medium  
  Area Expedition Conference STACOM  
  Notes IAM Approved no  
  Call Number IAM @ iam @ PGM2012 Serial (up) 1986  
Permanent link to this record
 

 
Author Debora Gil;Agnes Borras;Ruth Aris;Mariano Vazquez;Pierre Lafortune; Guillame Houzeaux edit   pdf
doi  isbn
openurl 
  Title What a difference in biomechanics cardiac fiber makes Type Conference Article
  Year 2012 Publication Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges Abbreviated Journal  
  Volume 7746 Issue Pages 253-260  
  Keywords  
  Abstract Computational simulations of the heart are a powerful tool for a comprehensive understanding of cardiac function and its intrinsic relationship with its muscular architecture. Cardiac biomechanical models require a vector field representing the orientation of cardiac fibers. A wrong orientation of the fibers can lead to a
non-realistic simulation of the heart functionality. In this paper we explore the impact of the fiber information on the simulated biomechanics of cardiac muscular anatomy. We have used the John Hopkins database to perform a biomechanical simulation using both a synthetic benchmark fiber distribution and the data obtained experimentally from DTI. Results illustrate how differences in fiber orientation affect heart deformation along cardiac cycle.
 
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-36960-5 Medium  
  Area Expedition Conference STACOM  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GBA2012 Serial (up) 1987  
Permanent link to this record
 

 
Author Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil edit   pdf
doi  isbn
openurl 
  Title A medial map capturing the essential geometry of organs Type Conference Article
  Year 2012 Publication ISBI Workshop on Open Source Medical Image Analysis software Abbreviated Journal  
  Volume Issue Pages 1691 - 1694  
  Keywords Medial Surface Representation, Volume Reconstruction,Geometry , Image reconstruction , Liver , Manifolds , Shape , Surface morphology , Surface reconstruction  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Accurate computation of one pixel wide medial surfaces is mandatory. Those surfaces must represent faithfully the geometry of the volume. Although morphological methods produce excellent results in 2D, their complexity and quality drops across dimensions, due to a more complex description of pixel neighborhoods. This paper introduces a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. Our experiments show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume  
  Address Barcelona,Spain  
  Corporate Author Thesis  
  Publisher IEEE Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1945-7928 ISBN 978-1-4577-1857-1 Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number IAM @ iam @ VGG2012a Serial (up) 1989  
Permanent link to this record
 

 
Author Patricia Marquez;Debora Gil;Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title A Complete Confidence Framework for Optical Flow Type Conference Article
  Year 2012 Publication 12th European Conference on Computer Vision – Workshops and Demonstrations Abbreviated Journal  
  Volume 7584 Issue 2 Pages 124-133  
  Keywords Optical flow, confidence measures, sparsification plots, error prediction plots  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.  
  Address  
  Corporate Author Thesis  
  Publisher Springer-Verlag Place of Publication Florence, Italy, October 7-13, 2012 Editor Andrea Fusiello, Vittorio Murino ,Rita Cucchiara  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-642-33867-0 Medium  
  Area Expedition Conference ECCVW  
  Notes IAM;ADAS; Approved no  
  Call Number IAM @ iam @ MGH2012b Serial (up) 1991  
Permanent link to this record
 

 
Author Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru edit  openurl
  Title Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs Type Conference Article
  Year 2011 Publication Workshop on Computational and Clinical Applications in Abdominal Imaging Abbreviated Journal  
  Volume 7029 Issue Pages 223-230  
  Keywords  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.  
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor In H. Yoshida et al  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ABDI  
  Notes IAM; MV Approved no  
  Call Number VGB2011 Serial (up) 2036  
Permanent link to this record
 

 
Author Carles Sanchez; Debora Gil; Antoni Rosell; Albert Andaluz; F. Javier Sanchez edit   pdf
isbn  openurl
  Title Segmentation of Tracheal Rings in Videobronchoscopy combining Geometry and Appearance Type Conference Article
  Year 2013 Publication Proceedings of the International Conference on Computer Vision Theory and Applications Abbreviated Journal  
  Volume 1 Issue Pages 153--161  
  Keywords Video-bronchoscopy, tracheal ring segmentation, trachea geometric and appearance model  
  Abstract Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways and minimal invasive interventions. Tracheal procedures are ordinary interventions that require measurement of the percentage of obstructed pathway for injury (stenosis) assessment. Visual assessment of stenosis in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error. Accurate detection of tracheal rings is the basis for automated estimation of the size of stenosed trachea. Processing of videobronchoscopic images acquired at the operating room is a challenging task due to the wide range of artifacts and acquisition conditions. We present a model of the geometric-appearance of tracheal rings for its detection in videobronchoscopic videos. Experiments on sequences acquired at the operating room, show a performance close to inter-observer variability  
  Address Barcelona; February 2013  
  Corporate Author Thesis  
  Publisher SciTePress Place of Publication Portugal Editor Sebastiano Battiato and José Braz  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-989-8565-47-1 Medium  
  Area 800 Expedition Conference VISAPP  
  Notes IAM;MV; 600.044; 600.047; 600.060; 605.203 Approved no  
  Call Number IAM @ iam @ SGR2013 Serial (up) 2123  
Permanent link to this record
 

 
Author Joan M. Nuñez; Debora Gil; Fernando Vilariño edit  doi
openurl 
  Title Finger joint characterization from X-ray images for rheymatoid arthritis assessment Type Conference Article
  Year 2013 Publication 6th International Conference on Biomedical Electronics and Devices Abbreviated Journal  
  Volume Issue Pages 288-292  
  Keywords Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde  
  Abstract In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection.  
  Address Barcelona; February 2013  
  Corporate Author Thesis  
  Publisher SciTePress Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area 800 Expedition Conference BIODEVICES  
  Notes IAM;MV; 600.057; 600.054;SIAI Approved no  
  Call Number IAM @ iam @ NGV2013 Serial (up) 2196  
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