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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
isbn  openurl
  Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
  Year (down) 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal  
  Volume 796 Issue 3 Pages 159-181  
  Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model  
  Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0065-2598 ISBN 978-94-007-7422-3 Medium  
  Area Expedition Conference  
  Notes IAM; 600.075 Approved no  
  Call Number IAM @ iam @ RGG2014 Serial 2197  
Permanent link to this record
 

 
Author Ferran Poveda edit  openurl
  Title Computer Graphics and Vision Techniques for the Study of the Muscular Fiber Architecture of the Myocardium Type Book Whole
  Year (down) 2013 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis Ph.D. thesis  
  Publisher Place of Publication Editor Debora Gil;Enric Marti  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number Admin @ si @ Pov2013 Serial 2417  
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Author Aura Hernandez-Sabate; Debora Gil edit   pdf
url  doi
isbn  openurl
  Title The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries Type Book Chapter
  Year (down) 2012 Publication Intravascular Ultrasound Abbreviated Journal  
  Volume Issue Pages 185-206  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis  
  Publisher Intech Place of Publication Editor Yasuhiro Honda  
  Language English Summary Language english Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-953-307-900-4 Medium  
  Area Expedition Conference  
  Notes IAM; ADAS Approved no  
  Call Number IAM @ iam @ HeG2012 Serial 1684  
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Author Carles Sanchez;F. Javier Sanchez; Antoni Rosell; Debora Gil edit   pdf
url  doi
isbn  openurl
  Title An illumination model of the trachea appearance in videobronchoscopy images Type Book Chapter
  Year (down) 2012 Publication Image Analysis and Recognition Abbreviated Journal LNCS  
  Volume 7325 Issue Pages 313-320  
  Keywords Bronchoscopy, tracheal ring, stenosis assesment, trachea appearance model, segmentation  
  Abstract Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways. This imaging modality provides realistic images and allows non-invasive minimal intervention procedures. Tracheal procedures are routinary interventions that require assessment of the percentage of obstructed pathway for injury (stenosis) detection. Visual assessment in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error.
This paper introduces an automatic method for the estimation of steneosed trachea percentage reduction in videobronchoscopic images. We look for tracheal rings , whose deformation determines the degree of obstruction. For ring extraction , we present a ring detector based on an illumination and appearance model. This model allows us to parametrise the ring detection. Finally, we can infer optimal estimation parameters for any video resolution.
 
  Address Aveiro, Portugal  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-31297-7 Medium  
  Area 800 Expedition Conference ICIAR  
  Notes MV;IAM Approved no  
  Call Number IAM @ iam @ SSR2012 Serial 1898  
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Author Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru; Miguel Angel Gonzalez Ballester edit   pdf
doi  isbn
openurl 
  Title Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs Type Book Chapter
  Year (down) 2012 Publication Workshop on Computational and Clinical Applications in Abdominal Imaging Abbreviated Journal  
  Volume 7029 Issue Pages 223–230  
  Keywords medial manifolds, abdomen.  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.
 
  Address Toronto; Canada;  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Berlin Editor H. Yoshida et al  
  Language English Summary Language English Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-28556-1 Medium  
  Area Expedition Conference ABDI  
  Notes IAM;MV Approved no  
  Call Number IAM @ iam @ VGB2012 Serial 1834  
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Author Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil edit   pdf
url  doi
isbn  openurl
  Title Optimal Medial Surface Generation for Anatomical Volume Representations Type Book Chapter
  Year (down) 2012 Publication Abdominal Imaging. Computational and Clinical Applications Abbreviated Journal LNCS  
  Volume 7601 Issue Pages 265-273  
  Keywords Medial surface representation; volume reconstruction  
  Abstract Medial representations are a widely used technique in abdominal organ shape representation and parametrization. Those methods require good medial manifolds as a starting point. Any medial
surface used to parametrize a volume should be simple enough to allow an easy manipulation and complete enough to allow an accurate reconstruction of the volume. Obtaining good quality medial
surfaces is still a problem with current iterative thinning methods. This forces the usage of generic, pre-calculated medial templates that are adapted to the final shape at the cost of a drop in volume reconstruction.
This paper describes an operator for generation of medial structures that generates clean and complete manifolds well suited for their further use in medial representations of abdominal organ volumes. While being simpler than thinning surfaces, experiments show its high performance in volume reconstruction and preservation of medial surface main branching topology.
 
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor Yoshida, Hiroyuki and Hawkes, David and Vannier, MichaelW.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-33611-9 Medium  
  Area Expedition Conference STACOM  
  Notes IAM Approved no  
  Call Number IAM @ iam @ VGG2012b Serial 1988  
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Author Jaume Garcia; Debora Gil; Aura Hernandez-Sabate edit   pdf
doi  openurl
  Title Endowing Canonical Geometries to Cardiac Structures Type Book Chapter
  Year (down) 2010 Publication Statistical Atlases And Computational Models Of The Heart Abbreviated Journal  
  Volume 6364 Issue Pages 124-133  
  Keywords  
  Abstract International conference on Cardiac electrophysiological simulation challenge
In this paper, we show that canonical (shape-based) geometries can be endowed to cardiac structures using tubular coordinates defined over their medial axis. We give an analytic formulation of these geometries by means of B-Splines. Since B-Splines present vector space structure PCA can be applied to their control points and statistical models relating boundaries and the interior of the anatomical structures can be derived. We demonstrate the applicability in two cardiac structures, the 3D Left Ventricular volume, and the 2D Left-Right ventricle set in 2D Short Axis view.
 
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin / Heidelberg Place of Publication Editor Camara, O.; Pop, M.; Rhode, K.; Sermesant, M.; Smith, N.; Young, A.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GGH2010b Serial 1515  
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Author Aura Hernandez-Sabate edit   pdf
isbn  openurl
  Title Exploring Arterial Dynamics and Structures in IntraVascular Ultrasound Sequences Type Book Whole
  Year (down) 2009 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Cardiovascular diseases are a leading cause of death in developed countries. Most of them are caused by arterial (specially coronary) diseases, mainly caused by plaque accumulation. Such pathology narrows blood flow (stenosis) and affects artery bio- mechanical elastic properties (atherosclerosis). In the last decades, IntraVascular UltraSound (IVUS) has become a usual imaging technique for the diagnosis and follow up of arterial diseases. IVUS is a catheter-based imaging technique which shows a sequence of cross sections of the artery under study. Inspection of a single image gives information about the percentage of stenosis. Meanwhile, inspection of longitudinal views provides information about artery bio-mechanical properties, which can prevent a fatal outcome of the cardiovascular disease. On one hand, dynamics of arteries (due to heart pumping among others) is a major artifact for exploring tissue bio-mechanical properties. On the other one, manual stenosis measurements require a manual tracing of vessel borders, which is a time-consuming task and might suffer from inter-observer variations. This PhD thesis proposes several image processing tools for exploring vessel dy- namics and structures. We present a physics-based model to extract, analyze and correct vessel in-plane rigid dynamics and to retrieve cardiac phase. Furthermore, we introduce a deterministic-statistical method for automatic vessel borders detection. In particular, we address adventitia layer segmentation. An accurate validation pro- tocol to ensure reliable clinical applicability of the methods is a crucial step in any proposal of an algorithm. In this thesis we take special care in designing a valida- tion protocol for each approach proposed and we contribute to the in vivo dynamics validation with a quantitative and objective score to measure the amount of motion suppressed.  
  Address  
  Corporate Author Thesis Ph.D. thesis  
  Publisher Ediciones Graficas Rey Place of Publication Editor Debora Gil  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-84-937261-6-4 Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ Her2009 Serial 1543  
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Author Jaume Garcia edit   pdf
openurl 
  Title Statistical Models of the Architecture and Function of the Left Ventricle Type Book Whole
  Year (down) 2009 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract Cardiovascular Diseases, specially those affecting the Left Ventricle (LV), are the leading cause of death in developed countries with approximately a 30% of all global deaths. In order to address this public health concern, physicians focus on diagnosis and therapy planning. On one hand, early and accurate detection of Regional Wall Motion Abnormalities (RWMA) significantly contributes to a quick diagnosis and prevents the patient to reach more severe stages. On the other hand, a thouroughly knowledge of the normal gross anatomy of the LV, as well as, the distribution of its muscular fibers is crucial for designing specific interventions and therapies (such as pacemaker implanction). Statistical models obtained from the analysis of different imaging modalities allow the computation of the normal ranges of variation within a given population. Normality models are a valuable tool for the definition of objective criterions quantifying the degree of (anomalous) deviation of the LV function and anatomy for a given subject. The creation of statistical models involve addressing three main issues: extraction of data from images, definition of a common domain for comparison of data across patients and designing appropriate statistical analysis schemes. In this PhD thesis we present generic image processing tools for the creation of statistical models of the LV anatomy and function. On one hand, we use differential geometry concepts to define a computational framework (the Normalized Parametric Domain, NPD) suitable for the comparison and fusion of several clinical scores obtained over the LV. On the other hand, we present a variational approach (the Harmonic Phase Flow, HPF) for the estimation of myocardial motion that provides dense and continuous vector fields without overestimating motion at injured areas. These tools are used for the creation of statistical models. Regarding anatomy, we obtain an atlas jointly modelling, both, LV gross anatomy and fiber architecture. Regarding function, we compute normality patterns of scores characterizing the (global and local) LV function and explore, for the first time, the configuration of local scores better suited for RWMA detection.  
  Address  
  Corporate Author Thesis Ph.D. thesis  
  Publisher Ediciones Graficas Rey Place of Publication Editor Debora Gil  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ Gar2009a Serial 1499  
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Author Debora Gil; Oriol Rodriguez-Leon; Petia Radeva; Aura Hernandez-Sabate edit   pdf
doi  isbn
openurl 
  Title Assessing Artery Motion Compensation in IVUS Type Book Chapter
  Year (down) 2007 Publication Computer Analysis Of Images And Patterns Abbreviated Journal LNCS  
  Volume 4673 Issue Pages 213-220  
  Keywords validation standards; quality measures; IVUS motion compensation; conservation laws; Fourier development  
  Abstract Cardiac dynamics suppression is a main issue for visual improvement and computation of tissue mechanical properties in IntraVascular UltraSound (IVUS). Although in recent times several motion compensation techniques have arisen, there is a lack of objective evaluation of motion reduction in in vivo pullbacks. We consider that the assessment protocol deserves special attention for the sake of a clinical applicability as reliable as possible. Our work focuses on defining a quality measure and a validation protocol assessing IVUS motion compensation. On the grounds of continuum mechanics laws we introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases.  
  Address  
  Corporate Author Thesis  
  Publisher Springerlink Place of Publication Heidelberg Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN 978-3-540-74271-5 Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GRR2007 Serial 1540  
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