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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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Year  |
2013 |
Publication |
Drug Discovery Today |
Abbreviated Journal |
DDT |
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18 |
Issue |
7-8 |
Pages |
365-371 |
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The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
Serial |
2190 |
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Author |
Sergio Vera; Debora Gil; Agnes Borras; Marius George Linguraru; Miguel Angel Gonzalez Ballester |
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Title |
Geometric Steerable Medial Maps |
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Journal Article |
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Year |
2013 |
Publication |
Machine Vision and Applications |
Abbreviated Journal |
MVA |
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Volume |
24 |
Issue |
6 |
Pages |
1255-1266 |
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Keywords |
Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction |
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In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume. |
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Springer Berlin Heidelberg |
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Editor |
Mubarak Shah |
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0932-8092 |
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IAM; 605.203; 600.060; 600.044 |
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IAM @ iam @ VGB2013 |
Serial |
2192 |
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Author |
Ferran Poveda; Debora Gil; Enric Marti; Albert Andaluz; Manel Ballester;Francesc Carreras Costa |
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Title |
Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography |
Type |
Journal Article |
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Year |
2013 |
Publication |
Revista Española de Cardiología |
Abbreviated Journal |
REC |
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Volume |
66 |
Issue |
10 |
Pages |
782-790 |
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Keywords |
Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band. |
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Abstract |
Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI).
We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart.
On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp. |
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Elsevier |
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IAM; 600.044; 600.060 |
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Call Number |
IAM @ iam @ PGM2013 |
Serial |
2194 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models |
Type |
Journal Article |
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Year |
2013 |
Publication |
British Journal of Pharmacology |
Abbreviated Journal |
BJP |
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Volume |
169 |
Issue |
6 |
Pages |
1189-202 |
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Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism. |
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IAM; 600.044; 605.203 |
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Call Number |
IAM @ iam @ RGG2013b |
Serial |
2195 |
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Author |
Joan M. Nuñez; Debora Gil; Fernando Vilariño |
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Title |
Finger joint characterization from X-ray images for rheymatoid arthritis assessment |
Type |
Conference Article |
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Year |
2013 |
Publication |
6th International Conference on Biomedical Electronics and Devices |
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Pages |
288-292 |
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Keywords |
Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde |
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Abstract |
In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection. |
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Barcelona; February 2013 |
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SciTePress |
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800 |
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BIODEVICES |
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IAM;MV; 600.057; 600.054;SIAI |
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IAM @ iam @ NGV2013 |
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2196 |
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Author |
Patricia Marquez; Debora Gil; Aura Hernandez-Sabate; Daniel Kondermann |
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Title |
When Is A Confidence Measure Good Enough? |
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Conference Article |
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Year |
2013 |
Publication |
9th International Conference on Computer Vision Systems |
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7963 |
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344-353 |
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Keywords |
Optical flow, confidence measure, performance evaluation |
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Abstract |
Confidence estimation has recently become a hot topic in image processing and computer vision.Yet, several definitions exist of the term “confidence” which are sometimes used interchangeably. This is a position paper, in which we aim to give an overview on existing definitions,
thereby clarifying the meaning of the used terms to facilitate further research in this field. Based on these clarifications, we develop a theory to compare confidence measures with respect to their quality. |
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St Petersburg; Russia; July 2013 |
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Springer Link |
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LNCS |
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0302-9743 |
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978-3-642-39401-0 |
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ICVS |
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IAM;ADAS; 600.044; 600.057; 600.060; 601.145 |
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IAM @ iam @ MGH2013a |
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2218 |
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Author |
Francesco Brughi |
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Title |
Artistic Heritage Motive Retrieval: an Explorative Study |
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Report |
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2013 |
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CVC Technical Report |
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176 |
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Master's thesis |
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IAM |
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Admin @ si @ Bru2013 |
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2410 |
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Author |
Ferran Poveda |
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Title |
Computer Graphics and Vision Techniques for the Study of the Muscular Fiber Architecture of the Myocardium |
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2013 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Ph.D. thesis |
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Debora Gil;Enric Marti |
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IAM |
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Admin @ si @ Pov2013 |
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2417 |
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Author |
Francesc Carreras; Jaume Garcia; Debora Gil; Sandra Pujadas; Chi ho Lion; R.Suarez-Arias; R.Leta; Xavier Alomar; Manuel Ballester; Guillem Pons-Llados |
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Title |
Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects |
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Journal Article |
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Year |
2012 |
Publication |
International Journal of Cardiovascular Imaging |
Abbreviated Journal |
IJCI |
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28 |
Issue |
2 |
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273-284 |
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Magnetic resonance imaging (MRI); Tagging MRI; Cardiac mechanics; Ventricular torsion |
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Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice. |
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Springer Netherlands |
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1569-5794 |
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IAM; |
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IAM @ iam @ CGG2012 |
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1496 |
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Author |
Aura Hernandez-Sabate; Debora Gil |
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Title |
The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries |
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Book Chapter |
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Year |
2012 |
Publication |
Intravascular Ultrasound |
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185-206 |
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Intech |
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Editor |
Yasuhiro Honda |
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English |
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english |
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978-953-307-900-4 |
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IAM; ADAS |
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IAM @ iam @ HeG2012 |
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1684 |
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