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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
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Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
Abbreviated Journal |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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0065-2598 |
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978-94-007-7422-3 |
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IAM; 600.075 |
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Call Number |
IAM @ iam @ RGG2014 |
Serial |
2197 |
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Author |
Patricia Marquez; Debora Gil; Aura Hernandez-Sabate; Daniel Kondermann |
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Title |
When Is A Confidence Measure Good Enough? |
Type |
Conference Article |
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Year |
2013 |
Publication |
9th International Conference on Computer Vision Systems |
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Volume |
7963 |
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Pages |
344-353 |
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Keywords |
Optical flow, confidence measure, performance evaluation |
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Abstract |
Confidence estimation has recently become a hot topic in image processing and computer vision.Yet, several definitions exist of the term “confidence” which are sometimes used interchangeably. This is a position paper, in which we aim to give an overview on existing definitions,
thereby clarifying the meaning of the used terms to facilitate further research in this field. Based on these clarifications, we develop a theory to compare confidence measures with respect to their quality. |
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St Petersburg; Russia; July 2013 |
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Springer Link |
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0302-9743 |
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978-3-642-39401-0 |
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ICVS |
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IAM;ADAS; 600.044; 600.057; 600.060; 601.145 |
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IAM @ iam @ MGH2013a |
Serial |
2218 |
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Author |
Francesco Brughi |
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Title |
Artistic Heritage Motive Retrieval: an Explorative Study |
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Report |
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2013 |
Publication |
CVC Technical Report |
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176 |
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Master's thesis |
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Admin @ si @ Bru2013 |
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2410 |
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Author |
Ferran Poveda |
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Title |
Computer Graphics and Vision Techniques for the Study of the Muscular Fiber Architecture of the Myocardium |
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2013 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Ph.D. thesis |
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Debora Gil;Enric Marti |
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IAM |
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Admin @ si @ Pov2013 |
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2417 |
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Author |
Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate |
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Title |
Local Analysis of Confidence Measures for Optical Flow Quality Evaluation |
Type |
Conference Article |
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Year |
2014 |
Publication |
9th International Conference on Computer Vision Theory and Applications |
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3 |
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Pages |
450-457 |
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Keywords |
Optical Flow; Confidence Measure; Performance Evaluation. |
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Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance. |
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Lisboa; January 2014 |
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VISAPP |
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Notes |
IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 |
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no |
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Call Number |
Admin @ si @ MGM2014 |
Serial |
2432 |
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Author |
Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical parameterization for volumetric meshing of the liver |
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Conference Article |
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Year |
2014 |
Publication |
SPIE – Medical Imaging |
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Volume |
9036 |
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Keywords |
Coordinate System; Anatomy Modeling; Parameterization |
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Abstract |
A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference. |
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Amsterdam; September 2014 |
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SPIE-MI |
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IAM; 600.075 |
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Admin @ si @ VGG2014 |
Serial |
2456 |
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Author |
Enric Marti; Antoni Gurgui; Debora Gil; Aura Hernandez-Sabate; Jaume Rocarias; Ferran Poveda |
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Title |
ABP on line: Seguimiento, estregas y evaluación en aprendizaje basado en proyectos |
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Miscellaneous |
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Year |
2014 |
Publication |
8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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CIDUI |
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IAM; ADAS; 600.076; 600.063; 600.075 |
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Admin @ si @ MGG2014 |
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2457 |
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Author |
Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; Jaume Rocarias; Debora Gil |
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Title |
Evaluación automática de prácticas en Moodle para el aprendizaje autónomo en Ingenierías |
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Miscellaneous |
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Year |
2014 |
Publication |
8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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CIDUI |
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IAM; 600.075;DAG |
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Admin @ si @ SRM2014 |
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2458 |
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Author |
Patricia Marquez; H. Kause; A. Fuster; Aura Hernandez-Sabate; L. Florack; Debora Gil; Hans van Assen |
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Title |
Factors Affecting Optical Flow Performance in Tagging Magnetic Resonance Imaging |
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Conference Article |
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2014 |
Publication |
17th International Conference on Medical Image Computing and Computer Assisted Intervention |
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Volume |
8896 |
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231-238 |
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Keywords |
Optical flow; Performance Evaluation; Synthetic Database; ANOVA; Tagging Magnetic Resonance Imaging |
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Changes in cardiac deformation patterns are correlated with cardiac pathologies. Deformation can be extracted from tagging Magnetic Resonance Imaging (tMRI) using Optical Flow (OF) techniques. For applications of OF in a clinical setting it is important to assess to what extent the performance of a particular OF method is stable across di erent clinical acquisition artifacts. This paper presents a statistical validation framework, based on ANOVA, to assess the motion and appearance factors that have the largest in uence on OF accuracy drop.
In order to validate this framework, we created a database of simulated tMRI data including the most common artifacts of MRI and test three di erent OF methods, including HARP. |
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Boston; USA; September 2014 |
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Springer International Publishing |
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0302-9743 |
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978-3-319-14677-5 |
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STACOM |
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IAM; ADAS; 600.060; 601.145; 600.076; 600.075 |
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Admin @ si @ MKF2014 |
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2495 |
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Author |
Jorge Bernal; Debora Gil; Carles Sanchez; F. Javier Sanchez |
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Title |
Discarding Non Informative Regions for Efficient Colonoscopy Image Analysis |
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Conference Article |
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Year |
2014 |
Publication |
1st MICCAI Workshop on Computer-Assisted and Robotic Endoscopy |
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8899 |
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1-10 |
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Image Segmentation; Polyps, Colonoscopy; Valley Information; Energy Maps |
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Abstract |
In this paper we present a novel polyp region segmentation method for colonoscopy videos. Our method uses valley information associated to polyp boundaries in order to provide an initial segmentation. This first segmentation is refined to eliminate boundary discontinuities caused by image artifacts or other elements of the scene. Experimental results over a publicly annotated database show that our method outperforms both general and specific segmentation methods by providing more accurate regions rich in polyp content. We also prove how image preprocessing is needed to improve final polyp region segmentation. |
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Boston; USA; September 2014 |
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Springer International Publishing |
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0302-9743 |
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978-3-319-13409-3 |
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CARE |
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MV; IAM; 600.044; 600.047; 600.060; 600.075 |
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Admin @ si @ BGS2014b |
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2503 |
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