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Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; B. Cardenas; G. Fonseka; E. Anton; Alvaro Pascual; Richard Frodsham; Zaida Sarrate |
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Title |
Time to match; when do homologous chromosomes become closer? |
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Journal Article |
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Year |
2022 |
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Chromosoma |
Abbreviated Journal |
CHRO |
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In most eukaryotes, pairing of homologous chromosomes is an essential feature of meiosis that ensures homologous recombination and segregation. However, when the pairing process begins, it is still under investigation. Contrasting data exists in Mus musculus, since both leptotene DSB-dependent and preleptotene DSB-independent mechanisms have been described. To unravel this contention, we examined homologous pairing in pre-meiotic and meiotic Mus musculus cells using a threedimensional fuorescence in situ hybridization-based protocol, which enables the analysis of the entire karyotype using DNA painting probes. Our data establishes in an unambiguously manner that 73.83% of homologous chromosomes are already paired at premeiotic stages (spermatogonia-early preleptotene spermatocytes). The percentage of paired homologous chromosomes increases to 84.60% at mid-preleptotene-zygotene stage, reaching 100% at pachytene stage. Importantly, our results demonstrate a high percentage of homologous pairing observed before the onset of meiosis; this pairing does not occur randomly, as the percentage was higher than that observed in somatic cells (19.47%) and between nonhomologous chromosomes (41.1%). Finally, we have also observed that premeiotic homologous pairing is asynchronous and independent of the chromosome size, GC content, or presence of NOR regions. |
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August, 2022 |
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IAM; 601.139; 600.145; 600.096 |
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Admin @ si @ SBG2022 |
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3719 |
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Author |
Sergio Vera; Debora Gil; Agnes Borras; Marius George Linguraru; Miguel Angel Gonzalez Ballester |
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Title |
Geometric Steerable Medial Maps |
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Journal Article |
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Year |
2013 |
Publication |
Machine Vision and Applications |
Abbreviated Journal |
MVA |
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24 |
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6 |
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1255-1266 |
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Keywords |
Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction |
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In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume. |
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Springer Berlin Heidelberg |
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Mubarak Shah |
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0932-8092 |
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IAM; 605.203; 600.060; 600.044 |
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IAM @ iam @ VGB2013 |
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2192 |
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Mireia Sole; Joan Blanco; Debora Gil; G. Fonseka; Richard Frodsham; Francesca Vidal; Zaida Sarrate |
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Title |
Noves perspectives en l estudi de la territorialitat cromosomica de cel·lules germinals masculines: estudis tridimensionals |
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2017 |
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Biologia de la Reproduccio |
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JBR |
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15 |
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73-78 |
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In somatic cells, chromosomes occupy specific nuclear regions called chromosome territories which are involved in the
maintenance and regulation of the genome. Preliminary data in male germ cells also suggest the importance of chromosome
territoriality in cell functionality. Nevertheless, the specific characteristics of testicular tissue (presence of different
cell types with different morphological characteristics, in different stages of development and with different ploidy)
makes difficult to achieve conclusive results. In this study we have developed a methodology to approach the threedimensional
study of all chromosome territories in male germ cells from C57BL/6J mice (Mus musculus). The method
includes the following steps: i) Optimized cell fixation to obtain an optimal preservation of the three-dimensionality cell
morphology, ii) Chromosome identification by FISH (Chromoprobe Multiprobe® OctoChrome™ Murine System; Cytocell)
and confocal microscopy (TCS-SP5, Leica Microsystems), iii) Cell type identification by immunofluorescence
iv) Image analysis using Matlab scripts, v) Numerical data extraction related to chromosome features, chromosome
radial position and chromosome relative position. This methodology allows the unequivocally identification and the
analysis of the chromosome territories of all spermatogenic stages. Results will provide information about the features
that determine chromosomal position, preferred associations between chromosomes, and the relationship between chromosome
positioning and genome regulation. |
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978-84-697-3767-5 |
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IAM; 600.096; 600.145 |
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Admin @ si @ SBG2017c |
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2961 |
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Author |
Katerine Diaz; Jesus Martinez del Rincon; Aura Hernandez-Sabate; Debora Gil |
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Title |
Continuous head pose estimation using manifold subspace embedding and multivariate regression |
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Journal Article |
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2018 |
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IEEE Access |
Abbreviated Journal |
ACCESS |
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6 |
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18325 - 18334 |
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Head Pose estimation; HOG features; Generalized Discriminative Common Vectors; B-splines; Multiple linear regression |
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In this paper, a continuous head pose estimation system is proposed to estimate yaw and pitch head angles from raw facial images. Our approach is based on manifold learningbased methods, due to their promising generalization properties shown for face modelling from images. The method combines histograms of oriented gradients, generalized discriminative common vectors and continuous local regression to achieve successful performance. Our proposal was tested on multiple standard face datasets, as well as in a realistic scenario. Results show a considerable performance improvement and a higher consistence of our model in comparison with other state-of-art methods, with angular errors varying between 9 and 17 degrees. |
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2169-3536 |
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ADAS; 600.118 |
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Admin @ si @ DMH2018b |
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3091 |
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Author |
Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester |
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Title |
Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography |
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Journal Article |
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2012 |
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Journal of American College of Cardiology |
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JACC |
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5 |
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7 |
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754-755 |
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It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1 |
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1936-878X |
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IAM |
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IAM @ iam @ PMG2012 |
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1985 |
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Author |
Jaume Garcia; Debora Gil; Sandra Pujades; Francesc Carreras |
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Valoracion de la Funcion del Ventriculo Izquierdo mediante Modelos Regionales Hiperparametricos |
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2008 |
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Revista Española de Cardiologia |
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61 |
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3 |
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79 |
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La mayoría de la enfermedades cardiovasculares afectan a las propiedades contráctiles de la banda ventricular helicoidal. Esto se refleja en una variación del comportamiento normal de la función ventricular. Parámetros locales tales como los strains, o la deformación experimentada por el tejido, son indicadores capaces de detectar anomalías funcionales en territorios específicos. A menudo, dichos parámetros son considerados de forma separada. En este trabajo presentamos un marco computacional (el Dominio Paramétrico Normalizado, DPN) que permite integrarlos en hiperparámetros funcionales y estudiar sus rangos de normalidad. Dichos rangos permiten valorar de forma objetiva la función regional de cualquier nuevo paciente. Para ello, consideramos secuencias de resonancia magnética etiquetada a nivel basal, medio y apical. Los hiperparámetros se obtienen a partir del movimiento intramural del VI estimado mediante el método Harmonic Phase Flow. El DPN se define a partir de en una parametrización del Ventrículo Izquierdo (VI) en sus coordenadas radiales y circunferencial basada en criterios anatómicos. El paso de los hiperparámetros al DPN hace posible la comparación entre distintos pacientes. Los rangos de normalidad se definen mediante análisis estadístico de valores de voluntarios sanos en 45 regiones del DPN a lo largo de 9 fases sistólicas. Se ha usado un conjunto de 19 (14 H; E: 30.7±7.5) voluntarios sanos para crear los patrones de normalidad y se han validado usando 2 controles sanos y 3 pacientes afectados de contractilidad global reducida. Para los controles los resultados regionales se han ajustado dentro de la normalidad, mientras que para los pacientes se han obtenido valores anormales en las zonas descritas, localizando y cuantificando así el diagnóstico empírico. |
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IAM; |
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IAM @ iam @ GRP2008 |
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1032 |
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Aura Hernandez-Sabate; Debora Gil; Jaume Garcia; Enric Marti |
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Image-based Cardiac Phase Retrieval in Intravascular Ultrasound Sequences |
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Journal Article |
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2011 |
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IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control |
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T-UFFC |
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58 |
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1 |
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60-72 |
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3-D exploring; ECG; band-pass filter; cardiac motion; cardiac phase retrieval; coronary arteries; electrocardiogram signal; image intensity local mean evolution; image-based cardiac phase retrieval; in vivo pullbacks acquisition; intravascular ultrasound sequences; longitudinal motion; signal extrema; time 36 ms; band-pass filters; biomedical ultrasonics; cardiovascular system; electrocardiography; image motion analysis; image retrieval; image sequences; medical image processing; ultrasonic imaging |
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Longitudinal motion during in vivo pullbacks acquisition of intravascular ultrasound (IVUS) sequences is a major artifact for 3-D exploring of coronary arteries. Most current techniques are based on the electrocardiogram (ECG) signal to obtain a gated pullback without longitudinal motion by using specific hardware or the ECG signal itself. We present an image-based approach for cardiac phase retrieval from coronary IVUS sequences without an ECG signal. A signal reflecting cardiac motion is computed by exploring the image intensity local mean evolution. The signal is filtered by a band-pass filter centered at the main cardiac frequency. Phase is retrieved by computing signal extrema. The average frame processing time using our setup is 36 ms. Comparison to manually sampled sequences encourages a deeper study comparing them to ECG signals. |
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0885-3010 |
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IAM;ADAS |
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IAM @ iam @ HGG2011 |
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1546 |
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Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities |
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Journal Article |
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2017 |
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Medical Image Analysis |
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MIA |
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35 |
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390-402 |
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Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points |
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Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies. |
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Elsevier B.V. |
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IAM; 600.060; 600.096; 600.075; 600.145 |
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Admin @ si @ GVB2017 |
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2775 |
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Debora Gil; Aura Hernandez-Sabate; Julien Enconniere; Saryani Asmayawati; Pau Folch; Juan Borrego-Carazo; Miquel Angel Piera |
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E-Pilots: A System to Predict Hard Landing During the Approach Phase of Commercial Flights |
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2022 |
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IEEE Access |
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ACCESS |
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10 |
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7489-7503 |
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More than half of all commercial aircraft operation accidents could have been prevented by executing a go-around. Making timely decision to execute a go-around manoeuvre can potentially reduce overall aviation industry accident rate. In this paper, we describe a cockpit-deployable machine learning system to support flight crew go-around decision-making based on the prediction of a hard landing event.
This work presents a hybrid approach for hard landing prediction that uses features modelling temporal dependencies of aircraft variables as inputs to a neural network. Based on a large dataset of 58177 commercial flights, the results show that our approach has 85% of average sensitivity with 74% of average specificity at the go-around point. It follows that our approach is a cockpit-deployable recommendation system that outperforms existing approaches. |
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IAM; 600.139; 600.118; 600.145 |
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Admin @ si @ GHE2022 |
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3721 |
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David Castells; Vinh Ngo; Juan Borrego-Carazo; Marc Codina; Carles Sanchez; Debora Gil; Jordi Carrabina |
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A Survey of FPGA-Based Vision Systems for Autonomous Cars |
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Journal Article |
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2022 |
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IEEE Access |
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ACESS |
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10 |
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132525-132563 |
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Autonomous automobile; Computer vision; field programmable gate arrays; reconfigurable architectures |
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On the road to making self-driving cars a reality, academic and industrial researchers are working hard to continue to increase safety while meeting technical and regulatory constraints Understanding the surrounding environment is a fundamental task in self-driving cars. It requires combining complex computer vision algorithms. Although state-of-the-art algorithms achieve good accuracy, their implementations often require powerful computing platforms with high power consumption. In some cases, the processing speed does not meet real-time constraints. FPGA platforms are often used to implement a category of latency-critical algorithms that demand maximum performance and energy efficiency. Since self-driving car computer vision functions fall into this category, one could expect to see a wide adoption of FPGAs in autonomous cars. In this paper, we survey the computer vision FPGA-based works from the literature targeting automotive applications over the last decade. Based on the survey, we identify the strengths and weaknesses of FPGAs in this domain and future research opportunities and challenges. |
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16 December 2022 |
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IEEE |
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IAM; 600.166 |
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Admin @ si @ CNB2022 |
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3760 |
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