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Debora Gil; Oriol Ramos Terrades; Raquel Perez |
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Topological Radiomics (TOPiomics): Early Detection of Genetic Abnormalities in Cancer Treatment Evolution |
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Book Chapter |
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2021 |
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Extended Abstracts GEOMVAP 2019, Trends in Mathematics 15 |
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15 |
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89–93 |
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Abnormalities in radiomic measures correlate to genomic alterations prone to alter the outcome of personalized anti-cancer treatments. TOPiomics is a new method for the early detection of variations in tumor imaging phenotype from a topological structure in multi-view radiomic spaces. |
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Springer Nature |
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IAM; DAG; 600.120; 600.145; 600.139 |
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Admin @ si @ GRP2021 |
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3594 |
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Author |
Aura Hernandez-Sabate; Debora Gil |
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Title |
The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries |
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Book Chapter |
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Year |
2012 |
Publication |
Intravascular Ultrasound |
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185-206 |
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Intech |
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Yasuhiro Honda |
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English |
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english |
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978-953-307-900-4 |
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IAM; ADAS |
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IAM @ iam @ HeG2012 |
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1684 |
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Author |
Misael Rosales; Petia Radeva; Oriol Rodriguez; Debora Gil |
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Title |
Suppression of IVUS Image Rotation. A Kinematic Approach |
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Book Chapter |
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Year |
2005 |
Publication |
Functional Imaging and Modeling of the Heart |
Abbreviated Journal |
LNCS |
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3504 |
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Pages |
889-892 |
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IntraVascular Ultrasound (IVUS) is an exploratory technique used in interventional procedures that shows cross section images of arteries and provides qualitative information about the causes and severity of the arterial lumen narrowing. Cross section analysis as well as visualization of plaque extension in a vessel segment during the catheter imaging pullback are the technique main advantages. However, IVUS sequence exhibits a periodic rotation artifact that makes difficult the longitudinal lesion inspection and hinders any segmentation algorithm. In this paper we propose a new kinematic method to estimate and remove the image rotation of IVUS images sequences. Results on several IVUS sequences show good results and prompt some of the clinical applications to vessel dynamics study, and relation to vessel pathology. |
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Springer Berlin / Heidelberg |
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Frangi, Alejandro and Radeva, Petia and Santos, Andres and Hernandez, Monica |
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Lecture Notes in Computer Science |
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LNCS |
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3504 |
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IAM;MILAB |
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IAM @ iam @ RRR2005 |
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1645 |
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Author |
Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil |
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Title |
Optimal Medial Surface Generation for Anatomical Volume Representations |
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Book Chapter |
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Year |
2012 |
Publication |
Abdominal Imaging. Computational and Clinical Applications |
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LNCS |
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7601 |
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265-273 |
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Keywords |
Medial surface representation; volume reconstruction |
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Medial representations are a widely used technique in abdominal organ shape representation and parametrization. Those methods require good medial manifolds as a starting point. Any medial
surface used to parametrize a volume should be simple enough to allow an easy manipulation and complete enough to allow an accurate reconstruction of the volume. Obtaining good quality medial
surfaces is still a problem with current iterative thinning methods. This forces the usage of generic, pre-calculated medial templates that are adapted to the final shape at the cost of a drop in volume reconstruction.
This paper describes an operator for generation of medial structures that generates clean and complete manifolds well suited for their further use in medial representations of abdominal organ volumes. While being simpler than thinning surfaces, experiments show its high performance in volume reconstruction and preservation of medial surface main branching topology. |
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Nice, France |
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Springer Berlin Heidelberg |
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Yoshida, Hiroyuki and Hawkes, David and Vannier, MichaelW. |
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Lecture Notes in Computer Science |
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0302-9743 |
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978-3-642-33611-9 |
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STACOM |
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IAM |
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IAM @ iam @ VGG2012b |
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1988 |
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Author |
H. Martin ; Jens Fagertun; Sergio Vera; Debora Gil |
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Title |
Medial structure generation for registration of anatomical structures |
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Book Chapter |
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2017 |
Publication |
Skeletonization, Theory, Methods and Applications |
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11 |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ MFV2017a |
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2935 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
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Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
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796 |
Issue |
3 |
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159-181 |
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β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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0065-2598 |
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978-94-007-7422-3 |
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IAM; 600.075 |
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IAM @ iam @ RGG2014 |
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2197 |
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Author |
Debora Gil; Petia Radeva |
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Title |
Inhibition of False Landmarks |
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Book Chapter |
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Year |
2004 |
Publication |
Recent Advances in Artificial Intelligence Research and Development |
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233-244 |
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We argue that a corner detector should be based on the degree of continuity of the tangent vector to the image level sets, work on the image domain and need no assumptions on neither the image local structure nor the particular geometry of the corner/junction. An operator measuring the degree of differentiability of the projection matrix on the image gradient fulfills the above requirements. Its high sensitivity to changes in vector directions makes it suitable for landmark location in real images prone to need smoothing to reduce the impact of noise. Because using smoothing kernels leads to corner misplacement, we suggest an alternative fake response remover based on the receptive field inhibition of spurious details. The combination of both orientation discontinuity detection and noise inhibition produce our Inhibition Orientation Energy (IOE) landmark locator. |
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IOS Press |
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Barcelona (Spain) |
Editor |
al, J.V. et |
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IAM;MILAB |
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Call Number |
IAM @ iam @ GiR2004a |
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1533 |
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Author |
Debora Gil |
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Title |
Geometric Differential Operators for Shape Modelling |
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Book Whole |
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Year |
2004 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Medical imaging feeds research in many computer vision and image processing fields: image filtering, segmentation, shape recovery, registration, retrieval and pattern matching. Because of their low contrast changes and large variety of artifacts and noise, medical imaging processing techniques relying on an analysis of the geometry of image level sets rather than on intensity values result in more robust treatment. From the starting point of treatment of intravascular images, this PhD thesis ad- dresses the design of differential image operators based on geometric principles for a robust shape modelling and restoration. Among all fields applying shape recovery, we approach filtering and segmentation of image objects. For a successful use in real images, the segmentation process should go through three stages: noise removing, shape modelling and shape recovery. This PhD addresses all three topics, but for the sake of algorithms as automated as possible, techniques for image processing will be designed to satisfy three main principles: a) convergence of the iterative schemes to non-trivial states avoiding image degeneration to a constant image and representing smooth models of the originals; b) smooth asymptotic behav- ior ensuring stabilization of the iterative process; c) fixed parameter values ensuring equal (domain free) performance of the algorithms whatever initial images/shapes. Our geometric approach to the generic equations that model the different processes approached enables defining techniques satisfying all the former requirements. First, we introduce a new curvature-based geometric flow for image filtering achieving a good compromise between noise removing and resemblance to original images. Sec- ond, we describe a new family of diffusion operators that restrict their scope to image level curves and serve to restore smooth closed models from unconnected sets of points. Finally, we design a regularization of snake (distance) maps that ensures its smooth convergence towards any closed shape. Experiments show that performance of the techniques proposed overpasses that of state-of-the-art algorithms. |
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Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Barcelona (Spain) |
Editor |
Jordi Saludes i Closa;Petia Radeva |
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84-933652-0-3 |
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prit |
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IAM; |
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IAM @ iam @ GIL2004 |
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1517 |
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Author |
Jaume Garcia; Debora Gil; Aura Hernandez-Sabate |
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Title |
Endowing Canonical Geometries to Cardiac Structures |
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Book Chapter |
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Year |
2010 |
Publication |
Statistical Atlases And Computational Models Of The Heart |
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6364 |
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124-133 |
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Abstract |
International conference on Cardiac electrophysiological simulation challenge
In this paper, we show that canonical (shape-based) geometries can be endowed to cardiac structures using tubular coordinates defined over their medial axis. We give an analytic formulation of these geometries by means of B-Splines. Since B-Splines present vector space structure PCA can be applied to their control points and statistical models relating boundaries and the interior of the anatomical structures can be derived. We demonstrate the applicability in two cardiac structures, the 3D Left Ventricular volume, and the 2D Left-Right ventricle set in 2D Short Axis view. |
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Springer Berlin / Heidelberg |
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Camara, O.; Pop, M.; Rhode, K.; Sermesant, M.; Smith, N.; Young, A. |
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Lecture Notes in Computer Science |
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LNCS |
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IAM |
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IAM @ iam @ GGH2010b |
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1515 |
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Author |
Debora Gil; Petia Radeva |
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Title |
Curvature Vector Flow to Assure Convergent Deformable Models for Shape Modelling |
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Book Chapter |
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Year |
2003 |
Publication |
Energy Minimization Methods In Computer Vision And Pattern Recognition |
Abbreviated Journal |
LNCS |
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2683 |
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357-372 |
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Initial condition; Convex shape; Non convex analysis; Increase; Segmentation; Gradient; Standard; Standards; Concave shape; Flow models; Tracking; Edge detection; Curvature |
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Poor convergence to concave shapes is a main limitation of snakes as a standard segmentation and shape modelling technique. The gradient of the external energy of the snake represents a force that pushes the snake into concave regions, as its internal energy increases when new inexion points are created. In spite of the improvement of the external energy by the gradient vector ow technique, highly non convex shapes can not be obtained, yet. In the present paper, we develop a new external energy based on the geometry of the curve to be modelled. By tracking back the deformation of a curve that evolves by minimum curvature ow, we construct a distance map that encapsulates the natural way of adapting to non convex shapes. The gradient of this map, which we call curvature vector ow (CVF), is capable of attracting a snake towards any contour, whatever its geometry. Our experiments show that, any initial snake condition converges to the curve to be modelled in optimal time. |
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Springer, Berlin |
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Lisbon, PORTUGAL |
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Springer, B. |
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Lecture Notes in Computer Science |
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LNCS |
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0302-9743 |
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3-540-40498-8 |
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IAM;MILAB |
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IAM @ iam @ GIR2003b |
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1535 |
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