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Author |
Aura Hernandez-Sabate; Debora Gil |
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Title |
The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Intravascular Ultrasound |
Abbreviated Journal |
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Volume |
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Pages |
185-206 |
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Thesis |
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Publisher |
Intech |
Place of Publication |
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Editor |
Yasuhiro Honda |
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Language |
English |
Summary Language |
english |
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ISBN |
978-953-307-900-4 |
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Notes |
IAM; ADAS |
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no |
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Call Number |
IAM @ iam @ HeG2012 |
Serial |
1684 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
Type |
Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
Abbreviated Journal |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Publisher |
Springer Netherlands |
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Edition |
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ISSN |
0065-2598 |
ISBN |
978-94-007-7422-3 |
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Notes |
IAM; 600.075 |
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no |
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Call Number |
IAM @ iam @ RGG2014 |
Serial |
2197 |
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Author |
Debora Gil; Jordi Gonzalez; Gemma Sanchez (eds) |
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Title |
Computer Vision: Advances in Research and Development |
Type |
Book Whole |
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Year |
2007 |
Publication |
Proceedings of the 2nd CVC International Workshop |
Abbreviated Journal |
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Publisher |
UAB |
Place of Publication |
Bellaterra (Spain) |
Editor |
Debora Gil; Jordi Gonzalez; Gemma Sanchez |
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Series Title |
2 |
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ISBN |
978-84-935251-4-9 |
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Notes |
IAM; ISE; DAG |
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no |
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Call Number |
IAM @ iam @ GGS2007 |
Serial |
1493 |
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Author |
Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil |
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Title |
Optimal Medial Surface Generation for Anatomical Volume Representations |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Abdominal Imaging. Computational and Clinical Applications |
Abbreviated Journal |
LNCS |
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Volume |
7601 |
Issue |
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Pages |
265-273 |
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Keywords |
Medial surface representation; volume reconstruction |
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Abstract |
Medial representations are a widely used technique in abdominal organ shape representation and parametrization. Those methods require good medial manifolds as a starting point. Any medial
surface used to parametrize a volume should be simple enough to allow an easy manipulation and complete enough to allow an accurate reconstruction of the volume. Obtaining good quality medial
surfaces is still a problem with current iterative thinning methods. This forces the usage of generic, pre-calculated medial templates that are adapted to the final shape at the cost of a drop in volume reconstruction.
This paper describes an operator for generation of medial structures that generates clean and complete manifolds well suited for their further use in medial representations of abdominal organ volumes. While being simpler than thinning surfaces, experiments show its high performance in volume reconstruction and preservation of medial surface main branching topology. |
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Address |
Nice, France |
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Publisher |
Springer Berlin Heidelberg |
Place of Publication |
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Editor |
Yoshida, Hiroyuki and Hawkes, David and Vannier, MichaelW. |
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Series Title |
Lecture Notes in Computer Science |
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Edition |
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ISSN |
0302-9743 |
ISBN |
978-3-642-33611-9 |
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Conference |
STACOM |
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Notes |
IAM |
Approved |
no |
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Call Number |
IAM @ iam @ VGG2012b |
Serial |
1988 |
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Permanent link to this record |
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Author |
Carles Sanchez;F. Javier Sanchez; Antoni Rosell; Debora Gil |
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Title |
An illumination model of the trachea appearance in videobronchoscopy images |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Image Analysis and Recognition |
Abbreviated Journal |
LNCS |
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Volume |
7325 |
Issue |
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Pages |
313-320 |
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Keywords |
Bronchoscopy, tracheal ring, stenosis assesment, trachea appearance model, segmentation |
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Abstract |
Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways. This imaging modality provides realistic images and allows non-invasive minimal intervention procedures. Tracheal procedures are routinary interventions that require assessment of the percentage of obstructed pathway for injury (stenosis) detection. Visual assessment in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error.
This paper introduces an automatic method for the estimation of steneosed trachea percentage reduction in videobronchoscopic images. We look for tracheal rings , whose deformation determines the degree of obstruction. For ring extraction , we present a ring detector based on an illumination and appearance model. This model allows us to parametrise the ring detection. Finally, we can infer optimal estimation parameters for any video resolution. |
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Address |
Aveiro, Portugal |
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Publisher |
Springer Berlin Heidelberg |
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Original Title |
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Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
LNCS |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0302-9743 |
ISBN |
978-3-642-31297-7 |
Medium |
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Area |
800 |
Expedition |
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Conference |
ICIAR |
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Notes |
MV;IAM |
Approved |
no |
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Call Number |
IAM @ iam @ SSR2012 |
Serial |
1898 |
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Permanent link to this record |
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Author |
Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru; Miguel Angel Gonzalez Ballester |
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Title |
Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Workshop on Computational and Clinical Applications in Abdominal Imaging |
Abbreviated Journal |
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Volume |
7029 |
Issue |
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Pages |
223–230 |
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Keywords |
medial manifolds, abdomen. |
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Abstract |
Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations. |
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Address |
Toronto; Canada; |
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Corporate Author |
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Thesis |
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Publisher |
Springer Link |
Place of Publication |
Berlin |
Editor |
H. Yoshida et al |
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Language |
English |
Summary Language |
English |
Original Title |
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Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
LNCS |
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Series Volume |
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Series Issue |
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Edition |
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ISSN |
0302-9743 |
ISBN |
978-3-642-28556-1 |
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Expedition |
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Conference |
ABDI |
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Notes |
IAM;MV |
Approved |
no |
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Call Number |
IAM @ iam @ VGB2012 |
Serial |
1834 |
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Permanent link to this record |
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Author |
Debora Gil; Oriol Rodriguez-Leor; Petia Radeva; Aura Hernandez-Sabate |
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Title |
Assessing Artery Motion Compensation in IVUS |
Type |
Book Chapter |
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Year |
2007 |
Publication |
Computer Analysis Of Images And Patterns |
Abbreviated Journal |
LNCS |
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Volume |
4673 |
Issue |
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Pages |
213-220 |
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Keywords |
validation standards; quality measures; IVUS motion compensation; conservation laws; Fourier development |
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Abstract |
Cardiac dynamics suppression is a main issue for visual improvement and computation of tissue mechanical properties in IntraVascular UltraSound (IVUS). Although in recent times several motion compensation techniques have arisen, there is a lack of objective evaluation of motion reduction in in vivo pullbacks. We consider that the assessment protocol deserves special attention for the sake of a clinical applicability as reliable as possible. Our work focuses on defining a quality measure and a validation protocol assessing IVUS motion compensation. On the grounds of continuum mechanics laws we introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases. |
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Publisher |
Springerlink |
Place of Publication |
Heidelberg |
Editor |
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Original Title |
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Series Editor |
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Series Title |
Lecture Notes in Computer Science |
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Series Issue |
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Edition |
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ISSN |
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ISBN |
978-3-540-74271-5 |
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Notes |
IAM;MILAB |
Approved |
no |
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Call Number |
IAM @ iam @ GRR2007 |
Serial |
1540 |
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Permanent link to this record |
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Author |
Hanne Kause; Aura Hernandez-Sabate; Patricia Marquez; Andrea Fuster; Luc Florack; Hans van Assen; Debora Gil |
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Title |
Confidence Measures for Assessing the HARP Algorithm in Tagged Magnetic Resonance Imaging |
Type |
Book Chapter |
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Year |
2015 |
Publication |
Statistical Atlases and Computational Models of the Heart. Revised selected papers of Imaging and Modelling Challenges 6th International Workshop, STACOM 2015, Held in Conjunction with MICCAI 2015 |
Abbreviated Journal |
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Volume |
9534 |
Issue |
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Pages |
69-79 |
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Abstract |
Cardiac deformation and changes therein have been linked to pathologies. Both can be extracted in detail from tagged Magnetic Resonance Imaging (tMRI) using harmonic phase (HARP) images. Although point tracking algorithms have shown to have high accuracies on HARP images, these vary with position. Detecting and discarding areas with unreliable results is crucial for use in clinical support systems. This paper assesses the capability of two confidence measures (CMs), based on energy and image structure, for detecting locations with reduced accuracy in motion tracking results. These CMs were tested on a database of simulated tMRI images containing the most common artifacts that may affect tracking accuracy. CM performance is assessed based on its capability for HARP tracking error bounding and compared in terms of significant differences detected using a multi comparison analysis of variance that takes into account the most influential factors on HARP tracking performance. Results showed that the CM based on image structure was better suited to detect unreliable optical flow vectors. In addition, it was shown that CMs can be used to detect optical flow vectors with large errors in order to improve the optical flow obtained with the HARP tracking algorithm. |
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Address |
Munich; Germany; January 2015 |
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Publisher |
Springer International Publishing |
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LNCS |
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Series Volume |
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Edition |
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ISSN |
0302-9743 |
ISBN |
978-3-319-28711-9 |
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STACOM |
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Notes |
ADAS; IAM; 600.075; 600.076; 600.060; 601.145 |
Approved |
no |
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Call Number |
Admin @ si @ KHM2015 |
Serial |
2734 |
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Permanent link to this record |
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Author |
Fernando Vilariño; Debora Gil; Petia Radeva |
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Title |
A Novel FLDA Formulation for Numerical Stability Analysis |
Type |
Book Chapter |
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Year |
2004 |
Publication |
Recent Advances in Artificial Intelligence Research and Development |
Abbreviated Journal |
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Volume |
113 |
Issue |
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Pages |
77-84 |
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Keywords |
Supervised Learning; Linear Discriminant Analysis; Numerical Stability; Computer Vision |
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Abstract |
Fisher Linear Discriminant Analysis (FLDA) is one of the most popular techniques used in classification applying dimensional reduction. The numerical scheme involves the inversion of the within-class scatter matrix, which makes FLDA potentially ill-conditioned when it becomes singular. In this paper we present a novel explicit formulation of FLDA in terms of the eccentricity ratio and eigenvector orientations of the within-class scatter matrix. An analysis of this function will characterize those situations where FLDA response is not reliable because of numerical instability. This can solve common situations of poor classification performance in computer vision. |
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Publisher |
IOS Press |
Place of Publication |
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Editor |
J. Vitrià, P. Radeva and I. Aguiló |
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ISBN |
978-1-58603-466-5 |
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Notes |
MV;IAM;MILAB;SIAI |
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no |
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Call Number |
IAM @ iam @ VGR2004 |
Serial |
1663 |
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Permanent link to this record |
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Author |
Debora Gil |
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Title |
Geometric Differential Operators for Shape Modelling |
Type |
Book Whole |
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Year |
2004 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
Abbreviated Journal |
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Abstract |
Medical imaging feeds research in many computer vision and image processing fields: image filtering, segmentation, shape recovery, registration, retrieval and pattern matching. Because of their low contrast changes and large variety of artifacts and noise, medical imaging processing techniques relying on an analysis of the geometry of image level sets rather than on intensity values result in more robust treatment. From the starting point of treatment of intravascular images, this PhD thesis ad- dresses the design of differential image operators based on geometric principles for a robust shape modelling and restoration. Among all fields applying shape recovery, we approach filtering and segmentation of image objects. For a successful use in real images, the segmentation process should go through three stages: noise removing, shape modelling and shape recovery. This PhD addresses all three topics, but for the sake of algorithms as automated as possible, techniques for image processing will be designed to satisfy three main principles: a) convergence of the iterative schemes to non-trivial states avoiding image degeneration to a constant image and representing smooth models of the originals; b) smooth asymptotic behav- ior ensuring stabilization of the iterative process; c) fixed parameter values ensuring equal (domain free) performance of the algorithms whatever initial images/shapes. Our geometric approach to the generic equations that model the different processes approached enables defining techniques satisfying all the former requirements. First, we introduce a new curvature-based geometric flow for image filtering achieving a good compromise between noise removing and resemblance to original images. Sec- ond, we describe a new family of diffusion operators that restrict their scope to image level curves and serve to restore smooth closed models from unconnected sets of points. Finally, we design a regularization of snake (distance) maps that ensures its smooth convergence towards any closed shape. Experiments show that performance of the techniques proposed overpasses that of state-of-the-art algorithms. |
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Thesis |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
Barcelona (Spain) |
Editor |
Jordi Saludes i Closa;Petia Radeva |
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Edition |
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ISBN |
84-933652-0-3 |
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prit |
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Notes |
IAM; |
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no |
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Call Number |
IAM @ iam @ GIL2004 |
Serial |
1517 |
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Permanent link to this record |