Abstract: Bronchoscopy biopsy can be used to diagnose lung cancer without risking complications of other interventions like transthoracic needle aspiration. During bronchoscopy, the clinician has to navigate through the bronchial tree to the target lesion. A main drawback is the difficulty to check whether the exploration is following the correct path. The usual guidance using fluoroscopy implies repeated radiation of the clinician, while alternative systems (like electromagnetic navigation) require specific equipment that increases intervention costs. We propose to compute the navigated path using anatomical landmarks extracted from the sole analysis of videobronchoscopy images. Such landmarks allow matching the current exploration to the path previously planned on a CT to indicate clinician whether the planning is being correctly followed or not. We present a feasibility study of our landmark based CT-video matching using bronchoscopic videos simulated on a virtual bronchoscopy interactive interface.

Abstract: Bronchoscopists use fluoroscopy to guide flexible bronchoscopy to the lesion to be biopsied without any kind of incision. Being fluoroscopy an imaging technique based on X-rays, the risk of developmental problems and cancer is increased in those subjects exposed to its application, so minimizing radiation is crucial. Alternative guiding systems such as electromagnetic navigation require specific equipment, increase the cost of the clinical procedure and still require fluoroscopy. In this paper we propose an image based guiding system based on the extraction of airway centres from intra-operative videos. Such anatomical landmarks are matched to the airway centreline extracted from a pre-planned CT to indicate the best path to the nodule. We present a
feasibility study of our navigation system using simulated bronchoscopic videos and a multi-expert validation of landmarks extraction in 3 intra-operative ultrathin explorations.

Abstract: Recent advances in endoscopic devices have increased their use for minimal invasive diagnostic and intervention procedures. Among all endoscopic modalities, bronchoscopy is one of the most frequent with around 261 millions of procedures per year. Although the use of bronchoscopy is spread among clinical facilities it presents some drawbacks, being the visual inspection for the assessment of anatomical measurements the most prevalent of them. In
particular, inaccuracies in the estimation of the degree of stenosis (the percentage of obstructed airway) decreases its diagnostic yield and might lead to erroneous treatments. An objective computation of tracheal stenosis in bronchoscopy videos would constitute a breakthrough for this non-invasive technique and a reduction in treatment cost.
This thesis settles the first steps towards on-line reliable extraction of anatomical information from videobronchoscopy for computation of objective measures. In particular, we focus on the computation of the degree of stenosis, which is obtained by comparing the area delimited by a healthy tracheal ring and the stenosed lumen. Reliable extraction of airway structures in interventional videobronchoscopy is a challenging task. This is mainly due to the large variety of acquisition conditions (positions and illumination), devices (different digitalizations) and in videos acquired at the operating room the unpredicted presence of surgical devices (such as probe ends). This thesis contributes to on-line stenosis assessment in several ways. We
propose a parametric strategy for the extraction of lumen and tracheal rings regions based on the characterization of their geometry and appearance that guide a deformable model. The geometric and appearance characterization is based on a physical model describing the way bronchoscopy images are obtained and includes local and global descriptions. In order to ensure a systematic applicability we present a statistical framework to select the optimal
parameters of our method. Experiments perform on the first public annotated database, show that the performance of our method is comparable to the one provided by clinicians and its computation time allows for a on-line implementation in the operating room.

Abstract: The fields of segmentation, tracking and behavior analysis demand for challenging video resources to test, in a scalable manner, complex scenarios like crowded environments or scenes with high semantics. Nevertheless, existing public databases cannot scale the presence of appearing agents, which would be useful to study long-term occlusions and crowds. Moreover, creating these resources is expensive and often too particularized to specific needs. We propose an augmented reality framework to increase the complexity of image sequences in terms of occlusions and crowds, in a scalable and controllable manner. Existing datasets can be increased with augmented sequences containing virtual agents. Such sequences are automatically annotated, thus facilitating evaluation in terms of segmentation, tracking, and behavior recognition. In order to easily specify the desired contents, we propose a natural language interface to convert input sentences into virtual agent behaviors. Experimental tests and validation in indoor, street, and soccer environments are provided to show the feasibility of the proposed approach in terms of robustness, scalability, and semantics.

Abstract: Advanced surveillance systems for behavior recognition in outdoor traffic scenes depend strongly on the particular configuration of the scenario. Scene-independent trajectory analysis techniques statistically infer semantics in locations where motion occurs, and such inferences are typically limited to abnormality. Thus, it is interesting to design contributions that automatically categorize more specific semantic regions. State-of-the-art approaches for unsupervised scene labeling exploit trajectory data to segment areas like sources, sinks, or waiting zones. Our method, in addition, incorporates scene-independent knowledge to assign more meaningful labels like crosswalks, sidewalks, or parking spaces. First, a spatiotemporal scene model is obtained from trajectory analysis. Subsequently, a so-called GI-MRF inference process reinforces spatial coherence, and incorporates taxonomy-guided smoothness constraints. Our method achieves automatic and effective labeling of conceptual regions in urban scenarios, and is robust to tracking errors. Experimental validation on 5 surveillance databases has been conducted to assess the generality and accuracy of the segmentations. The resulting scene models are used for model-based behavior analysis.