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	Author	Ferran Poveda; Debora Gil ;Albert Andaluz ;Enric Marti
	Title	Multiscale Tractography for Representing Heart Muscular Architecture			Type	Conference Article
	Year	2011	Publication	In MICCAI 2011 Workshop on Computational Diffusion MRI	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract	Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. Although the muscular architecture of the heart has been debated by countless researchers, the controversy is still alive. Diﬀusion Tensor MRI, DT-MRI, is a unique imaging technique for computational validation of the muscular structure of the heart. By the complex arrangement of myocites, existing techniques can not provide comprehensive descriptions of the global muscular architecture. In this paper we introduce a multiresolution reconstruction technique based on DT-MRI streamlining for simpliﬁed global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and indicate a global helical organization
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language	English	Summary Language	english	Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference	CDRMI
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ PGA2011			Serial	1681
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	Author	Patricia Marquez; Debora Gil; Aura Hernandez-Sabate
	Title	A Confidence Measure for Assessing Optical Flow Accuracy in the Absence of Ground Truth			Type	Conference Article
	Year	2011	Publication	IEEE International Conference on Computer Vision – Workshops	Abbreviated Journal
	Volume		Issue		Pages	2042-2049
	Keywords	IEEE International Conference on Computer Vision – Workshops
	Abstract	Optical flow is a valuable tool for motion analysis in autonomous navigation systems. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in real world sequences. This paper introduces a measure of optical flow accuracy for Lucas-Kanade based flows in terms of the numerical stability of the data-term. We call this measure optical flow condition number. A statistical analysis over ground-truth data show a good statistical correlation between the condition number and optical flow error. Experiments on driving sequences illustrate its potential for autonomous navigation systems.
	Address
	Corporate Author				Thesis
	Publisher	IEEE	Place of Publication	Barcelona (Spain)	Editor
	Language	English	Summary Language	English	Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference	ICCVW
	Notes	IAM; ADAS			Approved	no
	Call Number	IAM @ iam @ MGH2011			Serial	1682
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	Author	Aura Hernandez-Sabate; Debora Gil
	Title	The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries			Type	Book Chapter
	Year	2012	Publication	Intravascular Ultrasound	Abbreviated Journal
	Volume		Issue		Pages	185-206
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher	Intech	Place of Publication		Editor	Yasuhiro Honda
	Language	English	Summary Language	english	Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-953-307-900-4	Medium
	Area		Expedition		Conference
	Notes	IAM; ADAS			Approved	no
	Call Number	IAM @ iam @ HeG2012			Serial	1684
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	Author	Sergio Vera; Debora Gil; Antonio Lopez; Miguel Angel Gonzalez Ballester
	Title	Multilocal Creaseness Measure			Type	Journal
	Year	2012	Publication	The Insight Journal	Abbreviated Journal	IJ
	Volume		Issue		Pages
	Keywords	Ridges, Valley, Creaseness, Structure Tensor, Skeleton,
	Abstract	This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.
	Address
	Corporate Author	Alma IT Systems			Thesis
	Publisher		Place of Publication		Editor
	Language	english	Summary Language	english	Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM;ADAS;			Approved	no
	Call Number	IAM @ iam @ VGL2012			Serial	1840
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	Author	Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester
	Title	Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography			Type	Journal Article
	Year	2012	Publication	Journal of American College of Cardiology	Abbreviated Journal	JACC
	Volume	5	Issue	7	Pages	754-755
	Keywords
	Abstract	It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1936-878X	ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM			Approved	no
	Call Number	IAM @ iam @ PMG2012			Serial	1985
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	Author	Patricia Marquez;Debora Gil;Aura Hernandez-Sabate
	Title	A Complete Confidence Framework for Optical Flow			Type	Conference Article
	Year	2012	Publication	12th European Conference on Computer Vision – Workshops and Demonstrations	Abbreviated Journal
	Volume	7584	Issue	2	Pages	124-133
	Keywords	Optical flow, confidence measures, sparsification plots, error prediction plots
	Abstract	Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.
	Address
	Corporate Author				Thesis
	Publisher	Springer-Verlag	Place of Publication	Florence, Italy, October 7-13, 2012	Editor	Andrea Fusiello, Vittorio Murino ,Rita Cucchiara
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title	LNCS
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-3-642-33867-0	Medium
	Area		Expedition		Conference	ECCVW
	Notes	IAM;ADAS;			Approved	no
	Call Number	IAM @ iam @ MGH2012b			Serial	1991
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism,			Type	Journal Article
	Year	2013	Publication	Drug Discovery Today	Abbreviated Journal	DDT
	Volume	18	Issue	7-8	Pages	365-371
	Keywords
	Abstract	The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.
	Address
	Corporate Author				Thesis
	Publisher	Elsevier	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.057; 600.054			Approved	no
	Call Number	IAM @ iam @ RGG2013a			Serial	2190
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	Author	Sergio Vera; Debora Gil; Agnes Borras; Marius George Linguraru; Miguel Angel Gonzalez Ballester
	Title	Geometric Steerable Medial Maps			Type	Journal Article
	Year	2013	Publication	Machine Vision and Applications	Abbreviated Journal	MVA
	Volume	24	Issue	6	Pages	1255-1266
	Keywords	Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction
	Abstract	In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume.
	Address
	Corporate Author				Thesis
	Publisher	Springer Berlin Heidelberg	Place of Publication		Editor	Mubarak Shah
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0932-8092	ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 605.203; 600.060; 600.044			Approved	no
	Call Number	IAM @ iam @ VGB2013			Serial	2192
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	Author	Ferran Poveda; Debora Gil; Enric Marti; Albert Andaluz; Manel Ballester;Francesc Carreras Costa
	Title	Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography			Type	Journal Article
	Year	2013	Publication	Revista Española de Cardiología	Abbreviated Journal	REC
	Volume	66	Issue	10	Pages	782-790
	Keywords	Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band.
	Abstract	Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI). We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart. On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array. Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp.
	Address
	Corporate Author				Thesis
	Publisher	Elsevier	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.044; 600.060			Approved	no
	Call Number	IAM @ iam @ PGM2013			Serial	2194
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models			Type	Journal Article
	Year	2013	Publication	British Journal of Pharmacology	Abbreviated Journal	BJP
	Volume	169	Issue	6	Pages	1189-202
	Keywords
	Abstract	Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.044; 605.203			Approved	no
	Call Number	IAM @ iam @ RGG2013b			Serial	2195
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	Author	David Roche; Debora Gil; Jesus Giraldo
	Title	Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models?			Type	Book Chapter
	Year	2014	Publication	G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology	Abbreviated Journal
	Volume	796	Issue	3	Pages	159-181
	Keywords	β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model
	Abstract	Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.
	Address
	Corporate Author				Thesis
	Publisher	Springer Netherlands	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0065-2598	ISBN	978-94-007-7422-3	Medium
	Area		Expedition		Conference
	Notes	IAM; 600.075			Approved	no
	Call Number	IAM @ iam @ RGG2014			Serial	2197
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	Author	Debora Gil; David Roche; Agnes Borras; Jesus Giraldo
	Title	Terminating Evolutionary Algorithms at their Steady State			Type	Journal Article
	Year	2015	Publication	Computational Optimization and Applications	Abbreviated Journal	COA
	Volume	61	Issue	2	Pages	489-515
	Keywords	Evolutionary algorithms; Termination condition; Steady state; Differential evolution
	Abstract	Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications.
	Address
	Corporate Author				Thesis
	Publisher	Springer US	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0926-6003	ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; 600.044; 605.203; 600.060; 600.075			Approved	no
	Call Number	Admin @ si @ GRB2015			Serial	2560
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	Author	Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda
	Title	PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities			Type	Journal
	Year	2015	Publication	Journal of Technology and Science Education	Abbreviated Journal	JOTSE
	Volume	5	Issue	2	Pages	87-96
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; ADAS; 600.076; 600.075			Approved	no
	Call Number	Admin @ si @ MRG2015			Serial	2608
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	Author	Jorge Bernal; F. Javier Sanchez; Gloria Fernandez Esparrach; Debora Gil; Cristina Rodriguez de Miguel; Fernando Vilariño
	Title	WM-DOVA Maps for Accurate Polyp Highlighting in Colonoscopy: Validation vs. Saliency Maps from Physicians			Type	Journal Article
	Year	2015	Publication	Computerized Medical Imaging and Graphics	Abbreviated Journal	CMIG
	Volume	43	Issue		Pages	99-111
	Keywords	Polyp localization; Energy Maps; Colonoscopy; Saliency; Valley detection
	Abstract	We introduce in this paper a novel polyp localization method for colonoscopy videos. Our method is based on a model of appearance for polyps which defines polyp boundaries in terms of valley information. We propose the integration of valley information in a robust way fostering complete, concave and continuous boundaries typically associated to polyps. This integration is done by using a window of radial sectors which accumulate valley information to create WMDOVA1 energy maps related with the likelihood of polyp presence. We perform a double validation of our maps, which include the introduction of two new databases, including the first, up to our knowledge, fully annotated database with clinical metadata associated. First we assess that the highest value corresponds with the location of the polyp in the image. Second, we show that WM-DOVA energy maps can be comparable with saliency maps obtained from physicians' fixations obtained via an eye-tracker. Finally, we prove that our method outperforms state-of-the-art computational saliency results. Our method shows good performance, particularly for small polyps which are reported to be the main sources of polyp miss-rate, which indicates the potential applicability of our method in clinical practice.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0895-6111	ISBN		Medium
	Area		Expedition		Conference
	Notes	MV; IAM; 600.047; 600.060; 600.075;SIAI			Approved	no
	Call Number	Admin @ si @ BSF2015			Serial	2609
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	Author	Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; J.Roncaries; Debora Gil
	Title	Automatic evaluation of practices in Moodle for Self Learning in Engineering			Type	Journal
	Year	2015	Publication	Journal of Technology and Science Education	Abbreviated Journal	JOTSE
	Volume	5	Issue	2	Pages	97-106
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	IAM; DAG; 600.075; 600.077			Approved	no
	Call Number	Admin @ si @ SRM2015			Serial	2610
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