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David Roche, Debora Gil, & Jesus Giraldo. (2012). "Assessing agonist efficacy in an uncertain Em world " In A. Christopoulus and M. Bouvier (Ed.), 40th Keystone Symposia on mollecular and celular biology (79). Keystone Symposia.
Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
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Albert Andaluz. (2012). "Harmonic Phase Flow: User's guide ". Barcelona: CVC.
Abstract: HPF is a plugin for the computation of clinical scores under Osirix.
This manual provides a basic guide for experienced clinical staff. Chapter 1 provides the theoretical background in which this plugin is based.
Next, in chapter 2 we provide basic instructions for installing and uninstalling this plugin. chapter 3we shows a step-by-step scenario to compute clinical scores from tagged-MRI images with HPF. Finally, in chapter 4 we provide a quick guide for plugin developers
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Albert Andaluz, Francesc Carreras, Cristina Santa Marta, & Debora Gil. (2012). "Myocardial torsion estimation with Tagged-MRI in the OsiriX platform " In Wiro Niessen(Erasmus MC) and Marc Modat(UCL) (Ed.), ISBI Workshop on Open Source Medical Image Analysis software. IEEE.
Abstract: Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es
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Patricia Marquez, Debora Gil, & Aura Hernandez-Sabate. (2013). "Evaluation of the Capabilities of Confidence Measures for Assessing Optical Flow Quality " In ICCV Workshop on Computer Vision in Vehicle Technology: From Earth to Mars (pp. 624–631).
Abstract: Assessing Optical Flow (OF) quality is essential for its further use in reliable decision support systems. The absence of ground truth in such situations leads to the computation of OF Confidence Measures (CM) obtained from either input or output data. A fair comparison across the capabilities of the different CM for bounding OF error is required in order to choose the best OF-CM pair for discarding points where OF computation is not reliable. This paper presents a statistical probabilistic framework for assessing the quality of a given CM. Our quality measure is given in terms of the percentage of pixels whose OF error bound can not be determined by CM values. We also provide statistical tools for the computation of CM values that ensures a given accuracy of the flow field.
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A. M. Here, B. C. Lopez, Debora Gil, J. J. Camarero, & Jordi Martinez-Vilalta. (2013). "A new software to analyse wood anatomical features in conifer species " In International Symposium on Wood Structure in Plant Biology and Ecology.
Abstract: International Symposium on Wood Structure in Plant Biology and Ecology
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Enric Marti, Ferran Poveda, Antoni Gurgui, Jaume Rocarias, & Debora Gil. (2013). "Una propuesta de seguimiento, tutorías on line y evaluación en la metodología de Aprendizaje Basado en Proyectos ".
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Sergio Vera, Miguel Angel Gonzalez Ballester, & Debora Gil. (2013). "Volumetric Anatomical Parameterization and Meshing for Inter-patient Liver Coordinate System Deffinition " In 16th International Conference on Medical Image Computing and Computer Assisted Intervention.
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David Roche, Debora Gil, & Jesus Giraldo. (2013). "Detecting loss of diversity for an efficient termination of EAs " In 15th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing (pp. 561–566).
Abstract: Termination of Evolutionary Algorithms (EA) at its steady state so that useless iterations are not performed is a main point for its efficient application to black-box problems. Many EA algorithms evolve while there is still diversity in their population and, thus, they could be terminated by analyzing the behavior some measures of EA population diversity. This paper presents a numeric approximation to steady states that can be used to detect the moment EA population has lost its diversity for EA termination. Our condition has been applied to 3 EA paradigms based on diversity and a selection of functions
covering the properties most relevant for EA convergence.
Experiments show that our condition works regardless of the search space dimension and function landscape.
Keywords: EA termination; EA population diversity; EA steady state
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Sergio Vera, Miguel Angel Gonzalez Ballester, & Debora Gil. (2012). "A medial map capturing the essential geometry of organs " In ISBI Workshop on Open Source Medical Image Analysis software (1691 - 1694). IEEE.
Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Accurate computation of one pixel wide medial surfaces is mandatory. Those surfaces must represent faithfully the geometry of the volume. Although morphological methods produce excellent results in 2D, their complexity and quality drops across dimensions, due to a more complex description of pixel neighborhoods. This paper introduces a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. Our experiments show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume
Keywords: Medial Surface Representation, Volume Reconstruction,Geometry , Image reconstruction , Liver , Manifolds , Shape , Surface morphology , Surface reconstruction
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Joan M. Nuñez, Debora Gil, & Fernando Vilariño. (2013). "Finger joint characterization from X-ray images for rheymatoid arthritis assessment " In 6th International Conference on Biomedical Electronics and Devices (pp. 288–292). SciTePress.
Abstract: In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection.
Keywords: Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde
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