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Author Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda edit  doi
openurl 
  Title PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities Type Journal
  Year (down) 2015 Publication Journal of Technology and Science Education Abbreviated Journal JOTSE  
  Volume 5 Issue 2 Pages 87-96  
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  Address  
  Corporate Author Thesis  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; ADAS; 600.076; 600.075 Approved no  
  Call Number Admin @ si @ MRG2015 Serial 2608  
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Author Jorge Bernal; F. Javier Sanchez; Gloria Fernandez Esparrach; Debora Gil; Cristina Rodriguez de Miguel; Fernando Vilariño edit   pdf
doi  openurl
  Title WM-DOVA Maps for Accurate Polyp Highlighting in Colonoscopy: Validation vs. Saliency Maps from Physicians Type Journal Article
  Year (down) 2015 Publication Computerized Medical Imaging and Graphics Abbreviated Journal CMIG  
  Volume 43 Issue Pages 99-111  
  Keywords Polyp localization; Energy Maps; Colonoscopy; Saliency; Valley detection  
  Abstract We introduce in this paper a novel polyp localization method for colonoscopy videos. Our method is based on a model of appearance for polyps which defines polyp boundaries in terms of valley information. We propose the integration of valley information in a robust way fostering complete, concave and continuous boundaries typically associated to polyps. This integration is done by using a window of radial sectors which accumulate valley information to create WMDOVA1 energy maps related with the likelihood of polyp presence. We perform a double validation of our maps, which include the introduction of two new databases, including the first, up to our knowledge, fully annotated database with clinical metadata associated. First we assess that the highest value corresponds with the location of the polyp in the image. Second, we show that WM-DOVA energy maps can be comparable with saliency maps obtained from physicians' fixations obtained via an eye-tracker. Finally, we prove that our method outperforms state-of-the-art computational saliency results. Our method shows good performance, particularly for small polyps which are reported to be the main sources of polyp miss-rate, which indicates the potential applicability of our method in clinical practice.  
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  Series Volume Series Issue Edition  
  ISSN 0895-6111 ISBN Medium  
  Area Expedition Conference  
  Notes MV; IAM; 600.047; 600.060; 600.075;SIAI Approved no  
  Call Number Admin @ si @ BSF2015 Serial 2609  
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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
openurl 
  Title Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models Type Journal Article
  Year (down) 2013 Publication British Journal of Pharmacology Abbreviated Journal BJP  
  Volume 169 Issue 6 Pages 1189-202  
  Keywords  
  Abstract Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.  
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  Area Expedition Conference  
  Notes IAM; 600.044; 605.203 Approved no  
  Call Number IAM @ iam @ RGG2013b Serial 2195  
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Author David Roche; Debora Gil; Jesus Giraldo edit  url
doi  openurl
  Title Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, Type Journal Article
  Year (down) 2013 Publication Drug Discovery Today Abbreviated Journal DDT  
  Volume 18 Issue 7-8 Pages 365-371  
  Keywords  
  Abstract The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.057; 600.054 Approved no  
  Call Number IAM @ iam @ RGG2013a Serial 2190  
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Author Ferran Poveda; Debora Gil; Enric Marti; Albert Andaluz; Manel Ballester;Francesc Carreras Costa edit   pdf
url  doi
openurl 
  Title Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography Type Journal Article
  Year (down) 2013 Publication Revista Española de Cardiología Abbreviated Journal REC  
  Volume 66 Issue 10 Pages 782-790  
  Keywords Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band.  
  Abstract Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI).
We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart.
On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp.
 
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.044; 600.060 Approved no  
  Call Number IAM @ iam @ PGM2013 Serial 2194  
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Author Sergio Vera; Debora Gil; Agnes Borras; Marius George Linguraru; Miguel Angel Gonzalez Ballester edit   pdf
url  doi
openurl 
  Title Geometric Steerable Medial Maps Type Journal Article
  Year (down) 2013 Publication Machine Vision and Applications Abbreviated Journal MVA  
  Volume 24 Issue 6 Pages 1255-1266  
  Keywords Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction  
  Abstract In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume.
 
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication Editor Mubarak Shah  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0932-8092 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 605.203; 600.060; 600.044 Approved no  
  Call Number IAM @ iam @ VGB2013 Serial 2192  
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Author Alberto Hidalgo; Ferran Poveda; Enric Marti;Debora Gil;Albert Andaluz; Francesc Carreras; Manuel Ballester edit   pdf
url  doi
openurl 
  Title Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography Type Journal Article
  Year (down) 2012 Publication European Radiology Abbreviated Journal ECR  
  Volume 3 Issue 1 Pages 361-362  
  Keywords  
  Abstract Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model.
 
  Address Viena, Austria  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1869-4101 ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ HPM2012 Serial 1858  
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Author Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester edit   pdf
url  doi
openurl 
  Title Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography Type Journal Article
  Year (down) 2012 Publication Journal of American College of Cardiology Abbreviated Journal JACC  
  Volume 5 Issue 7 Pages 754-755  
  Keywords  
  Abstract It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1  
  Address  
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  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1936-878X ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ PMG2012 Serial 1985  
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Author Francesc Carreras; Jaume Garcia; Debora Gil; Sandra Pujadas; Chi ho Lion; R.Suarez-Arias; R.Leta; Xavier Alomar; Manuel Ballester; Guillem Pons-Llados edit  url
doi  openurl
  Title Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects Type Journal Article
  Year (down) 2012 Publication International Journal of Cardiovascular Imaging Abbreviated Journal IJCI  
  Volume 28 Issue 2 Pages 273-284  
  Keywords Magnetic resonance imaging (MRI); Tagging MRI; Cardiac mechanics; Ventricular torsion  
  Abstract Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1569-5794 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ CGG2012 Serial 1496  
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Author Sergio Vera; Debora Gil; Antonio Lopez; Miguel Angel Gonzalez Ballester edit   pdf
url  openurl
  Title Multilocal Creaseness Measure Type Journal
  Year (down) 2012 Publication The Insight Journal Abbreviated Journal IJ  
  Volume Issue Pages  
  Keywords Ridges, Valley, Creaseness, Structure Tensor, Skeleton,  
  Abstract This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.  
  Address  
  Corporate Author Alma IT Systems Thesis  
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  Language english Summary Language english Original Title  
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  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;ADAS; Approved no  
  Call Number IAM @ iam @ VGL2012 Serial 1840  
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