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Author |
Fernando Vilariño; Debora Gil; Petia Radeva |
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Title |
A Novel FLDA Formulation for Numerical Stability Analysis |
Type |
Book Chapter |
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Year |
2004 |
Publication |
Recent Advances in Artificial Intelligence Research and Development |
Abbreviated Journal |
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Volume |
113 |
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Pages |
77-84 |
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Keywords |
Supervised Learning; Linear Discriminant Analysis; Numerical Stability; Computer Vision |
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Abstract  |
Fisher Linear Discriminant Analysis (FLDA) is one of the most popular techniques used in classification applying dimensional reduction. The numerical scheme involves the inversion of the within-class scatter matrix, which makes FLDA potentially ill-conditioned when it becomes singular. In this paper we present a novel explicit formulation of FLDA in terms of the eccentricity ratio and eigenvector orientations of the within-class scatter matrix. An analysis of this function will characterize those situations where FLDA response is not reliable because of numerical instability. This can solve common situations of poor classification performance in computer vision. |
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IOS Press |
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J. Vitrià, P. Radeva and I. Aguiló |
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978-1-58603-466-5 |
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MV;IAM;MILAB;SIAI |
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no |
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Call Number |
IAM @ iam @ VGR2004 |
Serial |
1663 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
Type |
Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
Abbreviated Journal |
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Volume |
796 |
Issue |
3 |
Pages |
159-181 |
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Keywords |
β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Abstract |
Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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ISSN |
0065-2598 |
ISBN |
978-94-007-7422-3 |
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Notes |
IAM; 600.075 |
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Call Number |
IAM @ iam @ RGG2014 |
Serial |
2197 |
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Author |
Debora Gil; F. Javier Sanchez; Gloria Fernandez Esparrach; Jorge Bernal |
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Title |
3D Stable Spatio-temporal Polyp Localization in Colonoscopy Videos |
Type |
Book Chapter |
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Year |
2015 |
Publication |
Computer-Assisted and Robotic Endoscopy. Revised selected papers of Second International Workshop, CARE 2015, Held in Conjunction with MICCAI 2015 |
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Volume |
9515 |
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Pages |
140-152 |
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Keywords |
Colonoscopy, Polyp Detection, Polyp Localization, Region Extraction, Watersheds |
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Abstract |
Computational intelligent systems could reduce polyp miss rate in colonoscopy for colon cancer diagnosis and, thus, increase the efficiency of the procedure. One of the main problems of existing polyp localization methods is a lack of spatio-temporal stability in their response. We propose to explore the response of a given polyp localization across temporal windows in order to select
those image regions presenting the highest stable spatio-temporal response.
Spatio-temporal stability is achieved by extracting 3D watershed regions on the
temporal window. Stability in localization response is statistically determined by analysis of the variance of the output of the localization method inside each 3D region. We have explored the benefits of considering spatio-temporal stability in two different tasks: polyp localization and polyp detection. Experimental results indicate an average improvement of 21:5% in polyp localization and 43:78% in polyp detection. |
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LNCS |
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CARE |
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Notes |
IAM; MV; 600.075 |
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no |
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Call Number |
Admin @ si @ GSF2015 |
Serial |
2733 |
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Author |
Jaume Garcia |
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Title |
Statistical Models of the Architecture and Function of the Left Ventricle |
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Book Whole |
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Year |
2009 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Cardiovascular Diseases, specially those affecting the Left Ventricle (LV), are the leading cause of death in developed countries with approximately a 30% of all global deaths. In order to address this public health concern, physicians focus on diagnosis and therapy planning. On one hand, early and accurate detection of Regional Wall Motion Abnormalities (RWMA) significantly contributes to a quick diagnosis and prevents the patient to reach more severe stages. On the other hand, a thouroughly knowledge of the normal gross anatomy of the LV, as well as, the distribution of its muscular fibers is crucial for designing specific interventions and therapies (such as pacemaker implanction). Statistical models obtained from the analysis of different imaging modalities allow the computation of the normal ranges of variation within a given population. Normality models are a valuable tool for the definition of objective criterions quantifying the degree of (anomalous) deviation of the LV function and anatomy for a given subject. The creation of statistical models involve addressing three main issues: extraction of data from images, definition of a common domain for comparison of data across patients and designing appropriate statistical analysis schemes. In this PhD thesis we present generic image processing tools for the creation of statistical models of the LV anatomy and function. On one hand, we use differential geometry concepts to define a computational framework (the Normalized Parametric Domain, NPD) suitable for the comparison and fusion of several clinical scores obtained over the LV. On the other hand, we present a variational approach (the Harmonic Phase Flow, HPF) for the estimation of myocardial motion that provides dense and continuous vector fields without overestimating motion at injured areas. These tools are used for the creation of statistical models. Regarding anatomy, we obtain an atlas jointly modelling, both, LV gross anatomy and fiber architecture. Regarding function, we compute normality patterns of scores characterizing the (global and local) LV function and explore, for the first time, the configuration of local scores better suited for RWMA detection. |
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Thesis |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
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Editor |
Debora Gil |
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IAM |
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no |
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Call Number |
IAM @ iam @ Gar2009a |
Serial |
1499 |
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Author |
Aura Hernandez-Sabate |
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Title |
Exploring Arterial Dynamics and Structures in IntraVascular Ultrasound Sequences |
Type |
Book Whole |
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Year |
2009 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Cardiovascular diseases are a leading cause of death in developed countries. Most of them are caused by arterial (specially coronary) diseases, mainly caused by plaque accumulation. Such pathology narrows blood flow (stenosis) and affects artery bio- mechanical elastic properties (atherosclerosis). In the last decades, IntraVascular UltraSound (IVUS) has become a usual imaging technique for the diagnosis and follow up of arterial diseases. IVUS is a catheter-based imaging technique which shows a sequence of cross sections of the artery under study. Inspection of a single image gives information about the percentage of stenosis. Meanwhile, inspection of longitudinal views provides information about artery bio-mechanical properties, which can prevent a fatal outcome of the cardiovascular disease. On one hand, dynamics of arteries (due to heart pumping among others) is a major artifact for exploring tissue bio-mechanical properties. On the other one, manual stenosis measurements require a manual tracing of vessel borders, which is a time-consuming task and might suffer from inter-observer variations. This PhD thesis proposes several image processing tools for exploring vessel dy- namics and structures. We present a physics-based model to extract, analyze and correct vessel in-plane rigid dynamics and to retrieve cardiac phase. Furthermore, we introduce a deterministic-statistical method for automatic vessel borders detection. In particular, we address adventitia layer segmentation. An accurate validation pro- tocol to ensure reliable clinical applicability of the methods is a crucial step in any proposal of an algorithm. In this thesis we take special care in designing a valida- tion protocol for each approach proposed and we contribute to the in vivo dynamics validation with a quantitative and objective score to measure the amount of motion suppressed. |
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Thesis |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
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Editor |
Debora Gil |
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ISBN |
978-84-937261-6-4 |
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IAM; |
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no |
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Call Number |
IAM @ iam @ Her2009 |
Serial |
1543 |
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Author |
Debora Gil; Oriol Rodriguez-Leon; Petia Radeva; Aura Hernandez-Sabate |
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Title |
Assessing Artery Motion Compensation in IVUS |
Type |
Book Chapter |
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Year |
2007 |
Publication |
Computer Analysis Of Images And Patterns |
Abbreviated Journal |
LNCS |
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Volume |
4673 |
Issue |
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Pages |
213-220 |
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Keywords |
validation standards; quality measures; IVUS motion compensation; conservation laws; Fourier development |
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Abstract |
Cardiac dynamics suppression is a main issue for visual improvement and computation of tissue mechanical properties in IntraVascular UltraSound (IVUS). Although in recent times several motion compensation techniques have arisen, there is a lack of objective evaluation of motion reduction in in vivo pullbacks. We consider that the assessment protocol deserves special attention for the sake of a clinical applicability as reliable as possible. Our work focuses on defining a quality measure and a validation protocol assessing IVUS motion compensation. On the grounds of continuum mechanics laws we introduce a novel score measuring motion reduction in in vivo sequences. Synthetic experiments validate the proposed score as measure of motion parameters accuracy; while results in in vivo pullbacks show its reliability in clinical cases. |
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Springerlink |
Place of Publication |
Heidelberg |
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Lecture Notes in Computer Science |
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ISBN |
978-3-540-74271-5 |
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Notes |
IAM;MILAB |
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no |
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Call Number |
IAM @ iam @ GRR2007 |
Serial |
1540 |
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Author |
Hanne Kause; Aura Hernandez-Sabate; Patricia Marquez; Andrea Fuster; Luc Florack; Hans van Assen; Debora Gil |
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Title |
Confidence Measures for Assessing the HARP Algorithm in Tagged Magnetic Resonance Imaging |
Type |
Book Chapter |
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Year |
2015 |
Publication |
Statistical Atlases and Computational Models of the Heart. Revised selected papers of Imaging and Modelling Challenges 6th International Workshop, STACOM 2015, Held in Conjunction with MICCAI 2015 |
Abbreviated Journal |
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Volume |
9534 |
Issue |
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Pages |
69-79 |
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Abstract |
Cardiac deformation and changes therein have been linked to pathologies. Both can be extracted in detail from tagged Magnetic Resonance Imaging (tMRI) using harmonic phase (HARP) images. Although point tracking algorithms have shown to have high accuracies on HARP images, these vary with position. Detecting and discarding areas with unreliable results is crucial for use in clinical support systems. This paper assesses the capability of two confidence measures (CMs), based on energy and image structure, for detecting locations with reduced accuracy in motion tracking results. These CMs were tested on a database of simulated tMRI images containing the most common artifacts that may affect tracking accuracy. CM performance is assessed based on its capability for HARP tracking error bounding and compared in terms of significant differences detected using a multi comparison analysis of variance that takes into account the most influential factors on HARP tracking performance. Results showed that the CM based on image structure was better suited to detect unreliable optical flow vectors. In addition, it was shown that CMs can be used to detect optical flow vectors with large errors in order to improve the optical flow obtained with the HARP tracking algorithm. |
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Munich; Germany; January 2015 |
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Springer International Publishing |
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LNCS |
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ISSN |
0302-9743 |
ISBN |
978-3-319-28711-9 |
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STACOM |
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Notes |
ADAS; IAM; 600.075; 600.076; 600.060; 601.145 |
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no |
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Call Number |
Admin @ si @ KHM2015 |
Serial |
2734 |
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Author |
David Roche |
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Title |
A Statistical Framework for Terminating Evolutionary Algorithms at their Steady State |
Type |
Book Whole |
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Year |
2015 |
Publication |
PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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As any iterative technique, it is a necessary condition a stop criterion for terminating Evolutionary Algorithms (EA). In the case of optimization methods, the algorithm should stop at the time it has reached a steady state so it can not improve results anymore. Assessing the reliability of termination conditions for EAs is of prime importance. A wrong or weak stop criterion can negatively a ect both the computational e ort and the nal result.
In this Thesis, we introduce a statistical framework for assessing whether a termination condition is able to stop EA at its steady state. In one hand a numeric approximation to steady states to detect the point in which EA population has lost its diversity has been presented for EA termination. This approximation has been applied to di erent EA paradigms based on diversity and a selection of functions covering the properties most relevant for EA convergence. Experiments show that our condition works regardless of the search space dimension and function landscape and Di erential Evolution (DE) arises as the best paradigm. On the other hand, we use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in xspace.
Our theoretical framework is analyzed across several benchmark test functions
and two standard termination criteria based on function improvement in f-space and EA population x-space distribution for the DE paradigm. Results validate our statistical framework as a powerful tool for determining the capability of a measure for terminating EA and select the x-space distribution as the best-suited for accurately stopping DE in real-world applications. |
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July 2015 |
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Thesis |
Ph.D. thesis |
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Publisher |
Ediciones Graficas Rey |
Place of Publication |
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Editor |
Debora Gil;Jesus Giraldo |
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IAM; 600.075 |
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Admin @ si @ Roc2015 |
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2686 |
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Author |
Debora Gil; Oriol Ramos Terrades; Raquel Perez |
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Title |
Topological Radiomics (TOPiomics): Early Detection of Genetic Abnormalities in Cancer Treatment Evolution |
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Book Chapter |
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Year |
2021 |
Publication |
Extended Abstracts GEOMVAP 2019, Trends in Mathematics 15 |
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15 |
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89–93 |
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Abnormalities in radiomic measures correlate to genomic alterations prone to alter the outcome of personalized anti-cancer treatments. TOPiomics is a new method for the early detection of variations in tumor imaging phenotype from a topological structure in multi-view radiomic spaces. |
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Springer Nature |
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IAM; DAG; 600.120; 600.145; 600.139 |
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Admin @ si @ GRP2021 |
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3594 |
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Author |
Debora Gil; Jordi Gonzalez; Gemma Sanchez (eds) |
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Title |
Computer Vision: Advances in Research and Development |
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2007 |
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Proceedings of the 2nd CVC International Workshop |
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UAB |
Place of Publication |
Bellaterra (Spain) |
Editor |
Debora Gil; Jordi Gonzalez; Gemma Sanchez |
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2 |
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978-84-935251-4-9 |
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IAM; ISE; DAG |
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IAM @ iam @ GGS2007 |
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1493 |
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