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Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester |
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Title |
Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography |
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2012 |
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Journal of American College of Cardiology |
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JACC |
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5 |
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7 |
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754-755 |
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It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1 |
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1936-878X |
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IAM @ iam @ PMG2012 |
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1985 |
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Author |
Debora Gil; Petia Radeva |
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Title |
Shape Restoration via a Regularized Curvature Flow |
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2004 |
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Journal of Mathematical Imaging and Vision |
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21 |
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3 |
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205-223 |
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Any image filtering operator designed for automatic shape restoration should satisfy robustness (whatever the nature and degree of noise is) as well as non-trivial smooth asymptotic behavior. Moreover, a stopping criterion should be determined by characteristics of the evolved image rather than dependent on the number of iterations. Among the several PDE based techniques, curvature flows appear to be highly reliable for strongly noisy images compared to image diffusion processes.
In the present paper, we introduce a regularized curvature flow (RCF) that admits non-trivial steady states. It is based on a measure of the local curve smoothness that takes into account regularity of the curve curvature and serves as stopping term in the mean curvature flow. We prove that this measure decreases over the orbits of RCF, which endows the method with a natural stop criterion in terms of the magnitude of this measure. Further, in its discrete version it produces steady states consisting of piece-wise regular curves. Numerical experiments made on synthetic shapes corrupted with different kinds of noise show the abilities and limitations of each of the current geometric flows and the benefits of RCF. Finally, we present results on real images that illustrate the usefulness of the present approach in practical applications. |
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IAM;MILAB |
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IAM @ iam @ GiR2004c |
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1532 |
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Author |
Debora Gil; Jose Maria-Carazo; Roberto Marabini |
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On the nature of 2D crystal unbending |
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2006 |
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Journal of Structural Biology |
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156 |
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3 |
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546-555 |
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Electron microscopy |
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Crystal unbending, the process that aims to recover a perfect crystal from experimental data, is one of the more important steps in electron crystallography image processing. The unbending process involves three steps: estimation of the unit cell displacements from their ideal positions, extension of the deformation field to the whole image and transformation of the image in order to recover an ideal crystal. In this work, we present a systematic analysis of the second step oriented to address two issues. First, whether the unit cells remain undistorted and only the distance between them should be changed (rigid case) or should be modified with the same deformation suffered by the whole crystal (elastic case). Second, the performance of different extension algorithms (interpolation versus approximation) is explored. Our experiments show that there is no difference between elastic and rigid cases or among the extension algorithms. This implies that the deformation fields are constant over large areas. Furthermore, our results indicate that the main source of error is the transformation of the crystal image. |
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1047-8477 |
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IAM; |
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IAM @ iam @ GCM2006 |
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1519 |
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Author |
Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda |
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Title |
PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities |
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2015 |
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Journal of Technology and Science Education |
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JOTSE |
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5 |
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2 |
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87-96 |
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IAM; ADAS; 600.076; 600.075 |
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Admin @ si @ MRG2015 |
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2608 |
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Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; J.Roncaries; Debora Gil |
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Automatic evaluation of practices in Moodle for Self Learning in Engineering |
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2015 |
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Journal of Technology and Science Education |
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JOTSE |
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5 |
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2 |
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97-106 |
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IAM; DAG; 600.075; 600.077 |
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Admin @ si @ SRM2015 |
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2610 |
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Author |
Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso |
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Title |
Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation |
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Journal Article |
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2017 |
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Journal of Thoracic Oncology |
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JTO |
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12 |
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1S |
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S596-S597 |
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Thorax CT; diagnosis; Peripheral Pulmonary Nodule |
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A main weakness of virtual bronchoscopic navigation (VBN) is unsuccessful segmentation of distal branches approaching peripheral pulmonary nodules (PPN). CT scan acquisition protocol is pivotal for segmentation covering the utmost periphery. We hypothesize that application of continuous positive airway pressure (CPAP) during CT acquisition could improve visualization and segmentation of peripheral bronchi. The purpose of the present pilot study is to compare quality of segmentations under 4 CT acquisition modes: inspiration (INSP), expiration (EXP) and both with CPAP (INSP-CPAP and EXP-CPAP). |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ DGC2017a |
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2883 |
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Ester Conde; Susana Herandez; Rebeca Martinez; Barbara Angulo; Javier de Castro; Ana Collazo; Beatriz Jimenez; Alfonso Muriel; Jose Luis Mate; Teresa Moran; Ignacio Aranda; Bartomeu Massuti; Federico Rojo; Manuel Domine; Irene Sansano; Felipe Garcia; Enriqueta Felip; Nuria Mancheno; Oscar Juan; Julian Sanz; Jose Luis Gonzalez; Lidia Atienza; Esperanza Arriola; I. Abdulkader; J.Garcia; C. Camacho; D. Rodriguez; D. Teixido; N. Reguart; A.Gonzalez; M. Lazaro; MD. Lozano; J. Gomez; M. Lopez; L Pijuan; M Salido; E. Arriola; A. Company; A. Insa; I. Esteban; M. Saiz; E. Azkona; R. Alvarez; A. Artal; ML. Plaza; D. Aguiar; AB. Enguita, A. Benito; L. Paz; P. Garrido; F. Lopez |
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Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Patients with Non–Small Cell Lung Carcinoma: the ROSING Study |
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Journal Article |
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2019 |
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Journal of Thoracic Oncology |
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14 |
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12 |
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2120-2132 |
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Introduction
The ROS1 gene rearrangement has become an important biomarker in NSCLC. The College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology testing guidelines support the use of ROS1 immunohistochemistry (IHC) as a screening test, followed by confirmation with fluorescence in situ hybridization (FISH) or a molecular test in all positive results. We have evaluated a novel anti-ROS1 IHC antibody (SP384) in a large multicenter series to obtain real-world data.
Methods
A total of 43 ROS1 FISH–positive and 193 ROS1 FISH–negative NSCLC samples were studied. All specimens were screened by using two antibodies (clone D4D6 from Cell Signaling Technology and clone SP384 from Ventana Medical Systems), and the different interpretation criteria were compared with break-apart FISH (Vysis). FISH-positive samples were also analyzed with next-generation sequencing (Oncomine Dx Target Test Panel, Thermo Fisher Scientific).
Results
An H-score of 150 or higher or the presence of at least 70% of tumor cells with an intensity of staining of 2+ or higher by the SP384 clone was the optimal cutoff value (both with 93% sensitivity and 100% specificity). The D4D6 clone showed similar results, with an H-score of at least 100 (91% sensitivity and 100% specificity). ROS1 expression in normal lung was more frequent with use of the SP384 clone (p < 0.0001). The ezrin gene (EZR)-ROS1 variant was associated with membranous staining and an isolated green signal FISH pattern (p = 0.001 and p = 0.017, respectively).
Conclusions
The new SP384 ROS1 IHC clone showed excellent sensitivity without compromising specificity, so it is another excellent analytical option for the proposed testing algorithm. |
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IAM; 600.139; 600.145 |
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Admin @ si @ CHM2019 |
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3471 |
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Pere Serra; Carmen Centeno; Jose Sanz-Santos; Mohamed Torky; Sonia Baeza; Leire Mendiluce; Carlos Martinez-Barenys; Pedro de Castro; Jorge Abad; Antoni Rosell; Felipe Andreo |
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Is it necessary to sample the contralateral nodal stations by EBUS-TBNA in patients with lung cancer and clinical N0 / N1 on PET-CT? |
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2020 |
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Lung Cancer |
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142 |
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9-12 |
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Systematic mediastinal staging (sampling all visible nodes measuring ≥ 5 mm from N3 station to N1, regardless of PET/CT (positron emission tomography/computed tomography) by endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is a decisive step in patients with non-small cell lung cancer (NSCLC). We analyzed the prevalence of N3 disease and the utility of systematic staging in the subgroup of patients who underwent EBUS-TBNA staging without showing mediastinal lesions on the PET/CT (N0/N1). |
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IAM; 600.139; 600.145 |
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Admin @ si @ SCS2020 |
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3469 |
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Author |
Josep Llados; Enric Marti |
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A graph-edit algorithm for hand-drawn graphical document recognition and their automatic introduction into CAD systems |
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1999 |
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Machine Graphics & Vision |
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8 |
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195-211 |
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IAM @ iam @ LIM1999 |
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1568 |
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Josep Llados; Enric Marti |
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Graph-edit algorithms for hand-drawn graphical document recognition and their automatic introduction |
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1999 |
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Machine Graphics & Vision journal, special issue on Graph transformation |
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IAM @ iam @ LIM1999c |
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1569 |
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