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Author Debora Gil;Agnes Borras;Ruth Aris;Mariano Vazquez;Pierre Lafortune; Guillame Houzeaux edit   pdf
doi  isbn
openurl 
  Title What a difference in biomechanics cardiac fiber makes Type Conference Article
  Year 2012 Publication Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges Abbreviated Journal  
  Volume 7746 Issue Pages 253-260  
  Keywords  
  Abstract Computational simulations of the heart are a powerful tool for a comprehensive understanding of cardiac function and its intrinsic relationship with its muscular architecture. Cardiac biomechanical models require a vector field representing the orientation of cardiac fibers. A wrong orientation of the fibers can lead to a
non-realistic simulation of the heart functionality. In this paper we explore the impact of the fiber information on the simulated biomechanics of cardiac muscular anatomy. We have used the John Hopkins database to perform a biomechanical simulation using both a synthetic benchmark fiber distribution and the data obtained experimentally from DTI. Results illustrate how differences in fiber orientation affect heart deformation along cardiac cycle.
 
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-36960-5 Medium  
  Area Expedition Conference STACOM  
  Notes IAM Approved no  
  Call Number IAM @ iam @ GBA2012 Serial 1987  
Permanent link to this record
 

 
Author Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil edit   pdf
url  doi
isbn  openurl
  Title Optimal Medial Surface Generation for Anatomical Volume Representations Type Book Chapter
  Year 2012 Publication Abdominal Imaging. Computational and Clinical Applications Abbreviated Journal LNCS  
  Volume 7601 Issue Pages 265-273  
  Keywords Medial surface representation; volume reconstruction  
  Abstract Medial representations are a widely used technique in abdominal organ shape representation and parametrization. Those methods require good medial manifolds as a starting point. Any medial
surface used to parametrize a volume should be simple enough to allow an easy manipulation and complete enough to allow an accurate reconstruction of the volume. Obtaining good quality medial
surfaces is still a problem with current iterative thinning methods. This forces the usage of generic, pre-calculated medial templates that are adapted to the final shape at the cost of a drop in volume reconstruction.
This paper describes an operator for generation of medial structures that generates clean and complete manifolds well suited for their further use in medial representations of abdominal organ volumes. While being simpler than thinning surfaces, experiments show its high performance in volume reconstruction and preservation of medial surface main branching topology.
 
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication (up) Editor Yoshida, Hiroyuki and Hawkes, David and Vannier, MichaelW.  
  Language Summary Language Original Title  
  Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-33611-9 Medium  
  Area Expedition Conference STACOM  
  Notes IAM Approved no  
  Call Number IAM @ iam @ VGG2012b Serial 1988  
Permanent link to this record
 

 
Author Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil edit   pdf
doi  isbn
openurl 
  Title A medial map capturing the essential geometry of organs Type Conference Article
  Year 2012 Publication ISBI Workshop on Open Source Medical Image Analysis software Abbreviated Journal  
  Volume Issue Pages 1691 - 1694  
  Keywords Medial Surface Representation, Volume Reconstruction,Geometry , Image reconstruction , Liver , Manifolds , Shape , Surface morphology , Surface reconstruction  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Accurate computation of one pixel wide medial surfaces is mandatory. Those surfaces must represent faithfully the geometry of the volume. Although morphological methods produce excellent results in 2D, their complexity and quality drops across dimensions, due to a more complex description of pixel neighborhoods. This paper introduces a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. Our experiments show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume  
  Address Barcelona,Spain  
  Corporate Author Thesis  
  Publisher IEEE Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1945-7928 ISBN 978-1-4577-1857-1 Medium  
  Area Expedition Conference ISBI  
  Notes IAM Approved no  
  Call Number IAM @ iam @ VGG2012a Serial 1989  
Permanent link to this record
 

 
Author Sergio Vera; Debora Gil; Agnes Borras; F. Javier Sanchez; Frederic Perez; Marius G. Linguraru edit  openurl
  Title Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs Type Conference Article
  Year 2011 Publication Workshop on Computational and Clinical Applications in Abdominal Imaging Abbreviated Journal  
  Volume 7029 Issue Pages 223-230  
  Keywords  
  Abstract Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs, exploring the use of medial manifolds for the representation of multi-organ relations.  
  Address Nice, France  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication (up) Editor In H. Yoshida et al  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference ABDI  
  Notes IAM; MV Approved no  
  Call Number VGB2011 Serial 2036  
Permanent link to this record
 

 
Author David Roche; Debora Gil; Jesus Giraldo edit  url
doi  openurl
  Title Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, Type Journal Article
  Year 2013 Publication Drug Discovery Today Abbreviated Journal DDT  
  Volume 18 Issue 7-8 Pages 365-371  
  Keywords  
  Abstract The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.057; 600.054 Approved no  
  Call Number IAM @ iam @ RGG2013a Serial 2190  
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Author Sergio Vera; Debora Gil; Agnes Borras; Marius George Linguraru; Miguel Angel Gonzalez Ballester edit   pdf
url  doi
openurl 
  Title Geometric Steerable Medial Maps Type Journal Article
  Year 2013 Publication Machine Vision and Applications Abbreviated Journal MVA  
  Volume 24 Issue 6 Pages 1255-1266  
  Keywords Medial Representations ,Medial Manifolds Comparation , Surface , Reconstruction  
  Abstract In order to provide more intuitive and easily interpretable representations of complex shapes/organs, medial manifolds should reach a compromise between simplicity in geometry and capability for restoring the anatomy/shape of the organ/volume. Existing morphological methods show excellent results when applied to 2D objects, but their quality drops across dimensions.
This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial manifolds that avoids degenerated medial axis segments. Second, we introduce a continuous operator for accurate and efficient computation of medial structures of arbitrary dimension. We evaluate quantitatively the performance of our method with respect to existing approaches, by applying them to syn- thetic shapes of known medial geometry. We also show its higher performance for medical imaging applications in terms of simplicity of medial structures and capability for reconstructing the anatomical volume.
 
  Address  
  Corporate Author Thesis  
  Publisher Springer Berlin Heidelberg Place of Publication (up) Editor Mubarak Shah  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0932-8092 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 605.203; 600.060; 600.044 Approved no  
  Call Number IAM @ iam @ VGB2013 Serial 2192  
Permanent link to this record
 

 
Author Ferran Poveda; Debora Gil; Enric Marti; Albert Andaluz; Manel Ballester;Francesc Carreras Costa edit   pdf
url  doi
openurl 
  Title Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography Type Journal Article
  Year 2013 Publication Revista Española de Cardiología Abbreviated Journal REC  
  Volume 66 Issue 10 Pages 782-790  
  Keywords Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band.  
  Abstract Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI).
We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart.
On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp.
 
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.044; 600.060 Approved no  
  Call Number IAM @ iam @ PGM2013 Serial 2194  
Permanent link to this record
 

 
Author David Roche; Debora Gil; Jesus Giraldo edit  doi
openurl 
  Title Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models Type Journal Article
  Year 2013 Publication British Journal of Pharmacology Abbreviated Journal BJP  
  Volume 169 Issue 6 Pages 1189-202  
  Keywords  
  Abstract Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.044; 605.203 Approved no  
  Call Number IAM @ iam @ RGG2013b Serial 2195  
Permanent link to this record
 

 
Author Joan M. Nuñez; Debora Gil; Fernando Vilariño edit  doi
openurl 
  Title Finger joint characterization from X-ray images for rheymatoid arthritis assessment Type Conference Article
  Year 2013 Publication 6th International Conference on Biomedical Electronics and Devices Abbreviated Journal  
  Volume Issue Pages 288-292  
  Keywords Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde  
  Abstract In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection.  
  Address Barcelona; February 2013  
  Corporate Author Thesis  
  Publisher SciTePress Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area 800 Expedition Conference BIODEVICES  
  Notes IAM;MV; 600.057; 600.054 Approved no  
  Call Number IAM @ iam @ NGV2013 Serial 2196  
Permanent link to this record
 

 
Author David Roche; Debora Gil; Jesus Giraldo edit  doi
isbn  openurl
  Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
  Year 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal  
  Volume 796 Issue 3 Pages 159-181  
  Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model  
  Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication (up) Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0065-2598 ISBN 978-94-007-7422-3 Medium  
  Area Expedition Conference  
  Notes IAM; 600.075 Approved no  
  Call Number IAM @ iam @ RGG2014 Serial 2197  
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