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David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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2013 |
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Drug Discovery Today |
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DDT |
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18 |
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7-8 |
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365-371 |
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The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
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2190 |
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Author |
Jaume Garcia; David Rotger; Francesc Carreras; R.Leta; Petia Radeva |
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Title |
Contrast echography segmentation and tracking by trained deformable models |
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2003 |
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Proc. Computers in Cardiology |
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30 |
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173-176 |
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The objective of this work is to segment the human left ventricle myocardium (LVM) in contrast echocardiography imaging and thus track it along a cardiac cycle in order to extract quantitative data about heart function. Ultrasound images are hard to work with due to their speckle appearance. To overcome this we report the combination of active contour models (ACM) or snakes and active shape models (ASM). The ability of ACM in giving closed and smooth curves in addition to the power of the ASM in producing shapes similar to the ones learned, evoke to a robust algorithm. Meanwhile the snake is attracted towards image main features, ASM acts as a correction factor. The algorithm was tested independently on 180 frames and satisfying results were obtained: in 95% the maximum difference between automatic and experts segmentation was less than 12 pixels. |
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Centre de Visió per Computador – Dept. Informàtica, UAB Edifici O – Campus UAB, 08193 Bellater |
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0276-6547 |
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0-7803-8170-X |
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IAM;MILAB |
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IAM @ iam @ GRC2003 |
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1512 |
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Author |
Petia Radeva; Enric Marti |
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Title |
An improved model of snakes for model-based segmentation |
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1995 |
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Proceedings of Computer Analysis of Images and Patterns |
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515-520 |
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The main advantage of segmentation by snakes consists in its ability to incorporate smoothness constraints on the detected shapes that can occur. Likewise, we propose to model snakes with other properties that reflect the information provided about the object of interest in a different extent. We consider different kinds of snakes, those searching for contours with a certain direction, those preserving an object’s model, those seeking for symmetry, those expanding open, etc. The availability of such a collection of snakes allows not only the more complete use of the knowledge about the segmented object, but also to solve some problems of the existing snakes. Our experiments on segmentation of facial features justify the usefulness of snakes with different properties. |
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CAIP |
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MILAB;IAM |
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IAM @ iam @ RaM1995b |
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1632 |
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Author |
Paula Fritzsche; C.Roig; Ana Ripoll; Emilio Luque; Aura Hernandez-Sabate |
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Title |
A Performance Prediction Methodology for Data-dependent Parallel Applications |
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Conference Article |
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2006 |
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Proceedings of the IEEE International Conference on Cluster Computing |
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1-8 |
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The increase in the use of parallel distributed architectures in order to solve large-scale scientific problems has generated the need for performance prediction for both deterministic applications and non-deterministic applications. In particular, the performance prediction of data dependent programs is an extremely challenging problem because for a specific issue the input datasets may cause different execution times. Generally, a parallel application is characterized as a collection of tasks and their interrelations. If the application is time-critical it is not enough to work with only one value per task, and consequently knowledge of the distribution of task execution times is crucial. The development of a new prediction methodology to estimate the performance of data-dependent parallel applications is the primary target of this study. This approach makes it possible to evaluate the parallel performance of an application without the need of implementation. A real data-dependent arterial structure detection application model is used to apply the methodology proposed. The predicted times obtained using the new methodology for genuine datasets are compared with predicted times that arise from using only one execution value per task. Finally, the experimental study shows that the new methodology generates more precise predictions. |
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IAM @ iam @ FRR2006 |
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1497 |
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Author |
Miquel Angel Piera; Jose Luis Muñoz; Debora Gil; Gonzalo Martin; Jordi Manzano |
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Title |
A Socio-Technical Simulation Model for the Design of the Future Single Pilot Cockpit: An Opportunity to Improve Pilot Performance |
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Journal Article |
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2022 |
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IEEE Access |
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ACCESS |
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10 |
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22330-22343 |
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Human factors ; Performance evaluation ; Simulation; Sociotechnical systems ; System performance |
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The future deployment of single pilot operations must be supported by new cockpit computer services. Such services require an adaptive context-aware integration of technical functionalities with the concurrent tasks that a pilot must deal with. Advanced artificial intelligence supporting services and improved communication capabilities are the key enabling technologies that will render future cockpits more integrated with the present digitalized air traffic management system. However, an issue in the integration of such technologies is the lack of socio-technical analysis in the design of these teaming mechanisms. A key factor in determining how and when a service support should be provided is the dynamic evolution of pilot workload. This paper investigates how the socio-technical model-based systems engineering approach paves the way for the design of a digital assistant framework by formalizing this workload. The model was validated in an Airbus A-320 cockpit simulator, and the results confirmed the degraded pilot behavioral model and the performance impact according to different contextual flight deck information. This study contributes to practical knowledge for designing human-machine task-sharing systems. |
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Feb 2022 |
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IAM; |
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Admin @ si @ PMG2022 |
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3697 |
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Author |
Guillermo Torres; Sonia Baeza; Carles Sanchez; Ignasi Guasch; Antoni Rosell; Debora Gil |
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Title |
An Intelligent Radiomic Approach for Lung Cancer Screening |
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2022 |
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Applied Sciences |
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APPLSCI |
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12 |
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3 |
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1568 |
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Lung cancer; Early diagnosis; Screening; Neural networks; Image embedding; Architecture optimization |
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The efficiency of lung cancer screening for reducing mortality is hindered by the high rate of false positives. Artificial intelligence applied to radiomics could help to early discard benign cases from the analysis of CT scans. The available amount of data and the fact that benign cases are a minority, constitutes a main challenge for the successful use of state of the art methods (like deep learning), which can be biased, over-fitted and lack of clinical reproducibility. We present an hybrid approach combining the potential of radiomic features to characterize nodules in CT scans and the generalization of the feed forward networks. In order to obtain maximal reproducibility with minimal training data, we propose an embedding of nodules based on the statistical significance of radiomic features for malignancy detection. This representation space of lesions is the input to a feed
forward network, which architecture and hyperparameters are optimized using own-defined metrics of the diagnostic power of the whole system. Results of the best model on an independent set of patients achieve 100% of sensitivity and 83% of specificity (AUC = 0.94) for malignancy detection. |
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Jan 2022 |
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IAM; 600.139; 600.145 |
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Admin @ si @ TBS2022 |
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3699 |
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Author |
Albert Andaluz |
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Title |
LV Contour Segmentation in TMR images using Semantic Description of Tissue and Prior Knowledge Correction |
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2009 |
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CVC Technical Report |
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142 |
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Active Contour Models; Snakes; Active Shape Models; Deformable Templates; Left Ventricle Segmentation; Generalized Orthogonal Procrustes Analysis; Harmonic Phase Flow; Principal Component Analysis; Tagged Magnetic Resonance |
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The Diagnosis of Left Ventricle (LV) pathologies is related to regional wall motion analysis. Health indicator scores such as the rotation and the torsion are useful for the diagnose of the Left Ventricle (LV) function. However, this requires proper identification of LV segments. On one hand, manual segmentation is robust, but it is slow and requires medical expertise. On the other hand, the tag pattern in Tagged Magnetic Resonance (TMR) sequences is a problem for the automatic segmentation of the LV boundaries. Consequently, we propose a method based in the classical formulation of parametric Snakes, combined with Active Shape models. Our semantic definition of the LV is tagged tissue that experiences motion in the systolic cycle. This defines two energy potentials for the Snake convergence. Additionally, the mean shape corrects excessive deviation from the anatomical shape. We have validated our approach in 15 healthy volunteers and two short axis cuts. In this way, we have compared the automatic segmentations to manual shapes outlined by medical experts. Also, we have explored the accuracy of clinical scores computed using automatic contours. The results show minor divergence in the approximation and the manual segmentations as well as robust computation of clinical scores in all cases. From this we conclude that the proposed method is a promising support tool for clinical analysis. |
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Master's thesis |
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Bellaterra 08193, Barcelona, Spain |
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IAM; |
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IAM @ iam @ And2009 |
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1667 |
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Author |
Aura Hernandez-Sabate; Jose Elias Yauri; Pau Folch; Miquel Angel Piera; Debora Gil |
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Title |
Recognition of the Mental Workloads of Pilots in the Cockpit Using EEG Signals |
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2022 |
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Applied Sciences |
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APPLSCI |
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12 |
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5 |
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2298 |
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Cognitive states; Mental workload; EEG analysis; Neural networks; Multimodal data fusion |
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The commercial flightdeck is a naturally multi-tasking work environment, one in which interruptions are frequent come in various forms, contributing in many cases to aviation incident reports. Automatic characterization of pilots’ workloads is essential to preventing these kind of incidents. In addition, minimizing the physiological sensor network as much as possible remains both a challenge and a requirement. Electroencephalogram (EEG) signals have shown high correlations with specific cognitive and mental states, such as workload. However, there is not enough evidence in the literature to validate how well models generalize in cases of new subjects performing tasks with workloads similar to the ones included during the model’s training. In this paper, we propose a convolutional neural network to classify EEG features across different mental workloads in a continuous performance task test that partly measures working memory and working memory capacity. Our model is valid at the general population level and it is able to transfer task learning to pilot mental workload recognition in a simulated operational environment. |
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February 2022 |
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IAM; ADAS; 600.139; 600.145; 600.118 |
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Admin @ si @ HYF2022 |
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3720 |
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Author |
Aura Hernandez-Sabate; Debora Gil; Petia Radeva; E.N.Nofrerias |
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Title |
Anisotropic processing of image structures for adventitia detection in intravascular ultrasound images |
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Conference Article |
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2004 |
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Proc. Computers in Cardiology |
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31 |
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229-232 |
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The adventitia layer appears as a weak edge in IVUS images with a non-uniform grey level, which difficulties its detection. In order to enhance edges, we apply an anisotropic filter that homogenizes the grey level along the image significant structures (ridges, valleys and edges). A standard edge detector applied to the filtered image yields a set of candidate points prone to be unconnected. The final model is obtained by interpolating the former line segments along the tangent direction to the level curves of the filtered image with an anisotropic contour closing technique based on functional extension principles |
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Chicago (USA) |
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IAM; MILAB |
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IAM @ iam @ HGR2004 |
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1555 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Detecting loss of diversity for an efficient termination of EAs |
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2013 |
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15th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing |
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561 - 566 |
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EA termination; EA population diversity; EA steady state |
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Termination of Evolutionary Algorithms (EA) at its steady state so that useless iterations are not performed is a main point for its efficient application to black-box problems. Many EA algorithms evolve while there is still diversity in their population and, thus, they could be terminated by analyzing the behavior some measures of EA population diversity. This paper presents a numeric approximation to steady states that can be used to detect the moment EA population has lost its diversity for EA termination. Our condition has been applied to 3 EA paradigms based on diversity and a selection of functions
covering the properties most relevant for EA convergence.
Experiments show that our condition works regardless of the search space dimension and function landscape. |
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Timisoara; Rumania; |
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978-1-4799-3035-7 |
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SYNASC |
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IAM; 600.044; 600.060; 605.203 |
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Admin @ si @ RGG2013c |
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2299 |
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