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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Assessing agonist efficacy in an uncertain Em world |
Type |
Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
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Pages |
79 |
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Abstract |
The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Fairmont Banff Springs, Banff, Alberta, Canada |
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Keystone Symposia |
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Keystone Symposia |
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Editor |
A. Christopoulus and M. Bouvier |
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english |
Summary Language |
english |
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Keystone Symposia |
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KSMCB |
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IAM |
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no |
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Call Number |
IAM @ iam @ RGG2012 |
Serial |
1855 |
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Author |
Carles Sanchez |
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Title |
Tracheal ring detection in bronchoscopy |
Type |
Report |
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Year |
2011 |
Publication |
CVC Technical Report |
Abbreviated Journal |
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Volume |
168 |
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Keywords |
Bronchoscopy, tracheal ring, segmentation |
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Abstract |
Endoscopy is the process in which a camera is introduced inside a human.
Given that endoscopy provides realistic images (in contrast to other modalities) and allows non-invase minimal intervention procedures (which can aid in diagnosis and surgical interventions), its use has spreaded during last decades.
In this project we will focus on bronchoscopic procedures, during which the camera is introduced through the trachea in order to have a diagnostic of the patient. The diagnostic interventions are focused on: degree of stenosis (reduction in tracheal area), prosthesis or early diagnosis of tumors. In the first case, assessment of the luminal area and the calculation of the diameters of the tracheal rings are required. A main limitation is that all the process is done by hand,
which means that the doctor takes all the measurements and decisions just by looking at the screen. As far as we know there is no computational framework for helping the doctors in the diagnosis.
This project will consist of analysing bronchoscopic videos in order to extract useful information for the diagnostic of the degree of stenosis. In particular we will focus on segmentation of the tracheal rings. As a result of this project several strategies (for detecting tracheal rings) had been implemented in order to compare their performance. |
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Thesis |
Master's thesis |
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Editor |
Debora Gil, F.Javier Sanchez |
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Language |
english |
Summary Language |
english |
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IAM;MV |
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Call Number |
IAM @ iam @ San2011 |
Serial |
1841 |
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Author |
Alberto Hidalgo; Ferran Poveda; Enric Marti;Debora Gil;Albert Andaluz; Francesc Carreras; Manuel Ballester |
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Title |
Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography |
Type |
Journal Article |
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Year |
2012 |
Publication |
European Radiology |
Abbreviated Journal |
ECR |
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Volume |
3 |
Issue |
1 |
Pages |
361-362 |
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Abstract |
Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model. |
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Address |
Viena, Austria |
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Springer Link |
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ISSN |
1869-4101 |
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IAM |
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Call Number |
IAM @ iam @ HPM2012 |
Serial |
1858 |
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Author |
Albert Andaluz |
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Title |
Harmonic Phase Flow: User's guide |
Type |
Manual |
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Year |
2012 |
Publication |
CVC |
Abbreviated Journal |
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Abstract |
HPF is a plugin for the computation of clinical scores under Osirix.
This manual provides a basic guide for experienced clinical staff. Chapter 1 provides the theoretical background in which this plugin is based.
Next, in chapter 2 we provide basic instructions for installing and uninstalling this plugin. chapter 3we shows a step-by-step scenario to compute clinical scores from tagged-MRI images with HPF. Finally, in chapter 4 we provide a quick guide for plugin developers |
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Address |
Bellaterra, Barcelona (Spain) |
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Corporate Author |
Computer Vision Center |
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Publisher |
CVC |
Place of Publication |
Barcelona |
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english |
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english |
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IAM |
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Call Number |
IAM @ iam @ And2012 |
Serial |
1863 |
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Author |
Albert Andaluz; Francesc Carreras; Cristina Santa Marta;Debora Gil |
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Title |
Myocardial torsion estimation with Tagged-MRI in the OsiriX platform |
Type |
Conference Article |
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Year |
2012 |
Publication |
ISBI Workshop on Open Source Medical Image Analysis software |
Abbreviated Journal |
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Abstract |
Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es |
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Address |
Barcelona, Spain |
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IEEE |
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Editor |
Wiro Niessen (Erasmus MC) and Marc Modat (UCL) |
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ISBI |
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IAM |
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Call Number |
IAM @ iam @ ACS2012 |
Serial |
1900 |
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Author |
Patricia Marquez; Debora Gil; Aura Hernandez-Sabate |
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Title |
Evaluation of the Capabilities of Confidence Measures for Assessing Optical Flow Quality |
Type |
Conference Article |
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Year |
2013 |
Publication |
ICCV Workshop on Computer Vision in Vehicle Technology: From Earth to Mars |
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624-631 |
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Abstract |
Assessing Optical Flow (OF) quality is essential for its further use in reliable decision support systems. The absence of ground truth in such situations leads to the computation of OF Confidence Measures (CM) obtained from either input or output data. A fair comparison across the capabilities of the different CM for bounding OF error is required in order to choose the best OF-CM pair for discarding points where OF computation is not reliable. This paper presents a statistical probabilistic framework for assessing the quality of a given CM. Our quality measure is given in terms of the percentage of pixels whose OF error bound can not be determined by CM values. We also provide statistical tools for the computation of CM values that ensures a given accuracy of the flow field. |
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Address |
Sydney; Australia; December 2013 |
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CVTT:E2M |
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IAM; ADAS; 600.044; 600.057; 601.145 |
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no |
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Call Number |
Admin @ si @ MGH2013b |
Serial |
2351 |
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Author |
A. M. Here; B. C. Lopez; Debora Gil; J. J. Camarero; Jordi Martinez-Vilalta |
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Title |
A new software to analyse wood anatomical features in conifer species |
Type |
Conference Article |
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Year |
2013 |
Publication |
International Symposium on Wood Structure in Plant Biology and Ecology |
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Abstract |
International Symposium on Wood Structure in Plant Biology and Ecology |
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Address |
Naples; Italy; March 2013 |
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WSE |
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IAM |
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Admin @ si @ HLG2013 |
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2303 |
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Author |
Enric Marti; Ferran Poveda; Antoni Gurgui; Jaume Rocarias; Debora Gil |
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Title |
Una propuesta de seguimiento, tutorías on line y evaluación en la metodología de Aprendizaje Basado en Proyectos |
Type |
Miscellaneous |
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Year |
2013 |
Publication |
IV Congreso Internacional UNIVEST |
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Abstract |
Poster |
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Girona |
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UNIVEST |
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IAM |
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Admin @ si @ MPG2013a |
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2304 |
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Author |
Sergio Vera; Miguel Angel Gonzalez Ballester; Debora Gil |
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Title |
Volumetric Anatomical Parameterization and Meshing for Inter-patient Liver Coordinate System Deffinition |
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Conference Article |
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Year |
2013 |
Publication |
16th International Conference on Medical Image Computing and Computer Assisted Intervention |
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Address |
Nagoya; Japan; September 2013 |
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MICCAI |
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IAM |
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Admin @ si @ VGG2013 |
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2301 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Detecting loss of diversity for an efficient termination of EAs |
Type |
Conference Article |
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Year |
2013 |
Publication |
15th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing |
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561 - 566 |
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Keywords |
EA termination; EA population diversity; EA steady state |
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Abstract |
Termination of Evolutionary Algorithms (EA) at its steady state so that useless iterations are not performed is a main point for its efficient application to black-box problems. Many EA algorithms evolve while there is still diversity in their population and, thus, they could be terminated by analyzing the behavior some measures of EA population diversity. This paper presents a numeric approximation to steady states that can be used to detect the moment EA population has lost its diversity for EA termination. Our condition has been applied to 3 EA paradigms based on diversity and a selection of functions
covering the properties most relevant for EA convergence.
Experiments show that our condition works regardless of the search space dimension and function landscape. |
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Address |
Timisoara; Rumania; |
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978-1-4799-3035-7 |
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SYNASC |
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IAM; 600.044; 600.060; 605.203 |
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Admin @ si @ RGG2013c |
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2299 |
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