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Author |
Albert Andaluz; Francesc Carreras; Debora Gil; Jaume Garcia |
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Title |
Una aplicació amigable pel càlcul de indicadors clínics del ventricle esquerre |
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Miscellaneous |
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2010 |
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Forum Biocat 2010 |
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Lonja de Mar,Barcelona (Spain) |
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CVC |
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Biocat |
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Barcelona |
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Catalan |
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IAM |
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IAM @ iam @ ACG2010 |
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1483 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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Year |
2013 |
Publication |
Drug Discovery Today |
Abbreviated Journal |
DDT |
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Volume |
18 |
Issue |
7-8 |
Pages |
365-371 |
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Abstract |
The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
Serial |
2190 |
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Author |
Aura Hernandez-Sabate; Petia Radeva; Antonio Tovar; Debora Gil |
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Title |
Vessel structures alignment by spectral analysis of ivus sequences |
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Conference Article |
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Year |
2006 |
Publication |
Proc. of CVII, MICCAI Workshop |
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39-36 |
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Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS. |
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Copenhaguen (Denmark), |
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1st International Wokshop on Computer Vision for Intravascular and Intracardiac Imaging (CVII’06) |
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IAM; MILAB |
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Call Number |
IAM @ iam @ HRT2006 |
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1552 |
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Author |
Aura Hernandez-Sabate; Debora Gil; David Roche; Monica M. S. Matsumoto; Sergio S. Furuie |
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Title |
Inferring the Performance of Medical Imaging Algorithms |
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Conference Article |
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Year |
2011 |
Publication |
14th International Conference on Computer Analysis of Images and Patterns |
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Volume |
6854 |
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Pages |
520-528 |
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Keywords |
Validation, Statistical Inference, Medical Imaging Algorithms. |
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Evaluation of the performance and limitations of medical imaging algorithms is essential to estimate their impact in social, economic or clinical aspects. However, validation of medical imaging techniques is a challenging task due to the variety of imaging and clinical problems involved, as well as, the difficulties for systematically extracting a reliable solely ground truth. Although specific validation protocols are reported in any medical imaging paper, there are still two major concerns: definition of standardized methodologies transversal to all problems and generalization of conclusions to the whole clinical data set.
We claim that both issues would be fully solved if we had a statistical model relating ground truth and the output of computational imaging techniques. Such a statistical model could conclude to what extent the algorithm behaves like the ground truth from the analysis of a sampling of the validation data set. We present a statistical inference framework reporting the agreement and describing the relationship of two quantities. We show its transversality by applying it to validation of two different tasks: contour segmentation and landmark correspondence. |
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Address |
Sevilla |
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Springer-Verlag Berlin Heidelberg |
Place of Publication |
Berlin |
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Pedro Real; Daniel Diaz-Pernil; Helena Molina-Abril; Ainhoa Berciano; Walter Kropatsch |
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LNCS |
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CAIP |
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Notes |
IAM; ADAS |
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no |
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Call Number |
IAM @ iam @ HGR2011 |
Serial |
1676 |
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Author |
Ferran Poveda; Debora Gil ;Albert Andaluz ;Enric Marti |
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Title |
Multiscale Tractography for Representing Heart Muscular Architecture |
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Conference Article |
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Year |
2011 |
Publication |
In MICCAI 2011 Workshop on Computational Diffusion MRI |
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Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. Although the muscular architecture of the heart has been debated by countless researchers, the controversy is still alive. Diffusion Tensor MRI, DT-MRI, is a unique imaging technique for computational validation of the muscular structure of the heart. By the complex arrangement of myocites, existing techniques can not provide comprehensive descriptions of the global muscular architecture. In this paper we introduce a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and indicate a global helical organization |
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English |
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english |
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CDRMI |
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IAM |
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Call Number |
IAM @ iam @ PGA2011 |
Serial |
1681 |
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Author |
Debora Gil; Petia Radeva; Jordi Saludes; Josefina Mauri |
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Title |
Automatic Segmentation of Artery Wall in Coronary IVUS Images: A Probabilistic Approach |
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Conference Article |
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Year |
2000 |
Publication |
International Conference on Pattern Recognition |
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Volume |
4 |
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Pages |
352-355 |
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Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results. |
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IAM;MILAB |
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IAM @ iam @ GRS2000a |
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1537 |
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Author |
Debora Gil; Petia Radeva |
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Title |
Curvature Vector Flow to Assure Convergent Deformable Models for Shape Modelling |
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Book Chapter |
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Year |
2003 |
Publication |
Energy Minimization Methods In Computer Vision And Pattern Recognition |
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LNCS |
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2683 |
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357-372 |
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Keywords |
Initial condition; Convex shape; Non convex analysis; Increase; Segmentation; Gradient; Standard; Standards; Concave shape; Flow models; Tracking; Edge detection; Curvature |
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Poor convergence to concave shapes is a main limitation of snakes as a standard segmentation and shape modelling technique. The gradient of the external energy of the snake represents a force that pushes the snake into concave regions, as its internal energy increases when new inexion points are created. In spite of the improvement of the external energy by the gradient vector ow technique, highly non convex shapes can not be obtained, yet. In the present paper, we develop a new external energy based on the geometry of the curve to be modelled. By tracking back the deformation of a curve that evolves by minimum curvature ow, we construct a distance map that encapsulates the natural way of adapting to non convex shapes. The gradient of this map, which we call curvature vector ow (CVF), is capable of attracting a snake towards any contour, whatever its geometry. Our experiments show that, any initial snake condition converges to the curve to be modelled in optimal time. |
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Springer, Berlin |
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Lisbon, PORTUGAL |
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Springer, B. |
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Lecture Notes in Computer Science |
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LNCS |
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0302-9743 |
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3-540-40498-8 |
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IAM;MILAB |
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no |
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IAM @ iam @ GIR2003b |
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1535 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
An inference model for analyzing termination conditions of Evolutionary Algorithms |
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Conference Article |
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Year |
2011 |
Publication |
14th Congrès Català en Intel·ligencia Artificial |
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216-225 |
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Evolutionary Computation Convergence, Termination Conditions, Statistical Inference |
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In real-world problems, it is mandatory to design a termination condition for Evolutionary Algorithms (EAs) ensuring stabilization close to the unknown optimum. Distribution-based quantities are good candidates as far as suitable parameters are used. A main limitation for application to real-world problems is that such parameters strongly depend on the topology of the objective function, as well as, the EA paradigm used.
We claim that the termination problem would be fully solved if we had a model measuring to what extent a distribution-based quantity asymptotically behaves like the solution accuracy. We present a regression-prediction model that relates any two given quantities and reports if they can be statistically swapped as termination conditions. Our framework is applied to two issues. First, exploring if the parameters involved in the computation of distribution-based quantities influence their asymptotic behavior. Second, to what extent existing distribution-based quantities can be asymptotically exchanged for the accuracy of the EA solution. |
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Lleida, Catalonia (Spain) |
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Corporate Author |
Associació Catalana Intel·ligència Artificial |
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978-1-60750-841-0 |
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CCIA |
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IAM |
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Call Number |
IAM @ iam @ RGG2011a |
Serial |
1677 |
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Author |
Antoni Gurgui; Debora Gil; Enric Marti |
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Title |
Laplacian Unitary Domain for Texture Morphing |
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Conference Article |
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Year |
2015 |
Publication |
Proceedings of the 10th International Conference on Computer Vision Theory and Applications VISIGRAPP2015 |
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1 |
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693-699 |
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Facial; metamorphosis;LaplacianMorphing |
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Deformation of expressive textures is the gateway to realistic computer synthesis of expressions. By their good mathematical properties and flexible formulation on irregular meshes, most texture mappings rely on solutions to the Laplacian in the cartesian space. In the context of facial expression morphing, this approximation can be seen from the opposite point of view by neglecting the metric. In this paper, we use the properties of the Laplacian in manifolds to present a novel approach to warping expressive facial images in order to generate a morphing between them. |
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Munich; Germany; February 2015 |
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SciTePress |
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978-989-758-089-5 |
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VISAPP |
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IAM; 600.075 |
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Admin @ si @ GGM2015 |
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2614 |
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Author |
Misael Rosales; Petia Radeva; Oriol Rodriguez; Debora Gil |
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Title |
Suppression of IVUS Image Rotation. A Kinematic Approach |
Type |
Book Chapter |
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Year |
2005 |
Publication |
Functional Imaging and Modeling of the Heart |
Abbreviated Journal |
LNCS |
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3504 |
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Pages |
889-892 |
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Abstract |
IntraVascular Ultrasound (IVUS) is an exploratory technique used in interventional procedures that shows cross section images of arteries and provides qualitative information about the causes and severity of the arterial lumen narrowing. Cross section analysis as well as visualization of plaque extension in a vessel segment during the catheter imaging pullback are the technique main advantages. However, IVUS sequence exhibits a periodic rotation artifact that makes difficult the longitudinal lesion inspection and hinders any segmentation algorithm. In this paper we propose a new kinematic method to estimate and remove the image rotation of IVUS images sequences. Results on several IVUS sequences show good results and prompt some of the clinical applications to vessel dynamics study, and relation to vessel pathology. |
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Springer Berlin / Heidelberg |
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Frangi, Alejandro and Radeva, Petia and Santos, Andres and Hernandez, Monica |
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Lecture Notes in Computer Science |
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LNCS |
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3504 |
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IAM;MILAB |
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Call Number |
IAM @ iam @ RRR2005 |
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1645 |
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