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Albert Andaluz, Francesc Carreras, Cristina Santa Marta, & Debora Gil. (2012). "Myocardial torsion estimation with Tagged-MRI in the OsiriX platform " In Wiro Niessen(Erasmus MC) and Marc Modat(UCL) (Ed.), ISBI Workshop on Open Source Medical Image Analysis software. IEEE.
Abstract: Myocardial torsion (MT) plays a crucial role in the assessment of the functionality of the
left ventricle. For this purpose, the IAM group at the CVC has developed the Harmonic Phase Flow (HPF) plugin for the Osirix DICOM platform . We have validated its funcionalty on sequences acquired using different protocols and including healthy and pathological cases. Results show similar torsion trends for SPAMM acquisitions, with pathological cases introducing expected deviations from the ground truth. Finally, we provide the plugin free of charge at http://iam.cvc.uab.es
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Patricia Marquez, Debora Gil, & Aura Hernandez-Sabate. (2012). "Error Analysis for Lucas-Kanade Based Schemes " In 9th International Conference on Image Analysis and Recognition (Vol. 7324, pp. 184–191). Lecture Notes in Computer Science. Springer-Verlag Berlin Heidelberg.
Abstract: Optical flow is a valuable tool for motion analysis in medical imaging sequences. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in medical sequences. This paper presents an error analysis of Lucas-Kanade schemes in terms of intrinsic design errors and numerical stability of the algorithm. Our analysis provides a confidence measure that is naturally correlated to the accuracy of the flow field. Our experiments show the higher predictive value of our confidence measure compared to existing measures.
Keywords: Optical flow, Confidence measure, Lucas-Kanade, Cardiac Magnetic Resonance
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Carles Sanchez, F. Javier Sanchez, Antoni Rosell, & Debora Gil. (2012). "An illumination model of the trachea appearance in videobronchoscopy images " In Image Analysis and Recognition (Vol. 7325, pp. 313–320). Lecture Notes in Computer Science. Springer Berlin Heidelberg.
Abstract: Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways. This imaging modality provides realistic images and allows non-invasive minimal intervention procedures. Tracheal procedures are routinary interventions that require assessment of the percentage of obstructed pathway for injury (stenosis) detection. Visual assessment in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error.
This paper introduces an automatic method for the estimation of steneosed trachea percentage reduction in videobronchoscopic images. We look for tracheal rings , whose deformation determines the degree of obstruction. For ring extraction , we present a ring detector based on an illumination and appearance model. This model allows us to parametrise the ring detection. Finally, we can infer optimal estimation parameters for any video resolution.
Keywords: Bronchoscopy, tracheal ring, stenosis assesment, trachea appearance model, segmentation
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Alberto Hidalgo, Ferran Poveda, Enric Marti, Debora Gil, Albert Andaluz, Francesc Carreras, et al. (2012). "Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography " . European Radiology, 3(1), 361–362.
Abstract: Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model.
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David Roche, Debora Gil, & Jesus Giraldo. (2012). "Assessing agonist efficacy in an uncertain Em world " In A. Christopoulus and M. Bouvier (Ed.), 40th Keystone Symposia on mollecular and celular biology (79). Keystone Symposia.
Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.
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Sergio Vera, Debora Gil, Antonio Lopez, & Miguel Angel Gonzalez Ballester. (2012). "Multilocal Creaseness Measure " . The Insight Journal, .
Abstract: This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission.
Keywords: Ridges, Valley, Creaseness, Structure Tensor, Skeleton,
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Sergio Vera, Debora Gil, Agnes Borras, F. Javier Sanchez, Frederic Perez, Marius G. Linguraru, et al. (2012). "Computation and Evaluation of Medial Surfaces for Shape Representation of Abdominal Organs " In H. Yoshida et al (Ed.), Workshop on Computational and Clinical Applications in Abdominal Imaging (Vol. 7029, 223–230). Lecture Notes in Computer Science. Berlin: Springer Link.
Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.
Keywords: medial manifolds, abdomen.
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Debora Gil, Agnes Borras, Manuel Ballester, Francesc Carreras, Ruth Aris, Manuel Vazquez, et al. (2011). "MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis " In Association for Computing Machinery (Ed.), 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies. Barcelona, Spain.
Abstract: Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.
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Aura Hernandez-Sabate, & Debora Gil. (2012). "The Benefits of IVUS Dynamics for Retrieving Stable Models of Arteries " In Yasuhiro Honda (Ed.), Intravascular Ultrasound (pp. 185–206). Intech.
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Patricia Marquez, Debora Gil, & Aura Hernandez-Sabate. (2011). "A Confidence Measure for Assessing Optical Flow Accuracy in the Absence of Ground Truth " In IEEE International Conference on Computer Vision – Workshops (pp. 2042–2049). Barcelona (Spain): IEEE.
Abstract: Optical flow is a valuable tool for motion analysis in autonomous navigation systems. A reliable application requires determining the accuracy of the computed optical flow. This is a main challenge given the absence of ground truth in real world sequences. This paper introduces a measure of optical flow accuracy for Lucas-Kanade based flows in terms of the numerical stability of the data-term. We call this measure optical flow condition number. A statistical analysis over ground-truth data show a good statistical correlation between the condition number and optical flow error. Experiments on driving sequences illustrate its potential for autonomous navigation systems.
Keywords: IEEE International Conference on Computer Vision – Workshops
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