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Author Oriol Pujol; Debora Gil; Petia Radeva edit   pdf
doi  openurl
  Title Fundamentals of Stop and Go active models Type Journal Article
  Year 2005 Publication Image and Vision Computing Abbreviated Journal  
  Volume 23 Issue 8 Pages (down) 681-691  
  Keywords Deformable models; Geodesic snakes; Region-based segmentation  
  Abstract An efficient snake formulation should conform to the idea of picking the smoothest curve among all the shapes approximating an object of interest. In current geodesic snakes, the regularizing curvature also affects the convergence stage, hindering the latter at concave regions. In the present work, we make use of characteristic functions to define a novel geodesic formulation that decouples regularity and convergence. This term decoupling endows the snake with higher adaptability to non-convex shapes. Convergence is ensured by splitting the definition of the external force into an attractive vector field and a repulsive one. In our paper, we propose to use likelihood maps as approximation of characteristic functions of object appearance. The better efficiency and accuracy of our decoupled scheme are illustrated in the particular case of feature space-based segmentation.  
  Address  
  Corporate Author Thesis  
  Publisher Butterworth-Heinemann Place of Publication Newton, MA, USA Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0262-8856 ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB;HuPBA Approved no  
  Call Number IAM @ iam @ PGR2005 Serial 1629  
Permanent link to this record
 

 
Author Debora Gil; Oriol Rodriguez-Leor; Petia Radeva; Josepa Mauri edit   pdf
doi  openurl
  Title Myocardial Perfusion Characterization From Contrast Angiography Spectral Distribution Type Journal Article
  Year 2008 Publication IEEE Transactions on Medical Imaging Abbreviated Journal  
  Volume 27 Issue 5 Pages (down) 641-649  
  Keywords Contrast angiography; myocardial perfusion; spectral analysis.  
  Abstract Despite recovering a normal coronary flow after acute myocardial infarction, percutaneous coronary intervention does not guarantee a proper perfusion (irrigation) of the infarcted area. This damage in microcirculation integrity may detrimentally affect the patient survival. Visual assessment of the myocardium opacification in contrast angiography serves to define a subjective score of the microcirculation integrity myocardial blush analysis (MBA). Although MBA correlates with patient prognosis its visual assessment is a very difficult task that requires of a highly expertise training in order to achieve a good intraobserver and interobserver agreement. In this paper, we provide objective descriptors of the myocardium staining pattern by analyzing the spectrum of the image local statistics. The descriptors proposed discriminate among the different phenomena observed in the angiographic sequence and allow defining an objective score of the myocardial perfusion.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM;MILAB Approved no  
  Call Number IAM @ iam @ GRR2008 Serial 1541  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso edit  url
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type Journal Article
  Year 2017 Publication Journal of Thoracic Oncology Abbreviated Journal JTO  
  Volume 12 Issue 1S Pages (down) S596-S597  
  Keywords Thorax CT; diagnosis; Peripheral Pulmonary Nodule  
  Abstract A main weakness of virtual bronchoscopic navigation (VBN) is unsuccessful segmentation of distal branches approaching peripheral pulmonary nodules (PPN). CT scan acquisition protocol is pivotal for segmentation covering the utmost periphery. We hypothesize that application of continuous positive airway pressure (CPAP) during CT acquisition could improve visualization and segmentation of peripheral bronchi. The purpose of the present pilot study is to compare quality of segmentations under 4 CT acquisition modes: inspiration (INSP), expiration (EXP) and both with CPAP (INSP-CPAP and EXP-CPAP).  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ DGC2017a Serial 2883  
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Author Debora Gil; Jose Maria-Carazo; Roberto Marabini edit   pdf
doi  openurl
  Title On the nature of 2D crystal unbending Type Journal Article
  Year 2006 Publication Journal of Structural Biology Abbreviated Journal  
  Volume 156 Issue 3 Pages (down) 546-555  
  Keywords Electron microscopy  
  Abstract Crystal unbending, the process that aims to recover a perfect crystal from experimental data, is one of the more important steps in electron crystallography image processing. The unbending process involves three steps: estimation of the unit cell displacements from their ideal positions, extension of the deformation field to the whole image and transformation of the image in order to recover an ideal crystal. In this work, we present a systematic analysis of the second step oriented to address two issues. First, whether the unit cells remain undistorted and only the distance between them should be changed (rigid case) or should be modified with the same deformation suffered by the whole crystal (elastic case). Second, the performance of different extension algorithms (interpolation versus approximation) is explored. Our experiments show that there is no difference between elastic and rigid cases or among the extension algorithms. This implies that the deformation fields are constant over large areas. Furthermore, our results indicate that the main source of error is the transformation of the crystal image.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1047-8477 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ GCM2006 Serial 1519  
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Author Marta Diez-Ferrer; Debora Gil; Cristian Tebe; Carles Sanchez edit   pdf
doi  openurl
  Title Positive Airway Pressure to Enhance Computed Tomography Imaging for Airway Segmentation for Virtual Bronchoscopic Navigation Type Journal Article
  Year 2018 Publication Respiration Abbreviated Journal RES  
  Volume 96 Issue 6 Pages (down) 525-534  
  Keywords Multidetector computed tomography; Bronchoscopy; Continuous positive airway pressure; Image enhancement; Virtual bronchoscopic navigation  
  Abstract Abstract
RATIONALE:
Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.

OBJECTIVES:
To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.

METHODS:
CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. The 4 protocols explored differences between devices (flow vs. turbine), exposures (within seconds vs. 15-min) and pressure levels (10 vs. 14 cmH2O). Segmentation quality was evaluated with the number of airways and number of endpoints reached. A generalized mixed-effects model explored the estimated effect of each protocol.

MEASUREMENTS AND MAIN RESULTS:
Patient characteristics and lung function did not significantly differ between protocols. Compared to baseline inspiratory acquisitions, expiratory acquisitions after 15 min of 14 cmH2O PAP segmented 1.63-fold more airways (95% CI 1.07-2.48; p = 0.018) and reached 1.34-fold more endpoints (95% CI 1.08-1.66; p = 0.004). Inspiratory acquisitions performed immediately under 10 cmH2O PAP reached 1.20-fold (95% CI 1.09-1.33; p < 0.001) more endpoints; after 15 min the increase was 1.14-fold (95% CI 1.05-1.24; p < 0.001).

CONCLUSIONS:
CT acquisitions with PAP segment more airways and reach more endpoints than baseline inspiratory acquisitions. The improvement is particularly evident at end-expiration after 15 min of 14 cmH2O PAP. Further studies must confirm that the improvement increases diagnostic yield when using VBN to evaluate peripheral pulmonary lesions.
 
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.145 Approved no  
  Call Number Admin @ si @ DGT2018 Serial 3135  
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Author Debora Gil; David Roche; Agnes Borras; Jesus Giraldo edit  doi
openurl 
  Title Terminating Evolutionary Algorithms at their Steady State Type Journal Article
  Year 2015 Publication Computational Optimization and Applications Abbreviated Journal COA  
  Volume 61 Issue 2 Pages (down) 489-515  
  Keywords Evolutionary algorithms; Termination condition; Steady state; Differential evolution  
  Abstract Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications.  
  Address  
  Corporate Author Thesis  
  Publisher Springer US Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0926-6003 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.044; 605.203; 600.060; 600.075 Approved no  
  Call Number Admin @ si @ GRB2015 Serial 2560  
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Author Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel Angel Gonzalez Ballester edit   pdf
doi  openurl
  Title Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities Type Journal Article
  Year 2017 Publication Medical Image Analysis Abbreviated Journal MIA  
  Volume 35 Issue Pages (down) 390-402  
  Keywords Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points  
  Abstract Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier B.V. Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.060; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GVB2017 Serial 2775  
Permanent link to this record
 

 
Author David Roche; Debora Gil; Jesus Giraldo edit  url
doi  openurl
  Title Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, Type Journal Article
  Year 2013 Publication Drug Discovery Today Abbreviated Journal DDT  
  Volume 18 Issue 7-8 Pages (down) 365-371  
  Keywords  
  Abstract The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios.  
  Address  
  Corporate Author Thesis  
  Publisher Elsevier Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.057; 600.054 Approved no  
  Call Number IAM @ iam @ RGG2013a Serial 2190  
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Author Alberto Hidalgo; Ferran Poveda; Enric Marti;Debora Gil;Albert Andaluz; Francesc Carreras; Manuel Ballester edit   pdf
url  doi
openurl 
  Title Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography Type Journal Article
  Year 2012 Publication European Radiology Abbreviated Journal ECR  
  Volume 3 Issue 1 Pages (down) 361-362  
  Keywords  
  Abstract Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model.
 
  Address Viena, Austria  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1869-4101 ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number IAM @ iam @ HPM2012 Serial 1858  
Permanent link to this record
 

 
Author Francesc Carreras; Jaume Garcia; Debora Gil; Sandra Pujadas; Chi ho Lion; R.Suarez-Arias; R.Leta; Xavier Alomar; Manuel Ballester; Guillem Pons-Llados edit  url
doi  openurl
  Title Left ventricular torsion and longitudinal shortening: two fundamental components of myocardial mechanics assessed by tagged cine-MRI in normal subjects Type Journal Article
  Year 2012 Publication International Journal of Cardiovascular Imaging Abbreviated Journal IJCI  
  Volume 28 Issue 2 Pages (down) 273-284  
  Keywords Magnetic resonance imaging (MRI); Tagging MRI; Cardiac mechanics; Ventricular torsion  
  Abstract Cardiac magnetic resonance imaging (Cardiac MRI) has become a gold standard diagnostic technique for the assessment of cardiac mechanics, allowing the non-invasive calculation of left ventric- ular long axis longitudinal shortening (LVLS) and absolute myocardial torsion (AMT) between basal and apical left ventricular slices, a movement directly related to the helicoidal anatomic disposition of the myocardial fibers. The aim of this study is to determine AMT and LVLS behaviour and normal values from a group of healthy subjects. A group of 21 healthy volunteers (15 males) (age: 23–55 y.o., mean:30.7 ± 7.5) were prospectively included in an obser- vational study by Cardiac MRI. Left ventricular rotation (degrees) was calculated by custom-made software (Harmonic Phase Flow) in consecutive LV short axis planes tagged cine-MRI sequences. AMT was determined from the difference between basal and apical planes LV rotations. LVLS (%) was determined from the LV longitudinal and horizontal axis cine-MRI images. All the 21 cases studied were interpretable, although in three cases the value of the LV apical rotation could not be determined. The mean rotation of the basal and apical planes at end-systole were -3.71° ± 0.84° and 6.73° ± 1.69° (n:18) respectively, resulting in a LV mean AMT of 10.48° ± 1.63° (n:18). End-systolic mean LVLS was 19.07 ± 2.71%. Cardiac MRI allows for the calculation of AMT and LVLS, fundamental functional components of the ventricular twist mechanics conditioned, in turn, by the anatomical helical layout of the myocardial fibers. These values provide complementary information about systolic ventricular function in relation to the traditional parameters used in daily practice.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1569-5794 ISBN Medium  
  Area Expedition Conference  
  Notes IAM; Approved no  
  Call Number IAM @ iam @ CGG2012 Serial 1496  
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