|
|
Esmitt Ramirez, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2018). "Image-Based Bronchial Anatomy Codification for Biopsy Guiding in Video Bronchoscopy " In OR 2.0 Context-Aware Operating Theaters, Computer Assisted Robotic Endoscopy, Clinical Image-Based Procedures, and Skin Image Analysis (Vol. 11041).
Abstract: Bronchoscopy examinations allow biopsy of pulmonary nodules with minimum risk for the patient. Even for experienced bronchoscopists, it is difficult to guide the bronchoscope to most distal lesions and obtain an accurate diagnosis. This paper presents an image-based codification of the bronchial anatomy for bronchoscopy biopsy guiding. The 3D anatomy of each patient is codified as a binary tree with nodes representing bronchial levels and edges labeled using their position on images projecting the 3D anatomy from a set of branching points. The paths from the root to leaves provide a codification of navigation routes with spatially consistent labels according to the anatomy observes in video bronchoscopy explorations. We evaluate our labeling approach as a guiding system in terms of the number of bronchial levels correctly codified, also in the number of labels-based instructions correctly supplied, using generalized mixed models and computer-generated data. Results obtained for three independent observers prove the consistency and reproducibility of our guiding system. We trust that our codification based on viewer’s projection might be used as a foundation for the navigation process in Virtual Bronchoscopy systems.
Keywords: Biopsy guiding; Bronchoscopy; Lung biopsy; Intervention guiding; Airway codification
|
|
|
|
Esmitt Ramirez, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2018). "BronchoX: bronchoscopy exploration software for biopsy intervention planning " . Healthcare Technology Letters, 5(5), 177–182.
Abstract: Virtual bronchoscopy (VB) is a non-invasive exploration tool for intervention planning and navigation of possible pulmonary lesions (PLs). A VB software involves the location of a PL and the calculation of a route, starting from the trachea, to reach it. The selection of a VB software might be a complex process, and there is no consensus in the community of medical software developers in which is the best-suited system to use or framework to choose. The authors present Bronchoscopy Exploration (BronchoX), a VB software to plan biopsy interventions that generate physician-readable instructions to reach the PLs. The authors’ solution is open source, multiplatform, and extensible for future functionalities, designed by their multidisciplinary research and development group. BronchoX is a compound of different algorithms for segmentation, visualisation, and navigation of the respiratory tract. Performed results are a focus on the test the effectiveness of their proposal as an exploration software, also to measure its accuracy as a guiding system to reach PLs. Then, 40 different virtual planning paths were created to guide physicians until distal bronchioles. These results provide a functional software for BronchoX and demonstrate how following simple instructions is possible to reach distal lesions from the trachea.
|
|
|
|
Antonio Esteban Lansaque, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2016). "Stable Anatomical Structure Tracking for video-bronchoscopy Navigation " In 19th International Conference on Medical Image Computing and Computer Assisted Intervention Workshops.
Abstract: Bronchoscopy allows to examine the patient airways for detection of lesions and sampling of tissues without surgery. A main drawback in lung cancer diagnosis is the diculty to check whether the exploration is following the correct path to the nodule that has to be biopsied. The most extended guidance uses uoroscopy which implies repeated radiation of clinical sta and patients. Alternatives such as virtual bronchoscopy or electromagnetic navigation are very expensive and not completely robust to blood, mocus or deformations as to be extensively used. We propose a method that extracts and tracks stable lumen regions at di erent levels of the bronchial tree. The tracked regions are stored in a tree that encodes the anatomical structure of the scene which can be useful to retrieve the path to the lesion that the clinician should follow to do the biopsy. We present a multi-expert validation of our anatomical landmark extraction in 3 intra-operative ultrathin explorations.
Keywords: Lung cancer diagnosis; video-bronchoscopy; airway lumen detection; region tracking
|
|
|
|
Antonio Esteban Lansaque, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, Antoni Rosell, & Debora Gil. (2016). "Stable Airway Center Tracking for Bronchoscopic Navigation " In 28th Conference of the international Society for Medical Innovation and Technology.
Abstract: Bronchoscopists use X‐ray fluoroscopy to guide bronchoscopes to the lesion to be biopsied without any kind of incisions. Reducing exposure to X‐ray is important for both patients and doctors but alternatives like electromagnetic navigation require specific equipment and increase the cost of the clinical procedure. We propose a guiding system based on the extraction of airway centers from intra‐operative videos. Such anatomical landmarks could be
matched to the airway centerline extracted from a pre‐planned CT to indicate the best path to the lesion. We present an extraction of lumen centers
from intra‐operative videos based on tracking of maximal stable regions of energy maps.
|
|
|
|
Debora Gil, Sergio Vera, Agnes Borras, Albert Andaluz, & Miguel Angel Gonzalez Ballester. (2017). "Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities " . Medical Image Analysis, 35, 390–402.
Abstract: Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.
Keywords: Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points
|
|
|
|
Jose Luis Gomez, Manuel Silva, Antonio Seoane, Agnes Borras, Mario Noriega, German Ros, et al. (2023). "All for One, and One for All: UrbanSyn Dataset, the third Musketeer of Synthetic Driving Scenes ".
Abstract: We introduce UrbanSyn, a photorealistic dataset acquired through semi-procedurally generated synthetic urban driving scenarios. Developed using high-quality geometry and materials, UrbanSyn provides pixel-level ground truth, including depth, semantic segmentation, and instance segmentation with object bounding boxes and occlusion degree. It complements GTAV and Synscapes datasets to form what we coin as the 'Three Musketeers'. We demonstrate the value of the Three Musketeers in unsupervised domain adaptation for image semantic segmentation. Results on real-world datasets, Cityscapes, Mapillary Vistas, and BDD100K, establish new benchmarks, largely attributed to UrbanSyn. We make UrbanSyn openly and freely accessible (this http URL).
|
|
|
|
Debora Gil, Carles Sanchez, Agnes Borras, Marta Diez-Ferrer, & Antoni Rosell. (2019). "Segmentation of Distal Airways using Structural Analysis " . PloS one, 14(12).
Abstract: Segmentation of airways in Computed Tomography (CT) scans is a must for accurate support of diagnosis and intervention of many pulmonary disorders. In particular, lung cancer diagnosis would benefit from segmentations reaching most distal airways. We present a method that combines descriptors of bronchi local appearance and graph global structural analysis to fine-tune thresholds on the descriptors adapted for each bronchial level. We have compared our method to the top performers of the EXACT09 challenge and to a commercial software for biopsy planning evaluated in an own-collected data-base of high resolution CT scans acquired under different breathing conditions. Results on EXACT09 data show that our method provides a high leakage reduction with minimum loss in airway detection. Results on our data-base show the reliability across varying breathing conditions and a competitive performance for biopsy planning compared to a commercial solution.
|
|
|
|
Debora Gil, David Roche, Agnes Borras, & Jesus Giraldo. (2015). "Terminating Evolutionary Algorithms at their Steady State " . Computational Optimization and Applications, 61(2), 489–515.
Abstract: Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications.
Keywords: Evolutionary algorithms; Termination condition; Steady state; Differential evolution
|
|
|
|
Debora Gil, Antonio Esteban Lansaque, Agnes Borras, Esmitt Ramirez, & Carles Sanchez. (2020). "Intraoperative Extraction of Airways Anatomy in VideoBronchoscopy " . IEEE Access, 8, 159696–159704.
Abstract: A main bottleneck in bronchoscopic biopsy sampling is to efficiently reach the lesion navigating across bronchial levels. Any guidance system should be able to localize the scope position during the intervention with minimal costs and alteration of clinical protocols. With the final goal of an affordable image-based guidance, this work presents a novel strategy to extract and codify the anatomical structure of bronchi, as well as, the scope navigation path from videobronchoscopy. Experiments using interventional data show that our method accurately identifies the bronchial structure. Meanwhile, experiments using simulated data verify that the extracted navigation path matches the 3D route.
|
|
|
|
Debora Gil, Antonio Esteban Lansaque, Agnes Borras, & Carles Sanchez. (2019). "Enhancing virtual bronchoscopy with intra-operative data using a multi-objective GAN " . International Journal of Computer Assisted Radiology and Surgery, 7(1).
Abstract: This manuscript has been withdrawn by bioRxiv due to upload of an incorrect version of the manuscript by the authors. Therefore, this manuscript should not be cited as reference for this project.
|
|
