Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.

Abstract: IF = 3.32
Many facial-analysis approaches rely on robust and accurate automatic facial landmarking to correctly function. In this paper, we describe a statistical method for automatic facial-landmark localization. Our landmarking relies on a parsimonious mixture model of Gabor wavelet features, computed in coarse-to-fine fashion and complemented with a shape prior. We assess the accuracy and the robustness of the proposed approach in extensive cross-database conditions conducted on four face data sets (Face Recognition Grand Challenge, Cohn-Kanade, Bosphorus, and BioID). Our method has 99.33% accuracy on the Bosphorus database and 97.62% accuracy on the BioID database on the average, which improves the state of the art. We show that the method is not significantly affected by low-resolution images, small rotations, facial expressions, and natural occlusions such as beard and mustache. We further test the goodness of the landmarks in a facial expression recognition application and report landmarking-induced improvement over baseline on two separate databases for video-based expression recognition (Cohn-Kanade and BU-4DFE).

Abstract: Impact factor 2010: 2.92
Impact factor 2011/12?: 3.32
Head pose and eye location for gaze estimation have been separately studied in numerous works in the literature. Previous research shows that satisfactory accuracy in head pose and eye location estimation can be achieved in constrained settings. However, in the presence of nonfrontal faces, eye locators are not adequate to accurately locate the center of the eyes. On the other hand, head pose estimation techniques are able to deal with these conditions; hence, they may be suited to enhance the accuracy of eye localization. Therefore, in this paper, a hybrid scheme is proposed to combine head pose and eye location information to obtain enhanced gaze estimation. To this end, the transformation matrix obtained from the head pose is used to normalize the eye regions, and in turn, the transformation matrix generated by the found eye location is used to correct the pose estimation procedure. The scheme is designed to enhance the accuracy of eye location estimations, particularly in low-resolution videos, to extend the operative range of the eye locators, and to improve the accuracy of the head pose tracker. These enhanced estimations are then combined to obtain a novel visual gaze estimation system, which uses both eye location and head information to refine the gaze estimates. From the experimental results, it can be derived that the proposed unified scheme improves the accuracy of eye estimations by 16% to 23%. Furthermore, it considerably extends its operating range by more than 15° by overcoming the problems introduced by extreme head poses. Moreover, the accuracy of the head pose tracker is improved by 12% to 24%. Finally, the experimentation on the proposed combined gaze estimation system shows that it is accurate (with a mean error between 2° and 5°) and that it can be used in cases where classic approaches would fail without imposing restraints on the position of the head.

Abstract: Impact factor 2010: 5.308
Impact factor 2011/12?: 5.96
Locating the center of the eyes allows for valuable information to be captured and used in a wide range of applications. Accurate eye center location can be determined using commercial eye-gaze trackers, but additional constraints and expensive hardware make these existing solutions unattractive and impossible to use on standard (i.e., visible wavelength), low-resolution images of eyes. Systems based solely on appearance are proposed in the literature, but their accuracy does not allow us to accurately locate and distinguish eye centers movements in these low-resolution settings. Our aim is to bridge this gap by locating the center of the eye within the area of the pupil on low-resolution images taken from a webcam or a similar device. The proposed method makes use of isophote properties to gain invariance to linear lighting changes (contrast and brightness), to achieve in-plane rotational invariance, and to keep low-computational costs. To further gain scale invariance, the approach is applied to a scale space pyramid. In this paper, we extensively test our approach for its robustness to changes in illumination, head pose, scale, occlusion, and eye rotation. We demonstrate that our system can achieve a significant improvement in accuracy over state-of-the-art techniques for eye center location in standard low-resolution imagery.

Abstract: Impact factor 2010: 2.92
IF 2011/2012?: 3.32
Interest point detection is an important research area in the field of image processing and computer vision. In particular, image retrieval and object categorization heavily rely on interest point detection from which local image descriptors are computed for image matching. In general, interest points are based on luminance, and color has been largely ignored. However, the use of color increases the distinctiveness of interest points. The use of color may therefore provide selective search reducing the total number of interest points used for image matching. This paper proposes color interest points for sparse image representation. To reduce the sensitivity to varying imaging conditions, light-invariant interest points are introduced. Color statistics based on occurrence probability lead to color boosted points, which are obtained through saliency-based feature selection. Furthermore, a principal component analysis-based scale selection method is proposed, which gives a robust scale estimation per interest point. From large-scale experiments, it is shown that the proposed color interest point detector has higher repeatability than a luminance-based one. Furthermore, in the context of image retrieval, a reduced and predictable number of color features show an increase in performance compared to state-of-the-art interest points. Finally, in the context of object recognition, for the Pascal VOC 2007 challenge, our method gives comparable performance to state-of-the-art methods using only a small fraction of the features, reducing the computing time considerably.

Abstract: Medial representations are powerful tools for describing and parameterizing the volumetric shape of anatomical structures. Existing methods show excellent results when applied to 2D
objects, but their quality drops across dimensions. This paper contributes to the computation of medial manifolds in two aspects. First, we provide a standard scheme for the computation of medial
manifolds that avoid degenerated medial axis segments; second, we introduce an energy based method which performs independently of the dimension. We evaluate quantitatively the performance of our
method with respect to existing approaches, by applying them to synthetic shapes of known medial geometry. Finally, we show results on shape representation of multiple abdominal organs,
exploring the use of medial manifolds for the representation of multi-organ relations.

Abstract: The aim of writer identification is determining the writer of a piece of handwriting from a set of writers. In this paper we present a system for writer identification in old handwritten music scores. Even though an important amount of compositions contains handwritten text in the music scores, the aim of our work is to use only music notation to determine the author. The steps of the system proposed are the following. First of all, the music sheet is preprocessed and normalized for obtaining a single binarized music line, without the staff lines. Afterwards, 100 features are extracted for every music line, which are subsequently used in a k-NN classifier that compares every feature vector with prototypes stored in a database. By applying feature selection and extraction methods on the original feature set, the performance is increased. The proposed method has been tested on a database of old music scores from the 17th to 19th centuries, achieving a recognition rate of about 95%.