Abstract: Colorectal cancer is the fourth most common cause of cancer death worldwide and its survival rate depends on the stage in which it is detected on hence the necessity for an early colon screening. There are several screening techniques but colonoscopy is still nowadays the gold standard, although it has some drawbacks such as the miss rate. Our contribution, in the field of intelligent systems for colonoscopy, aims at providing a polyp localization and a polyp segmentation system based on a model of appearance for polyps. To develop both methods we define a model of appearance for polyps, which describes a polyp as enclosed by intensity valleys. The novelty of our contribution resides on the fact that we include in our model aspects of the image formation and we also consider the presence of other elements from the endoluminal scene such as specular highlights and blood vessels, which have an impact on the performance of our methods. In order to develop our polyp localization method we accumulate valley information in order to generate energy maps, which are also used to guide the polyp segmentation. Our methods achieve promising results in polyp localization and segmentation. As we want to explore the usability of our methods we present a comparative analysis between physicians fixations obtained via an eye tracking device and our polyp localization method. The results show that our method is indistinguishable to novice physicians although it is far from expert physicians.

Abstract: The automatic segmentation of multiple subcortical structures in brain Magnetic Resonance Images (MRI) still remains a challenging task. In this paper, we address this problem using sparse representation and discriminative dictionary learning, which have shown promising results in compression, image denoising and recently in MRI segmentation. Particularly, we use multiclass dictionaries learned from a set of brain atlases to simultaneously segment multiple subcortical structures.
We also impose dictionary atoms to be specialized in one given class using label consistent K-SVD, which can alleviate the bias produced by unbalanced libraries, present when dealing with small structures. The proposed method is compared with other state of the art approaches for the segmentation of the Basal Ganglia of 35 subjects of a public dataset.
The promising results of the segmentation method show the eciency of the multiclass discriminative dictionary learning algorithms in MRI segmentation problems.

Abstract: X-ray angiography is widely used in cardiac disease diagnosis during or prior to intravascular interventions. The diaphragm motion and the heart beating induce gray-level changes, which are one of the main obstacles in quantitative analysis of myocardial perfusion. In this paper we focus on detecting the diaphragm border in both single images or whole X-ray angiography sequences. We show that the proposed method outperforms state of the art approaches. We extend a previous publicly available data set, adding new ground truth data. We also compose another set of more challenging images, thus having two separate data sets of increasing difficulty. Finally, we show three applications of our method: (1) a strategy to reduce false positives in vessel enhanced images; (2) a digital diaphragm removal algorithm; (3) an improvement in Myocardial Blush Grade semi-automatic estimation.

Abstract: This paper presents an effective unsupervised sparse feature learning algorithm to train deep convolutional networks on hyperspectral images. Deep convolutional hierarchical representations are learned and then used for pixel classification. Features in lower layers present less abstract representations of data, while higher layers represent more abstract and complex characteristics. We successfully illustrate the performance of the extracted representations in a challenging AVIRIS hyperspectral image classification problem, compared to standard dimensionality reduction methods like principal component analysis (PCA) and its kernel counterpart (kPCA). The proposed method largely outperforms the previous state-ofthe-art results on the same experimental setting. Results show that single layer networks can extract powerful discriminative features only when the receptive field accounts for neighboring pixels. Regarding the deep architecture, we can conclude that: (1) additional layers in a deep architecture significantly improve the performance w.r.t. single layer variants; (2) the max-pooling step in each layer is mandatory to achieve satisfactory results; and (3) the performance gain w.r.t. the number of layers is upper bounded, since the spatial resolution is reduced at each pooling, resulting in too spatially coarse output features.

Abstract: Wireless Capsule Endoscopy (WCE) is a technique for inner-visualization of the entire small intestine and, thus, offers an interesting perspective on intestinal motility. The two major drawbacks of this technique are: 1) huge amount of data acquired by WCE makes the motility analysis tedious and 2) since the capsule is the first tool that offers complete inner-visualization of the small intestine,the exact importance of the observed events is still an open issue. Therefore, in this thesis, a novel computer-aided system for intestinal motility analysis is presented. The goal of the system is to provide an easily-comprehensible visual description of motility-related intestinal events to a physician. In order to do so, several tools based either on computer vision concepts or on machine learning techniques are presented. A method for transforming 3D video signal to a holistic image of intestinal motility, called motility bar, is proposed. The method calculates the optimal mapping from video into image from the intestinal motility point of view.
To characterize intestinal motility, methods for automatic extraction of motility information from WCE are presented. Two of them are based on the motility bar and two of them are based on frame-per-frame analysis. In particular, four algorithms dealing with the problems of intestinal contraction detection, lumen size estimation, intestinal content characterization and wrinkle frame detection are proposed and validated. The results of the algorithms are converted into sequential features using an online statistical test. This test is designed to work with multivariate data streams. To this end, we propose a novel formulation of concentration inequality that is introduced into a robust adaptive windowing algorithm for multivariate data streams. The algorithm is used to obtain robust representation of segments with constant intestinal motility activity. The obtained sequential features are shown to be discriminative in the problem of abnormal motility characterization.
Finally, we tackle the problem of efficient labeling. To this end, we incorporate active learning concepts to the problems present in WCE data and propose two approaches. The first one is based the concepts of sequential learning and the second one adapts the partition-based active learning to an error-free labeling scheme. All these steps are sufficient to provide an extensive visual description of intestinal motility that can be used by an expert as decision support system.

Abstract: By increasing popularity of wearable cameras, life-logging data analysis is becoming more and more important and useful to derive significant events out of this substantial collection of images. In this study, we introduce a new tracking method applied to visual life-logging, called bag-of-tracklets, which is based on detecting, localizing and tracking of people. Given the low spatial and temporal resolution of the image data, our model generates and groups tracklets in a unsupervised framework and extracts image sequences of person appearance according to a similarity score of the bag-of-tracklets. The model output is a meaningful sequence of events expressing human appearance and tracking them in life-logging data. The achieved results prove the robustness of our model in terms of efficiency and accuracy despite the low spatial and temporal resolution of the data.

Abstract: In this paper, we propose a novel way to perform top-down semantic feedback in convolutional deep networks for efficient and accurate image parsing. We also show how to add global appearance/semantic features, which have shown to improve image parsing performance in state-of-the-art methods, and was not present in previous convolutional approaches. The proposed method is characterised by an efficient training and a sufficiently fast testing. We use the well known SIFTflow dataset to numerically show the advantages provided by our contributions, and to compare with state-of-the-art image parsing convolutional based approaches.

Abstract: We address the problem of estimating high-level semantic labels for videos of recorded people by means of analysing their facial expressions. This problem, to which we refer as facial behavior categorization, is a weakly-supervised learning problem where we do not have access to frame-by-frame facial gesture annotations but only weak-labels at the video level are available. Therefore, the goal is to learn a set of discriminative expressions and how they determine the video weak-labels. Facial behavior categorization can be posed as a Multi-Instance-Learning (MIL) problem and we propose a novel MIL method called Regularized Multi-Concept MIL to solve it. In contrast to previous approaches applied in facial behavior analysis, RMC-MIL follows a Multi-Concept assumption which allows different facial expressions (concepts) to contribute differently to the video-label. Moreover, to handle with the high-dimensional nature of facial-descriptors, RMC-MIL uses a discriminative approach to model the concepts and structured sparsity regularization to discard non-informative features. RMC-MIL is posed as a convex-constrained optimization problem where all the parameters are jointly learned using the Projected-Quasi-Newton method. In our experiments, we use two public data-sets to show the advantages of the Regularized Multi-Concept approach and its improvement compared to existing MIL methods. RMC-MIL outperforms state-of-the-art results in the UNBC data-set for pain detection.