Abstract: Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium. Because of the potential of E. coli as a model organism, elucidating aging and protein aggregation in this bacterium may pave the way to significant advances in our global understanding of aging. A first obstacle along this path is to decipher the mechanisms by which protein aggregates are targeted to specific intercellular locations. Here, using an integrated approach based on individual-based modeling, time-lapse fluorescence microscopy and automated image analysis, we show that the movement of aging-related protein aggregates in E. coli is purely diffusive (Brownian). Using single-particle tracking of protein aggregates in live E. coli cells, we estimated the average size and diffusion constant of the aggregates. Our results provide evidence that the aggregates passively diffuse within the cell, with diffusion constants that depend on their size in agreement with the Stokes-Einstein law. However, the aggregate displacements along the cell long axis are confined to a region that roughly corresponds to the nucleoid-free space in the cell pole, thus confirming the importance of increased macromolecular crowding in the nucleoids. We thus used 3D individual-based modeling to show that these three ingredients (diffusion, aggregation and diffusion hindrance in the nucleoids) are sufficient and necessary to reproduce the available experimental data on aggregate localization in the cells. Taken together, our results strongly support the hypothesis that the localization of aging-related protein aggregates in the poles of E. coli results from the coupling of passive diffusion-aggregation with spatially non-homogeneous macromolecular crowding. They further support the importance of “soft” intracellular structuring (based on macromolecular crowding) in diffusion-based protein localization in E. coli.

Abstract: Multiple Instance Learning (MIL) has become an important topic in the pattern recognition community, and many solutions to this problemhave been proposed until now. Despite this fact, there is a lack of comparative studies that shed light into the characteristics and behavior of the different methods. In this work we provide such an analysis focused on the classification task (i.e.,leaving out other learning tasks such as regression). In order to perform our study, we implemented
fourteen methods grouped into three different families. We analyze the performance of the approaches across a variety of well-known databases, and we also study their behavior in synthetic scenarios in order to highlight their characteristics. As a result of this analysis, we conclude that methods that extract global bag-level information show a clearly superior performance in general. In this sense, the analysis permits us to understand why some types of methods are more successful than others, and it permits us to establish guidelines in the design of new MIL
methods.

Abstract: We present a new document image descriptor based on multi-scale runlength
histograms. This descriptor does not rely on layout analysis and can be
computed efficiently. We show how this descriptor can achieve state-of-theart
results on two very different public datasets in classification and retrieval
tasks. Moreover, we show how we can compress and binarize these descriptors
to make them suitable for large-scale applications. We can achieve state-ofthe-
art results in classification using binary descriptors of as few as 16 to 64
bits.

Abstract: Historical records of daily activities provide intriguing insights into the life of our ancestors, useful for demography studies and genealogical research. Automatic processing of historical documents, however, has mostly been focused on single works of literature and less on social records, which tend to have a distinct layout, structure, and vocabulary. Such information is usually collected by expert demographers that devote a lot of time to manually transcribe them. This paper presents a new database, compiled from a marriage license books collection, to support research in automatic handwriting recognition for historical documents containing social records. Marriage license books are documents that were used for centuries by ecclesiastical institutions to register marriage licenses. Books from this collection are handwritten and span nearly half a millennium until the beginning of the 20th century. In addition, a study is presented about the capability of state-of-the-art handwritten text recognition systems, when applied to the presented database. Baseline results are reported for reference in future studies.

Abstract: Structural pattern recognition approaches offer the most expressive, convenient, powerful but computational expensive representations of underlying relational information. To benefit from mature, less expensive and efficient state-of-the-art machine learning models of statistical pattern recognition they must be mapped to a low-dimensional vector space. Our method of explicit graph embedding bridges the gap between structural and statistical pattern recognition. We extract the topological, structural and attribute information from a graph and encode numeric details by fuzzy histograms and symbolic details by crisp histograms. The histograms are concatenated to achieve a simple and straightforward embedding of graph into a low-dimensional numeric feature vector. Experimentation on standard public graph datasets shows that our method outperforms the state-of-the-art methods of graph embedding for richly attributed graphs.

Abstract: We propose a saliency model termed SIM (saliency by induction mechanisms), which is based on a low-level spatiochromatic model that has successfully predicted chromatic induction phenomena. In so doing, we hypothesize that the low-level visual mechanisms that enhance or suppress image detail are also responsible for making some image regions more salient. Moreover, SIM adds geometrical grouplets to enhance complex low-level features such as corners, and suppress relatively simpler features such as edges. Since our model has been fitted on psychophysical chromatic induction data, it is largely nonparametric. SIM outperforms state-of-the-art methods in predicting eye fixations on two datasets and using two metrics.