Abstract: Otolith end organs of vertebrates sense linear accelerations of the head and gravitation. The hair cells on their epithelia are responsible for transduction. In mammals, the striola, parallel to the line where hair cells reverse their polarization, is a narrow region centered on a curve with curvature and torsion. It has been shown that the striolar region is functionally different from the rest, being involved in a phasic vestibular pathway. We propose a mathematical and computational model that explains the necessity of this amazing geometry for the striola to be able to carry out its function. Our hypothesis, related to the biophysics of the hair cells and to the physiology of their afferent neurons, is that striolar afferents collect information from several type I hair cells to detect the jerk in a large domain of acceleration directions. This predicts a mean number of two calyces for afferent neurons, as measured in rodents. The domain of acceleration directions sensed by our striolar model is compatible with the experimental results obtained on monkeys considering all afferents. Therefore, the main result of our study is that phasic and tonic vestibular afferents cover the same geometrical fields, but at different dynamical and frequency domains.

Abstract: Aggregates of misfolded proteins are a hallmark of many age-related diseases. Recently, they have been linked to aging of Escherichia coli (E. coli) where protein aggregates accumulate at the old pole region of the aging bacterium. Because of the potential of E. coli as a model organism, elucidating aging and protein aggregation in this bacterium may pave the way to significant advances in our global understanding of aging. A first obstacle along this path is to decipher the mechanisms by which protein aggregates are targeted to specific intercellular locations. Here, using an integrated approach based on individual-based modeling, time-lapse fluorescence microscopy and automated image analysis, we show that the movement of aging-related protein aggregates in E. coli is purely diffusive (Brownian). Using single-particle tracking of protein aggregates in live E. coli cells, we estimated the average size and diffusion constant of the aggregates. Our results provide evidence that the aggregates passively diffuse within the cell, with diffusion constants that depend on their size in agreement with the Stokes-Einstein law. However, the aggregate displacements along the cell long axis are confined to a region that roughly corresponds to the nucleoid-free space in the cell pole, thus confirming the importance of increased macromolecular crowding in the nucleoids. We thus used 3D individual-based modeling to show that these three ingredients (diffusion, aggregation and diffusion hindrance in the nucleoids) are sufficient and necessary to reproduce the available experimental data on aggregate localization in the cells. Taken together, our results strongly support the hypothesis that the localization of aging-related protein aggregates in the poles of E. coli results from the coupling of passive diffusion-aggregation with spatially non-homogeneous macromolecular crowding. They further support the importance of “soft” intracellular structuring (based on macromolecular crowding) in diffusion-based protein localization in E. coli.

Abstract: In this chapter we describe a system for document retrieval and classification following the interactive-predictive framework. In particular, the system addresses two different scenarios of document analysis: document classification based on visual appearance and logo detection. These two classical problems of document analysis are formulated following the interactive-predictive model, taking the user interaction into account to make easier the process of annotating and labelling the documents. A system implementing this model in a real scenario is presented and analyzed. This system also takes advantage of active learning techniques to speed up the task of labelling the documents.

Abstract: Pedestrian detection is of paramount interest for many applications, e.g. Advanced Driver Assistance Systems, Intelligent Video Surveillance and Multimedia systems. Most promising pedestrian detectors rely on appearance-based classifiers trained with annotated data. However, the required annotation step represents an intensive and subjective task for humans, what makes worth to minimize their intervention in this process by using computational tools like realistic virtual worlds. The reason to use these kind of tools relies in the fact that they allow the automatic generation of precise and rich annotations of visual information. Nevertheless, the use of this kind of data comes with the following question: can a pedestrian appearance model learnt with virtual-world data work successfully for pedestrian detection in real-world scenarios?. To answer this question, we conduct different experiments that suggest a positive answer. However, the pedestrian classifiers trained with virtual-world data can suffer the so called dataset shift problem as real-world based classifiers does. Accordingly, we have designed different domain adaptation techniques to face this problem, all of them integrated in a same framework (V-AYLA). We have explored different methods to train a domain adapted pedestrian classifiers by collecting a few pedestrian samples from the target domain (real world) and combining them with many samples of the source domain (virtual world). The extensive experiments we present show that pedestrian detectors developed within the V-AYLA framework do achieve domain adaptation. Ideally, we would like to adapt our system without any human intervention. Therefore, as a first proof of concept we also propose an unsupervised domain adaptation technique that avoids human intervention during the adaptation process. To the best of our knowledge, this Thesis work is the first demonstrating adaptation of virtual and real worlds for developing an object detector. Last but not least, we also assessed a different strategy to avoid the dataset shift that consists in collecting real-world samples and retrain with them in such a way that no bounding boxes of real-world pedestrians have to be provided. We show that the generated classifier is competitive with respect to the counterpart trained with samples collected by manually annotating pedestrian bounding boxes. The results presented on this Thesis not only end with a proposal for adapting a virtual-world pedestrian detector to the real world, but also it goes further by pointing out a new methodology that would allow the system to adapt to different situations, which we hope will provide the foundations for future research in this unexplored area.

Abstract: Recognizing object categories in real world images is a challenging problem in computer vision. The deformable part based framework is currently the most successful approach for object detection. Generally, HOG are used for image representation within the part-based framework. For action recognition, the bag-of-word framework has shown to provide promising results. Within the bag-of-words framework, local image patches are described by SIFT descriptor. Contrary to object detection and action recognition, combining color and shape has shown to provide the best performance for object and scene recognition.
In the first part of this thesis, we analyze the problem of person detection in still images. Standard person detection approaches rely on intensity based features for image representation while ignoring the color. Channel based descriptors is one of the most commonly used approaches in object recognition. This inspires us to evaluate incorporating color information using the channel based fusion approach for the task of person detection.
In the second part of the thesis, we investigate the problem of object detection in still images. Due to high dimensionality, channel based fusion increases the computational cost. Moreover, channel based fusion has been found to obtain inferior results for object category where one of the visual varies significantly. On the other hand, late fusion is known to provide improved results for a wide range of object categories. A consequence of late fusion strategy is the need of a pure color descriptor. Therefore, we propose to use Color attributes as an explicit color representation for object detection. Color attributes are compact and computationally efficient. Consequently color attributes are combined with traditional shape features providing excellent results for object detection task.
Finally, we focus on the problem of action detection and classification in still images. We investigate the potential of color for action classification and detection in still images. We also evaluate different fusion approaches for combining color and shape information for action recognition. Additionally, an analysis is performed to validate the contribution of color for action recognition. Our results clearly demonstrate that combining color and shape information significantly improve the performance of both action classification and detection in still images.

Abstract: We present in this paper a novel lumen centre detection for gastrointestinal and respiratory endoscopic images. The proposed method is based on the appearance and geometry of the lumen, which we defined as the darkest image region which centre is a hub of image gradients. Experimental results validated on the first public annotated gastro-respiratory database prove the reliability of the method for a wide range of images (with precision over 95 %).

Abstract: More realistic and accurate models of the scene illumination and object reflectance can greatly improve the quality of many computer vision and computer graphics tasks. Using such model, a more profound knowledge about the interaction of light with object surfaces can be established which proves crucial to a variety of computer vision applications. In the current work, we investigate the various existing approaches to illumination and reflectance modeling and form an analysis on their shortcomings in capturing the complexity of real-world scenes. Based on this analysis we propose improvements to different aspects of reflectance and illumination estimation in order to more realistically model the real-world scenes in the presence of complex lighting phenomena (i.e, multiple illuminants, interreflections and shadows). Moreover, we captured our own multi-illuminant dataset which consists of complex scenes and illumination conditions both outdoor and in laboratory conditions. In addition we investigate the use of synthetic data to facilitate the construction of datasets and improve the process of obtaining ground-truth information.