Abstract: Image based human detection remains as a challenging problem. Most promising detectors rely on classifiers trained with labelled samples. However, labelling is a manual labor intensive step. To overcome this problem we propose to collect images of pedestrians from a virtual city, i.e., with automatic labels, and train a pedestrian detector with them, which works fine when such virtual-world data are similar to testing one, i.e., real-world pedestrians in urban areas. When testing data is acquired in different conditions than training one, e.g., human detection in personal photo albums, dataset shift appears. In previous work, we cast this problem as one of domain adaptation and solve it with an active learning procedure. In this work, we focus on the same problem but evaluating a different set of faster to compute features, i.e., Haar, EOH and their combination. In particular, we train a classifier with virtual-world data, using such features and Real AdaBoost as learning machine. This classifier is applied to real-world training images. Then, a human oracle interactively corrects the wrong detections, i.e., few miss detections are manually annotated and some false ones are pointed out too. A low amount of manual annotation is fixed as restriction. Real- and virtual-world difficult samples are combined within what we call cool world and we retrain the classifier with this data. Our experiments show that this adapted classifier is equivalent to the one trained with only real-world data but requiring 90% less manual annotations.

Abstract: Training vision-based pedestrian detectors using synthetic datasets (virtual world) is a useful technique to collect automatically the training examples with their pixel-wise ground truth. However, as it is often the case, these detectors must operate in real-world images, experiencing a significant drop of their performance. In fact, this effect also occurs among different real-world datasets, i.e. detectors' accuracy drops when the training data (source domain) and the application scenario (target domain) have inherent differences. Therefore, in order to avoid this problem, it is required to adapt the detector trained with synthetic data to operate in the real-world scenario. In this paper, we propose a domain adaptation approach based on boosting LDA exemplar classifiers from both virtual and real worlds. We evaluate our proposal on multiple real-world pedestrian detection datasets. The results show that our method can efficiently adapt the exemplar classifiers from virtual to real world, avoiding drops in average precision over the 15%.

Abstract: Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.

Abstract: The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed.