Abstract: Radiomics is an emerging technique for the quantification of imaging data that has recently shown great promise for deeper phenotyping of cardiovascular disease. Thus far, the technique has been mostly applied in single-centre studies. However, one of the main difficulties in multi-centre imaging studies is the inherent variability of image characteristics due to centre differences. In this paper, a comprehensive analysis of radiomics variability under several image- and feature-based normalisation techniques was conducted using a multi-centre cardiovascular magnetic resonance dataset. 218 subjects divided into healthy (n = 112) and hypertrophic cardiomyopathy (n = 106, HCM) groups from five different centres were considered. First and second order texture radiomic features were extracted from three regions of interest, namely the left and right ventricular cavities and the left ventricular myocardium. Two methods were used to assess features’ variability. First, feature distributions were compared across centres to obtain a distribution similarity index. Second, two classification tasks were proposed to assess: (1) the amount of centre-related information encoded in normalised features (centre identification) and (2) the generalisation ability for a classification model when trained on these features (healthy versus HCM classification). The results showed that the feature-based harmonisation technique ComBat is able to remove the variability introduced by centre information from radiomic features, at the expense of slightly degrading classification performance. Piecewise linear histogram matching normalisation gave features with greater generalisation ability for classification ( balanced accuracy in between 0.78 ± 0.08 and 0.79 ± 0.09). Models trained with features from images without normalisation showed the worst performance overall ( balanced accuracy in between 0.45 ± 0.28 and 0.60 ± 0.22). In conclusion, centre-related information removal did not imply good generalisation ability for classification.

Abstract: We present EgoACO, a deep neural architecture for video action recognition that learns to pool action-context-object descriptors from frame level features by leveraging the verb-noun structure of action labels in egocentric video datasets. The core component of EgoACO is class activation pooling (CAP), a differentiable pooling operation that combines ideas from bilinear pooling for fine-grained recognition and from feature learning for discriminative localization. CAP uses self-attention with a dictionary of learnable weights to pool from the most relevant feature regions. Through CAP, EgoACO learns to decode object and scene context descriptors from video frame features. For temporal modeling in EgoACO, we design a recurrent version of class activation pooling termed Long Short-Term Attention (LSTA). LSTA extends convolutional gated LSTM with built-in spatial attention and a re-designed output gate. Action, object and context descriptors are fused by a multi-head prediction that accounts for the inter-dependencies between noun-verb-action structured labels in egocentric video datasets. EgoACO features built-in visual explanations, helping learning and interpretation. Results on the two largest egocentric action recognition datasets currently available, EPIC-KITCHENS and EGTEA, show that by explicitly decoding action-context-object descriptors, EgoACO achieves state-of-the-art recognition performance.

Abstract: Speckle noise negatively affects medical ultrasound image shape interpretation and boundary detection. Speckle removal filters are widely used to selectively remove speckle noise without destroying important image features to enhance object boundaries. In this article, a fully automatic bilateral filter tailored to ultrasound images is proposed. The edge preservation property is obtained by embedding noise statistics in the filter framework. Consequently, the filter is able to tackle the multiplicative behavior modulating the smoothing strength with respect to local statistics. The in silico experiments clearly showed that the speckle reducing bilateral filter (SRBF) has superior performances to most of the state of the art filtering methods. The filter is tested on 50 in vivo US images and its influence on a segmentation task is quantified. The results using SRBF filtered data sets show a superior performance to using oriented anisotropic diffusion filtered images. This improvement is due to the adaptive support of SRBF and the embedded noise statistics, yielding a more homogeneous smoothing. SRBF results in a fully automatic, fast and flexible algorithm potentially suitable in wide ranges of speckle noise sizes, for different medical applications (IVUS, B-mode, 3-D matrix array US).