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Author (up) Victor M. Campello; Carlos Martin-Isla; Cristian Izquierdo; Andrea Guala; Jose F. Rodriguez Palomares; David Vilades; Martin L. Descalzo; Mahir Karakas; Ersin Cavus; Zahra Zahra Raisi-Estabragh; Steffen E. Petersen; Sergio Escalera; Santiago Segui; Karim Lekadir edit  doi
openurl 
  Title Minimising multi-centre radiomics variability through image normalisation: a pilot study Type Journal Article
  Year 2022 Publication Scientific Reports Abbreviated Journal ScR  
  Volume 12 Issue 1 Pages 12532  
  Keywords  
  Abstract Radiomics is an emerging technique for the quantification of imaging data that has recently shown great promise for deeper phenotyping of cardiovascular disease. Thus far, the technique has been mostly applied in single-centre studies. However, one of the main difficulties in multi-centre imaging studies is the inherent variability of image characteristics due to centre differences. In this paper, a comprehensive analysis of radiomics variability under several image- and feature-based normalisation techniques was conducted using a multi-centre cardiovascular magnetic resonance dataset. 218 subjects divided into healthy (n = 112) and hypertrophic cardiomyopathy (n = 106, HCM) groups from five different centres were considered. First and second order texture radiomic features were extracted from three regions of interest, namely the left and right ventricular cavities and the left ventricular myocardium. Two methods were used to assess features’ variability. First, feature distributions were compared across centres to obtain a distribution similarity index. Second, two classification tasks were proposed to assess: (1) the amount of centre-related information encoded in normalised features (centre identification) and (2) the generalisation ability for a classification model when trained on these features (healthy versus HCM classification). The results showed that the feature-based harmonisation technique ComBat is able to remove the variability introduced by centre information from radiomic features, at the expense of slightly degrading classification performance. Piecewise linear histogram matching normalisation gave features with greater generalisation ability for classification ( balanced accuracy in between 0.78 ± 0.08 and 0.79 ± 0.09). Models trained with features from images without normalisation showed the worst performance overall ( balanced accuracy in between 0.45 ± 0.28 and 0.60 ± 0.22). In conclusion, centre-related information removal did not imply good generalisation ability for classification.  
  Address 2022/07/22  
  Corporate Author Thesis  
  Publisher Springer Nature Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes HuPBA Approved no  
  Call Number Admin @ si @ CMI2022 Serial 3749  
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