|
|
Debora Gil, Jaume Garcia, Aura Hernandez-Sabate, & Enric Marti. (2010). "Manifold parametrization of the left ventricle for a statistical modelling of its complete anatomy " In 8th Medical Imaging (Vol. 7623, 304). SPIE.
Abstract: Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature.
|
|
|
|
Marta Ligero, Guillermo Torres, Carles Sanchez, Katerine Diaz, Raquel Perez, & Debora Gil. (2019). "Selection of Radiomics Features based on their Reproducibility " In 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (pp. 403–408).
Abstract: Dimensionality reduction is key to alleviate machine learning artifacts in clinical applications with Small Sample Size (SSS) unbalanced datasets. Existing methods rely on either the probabilistic distribution of training data or the discriminant power of the reduced space, disregarding the impact of repeatability and uncertainty in features.In the present study is proposed the use of reproducibility of radiomics features to select features with high inter-class correlation coefficient (ICC). The reproducibility includes the variability introduced in the image acquisition, like medical scans acquisition parameters and convolution kernels, that affects intensity-based features and tumor annotations made by physicians, that influences morphological descriptors of the lesion.For the reproducibility of radiomics features three studies were conducted on cases collected at Vall Hebron Oncology Institute (VHIO) on responders to oncology treatment. The studies focused on the variability due to the convolution kernel, image acquisition parameters, and the inter-observer lesion identification. The features selected were those features with a ICC higher than 0.7 in the three studies.The selected features based on reproducibility were evaluated for lesion malignancy classification using a different database. Results show better performance compared to several state-of-the-art methods including Principal Component Analysis (PCA), Kernel Discriminant Analysis via QR decomposition (KDAQR), LASSO, and an own built Convolutional Neural Network.
|
|
|
|
Petia Radeva, Joan Serrat, & Enric Marti. (1995). "A snake for model-based segmentation " In Proc. Conf. Fifth Int Computer Vision (pp. 816–821).
Abstract: Despite the promising results of numerous applications, the hitherto proposed snake techniques share some common problems: snake attraction by spurious edge points, snake degeneration (shrinking and attening), convergence and stability of the deformation process, snake initialization and local determination of the parameters of elasticity. We argue here that these problems can be solved only when all the snake aspects are considered. The snakes proposed here implement a new potential eld and external force in order to provide a deformation convergence, attraction by both near and far edges as well as snake behaviour selective according to the edge orientation. Furthermore, we conclude that in the case of model-based seg mentation, the internal force should include structural information about the expected snake shape. Experiments using this kind of snakes for segmenting bones in complex hand radiographs show a signi cant improvement.
Keywords: snakes; elastic matching; model-based segmenta tion
|
|
|
|
Debora Gil, Oriol Rodriguez-Leon, Petia Radeva, & Josepa Mauri. (2008). "Myocardial Perfusion Characterization From Contrast Angiography Spectral Distribution " . IEEE Transactions on Medical Imaging, 27(5), 641–649.
Abstract: Despite recovering a normal coronary flow after acute myocardial infarction, percutaneous coronary intervention does not guarantee a proper perfusion (irrigation) of the infarcted area. This damage in microcirculation integrity may detrimentally affect the patient survival. Visual assessment of the myocardium opacification in contrast angiography serves to define a subjective score of the microcirculation integrity myocardial blush analysis (MBA). Although MBA correlates with patient prognosis its visual assessment is a very difficult task that requires of a highly expertise training in order to achieve a good intraobserver and interobserver agreement. In this paper, we provide objective descriptors of the myocardium staining pattern by analyzing the spectrum of the image local statistics. The descriptors proposed discriminate among the different phenomena observed in the angiographic sequence and allow defining an objective score of the myocardial perfusion.
Keywords: Contrast angiography; myocardial perfusion; spectral analysis.
|
|
|
|
Antoni Gurgui, Debora Gil, & Enric Marti. (2015). "Laplacian Unitary Domain for Texture Morphing " In Proceedings of the 10th International Conference on Computer Vision Theory and Applications VISIGRAPP2015 (Vol. 1, pp. 693–699). SciTePress.
Abstract: Deformation of expressive textures is the gateway to realistic computer synthesis of expressions. By their good mathematical properties and flexible formulation on irregular meshes, most texture mappings rely on solutions to the Laplacian in the cartesian space. In the context of facial expression morphing, this approximation can be seen from the opposite point of view by neglecting the metric. In this paper, we use the properties of the Laplacian in manifolds to present a novel approach to warping expressive facial images in order to generate a morphing between them.
Keywords: Facial; metamorphosis;LaplacianMorphing
|
|
|
|
Petia Radeva, & Enric Marti. (1995). Facial Features Segmentation by Model-Based Snakes In International Conference on Computing Analysis and Image Processing. Bellaterra (Barcelona), Spain.
Abstract: Deformable models have recently been accepted as a standard technique to segment different features in facial images. Despite they give a good approximation of the salient features in a facial image, the resulting shapes of the segmentation process seem somewhat artificial with respect to the natural feature shapes. In this paper we show that active contour models (in particular, rubber snakes) give more close and natural representation of the detected feature shape. Besides, using snakes for facial segmentation frees us from the problem of determination of the numerous weigths of deformable models. Another advantage of rubber snakes is their reduced computational cost. Our experiments using rubber snakes for segmentation of facial snapshots have shown a significant improvement compared to deformable models.
|
|
|
|
Debora Gil, Agnes Borras, Manuel Ballester, Francesc Carreras, Ruth Aris, Manuel Vazquez, et al. (2011). "MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis " In Association for Computing Machinery (Ed.), 14th International Symposium on Applied Sciences in Biomedical and Communication Technologies. Barcelona, Spain.
Abstract: Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization.
|
|
|
|
Ferran Poveda, Jaume Garcia, Enric Marti, & Debora Gil. (2010). "Validation of the myocardial architecture in DT-MRI tractography " In Medical Image Computing in Catalunya: Graduate Student Workshop (pp. 29–30). Girona (Spain).
Abstract: Deep understanding of myocardial structure may help to link form and funcion of the heart unraveling crucial knowledge for medical and surgical clinical procedures and studies. In this work we introduce two visualization techniques based on DT-MRI streamlining able to decipher interesting properties of the architectural organization of the heart.
|
|
|
|
Ferran Poveda, Debora Gil, Enric Marti, Albert Andaluz, Manel Ballester, & Francesc Carreras Costa. (2013). "Helical structure of the cardiac ventricular anatomy assessed by Diffusion Tensor Magnetic Resonance Imaging multi-resolution tractography " . Revista Española de Cardiología, 66(10), 782–790.
Abstract: Deep understanding of myocardial structure linking morphology and function of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Several conceptual models of myocardial fiber organization have been proposed but the lack of an automatic and objective methodology prevented an agreement. We sought to deepen in this knowledge through advanced computer graphic representations of the myocardial fiber architecture by diffusion tensor magnetic resonance imaging (DT-MRI).
We performed automatic tractography reconstruction of unsegmented DT-MRI canine heart datasets coming from the public database of the Johns Hopkins University. Full scale tractographies have been build with 200 seeds and are composed by streamlines computed on the vectorial field of primary eigenvectors given at the diffusion tensor volumes. Also, we introduced a novel multi-scale visualization technique in order to obtain a simplified tractography. This methodology allowed to keep the main geometric features of the fiber tracts, making easier to decipher the main properties of the architectural organization of the heart.
On the analysis of the output from our tractographic representations we found exact correlation with low-level details of myocardial architecture, but also with the more abstract conceptualization of a continuous helical ventricular myocardial fiber array.
Objective analysis of myocardial architecture by an automated method, including the entire myocardium and using several 3D levels of complexity, reveals a continuous helical myocardial fiber arrangement of both right and left ventricles, supporting the anatomical model of the helical ventricular myocardial band described by Torrent-Guasp.
Keywords: Heart;Diffusion magnetic resonance imaging;Diffusion tractography;Helical heart;Myocardial ventricular band.
|
|
|
|
Alberto Hidalgo, Ferran Poveda, Enric Marti, Debora Gil, Albert Andaluz, Francesc Carreras, et al. (2012). "Evidence of continuous helical structure of the cardiac ventricular anatomy assessed by diffusion tensor imaging magnetic resonance multiresolution tractography " . European Radiology, 3(1), 361–362.
Abstract: Deep understanding of myocardial structure linking morphology and func- tion of the heart would unravel crucial knowledge for medical and surgical clinical procedures and studies. Diffusion tensor MRI provides a discrete measurement of the 3D arrangement of myocardial fibres by the observation of local anisotropic
diffusion of water molecules in biological tissues. In this work, we present a multi- scale visualisation technique based on DT-MRI streamlining capable of uncovering additional properties of the architectural organisation of the heart. Methods and Materials: We selected the John Hopkins University (JHU) Canine Heart Dataset, where the long axis cardiac plane is aligned with the scanner’s Z- axis. Their equipment included a 4-element passed array coil emitting a 1.5 T. For DTI acquisition, a 3D-FSE sequence is apply. We used 200 seeds for full-scale tractography, while we applied a MIP mapping technique for simplified tractographic reconstruction. In this case, we reduced each DTI 3D volume dimensions by order- two magnitude before streamlining.
Our simplified tractographic reconstruction method keeps the main geometric features of fibres, allowing for an easier identification of their global morphological disposition, including the ventricular basal ring. Moreover, we noticed a clearly visible helical disposition of the myocardial fibres, in line with the helical myocardial band ventricular structure described by Torrent-Guasp. Finally, our simplified visualisation with single tracts identifies the main segments of the helical ventricular architecture.
DT-MRI makes possible the identification of a continuous helical architecture of the myocardial fibres, which validates Torrent-Guasp’s helical myocardial band ventricular anatomical model.
|
|
