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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
openurl 
  Title Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models Type (up) Journal Article
  Year 2013 Publication British Journal of Pharmacology Abbreviated Journal BJP  
  Volume 169 Issue 6 Pages 1189-202  
  Keywords  
  Abstract Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.  
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  Notes IAM; 600.044; 605.203 Approved no  
  Call Number IAM @ iam @ RGG2013b Serial 2195  
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Author Debora Gil; David Roche; Agnes Borras; Jesus Giraldo edit  doi
openurl 
  Title Terminating Evolutionary Algorithms at their Steady State Type (up) Journal Article
  Year 2015 Publication Computational Optimization and Applications Abbreviated Journal COA  
  Volume 61 Issue 2 Pages 489-515  
  Keywords Evolutionary algorithms; Termination condition; Steady state; Differential evolution  
  Abstract Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications.  
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  Publisher Springer US Place of Publication Editor  
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  Series Volume Series Issue Edition  
  ISSN 0926-6003 ISBN Medium  
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  Notes IAM; 600.044; 605.203; 600.060; 600.075 Approved no  
  Call Number Admin @ si @ GRB2015 Serial 2560  
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Author Jorge Bernal; F. Javier Sanchez; Gloria Fernandez-Esparrach; Debora Gil; Cristina Rodriguez de Miguel; Fernando Vilariño edit   pdf
doi  openurl
  Title WM-DOVA Maps for Accurate Polyp Highlighting in Colonoscopy: Validation vs. Saliency Maps from Physicians Type (up) Journal Article
  Year 2015 Publication Computerized Medical Imaging and Graphics Abbreviated Journal CMIG  
  Volume 43 Issue Pages 99-111  
  Keywords Polyp localization; Energy Maps; Colonoscopy; Saliency; Valley detection  
  Abstract We introduce in this paper a novel polyp localization method for colonoscopy videos. Our method is based on a model of appearance for polyps which defines polyp boundaries in terms of valley information. We propose the integration of valley information in a robust way fostering complete, concave and continuous boundaries typically associated to polyps. This integration is done by using a window of radial sectors which accumulate valley information to create WMDOVA1 energy maps related with the likelihood of polyp presence. We perform a double validation of our maps, which include the introduction of two new databases, including the first, up to our knowledge, fully annotated database with clinical metadata associated. First we assess that the highest value corresponds with the location of the polyp in the image. Second, we show that WM-DOVA energy maps can be comparable with saliency maps obtained from physicians' fixations obtained via an eye-tracker. Finally, we prove that our method outperforms state-of-the-art computational saliency results. Our method shows good performance, particularly for small polyps which are reported to be the main sources of polyp miss-rate, which indicates the potential applicability of our method in clinical practice.  
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  ISSN 0895-6111 ISBN Medium  
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  Notes MV; IAM; 600.047; 600.060; 600.075 Approved no  
  Call Number Admin @ si @ BSF2015 Serial 2609  
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Author Carles Sanchez; Jorge Bernal; F. Javier Sanchez; Antoni Rosell; Marta Diez-Ferrer; Debora Gil edit  doi
openurl 
  Title Towards On-line Quantification of Tracheal Stenosis from Videobronchoscopy Type (up) Journal Article
  Year 2015 Publication International Journal of Computer Assisted Radiology and Surgery Abbreviated Journal IJCAR  
  Volume 10 Issue 6 Pages 935-945  
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  Notes IAM; MV; 600.075 Approved no  
  Call Number Admin @ si @ SBS2015a Serial 2611  
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Author Debora Gil; Sergio Vera; Agnes Borras; Albert Andaluz; Miguel Angel Gonzalez Ballester edit   pdf
doi  openurl
  Title Anatomical Medial Surfaces with Efficient Resolution of Branches Singularities Type (up) Journal Article
  Year 2017 Publication Medical Image Analysis Abbreviated Journal MIA  
  Volume 35 Issue Pages 390-402  
  Keywords Medial Representations; Shape Recognition; Medial Branching Stability ; Singular Points  
  Abstract Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a con dent application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an ecient GPU-CPU implementation using standard image processing tools. We show the method computational eciency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies.  
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  Publisher Elsevier B.V. Place of Publication Editor  
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  Notes IAM; 600.060; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ GVB2017 Serial 2775  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso edit  url
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type (up) Journal Article
  Year 2017 Publication Journal of Thoracic Oncology Abbreviated Journal JTO  
  Volume 12 Issue 1S Pages S596-S597  
  Keywords Thorax CT; diagnosis; Peripheral Pulmonary Nodule  
  Abstract A main weakness of virtual bronchoscopic navigation (VBN) is unsuccessful segmentation of distal branches approaching peripheral pulmonary nodules (PPN). CT scan acquisition protocol is pivotal for segmentation covering the utmost periphery. We hypothesize that application of continuous positive airway pressure (CPAP) during CT acquisition could improve visualization and segmentation of peripheral bronchi. The purpose of the present pilot study is to compare quality of segmentations under 4 CT acquisition modes: inspiration (INSP), expiration (EXP) and both with CPAP (INSP-CPAP and EXP-CPAP).  
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  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ DGC2017a Serial 2883  
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Author H.Martin Kjer; Jens Fagertuna; Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester; Rasmus R. Paulsena edit   pdf
url  openurl
  Title Free-form image registration of human cochlear uCT data using skeleton similarity as anatomical prior Type (up) Journal Article
  Year 2016 Publication Patter Recognition Letters Abbreviated Journal PRL  
  Volume 76 Issue 1 Pages 76-82  
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  Notes IAM; 600.060 Approved no  
  Call Number Admin @ si @ MFV2017b Serial 2941  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Noelia Cubero de Frutos; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell edit  doi
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type (up) Journal Article
  Year 2017 Publication European Respiratory Journal Abbreviated Journal ERJ  
  Volume 48 Issue 60 Pages PA776  
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  Notes IAM; 600.096; 600.075; 600.145 Approved no  
  Call Number Admin @ si @ DGC2017b Serial 2944  
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Author Debora Gil; Rosa Maria Ortiz; Carles Sanchez; Antoni Rosell edit  doi
openurl 
  Title Objective endoscopic measurements of central airway stenosis. A pilot study Type (up) Journal Article
  Year 2018 Publication Respiration Abbreviated Journal RES  
  Volume 95 Issue Pages 63–69  
  Keywords Bronchoscopy; Tracheal stenosis; Airway stenosis; Computer-assisted analysis  
  Abstract Endoscopic estimation of the degree of stenosis in central airway obstruction is subjective and highly variable. Objective: To determine the benefits of using SENSA (System for Endoscopic Stenosis Assessment), an image-based computational software, for obtaining objective stenosis index (SI) measurements among a group of expert bronchoscopists and general pulmonologists. Methods: A total of 7 expert bronchoscopists and 7 general pulmonologists were enrolled to validate SENSA usage. The SI obtained by the physicians and by SENSA were compared with a reference SI to set their precision in SI computation. We used SENSA to efficiently obtain this reference SI in 11 selected cases of benign stenosis. A Web platform with three user-friendly microtasks was designed to gather the data. The users had to visually estimate the SI from videos with and without contours of the normal and the obstructed area provided by SENSA. The users were able to modify the SENSA contours to define the reference SI using morphometric bronchoscopy. Results: Visual SI estimation accuracy was associated with neither bronchoscopic experience (p = 0.71) nor the contours of the normal and the obstructed area provided by the system (p = 0.13). The precision of the SI by SENSA was 97.7% (95% CI: 92.4-103.7), which is significantly better than the precision of the SI by visual estimation (p < 0.001), with an improvement by at least 15%. Conclusion: SENSA provides objective SI measurements with a precision of up to 99.5%, which can be calculated from any bronchoscope using an affordable scalable interface. Providing normal and obstructed contours on bronchoscopic videos does not improve physicians' visual estimation of the SI.  
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  Notes IAM; 600.075; 600.096; 600.145 Approved no  
  Call Number Admin @ si @ GOS2018 Serial 3043  
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Author Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Cubero Noelia; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell edit  url
openurl 
  Title Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation Type (up) Journal Article
  Year 2016 Publication Chest Journal Abbreviated Journal CHEST  
  Volume 150 Issue 4 Pages 1003A  
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  Notes IAM; 600.096; 600.075 Approved no  
  Call Number Admin @ si @ DGC2016 Serial 3099  
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