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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
openurl 
  Title Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models Type Journal Article
  Year 2013 Publication British Journal of Pharmacology Abbreviated Journal BJP  
  Volume 169 Issue 6 Pages 1189-202  
  Keywords  
  Abstract Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM; 600.044; 605.203 Approved no  
  Call Number IAM @ iam @ RGG2013b Serial 2195  
Permanent link to this record
 

 
Author Joan M. Nuñez; Debora Gil; Fernando Vilariño edit  doi
openurl 
  Title Finger joint characterization from X-ray images for rheymatoid arthritis assessment Type Conference Article
  Year 2013 Publication 6th International Conference on Biomedical Electronics and Devices Abbreviated Journal  
  Volume Issue Pages 288-292  
  Keywords Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde  
  Abstract In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection.  
  Address Barcelona; February 2013  
  Corporate Author Thesis  
  Publisher SciTePress Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area 800 Expedition Conference BIODEVICES  
  Notes IAM;MV; 600.057; 600.054 Approved no  
  Call Number IAM @ iam @ NGV2013 Serial 2196  
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Author David Roche; Debora Gil; Jesus Giraldo edit  doi
isbn  openurl
  Title Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? Type Book Chapter
  Year 2014 Publication G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology Abbreviated Journal  
  Volume 796 Issue 3 Pages 159-181  
  Keywords β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model  
  Abstract Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists.  
  Address  
  Corporate Author Thesis  
  Publisher Springer Netherlands Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0065-2598 ISBN 978-94-007-7422-3 Medium  
  Area Expedition Conference  
  Notes IAM; 600.075 Approved no  
  Call Number IAM @ iam @ RGG2014 Serial 2197  
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Author Patricia Marquez; Debora Gil; Aura Hernandez-Sabate; Daniel Kondermann edit   pdf
url  doi
isbn  openurl
  Title When Is A Confidence Measure Good Enough? Type Conference Article
  Year 2013 Publication 9th International Conference on Computer Vision Systems Abbreviated Journal  
  Volume 7963 Issue Pages 344-353  
  Keywords Optical flow, confidence measure, performance evaluation  
  Abstract Confidence estimation has recently become a hot topic in image processing and computer vision.Yet, several definitions exist of the term “confidence” which are sometimes used interchangeably. This is a position paper, in which we aim to give an overview on existing definitions,
thereby clarifying the meaning of the used terms to facilitate further research in this field. Based on these clarifications, we develop a theory to compare confidence measures with respect to their quality.
 
  Address St Petersburg; Russia; July 2013  
  Corporate Author Thesis  
  Publisher Springer Link Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title LNCS  
  Series Volume Series Issue Edition  
  ISSN 0302-9743 ISBN 978-3-642-39401-0 Medium  
  Area Expedition Conference ICVS  
  Notes IAM;ADAS; 600.044; 600.057; 600.060; 601.145 Approved no  
  Call Number IAM @ iam @ MGH2013a Serial 2218  
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Author Francesco Brughi edit  openurl
  Title Artistic Heritage Motive Retrieval: an Explorative Study Type Report
  Year 2013 Publication CVC Technical Report Abbreviated Journal  
  Volume 176 Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis Master's thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number Admin @ si @ Bru2013 Serial 2410  
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Author Ferran Poveda edit  openurl
  Title Computer Graphics and Vision Techniques for the Study of the Muscular Fiber Architecture of the Myocardium Type Book Whole
  Year 2013 Publication PhD Thesis, Universitat Autonoma de Barcelona-CVC Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address  
  Corporate Author Thesis Ph.D. thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes IAM Approved no  
  Call Number Admin @ si @ Pov2013 Serial 2417  
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Author Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate edit   pdf
openurl 
  Title Local Analysis of Confidence Measures for Optical Flow Quality Evaluation Type Conference Article
  Year 2014 Publication 9th International Conference on Computer Vision Theory and Applications Abbreviated Journal  
  Volume 3 Issue Pages 450-457  
  Keywords Optical Flow; Confidence Measure; Performance Evaluation.  
  Abstract Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance.
 
  Address Lisboa; January 2014  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference VISAPP  
  Notes IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 Approved no  
  Call Number Admin @ si @ MGM2014 Serial 2432  
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Author Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester edit   pdf
doi  openurl
  Title Anatomical parameterization for volumetric meshing of the liver Type Conference Article
  Year 2014 Publication SPIE – Medical Imaging Abbreviated Journal  
  Volume 9036 Issue Pages  
  Keywords Coordinate System; Anatomy Modeling; Parameterization  
  Abstract A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference.
 
  Address Amsterdam; September 2014  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference SPIE-MI  
  Notes IAM; 600.075 Approved no  
  Call Number Admin @ si @ VGG2014 Serial 2456  
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Author Enric Marti; Antoni Gurgui; Debora Gil; Aura Hernandez-Sabate; Jaume Rocarias; Ferran Poveda edit   pdf
openurl 
  Title ABP on line: Seguimiento, estregas y evaluación en aprendizaje basado en proyectos Type Miscellaneous
  Year 2014 Publication 8th International Congress on University Teaching and Innovation Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address Tarragona; juliol 2014  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CIDUI  
  Notes IAM; ADAS; 600.076; 600.063; 600.075 Approved no  
  Call Number Admin @ si @ MGG2014 Serial 2457  
Permanent link to this record
 

 
Author Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; Jaume Rocarias; Debora Gil edit   pdf
openurl 
  Title Evaluación automática de prácticas en Moodle para el aprendizaje autónomo en Ingenierías Type Miscellaneous
  Year 2014 Publication 8th International Congress on University Teaching and Innovation Abbreviated Journal  
  Volume Issue Pages  
  Keywords  
  Abstract  
  Address Tarragona; juliol 2014  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor (up) Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference CIDUI  
  Notes IAM; 600.075;DAG Approved no  
  Call Number Admin @ si @ SRM2014 Serial 2458  
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