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Antoni Rosell; Sonia Baeza; S. Garcia-Reina; JL. Mate; Ignasi Guasch; I. Nogueira; I. Garcia-Olive; Guillermo Torres; Carles Sanchez; Debora Gil |
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Radiomics to increase the effectiveness of lung cancer screening programs. Radiolung preliminary results. |
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2022 |
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European Respiratory Journal |
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ERJ |
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60 |
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66 |
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IAM |
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Admin @ si @ RBG2022c |
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3835 |
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Author |
Ferran Poveda; Enric Marti; Debora Gil; Francesc Carreras; Manel Ballester |
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Title |
Helical Structure of Ventricular Anatomy by Diffusion Tensor Cardiac MR Tractography |
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Journal Article |
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2012 |
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Journal of American College of Cardiology |
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JACC |
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5 |
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7 |
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754-755 |
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It is widely accepted that myocardial fiber architecture plays a critical role in myocardial contractility and relaxation (1). However, there is a lack of consensus about the distribution of the myocardial fibers and their spatial arrangement in the left and right ventricles. An understanding of the cardiac architecture should benefit the ventricular functional assessment, left ventricular reconstructive surgery planning, or resynchronization therapy in heart failure. Researchers have proposed several conceptual models to describe the architecture of the heart, ranging from gross dissection to histological presentation. The cardiac mesh model (2) proposes that the myocytes are arranged longitudinally and radially change their angulation along the myocardial depth. By contrast, the helical ventricular myocardial model states that the ventricular myocardium is a continuous anatomical helical layout of myocardial fibers (1 |
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1936-878X |
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IAM @ iam @ PMG2012 |
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1985 |
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David Roche; Debora Gil; Jesus Giraldo |
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Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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2013 |
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Drug Discovery Today |
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DDT |
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18 |
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7-8 |
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365-371 |
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The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
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2190 |
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Debora Gil; Petia Radeva |
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Title |
Curvature based Distance Maps |
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Report |
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2003 |
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CVC Technical Report |
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70 |
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Computer Vision Center |
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IAM;MILAB |
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IAM @ iam @ GIR2003a |
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1534 |
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Debora Gil; Jaume Garcia; Aura Hernandez-Sabate; Enric Marti |
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Manifold parametrization of the left ventricle for a statistical modelling of its complete anatomy |
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2010 |
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8th Medical Imaging |
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7623 |
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762304 |
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304 |
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Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature. |
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SPIE |
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IAM |
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IAM @ iam @ GGH2010a |
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1522 |
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Author |
Jaume Garcia |
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Title |
Generalized Active Shape Models Applied to Cardiac Function Analysis |
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Report |
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2004 |
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CVC Technical Report |
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78 |
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Cardiac Analysis; Deformable Models; Active Contour Models; Active Shape Models; Tagged MRI; HARP; Contrast Echocardiography. |
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Medical imaging is very useful in the assessment and treatment of many diseases. To deal with the great amount of data provided by imaging scanners and extract quantitative information that physicians can interpret, many analysis algorithms have been developed. Any process of analysis always consists of a first step of segmenting some particular structure. In medical imaging, structures are not always well defined and suffer from noise artifacts thus, ordinary segmentation methods are not well suited. The ones that seem to give better results are those based on deformable models. Nevertheless, despite their capability of mixing image features together with smoothness constraints that may compensate for image irregularities, these are naturally local methods, i. e., each node of the active contour evolve taking into account information about its neighbors and some other weak constraints about flexibility and smoothness, but not about the global shape that they should find. Due to the fact that structures to be segmented are the same for all cases but with some inter and intra-patient variation, the incorporation of a priori knowledge about shape in the segmentation method will provide robustness to it. Active Shape Models is an algorithm based on the creation of a shape model called Point Distribution Model. It performs a segmentation using only shapes similar than those previously learned from a training set that capture most of the variation presented by the structure. This algorithm works by updating shape nodes along a normal segment which often can be too restrictive. For this reason we propose a generalization of this algorithm that we call Generalized Active Shape Models and fully integrates the a priori knowledge given by the Point Distribution Model with deformable models or any other appropriate segmentation method. Two different applications to cardiac imaging of this generalized method are developed and promising results are shown. |
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CVC (UAB) |
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Master's thesis |
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IAM; |
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IAM @ iam @ Gar2004 |
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1513 |
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Maurizio Mencuccini; Jordi Martinez-Vilalta; Josep Piñol; Lasse Loepfe; Mireia Burnat ; Xavier Alvarez; Juan Camacho; Debora Gil |
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Title |
A quantitative and statistically robust method for the determination of xylem conduit spatial distribution |
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Journal Article |
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2010 |
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American Journal of Botany |
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AJB |
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97 |
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8 |
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1247-1259 |
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Geyer; hydraulic conductivity; point pattern analysis; Ripley; Spatstat; vessel clusters; xylem anatomy; xylem network |
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Premise of the study: Because of their limited length, xylem conduits need to connect to each other to maintain water transport from roots to leaves. Conduit spatial distribution in a cross section plays an important role in aiding this connectivity. While indices of conduit spatial distribution already exist, they are not well defined statistically. * Methods: We used point pattern analysis to derive new spatial indices. One hundred and five cross-sectional images from different species were transformed into binary images. The resulting point patterns, based on the locations of the conduit centers-of-area, were analyzed to determine whether they departed from randomness. Conduit distribution was then modeled using a spatially explicit stochastic model. * Key results: The presence of conduit randomness, uniformity, or aggregation depended on the spatial scale of the analysis. The large majority of the images showed patterns significantly different from randomness at least at one spatial scale. A strong phylogenetic signal was detected in the spatial variables. * Conclusions: Conduit spatial arrangement has been largely conserved during evolution, especially at small spatial scales. Species in which conduits were aggregated in clusters had a lower conduit density compared to those with uniform distribution. Statistically sound spatial indices must be employed as an aid in the characterization of distributional patterns across species and in models of xylem water transport. Point pattern analysis is a very useful tool in identifying spatial patterns. |
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IAM; |
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IAM @ iam @ MMG2010 |
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1623 |
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Oriol Pujol; Debora Gil; Petia Radeva |
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Title |
Fundamentals of Stop and Go active models |
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2005 |
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Image and Vision Computing |
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23 |
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8 |
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681-691 |
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Deformable models; Geodesic snakes; Region-based segmentation |
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An efficient snake formulation should conform to the idea of picking the smoothest curve among all the shapes approximating an object of interest. In current geodesic snakes, the regularizing curvature also affects the convergence stage, hindering the latter at concave regions. In the present work, we make use of characteristic functions to define a novel geodesic formulation that decouples regularity and convergence. This term decoupling endows the snake with higher adaptability to non-convex shapes. Convergence is ensured by splitting the definition of the external force into an attractive vector field and a repulsive one. In our paper, we propose to use likelihood maps as approximation of characteristic functions of object appearance. The better efficiency and accuracy of our decoupled scheme are illustrated in the particular case of feature space-based segmentation. |
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Butterworth-Heinemann |
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Newton, MA, USA |
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0262-8856 |
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IAM;MILAB;HuPBA |
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IAM @ iam @ PGR2005 |
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1629 |
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Author |
Petia Radeva; Amir Amini; Jintao Huang; Enric Marti |
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Title |
Deformable B-Solids: application for localization and tracking of MRI-SPAMM data |
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Report |
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1996 |
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CVC Technical Report |
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8 |
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To date, MRI-SPAMM data from different image slices have been analyzed independently. In this paper, we propose an approach for 3D tag localization and tracking of SPAMM data by a novel deformable B-solid. The solid is defined in terms of a 3D tensor product B-spline. The isoparametric curves of the B-spline solid have special importance. These are termed implicit snakes as they deform under image forces from tag lines in different image slices. The localization and tracking of tag lines is performed under constraints of continuity and smoothness of the B-solid. The framework unifies the problems of localization, and displacement fitting and interpolation into the same procedure utilizing B-spline bases for interpolation. To track motion from boundaries and restrict image forces to the myocardium, a volumetric model is employed as a pair of coupled endocardial and epicardial B-spline surfaces. To recover deformations in the LV an energy-minimization problem is posed where both tag and ... |
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CVC (UAB) |
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MILAB;IAM |
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IAM @ iam @ RHM1996 |
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1631 |
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Aura Hernandez-Sabate; Lluis Albarracin; F. Javier Sanchez |
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Title |
Graph-Based Problem Explorer: A Software Tool to Support Algorithm Design Learning While Solving the Salesperson Problem |
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2020 |
Publication |
Mathematics |
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MATH |
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20 |
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8(9) |
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1595 |
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STEM education; Project-based learning; Coding; software tool |
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In this article, we present a sequence of activities in the form of a project in order to promote
learning on design and analysis of algorithms. The project is based on the resolution of a real problem, the salesperson problem, and it is theoretically grounded on the fundamentals of mathematical modelling. In order to support the students’ work, a multimedia tool, called Graph-based Problem Explorer (GbPExplorer), has been designed and refined to promote the development of computer literacy in engineering and science university students. This tool incorporates several modules to allow coding different algorithmic techniques solving the salesman problem. Based on an educational design research along five years, we observe that working with GbPExplorer during the project provides students with the possibility of representing the situation to be studied in the form of graphs and analyze them from a computational point of view. |
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September 2020 |
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IAM; ISE |
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Admin @ si @ |
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3722 |
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