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Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; Alvaro Pascual; B. Cardenas; G. Fonseka; E. Anton; Richard Frodsham; Francesca Vidal; Zaida Sarrate |
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Chromosomal positioning in spermatogenic cells is influenced by chromosomal factors associated with gene activity, bouquet formation, and meiotic sex-chromosome inactivation |
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Year |
2021 |
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Chromosoma |
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130 |
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163-175 |
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Chromosome territoriality is not random along the cell cycle and it is mainly governed by intrinsic chromosome factors and gene expression patterns. Conversely, very few studies have explored the factors that determine chromosome territoriality and its influencing factors during meiosis. In this study, we analysed chromosome positioning in murine spermatogenic cells using three-dimensionally fluorescence in situ hybridization-based methodology, which allows the analysis of the entire karyotype. The main objective of the study was to decipher chromosome positioning in a radial axis (all analysed germ-cell nuclei) and longitudinal axis (only spermatozoa) and to identify the chromosomal factors that regulate such an arrangement. Results demonstrated that the radial positioning of chromosomes during spermatogenesis was cell-type specific and influenced by chromosomal factors associated to gene activity. Chromosomes with specific features that enhance transcription (high GC content, high gene density and high numbers of predicted expressed genes) were preferentially observed in the inner part of the nucleus in virtually all cell types. Moreover, the position of the sex chromosomes was influenced by their transcriptional status, from the periphery of the nucleus when its activity was repressed (pachytene) to a more internal position when it is partially activated (spermatid). At pachytene, chromosome positioning was also influenced by chromosome size due to the bouquet formation. Longitudinal chromosome positioning in the sperm nucleus was not random either, suggesting the importance of ordered longitudinal positioning for the release and activation of the paternal genome after fertilisation. |
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IAM; 600.145 |
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Admin @ si @ SBG2021 |
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3592 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
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2014 |
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G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
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796 |
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3 |
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159-181 |
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β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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0065-2598 |
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978-94-007-7422-3 |
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IAM; 600.075 |
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IAM @ iam @ RGG2014 |
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2197 |
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Enric Marti; Jordi Regincos; Juan Jose Villanueva; Jaime Lopez-Krahe |
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Line drawing interpretation as polyhedral objects to man-machine interaction in CAD systems |
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1994 |
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Advances in Pattern Recognition and Image Analysis, |
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158-169 |
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World Scientific Pub. |
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981-02-1872-9 |
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IAM;ISE |
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IAM @ iam @ MRL1994 |
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1609 |
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Author |
Debora Gil; Antonio Esteban Lansaque; Sebastian Stefaniga; Mihail Gaianu; Carles Sanchez |
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Title |
Data Augmentation from Sketch |
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Conference Article |
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2019 |
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International Workshop on Uncertainty for Safe Utilization of Machine Learning in Medical Imaging |
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11840 |
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155-162 |
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Data augmentation; cycleGANs; Multi-objective optimization |
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State of the art machine learning methods need huge amounts of data with unambiguous annotations for their training. In the context of medical imaging this is, in general, a very difficult task due to limited access to clinical data, the time required for manual annotations and variability across experts. Simulated data could serve for data augmentation provided that its appearance was comparable to the actual appearance of intra-operative acquisitions. Generative Adversarial Networks (GANs) are a powerful tool for artistic style transfer, but lack a criteria for selecting epochs ensuring also preservation of intra-operative content.
We propose a multi-objective optimization strategy for a selection of cycleGAN epochs ensuring a mapping between virtual images and the intra-operative domain preserving anatomical content. Our approach has been applied to simulate intra-operative bronchoscopic videos and chest CT scans from virtual sketches generated using simple graphical primitives. |
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Shenzhen; China; October 2019 |
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IAM; 600.145; 601.337; 600.139; 600.145 |
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Admin @ si @ GES2019 |
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3359 |
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Author |
Guillermo Torres; Debora Gil |
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A multi-shape loss function with adaptive class balancing for the segmentation of lung structures |
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Journal Article |
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2020 |
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International Journal of Computer Assisted Radiology and Surgery |
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IJCAR |
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15 |
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1 |
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S154-55 |
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Admin @ si @ ToG2020 |
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3590 |
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Author |
Carles Sanchez; Debora Gil; Antoni Rosell; Albert Andaluz; F. Javier Sanchez |
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Title |
Segmentation of Tracheal Rings in Videobronchoscopy combining Geometry and Appearance |
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Conference Article |
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2013 |
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Proceedings of the International Conference on Computer Vision Theory and Applications |
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1 |
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153--161 |
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Video-bronchoscopy, tracheal ring segmentation, trachea geometric and appearance model |
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Videobronchoscopy is a medical imaging technique that allows interactive navigation inside the respiratory pathways and minimal invasive interventions. Tracheal procedures are ordinary interventions that require measurement of the percentage of obstructed pathway for injury (stenosis) assessment. Visual assessment of stenosis in videobronchoscopic sequences requires high expertise of trachea anatomy and is prone to human error. Accurate detection of tracheal rings is the basis for automated estimation of the size of stenosed trachea. Processing of videobronchoscopic images acquired at the operating room is a challenging task due to the wide range of artifacts and acquisition conditions. We present a model of the geometric-appearance of tracheal rings for its detection in videobronchoscopic videos. Experiments on sequences acquired at the operating room, show a performance close to inter-observer variability |
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Barcelona; February 2013 |
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SciTePress |
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Portugal |
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Sebastiano Battiato and José Braz |
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978-989-8565-47-1 |
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800 |
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VISAPP |
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IAM;MV; 600.044; 600.047; 600.060; 605.203 |
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IAM @ iam @ SGR2013 |
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2123 |
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Author |
Josep Llados; Ernest Valveny; Enric Marti |
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Title |
Symbol Recognition in Document Image Analysis: Methods and Challenges |
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Journal Article |
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2000 |
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Recent Research Developments in Pattern Recognition, Transworld Research Network, |
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1 |
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151–178. |
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81-86846-61-1 |
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DAG;IAM |
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IAM @ iam @ LVM2000 |
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1575 |
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Author |
Debora Gil; Oriol Ramos Terrades; Elisa Minchole; Carles Sanchez; Noelia Cubero de Frutos; Marta Diez-Ferrer; Rosa Maria Ortiz; Antoni Rosell |
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Title |
Classification of Confocal Endomicroscopy Patterns for Diagnosis of Lung Cancer |
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Conference Article |
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2017 |
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6th Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging |
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10550 |
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151-159 |
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Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.
The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.
We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results. |
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Quebec; Canada; September 2017 |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ GRM2017 |
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2957 |
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Author |
Josep Llados; Jaime Lopez-Krahe; Enric Marti |
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Title |
A system to understand hand-drawn floor plans using subgraph isomorphism and Hough transform |
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Book Chapter |
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Year |
1997 |
Publication |
Machine Vision and Applications |
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10 |
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3 |
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150-158 |
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Line drawings – Hough transform – Graph matching – CAD systems – Graphics recognition |
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Presently, man-machine interface development is a widespread research activity. A system to understand hand drawn architectural drawings in a CAD environment is presented in this paper. To understand a document, we have to identify its building elements and their structural properties. An attributed graph structure is chosen as a symbolic representation of the input document and the patterns to recognize in it. An inexact subgraph isomorphism procedure using relaxation labeling techniques is performed. In this paper we focus on how to speed up the matching. There is a building element, the walls, characterized by a hatching pattern. Using a straight line Hough transform (SLHT)-based method, we recognize this pattern, characterized by parallel straight lines, and remove from the input graph the edges belonging to this pattern. The isomorphism is then applied to the remainder of the input graph. When all the building elements have been recognized, the document is redrawn, correcting the inaccurate strokes obtained from a hand-drawn input. |
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DAG;IAM |
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IAM @ iam @ LLM1997a |
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1566 |
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Author |
Debora Gil; F. Javier Sanchez; Gloria Fernandez Esparrach; Jorge Bernal |
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Title |
3D Stable Spatio-temporal Polyp Localization in Colonoscopy Videos |
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Book Chapter |
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2015 |
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Computer-Assisted and Robotic Endoscopy. Revised selected papers of Second International Workshop, CARE 2015, Held in Conjunction with MICCAI 2015 |
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9515 |
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140-152 |
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Colonoscopy, Polyp Detection, Polyp Localization, Region Extraction, Watersheds |
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Computational intelligent systems could reduce polyp miss rate in colonoscopy for colon cancer diagnosis and, thus, increase the efficiency of the procedure. One of the main problems of existing polyp localization methods is a lack of spatio-temporal stability in their response. We propose to explore the response of a given polyp localization across temporal windows in order to select
those image regions presenting the highest stable spatio-temporal response.
Spatio-temporal stability is achieved by extracting 3D watershed regions on the
temporal window. Stability in localization response is statistically determined by analysis of the variance of the output of the localization method inside each 3D region. We have explored the benefits of considering spatio-temporal stability in two different tasks: polyp localization and polyp detection. Experimental results indicate an average improvement of 21:5% in polyp localization and 43:78% in polyp detection. |
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CARE |
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IAM; MV; 600.075 |
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Admin @ si @ GSF2015 |
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2733 |
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