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Katerine Diaz; Jesus Martinez del Rincon; Aura Hernandez-Sabate; Marçal Rusiñol; Francesc J. Ferri |
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Fast Kernel Generalized Discriminative Common Vectors for Feature Extraction |
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2018 |
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Journal of Mathematical Imaging and Vision |
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JMIV |
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60 |
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4 |
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512-524 |
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This paper presents a supervised subspace learning method called Kernel Generalized Discriminative Common Vectors (KGDCV), as a novel extension of the known Discriminative Common Vectors method with Kernels. Our method combines the advantages of kernel methods to model complex data and solve nonlinear
problems with moderate computational complexity, with the better generalization properties of generalized approaches for large dimensional data. These attractive combination makes KGDCV specially suited for feature extraction and classification in computer vision, image processing and pattern recognition applications. Two different approaches to this generalization are proposed, a first one based on the kernel trick (KT) and a second one based on the nonlinear projection trick (NPT) for even higher efficiency. Both methodologies
have been validated on four different image datasets containing faces, objects and handwritten digits, and compared against well known non-linear state-of-art methods. Results show better discriminant properties than other generalized approaches both linear or kernel. In addition, the KGDCV-NPT approach presents a considerable computational gain, without compromising the accuracy of the model. |
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DAG; ADAS; 600.086; 600.130; 600.121; 600.118; 600.129;IAM |
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Admin @ si @ DMH2018a |
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3062 |
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Katerine Diaz; Jesus Martinez del Rincon; Marçal Rusiñol; Aura Hernandez-Sabate |
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Title |
Feature Extraction by Using Dual-Generalized Discriminative Common Vectors |
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2019 |
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Journal of Mathematical Imaging and Vision |
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JMIV |
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61 |
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3 |
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331-351 |
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Online feature extraction; Generalized discriminative common vectors; Dual learning; Incremental learning; Decremental learning |
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In this paper, a dual online subspace-based learning method called dual-generalized discriminative common vectors (Dual-GDCV) is presented. The method extends incremental GDCV by exploiting simultaneously both the concepts of incremental and decremental learning for supervised feature extraction and classification. Our methodology is able to update the feature representation space without recalculating the full projection or accessing the previously processed training data. It allows both adding information and removing unnecessary data from a knowledge base in an efficient way, while retaining the previously acquired knowledge. The proposed method has been theoretically proved and empirically validated in six standard face recognition and classification datasets, under two scenarios: (1) removing and adding samples of existent classes, and (2) removing and adding new classes to a classification problem. Results show a considerable computational gain without compromising the accuracy of the model in comparison with both batch methodologies and other state-of-art adaptive methods. |
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DAG; ADAS; 600.084; 600.118; 600.121; 600.129;IAM |
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Admin @ si @ DRR2019 |
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3172 |
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M. Gomez; J. Mauri; Eduard Fernandez-Nofrerias; Oriol Rodriguez-Leor; Carme Julia; Debora Gil; Petia Radeva |
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Reconstrucción de un modelo espacio-temporal de la luz del vaso a partir de secuencias de ecografía intracoronaria |
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2002 |
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XXXVIII Congreso Nacional de la Sociedad Española de Cardiología. |
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IAM;ADAS;MILAB |
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IAM @ iam @ GMF2002d |
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1516 |
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Mariano Vazquez; Ruth Aris; Guillaume Hozeaux; R.Aubry; P.Villar;Jaume Garcia ; Debora Gil; Francesc Carreras |
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A massively parallel computational electrophysiology model of the heart |
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2011 |
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International Journal for Numerical Methods in Biomedical Engineering |
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IJNMBE |
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27 |
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1911-1929 |
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computational electrophysiology; parallelization; finite element methods |
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This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale. |
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Swansea (UK) |
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John Wiley & Sons, Ltd. |
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John Wiley & Sons, Ltd. |
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IAM |
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IAM @ iam @ VAH2011 |
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1198 |
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Marta Diez-Ferrer; Arturo Morales; Rosa Lopez Lisbona; Noelia Cubero; Cristian Tebe; Susana Padrones; Samantha Aso; Jordi Dorca; Debora Gil; Antoni Rosell |
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Ultrathin Bronchoscopy with and without Virtual Bronchoscopic Navigation: Influence of Segmentation on Diagnostic Yield |
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2019 |
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Respiration |
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RES |
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97 |
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3 |
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252-258 |
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Lung cancer; Peripheral lung lesion; Diagnosis; Bronchoscopy; Ultrathin bronchoscopy; Virtual bronchoscopic navigation |
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Background: Bronchoscopy is a safe technique for diagnosing peripheral pulmonary lesions (PPLs), and virtual bronchoscopic navigation (VBN) helps guide the bronchoscope to PPLs. Objectives: We aimed to compare the diagnostic yield of VBN-guided and unguided ultrathin bronchoscopy (UTB) and explore clinical and technical factors associated with better results. We developed a diagnostic algorithm for deciding whether to use VBN to reach PPLs or choose an alternative diagnostic approach. Methods: We compared diagnostic yield between VBN-UTB (prospective cases) and unguided UTB (historical controls) and analyzed the VBN-UTB subgroup to identify clinical and technical variables that could predict the success of VBN-UTB. Results: Fifty-five cases and 110 controls were included. The overall diagnostic yield did not differ between the VBN-guided and unguided arms (47 and 40%, respectively; p = 0.354). Although the yield was slightly higher for PPLs ≤20 mm in the VBN-UTB arm, the difference was not significant (p = 0.069). No other clinical characteristics were associated with a higher yield in a subgroup analysis, but an 85% diagnostic yield was observed when segmentation was optimal and the PPL was endobronchial (vs. 30% when segmentation was suboptimal and 20% when segmentation was optimal but the PPL was extrabronchial). Conclusions: VBN-guided UTB is not superior to unguided UTB. A greater impact of VBN-guided over unguided UTB is highly dependent on both segmentation quality and an endobronchial location of the PPL. Segmentation quality should be considered before starting a procedure, when an alternative technique that may improve yield can be chosen, saving time and resources. |
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IAM; 600.145; 600.139 |
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Admin @ si @ DML2019 |
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3134 |
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Marta Diez-Ferrer; Debora Gil; Cristian Tebe; Carles Sanchez |
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Positive Airway Pressure to Enhance Computed Tomography Imaging for Airway Segmentation for Virtual Bronchoscopic Navigation |
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Journal Article |
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2018 |
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Abbreviated Journal |
RES |
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96 |
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6 |
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525-534 |
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Multidetector computed tomography; Bronchoscopy; Continuous positive airway pressure; Image enhancement; Virtual bronchoscopic navigation |
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Abstract
RATIONALE:
Virtual bronchoscopic navigation (VBN) guidance to peripheral pulmonary lesions is often limited by insufficient segmentation of the peripheral airways.
OBJECTIVES:
To test the effect of applying positive airway pressure (PAP) during CT acquisition to improve segmentation, particularly at end-expiration.
METHODS:
CT acquisitions in inspiration and expiration with 4 PAP protocols were recorded prospectively and compared to baseline inspiratory acquisitions in 20 patients. The 4 protocols explored differences between devices (flow vs. turbine), exposures (within seconds vs. 15-min) and pressure levels (10 vs. 14 cmH2O). Segmentation quality was evaluated with the number of airways and number of endpoints reached. A generalized mixed-effects model explored the estimated effect of each protocol.
MEASUREMENTS AND MAIN RESULTS:
Patient characteristics and lung function did not significantly differ between protocols. Compared to baseline inspiratory acquisitions, expiratory acquisitions after 15 min of 14 cmH2O PAP segmented 1.63-fold more airways (95% CI 1.07-2.48; p = 0.018) and reached 1.34-fold more endpoints (95% CI 1.08-1.66; p = 0.004). Inspiratory acquisitions performed immediately under 10 cmH2O PAP reached 1.20-fold (95% CI 1.09-1.33; p < 0.001) more endpoints; after 15 min the increase was 1.14-fold (95% CI 1.05-1.24; p < 0.001).
CONCLUSIONS:
CT acquisitions with PAP segment more airways and reach more endpoints than baseline inspiratory acquisitions. The improvement is particularly evident at end-expiration after 15 min of 14 cmH2O PAP. Further studies must confirm that the improvement increases diagnostic yield when using VBN to evaluate peripheral pulmonary lesions. |
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IAM; 600.145 |
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Admin @ si @ DGT2018 |
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3135 |
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Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso |
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Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation |
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2017 |
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Journal of Thoracic Oncology |
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JTO |
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12 |
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1S |
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S596-S597 |
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Thorax CT; diagnosis; Peripheral Pulmonary Nodule |
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A main weakness of virtual bronchoscopic navigation (VBN) is unsuccessful segmentation of distal branches approaching peripheral pulmonary nodules (PPN). CT scan acquisition protocol is pivotal for segmentation covering the utmost periphery. We hypothesize that application of continuous positive airway pressure (CPAP) during CT acquisition could improve visualization and segmentation of peripheral bronchi. The purpose of the present pilot study is to compare quality of segmentations under 4 CT acquisition modes: inspiration (INSP), expiration (EXP) and both with CPAP (INSP-CPAP and EXP-CPAP). |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ DGC2017a |
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2883 |
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Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Cubero Noelia; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell |
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Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation |
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2016 |
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Chest Journal |
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CHEST |
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150 |
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1003A |
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IAM; 600.096; 600.075 |
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Admin @ si @ DGC2016 |
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3099 |
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Marta Diez-Ferrer; Debora Gil; Elena Carreño; Susana Padrones; Samantha Aso; Vanesa Vicens; Noelia Cubero de Frutos; Rosa Lopez Lisbona; Carles Sanchez; Agnes Borras; Antoni Rosell |
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Positive Airway Pressure-Enhanced CT to Improve Virtual Bronchoscopic Navigation |
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2017 |
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European Respiratory Journal |
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ERJ |
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Admin @ si @ DGC2017b |
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3632 |
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Marta Ligero; Alonso Garcia Ruiz; Cristina Viaplana; Guillermo Villacampa; Maria V Raciti; Jaid Landa; Ignacio Matos; Juan Martin Liberal; Maria Ochoa de Olza; Cinta Hierro; Joaquin Mateo; Macarena Gonzalez; Rafael Morales Barrera; Cristina Suarez; Jordi Rodon; Elena Elez; Irene Braña; Eva Muñoz-Couselo; Ana Oaknin; Roberta Fasani; Paolo Nuciforo; Debora Gil; Carlota Rubio Perez; Joan Seoane; Enriqueta Felip; Manuel Escobar; Josep Tabernero; Joan Carles; Rodrigo Dienstmann; Elena Garralda; Raquel Perez Lopez |
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A CT-based radiomics signature is associated with response to immune checkpoint inhibitors in advanced solid tumors |
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2021 |
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Radiology |
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299 |
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109-119 |
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Background Reliable predictive imaging markers of response to immune checkpoint inhibitors are needed. Purpose To develop and validate a pretreatment CT-based radiomics signature to predict response to immune checkpoint inhibitors in advanced solid tumors. Materials and Methods In this retrospective study, a radiomics signature was developed in patients with advanced solid tumors (including breast, cervix, gastrointestinal) treated with anti-programmed cell death-1 or programmed cell death ligand-1 monotherapy from August 2012 to May 2018 (cohort 1). This was tested in patients with bladder and lung cancer (cohorts 2 and 3). Radiomics variables were extracted from all metastases delineated at pretreatment CT and selected by using an elastic-net model. A regression model combined radiomics and clinical variables with response as the end point. Biologic validation of the radiomics score with RNA profiling of cytotoxic cells (cohort 4) was assessed with Mann-Whitney analysis. Results The radiomics signature was developed in 85 patients (cohort 1: mean age, 58 years ± 13 [standard deviation]; 43 men) and tested on 46 patients (cohort 2: mean age, 70 years ± 12; 37 men) and 47 patients (cohort 3: mean age, 64 years ± 11; 40 men). Biologic validation was performed in a further cohort of 20 patients (cohort 4: mean age, 60 years ± 13; 14 men). The radiomics signature was associated with clinical response to immune checkpoint inhibitors (area under the curve [AUC], 0.70; 95% CI: 0.64, 0.77; P < .001). In cohorts 2 and 3, the AUC was 0.67 (95% CI: 0.58, 0.76) and 0.67 (95% CI: 0.56, 0.77; P < .001), respectively. A radiomics-clinical signature (including baseline albumin level and lymphocyte count) improved on radiomics-only performance (AUC, 0.74 [95% CI: 0.63, 0.84; P < .001]; Akaike information criterion, 107.00 and 109.90, respectively). Conclusion A pretreatment CT-based radiomics signature is associated with response to immune checkpoint inhibitors, likely reflecting the tumor immunophenotype. © RSNA, 2021 Online supplemental material is available for this article. See also the editorial by Summers in this issue. |
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Admin @ si @ LGV2021 |
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