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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Multiple active receptor conformation, agonist efficacy and maximum effect of the system: the conformation-based operational model of agonism, |
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Journal Article |
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Year |
2013 |
Publication |
Drug Discovery Today |
Abbreviated Journal |
DDT |
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Volume |
18 |
Issue |
7-8 |
Pages |
365-371 |
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Abstract |
The operational model of agonism assumes that the maximum effect a particular receptor system can achieve (the Em parameter) is fixed. Em estimates are above but close to the asymptotic maximum effects of endogenous agonists. The concept of Em is contradicted by superagonists and those positive allosteric modulators that significantly increase the maximum effect of endogenous agonists. An extension of the operational model is proposed that assumes that the Em parameter does not necessarily have a single value for a receptor system but has multiple values associated to multiple active receptor conformations. The model provides a mechanistic link between active receptor conformation and agonist efficacy, which can be useful for the analysis of agonist response under different receptor scenarios. |
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Elsevier |
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IAM; 600.057; 600.054 |
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IAM @ iam @ RGG2013a |
Serial |
2190 |
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Author |
Sergio Vera; Debora Gil; Antonio Lopez; Miguel Angel Gonzalez Ballester |
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Title |
Multilocal Creaseness Measure |
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Journal |
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Year |
2012 |
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The Insight Journal |
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IJ |
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Ridges, Valley, Creaseness, Structure Tensor, Skeleton, |
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This document describes the implementation using the Insight Toolkit of an algorithm for detecting creases (ridges and valleys) in N-dimensional images, based on the Local Structure Tensor of the image. In addition to the filter used to calculate the creaseness image, a filter for the computation of the structure tensor is also included in this submission. |
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Alma IT Systems |
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english |
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english |
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IAM;ADAS; |
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IAM @ iam @ VGL2012 |
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1840 |
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Author |
Ferran Poveda; Debora Gil;Enric Marti |
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Title |
Multi-resolution DT-MRI cardiac tractography |
Type |
Conference Article |
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Year |
2012 |
Publication |
Statistical Atlases And Computational Models Of The Heart: Imaging and Modelling Challenges |
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Volume |
7746 |
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Pages |
270-277 |
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Even using objective measures from DT-MRI no consensus about myocardial architecture has been achieved so far. Streamlining provides good reconstructions at low level of detail, but falls short to give global abstract interpretations. In this paper, we present a multi-resolution methodology that is able to produce simplified representations of cardiac architecture. Our approach produces a reduced set of tracts that are representative of the main geometric features of myocardial anatomical structure. Experiments show that fiber geometry is preserved along reductions, which validates the simplified model for interpretation of cardiac architecture. |
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Nice, France |
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Springer Berlin Heidelberg |
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LNCS |
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0302-9743 |
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978-3-642-36960-5 |
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STACOM |
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IAM |
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IAM @ iam @ PGM2012 |
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1986 |
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Josefina Mauri; Eduard Fernandez-Nofrerias; B. Garcia del Blanco; E. Iraculis; J.A. Gomez-Hospital; J. Comin; M.A. Sanchez Corral; F. Jara; A. Cequier; E. Esplugas; Debora Gil; J. Saludes; Petia Radeva; Ricardo Toledo; Juan J.Villanueva |
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Title |
Moviment del vas en l anàlisi d imatges d ecografia intracoronària: un model matemàtic |
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Conference Article |
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Year |
2000 |
Publication |
Congrés de la Societat Catalana de Cardiologia. |
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IAM;RV;ISE;MILAB;ADAS |
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IAM @ iam @ MNG2000 |
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1621 |
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Author |
Misael Rosales; Petia Radeva;Oriol Rodriguez-Leon; Debora Gil |
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Title |
Modelling of image-catheter motion for 3-D IVUS |
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Journal Article |
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Year |
2009 |
Publication |
Medical image analysis |
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MIA |
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13 |
Issue |
1 |
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91-104 |
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Keywords |
Intravascular ultrasound (IVUS); Motion estimation; Motion decomposition; Fourier |
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Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS. |
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IAM;MILAB |
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Call Number |
IAM @ iam @ RRR2009 |
Serial |
1646 |
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Author |
Jaume Garcia; Debora Gil; Francesc Carreras; Sandra Pujades; R.Leta |
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Title |
Modelització 4-Dimensional de la Funció Siatólica del Ventricle Esquerre |
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Conference Article |
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Year |
2007 |
Publication |
XIX Congrés de la Societat Catalana de Cardiologia de Barcelona |
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133-134 |
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Abstract |
L’evolució tecnològica en el tractament de les imatges mèdiques permet reconstruir, amb el software apropiat, imatges tridimensionals de les estructures cardiovasculars i dotar-les de moviment. Les imatges 4D resultants faciliten l’estudi de la fisiopatologia de la insuficiència cardíaca en base als transtorns de l’activació electromecànica ventricular, el que pot ser d’interès en el procés de selecció de pacients candidats a teràpies de resincronització. Presentem els resultats preliminars de la reconstrucció 4D del ventricle esquerre (VE) a partir de les seqüències de tagging miocàrdic del VE. |
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Barcelona (Spain) |
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IAM |
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IAM @ iam @ GGC2007 |
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1505 |
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Author |
Oriol Rodriguez-Leon.A.Carol;H.Tizon; Eduard Fernandez-Nofrerias; Josefina Mauri; Vicente del Valle; Debora Gil; Aura Hernandez-Sabate; Petia Radeva |
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Title |
Model estadístic-determinístic per la segmentació de l adventicia en imatges d ecografía intracoronaria |
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Journal Article |
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Year |
2005 |
Publication |
Rev Societat Catalana Cardiologia |
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5 |
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41 |
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IAM;MILAB |
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IAM @ iam @ RCT2005 |
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1637 |
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Debora Gil; Agnes Borras; Manuel Ballester; Francesc Carreras; Ruth Aris; Manuel Vazquez; Enric Marti; Ferran Poveda |
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Title |
MIOCARDIA: Integrating cardiac function and muscular architecture for a better diagnosis |
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Conference Article |
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Year |
2011 |
Publication |
14th International Symposium on Applied Sciences in Biomedical and Communication Technologies |
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Deep understanding of myocardial structure of the heart would unravel crucial knowledge for clinical and medical procedures. The MIOCARDIA project is a multidisciplinary project in cooperation with l'Hospital de la Santa Creu i de Sant Pau, Clinica la Creu Blanca and Barcelona Supercomputing Center. The ultimate goal of this project is defining a computational model of the myocardium. The model takes into account the deep interrelation between the anatomy and the mechanics of the heart. The paper explains the workflow of the MIOCARDIA project. It also introduces a multiresolution reconstruction technique based on DT-MRI streamlining for simplified global myocardial model generation. Our reconstructions can restore the most complex myocardial structures and provides evidences of a global helical organization. |
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Barcelona; Spain |
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Association for Computing Machinery |
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Barcelona, Spain |
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Association for Computing Machinery |
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english |
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english |
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978-1-4503-0913-4 |
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ISABEL |
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IAM |
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IAM @ iam @ GGB2011 |
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1691 |
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Author |
Jose Elias Yauri; Aura Hernandez-Sabate; Pau Folch; Debora Gil |
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Title |
Mental Workload Detection Based on EEG Analysis |
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Conference Article |
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2021 |
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Artificial Intelligent Research and Development. Proceedings 23rd International Conference of the Catalan Association for Artificial Intelligence. |
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339 |
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268-277 |
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Cognitive states; Mental workload; EEG analysis; Neural Networks. |
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The study of mental workload becomes essential for human work efficiency, health conditions and to avoid accidents, since workload compromises both performance and awareness. Although workload has been widely studied using several physiological measures, minimising the sensor network as much as possible remains both a challenge and a requirement.
Electroencephalogram (EEG) signals have shown a high correlation to specific cognitive and mental states like workload. However, there is not enough evidence in the literature to validate how well models generalize in case of new subjects performing tasks of a workload similar to the ones included during model’s training.
In this paper we propose a binary neural network to classify EEG features across different mental workloads. Two workloads, low and medium, are induced using two variants of the N-Back Test. The proposed model was validated in a dataset collected from 16 subjects and shown a high level of generalization capability: model reported an average recall of 81.81% in a leave-one-out subject evaluation. |
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Virtual; October 20-22 2021 |
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CCIA |
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IAM; 600.139; 600.118; 600.145 |
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Admin @ si @ |
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3723 |
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Author |
H. Martin ; Jens Fagertun; Sergio Vera; Debora Gil |
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Title |
Medial structure generation for registration of anatomical structures |
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Book Chapter |
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2017 |
Publication |
Skeletonization, Theory, Methods and Applications |
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11 |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ MFV2017a |
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2935 |
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