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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Assessing agonist efficacy in an uncertain Em world |
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Conference Article |
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Year |
2012 |
Publication |
40th Keystone Symposia on mollecular and celular biology |
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79 |
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The operational model of agonism has been widely used for the analysis of agonist action since its formulation in 1983. The model includes the Em parameter, which is defined as the maximum response of the system. The methods for Em estimation provide Em values not significantly higher than the maximum responses achieved by full agonists. However, it has been found that that some classes of compounds as, for instance, superagonists and positive allosteric modulators can increase the full agonist maximum response, implying upper limits for Em and thereby posing doubts on the validity of Em estimates. Because of the correlation between Em and operational efficacy, τ, wrong Em estimates will yield wrong τ estimates.
In this presentation, the operational model of agonism and various methods for the simulation of allosteric modulation will be analyzed. Alternatives for curve fitting will be presented and discussed. |
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Fairmont Banff Springs, Banff, Alberta, Canada |
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Keystone Symposia |
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Keystone Symposia |
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A. Christopoulus and M. Bouvier |
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english |
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english |
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Keystone Symposia |
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KSMCB |
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IAM |
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no |
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IAM @ iam @ RGG2012 |
Serial |
1855 |
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Author |
Debora Gil; Petia Radeva; Jordi Saludes; J. Mauri |
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Title |
Automatic Segmentation of Artery Wall in Coronary IVUS Images: A Probabilistic Approach |
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Conference Article |
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Year |
2000 |
Publication |
International Conference on Pattern Recognition |
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4 |
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352-355 |
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Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results. |
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IAM;MILAB |
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IAM @ iam @ GRS2000a |
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1537 |
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Author |
Debora Gil; Petia Radeva; Jordi Saludes; J. Mauri |
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Title |
Automatic Segmentation of Artery Wall in Coronary IVUS Images: a Probabilistic Approach |
Type |
Conference Article |
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Year |
2000 |
Publication |
Proceedings of CIC’2000 |
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Intravascular ultrasound images represent a unique tool to analyze the morphology of arteries and vessels (plaques, restenosis, etc). The poor quality of these images makes unsupervised segmentation based on traditional segmentation algorithms (such as edge or ridge/valley detection) fail to achieve the expected results. In this paper we present a probabilistic flexible template to separate different regions in the image. In particular, we use elliptic templates to model and detect the shape of the vessel inner wall in IVUS images. We present the results of successful segmentation obtained from patients undergoing stent treatment. A physician team has validated these results. |
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Cambridge, Massachussets |
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CIC |
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IAM;MILAB |
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IAM @ iam @ GRS2000 |
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1538 |
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Author |
J. Mauri; Eduard Fernandez-Nofrerias; J. Comin; B. Garcia del Blanco; E. Iraculis; J.A. Gomez-Hospital; P. Valdovinos; F. Jara; A. Cequier; E. Esplugas; Oriol Pujol; Cristina Cañero; Debora Gil; Petia Radeva; Ricardo Toledo |
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Title |
Avaluació del Conjunt Stent/Artèria mitjançant ecografia intracoronària: lentorn informàtic |
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Conference Article |
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Year |
2000 |
Publication |
Congrés de la Societat Catalana de Cardiologia. |
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IAM;RV;MILAB;ADAS;HuPBA |
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IAM @ iam @ MNC2000 |
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1622 |
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Author |
Carles Sanchez; Miguel Viñas; Coen Antens; Agnes Borras; Debora Gil |
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Title |
Back to Front Architecture for Diagnosis as a Service |
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Conference Article |
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Year |
2018 |
Publication |
20th International Symposium on Symbolic and Numeric Algorithms for Scientific Computing |
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343-346 |
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Software as a Service (SaaS) is a cloud computing model in which a provider hosts applications in a server that customers use via internet. Since SaaS does not require to install applications on customers' own computers, it allows the use by multiple users of highly specialized software without extra expenses for hardware acquisition or licensing. A SaaS tailored for clinical needs not only would alleviate licensing costs, but also would facilitate easy access to new methods for diagnosis assistance. This paper presents a SaaS client-server architecture for Diagnosis as a Service (DaaS). The server is based on docker technology in order to allow execution of softwares implemented in different languages with the highest portability and scalability. The client is a content management system allowing the design of websites with multimedia content and interactive visualization of results allowing user editing. We explain a usage case that uses our DaaS as crowdsourcing platform in a multicentric pilot study carried out to evaluate the clinical benefits of a software for assessment of central airway obstruction. |
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Timisoara; Rumania; September 2018 |
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SYNASC |
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IAM; 600.145 |
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Admin @ si @ SVA2018 |
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3360 |
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Author |
Sonia Baeza; Debora Gil; Carles Sanchez; Guillermo Torres; Ignasi Garcia Olive; Ignasi Guasch; Samuel Garcia Reina; Felipe Andreo; Jose Luis Mate; Jose Luis Vercher; Antonio Rosell |
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Title |
Biopsia virtual radiomica para el diagnóstico histológico de nódulos pulmonares – Resultados intermedios del proyecto Radiolung |
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Conference Article |
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2023 |
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SEPAR |
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Pòster |
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Granada; Spain; June 2023 |
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SEPAR |
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Admin @ si @ BGS2023 |
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3951 |
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Author |
Oriol Rodriguez-Leor; Debora Gil; Eduard Fernandez-Nofrerias; H. Tizon; S. Montserrat; Vicente del Valle; J. Mauri |
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Title |
Caracterització de la Perfusió Miocàrdica mitjançant anàlisi estadístic de l espectre en l angiografia de contrast |
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Conference Article |
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Year |
2007 |
Publication |
XIX Congrés de la Societat Catalana de Cardiologia de Barcelona |
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130 |
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La valoració de la integritat de la microcirculació coronària aporta informació pronòstica en pacients amb infart agut de miocardi en els que es realitza angioplastia primària. Aquesta valoració és subjectiva i presenta una important variabilitat si no es duta a terme per personal experimentat. Presentem una eina d’anàlisi d’imatge que permet fer una valoració de la microcirculació coronària a partir de seqüències d’angiografia. Hem analitzat les variacions locals en el nivell de gris de la imatge durant la seqüència angiogràfica. Hem identificat els principals fenòmens observats (respiració, batec cardíac, tinció arterial, tinció miocàrdica i soroll radiològic) mitjançant un anàlisi estadístic de l’espectre de Fourier de l’evolució al llarg del temps de la mitja local. Aquest mateix anàlisis permet determinat la influència de cadascun d’ells en la extracció del patró de tinció i selecciona la respiració com el fenomen que més distorsiona el patró de tinció original. Els descriptors proposats s’obtenen fora del rang espectral respiratori. Hem testat la seva capacitat per a detectar els tres fenòmens principals (tinció miocàrdica (MS), tinció arterial (AS) i soroll (NS)) independentment de la respiració. La capacitat de discriminació dels descriptors ha estat valorada mitjançant un mètode de crossvalidation en 30 seqüències d’angiografia. Els descriptors emprats permeten caracteritzar la tinció miocàrdica amb una alta eficiència i fiabilitat. A més no hi ha diferències significatives en l’anàlisi de les seqüències obtingudes amb el pacient respirant amb normalitat o en apnea |
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Barcelona (Spain) |
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IAM |
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IAM @ iam @ RGF2007 |
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1639 |
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Author |
Jaume Garcia; Debora Gil; Joel Barajas; Francesc Carreras; Sandra Pujades; Petia Radeva |
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Title |
Characterization of ventricular torsion in healthy subjects using Gabor filters and a variational framework |
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Conference Article |
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2006 |
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Proc. Computers in Cardiology |
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877-880 |
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In this work, we present a fully automated method for tissue deformation estimation in tagged magnetic resonance images (TMRI). Gabor filter banks, tuned independently for each left ventricle level, provide optimally filtered complex images which phase remains constant along the cardiac cycle. This fact can be thought as the brightness constancy condition required by classical optical flow (OF) methods. Pairs of these filtered sequences, together with a variational formulation are used in a second step to obtain dense continuous deformation maps that we call Harmonic Phase Flow. This method has been used to determine reference values of ventricular torsion (VT) in a set of 8 healthy volunteers. The results encourage the use of VT as a useful parameter for ventricular function assessment in clinical routine. |
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IAM;MILAB |
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IAM @ iam @ GGB2006a |
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1509 |
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Author |
Mireia Sole; Joan Blanco; Debora Gil; Oliver Valero; G. Fonseka; M. Lawrie; Francesca Vidal; Zaida Sarrate |
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Title |
Chromosome Territories in Mice Spermatogenesis: A new three-dimensional methodology of study |
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Conference Article |
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2017 |
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11th European CytoGenesis Conference |
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Florencia; Italia; July 2017 |
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ECA |
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IAM; 600.096; 600.145 |
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Admin @ si @ SBG2017a |
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2936 |
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Debora Gil; Oriol Ramos Terrades; Elisa Minchole; Carles Sanchez; Noelia Cubero de Frutos; Marta Diez-Ferrer; Rosa Maria Ortiz; Antoni Rosell |
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Title |
Classification of Confocal Endomicroscopy Patterns for Diagnosis of Lung Cancer |
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Conference Article |
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2017 |
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6th Workshop on Clinical Image-based Procedures: Translational Research in Medical Imaging |
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10550 |
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151-159 |
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Confocal Laser Endomicroscopy (CLE) is an emerging imaging technique that allows the in-vivo acquisition of cell patterns of potentially malignant lesions. Such patterns could discriminate between inflammatory and neoplastic lesions and, thus, serve as a first in-vivo biopsy to discard cases that do not actually require a cell biopsy.
The goal of this work is to explore whether CLE images obtained during videobronchoscopy contain enough visual information to discriminate between benign and malign peripheral lesions for lung cancer diagnosis. To do so, we have performed a pilot comparative study with 12 patients (6 adenocarcinoma and 6 benign-inflammatory) using 2 different methods for CLE pattern analysis: visual analysis by 3 experts and a novel methodology that uses graph methods to find patterns in pre-trained feature spaces. Our preliminary results indicate that although visual analysis can only achieve a 60.2% of accuracy, the accuracy of the proposed unsupervised image pattern classification raises to 84.6%.
We conclude that CLE images visual information allow in-vivo detection of neoplastic lesions and graph structural analysis applied to deep-learning feature spaces can achieve competitive results. |
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Quebec; Canada; September 2017 |
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CLIP |
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IAM; 600.096; 600.075; 600.145 |
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Admin @ si @ GRM2017 |
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2957 |
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