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Author |
Debora Gil; Jaume Garcia; Aura Hernandez-Sabate; Enric Marti |
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Title |
Manifold parametrization of the left ventricle for a statistical modelling of its complete anatomy |
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Conference Article |
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2010 |
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8th Medical Imaging |
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7623 |
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762304 |
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304 |
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Distortion of Left Ventricle (LV) external anatomy is related to some dysfunctions, such as hypertrophy. The architecture of myocardial fibers determines LV electromechanical activation patterns as well as mechanics. Thus, their joined modelling would allow the design of specific interventions (such as peacemaker implantation and LV remodelling) and therapies (such as resynchronization). On one hand, accurate modelling of external anatomy requires either a dense sampling or a continuous infinite dimensional approach, which requires non-Euclidean statistics. On the other hand, computation of fiber models requires statistics on Riemannian spaces. Most approaches compute separate statistical models for external anatomy and fibers architecture. In this work we propose a general mathematical framework based on differential geometry concepts for computing a statistical model including, both, external and fiber anatomy. Our framework provides a continuous approach to external anatomy supporting standard statistics. We also provide a straightforward formula for the computation of the Riemannian fiber statistics. We have applied our methodology to the computation of complete anatomical atlas of canine hearts from diffusion tensor studies. The orientation of fibers over the average external geometry agrees with the segmental description of orientations reported in the literature. |
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IAM @ iam @ GGH2010a |
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1522 |
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Author |
Aura Hernandez-Sabate |
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Title |
Exploring Arterial Dynamics and Structures in IntraVascular Ultrasound Sequences |
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2009 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Cardiovascular diseases are a leading cause of death in developed countries. Most of them are caused by arterial (specially coronary) diseases, mainly caused by plaque accumulation. Such pathology narrows blood flow (stenosis) and affects artery bio- mechanical elastic properties (atherosclerosis). In the last decades, IntraVascular UltraSound (IVUS) has become a usual imaging technique for the diagnosis and follow up of arterial diseases. IVUS is a catheter-based imaging technique which shows a sequence of cross sections of the artery under study. Inspection of a single image gives information about the percentage of stenosis. Meanwhile, inspection of longitudinal views provides information about artery bio-mechanical properties, which can prevent a fatal outcome of the cardiovascular disease. On one hand, dynamics of arteries (due to heart pumping among others) is a major artifact for exploring tissue bio-mechanical properties. On the other one, manual stenosis measurements require a manual tracing of vessel borders, which is a time-consuming task and might suffer from inter-observer variations. This PhD thesis proposes several image processing tools for exploring vessel dy- namics and structures. We present a physics-based model to extract, analyze and correct vessel in-plane rigid dynamics and to retrieve cardiac phase. Furthermore, we introduce a deterministic-statistical method for automatic vessel borders detection. In particular, we address adventitia layer segmentation. An accurate validation pro- tocol to ensure reliable clinical applicability of the methods is a crucial step in any proposal of an algorithm. In this thesis we take special care in designing a valida- tion protocol for each approach proposed and we contribute to the in vivo dynamics validation with a quantitative and objective score to measure the amount of motion suppressed. |
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Ph.D. thesis |
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Ediciones Graficas Rey |
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Debora Gil |
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978-84-937261-6-4 |
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IAM; |
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IAM @ iam @ Her2009 |
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1543 |
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Author |
Aura Hernandez-Sabate |
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Title |
Automatic adventitia segmentation in IntraVascular UltraSound images |
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2005 |
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CVC Technical Report |
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85 |
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A usual tool in cardiac disease diagnosis is vessel plaque assessment by analysis of IVUS sequences. Manual detection of lumen-intima, intima-media and media-adventitia vessel borders is the main activity of physicians in the process of plaque quantification. Large variety in vessel border descriptors, as well as, shades, artifacts and blurred response due to ultrasound physical properties troubles automated media-adventitia segmentation. This experimental work presents a solution to such a complex problem. The process blends advanced anisotropic filtering operators and statistic classification techniques, achieving an efficient vessel border modelling strategy. First of all, we introduce the theoretic base of the method. After that, we show the steps of the algorithm, validating the method with statistics that show that the media-adventitia border detection achieves an accuracy in the range of inter-observer variability regardless of plaque nature, vessel geometry and incomplete vessel borders. Finally, we present a little Matlab application to the automatic media-adventitia border. |
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Master's thesis |
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08193 Bellaterra, Barcelona (Spain) |
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IAM; |
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IAM @ iam @ Her2005 |
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1544 |
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Author |
Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
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Title |
A Deterministic-Statistical Strategy for Adventitia Segmentation in IVUS images |
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2005 |
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CVC Technical Report |
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89 |
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A useful tool for some specific studies in cardiac disease diagnosis is vessel plaque assessment by analysis of IVUS sequences. Manual detection of luminal (inner) and media-adventitia (external) vessel borders is the main activity of physicians in the process of lumen narrowing (plaque) quantification. Difficult definition of vessel border descriptors, as well as, shades, artifacts and blurred signal response due to ultrasound physical properties troubles automated adventitia segmentation. In order to efficiently approach such a complex problem, we propose blending advanced anisotropic filtering operators and statistical classification techniques into a vessel border modelling strategy. Our systematic statistical analysis shows that the reported adventitia detection achieves an accuracy in the range of inter-observer variability regardless of plaque nature, vessel geometry and incomplete vessel borders. |
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IAM; MILAB |
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IAM @ iam @ HGR2005a |
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1548 |
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Author |
Aura Hernandez-Sabate; Monica Mitiko; Sergio Shiguemi; Debora Gil |
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Title |
A validation protocol for assessing cardiac phase retrieval in IntraVascular UltraSound |
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Conference Article |
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Year |
2010 |
Publication |
Computing in Cardiology |
Abbreviated Journal |
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37 |
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899-902 |
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A good reliable approach to cardiac triggering is of utmost importance in obtaining accurate quantitative results of atherosclerotic plaque burden from the analysis of IntraVascular UltraSound. Although, in the last years, there has been an increase in research of methods for retrospective gating, there is no general consensus in a validation protocol. Many methods are based on quality assessment of longitudinal cuts appearance and those reporting quantitative numbers do not follow a standard protocol. Such heterogeneity in validation protocols makes faithful comparison across methods a difficult task. We propose a validation protocol based on the variability of the retrieved cardiac phase and explore the capability of several quality measures for quantifying such variability. An ideal detector, suitable for its application in clinical practice, should produce stable phases. That is, it should always sample the same cardiac cycle fraction. In this context, one should measure the variability (variance) of a candidate sampling with respect a ground truth (reference) sampling, since the variance would indicate how spread we are aiming a target. In order to quantify the deviation between the sampling and the ground truth, we have considered two quality scores reported in the literature: signed distance to the closest reference sample and distance to the right of each reference sample. We have also considered the residuals of the regression line of reference against candidate sampling. The performance of the measures has been explored on a set of synthetic samplings covering different cardiac cycle fractions and variabilities. From our simulations, we conclude that the metrics related to distances are sensitive to the shift considered while the residuals are robust against fraction and variabilities as far as one can establish a pair-wise correspondence between candidate and reference. We will further investigate the impact of false positive and negative detections in experimental data. |
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IEEE |
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0276-6547 |
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978-1-4244-7318-2 |
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CINC |
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IAM @ iam @ HSM2010 |
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1551 |
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Aura Hernandez-Sabate; Petia Radeva; Antonio Tovar; Debora Gil |
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Title |
Vessel structures alignment by spectral analysis of ivus sequences |
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Conference Article |
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2006 |
Publication |
Proc. of CVII, MICCAI Workshop |
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39-36 |
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Three-dimensional intravascular ultrasound (IVUS) allows to visualize and obtain volumetric measurements of coronary lesions through an exploration of the cross sections and longitudinal views of arteries. However, the visualization and subsequent morpho-geometric measurements in IVUS longitudinal cuts are subject to distortion caused by periodic image/vessel motion around the IVUS catheter. Usually, to overcome the image motion artifact ECG-gating and image-gated approaches are proposed, leading to slowing the pullback acquisition or disregarding part of IVUS data. In this paper, we argue that the image motion is due to 3-D vessel geometry as well as cardiac dynamics, and propose a dynamic model based on the tracking of an elliptical vessel approximation to recover the rigid transformation and align IVUS images without loosing any IVUS data. We report an extensive validation with synthetic simulated data and in vivo IVUS sequences of 30 patients achieving an average reduction of the image artifact of 97% in synthetic data and 79% in real-data. Our study shows that IVUS alignment improves longitudinal analysis of the IVUS data and is a necessary step towards accurate reconstruction and volumetric measurements of 3-D IVUS. |
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Copenhaguen (Denmark), |
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1st International Wokshop on Computer Vision for Intravascular and Intracardiac Imaging (CVII’06) |
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IAM; MILAB |
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IAM @ iam @ HRT2006 |
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1552 |
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Aura Hernandez-Sabate; Debora Gil; Josefina Mauri; Petia Radeva |
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Title |
Reducing cardiac motion in IVUS sequences |
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Conference Article |
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2006 |
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Proceeding of Computers in Cardiology |
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33 |
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685-688 |
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Cardiac vessel displacement is a main artifact in IVUS sequences. It hinders visualization of the main structures in an appropriate orientation and alignment and affects extracting vessel measurements. In this paper, we present a novel approach for image sequence alignment based on spectral analysis, which removes rigid dynamics, preserving at the same time the vessel geometry. First, we suppress the translation by taking, for each frame, the center of mass of the image as origin of coordinates. In polar coordinates with such point as origin, the rotation appears as a horizontal displacement. The translation induces a phase shift in the Fourier coefficients of two consecutive polar images. We estimate the phase by adjusting a regression plane to the phases of the principal frequencies. Experiments show that the presented strategy suppress cardiac motion regardless of the acquisition device. 1. |
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IAM; MILAB |
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IAM @ iam @ HGM2006a |
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1554 |
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Aura Hernandez-Sabate; Debora Gil; Petia Radeva; E.N.Nofrerias |
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Title |
Anisotropic processing of image structures for adventitia detection in intravascular ultrasound images |
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2004 |
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Proc. Computers in Cardiology |
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31 |
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229-232 |
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The adventitia layer appears as a weak edge in IVUS images with a non-uniform grey level, which difficulties its detection. In order to enhance edges, we apply an anisotropic filter that homogenizes the grey level along the image significant structures (ridges, valleys and edges). A standard edge detector applied to the filtered image yields a set of candidate points prone to be unconnected. The final model is obtained by interpolating the former line segments along the tangent direction to the level curves of the filtered image with an anisotropic contour closing technique based on functional extension principles |
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Chicago (USA) |
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IAM @ iam @ HGR2004 |
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1555 |
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Oriol Rodriguez-Leon.A.Carol;H.Tizon; Eduard Fernandez-Nofrerias; Josefina Mauri; Vicente del Valle; Debora Gil; Aura Hernandez-Sabate; Petia Radeva |
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Model estadístic-determinístic per la segmentació de l adventicia en imatges d ecografía intracoronaria |
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2005 |
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Rev Societat Catalana Cardiologia |
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5 |
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41 |
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IAM @ iam @ RCT2005 |
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1637 |
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Oriol Rodriguez-Leon; Josefina Mauri;Eduard Fernandez-Nofrerias; Antonio Tovar; Vicente del Valle; Aura Hernandez-Sabate; Debora Gil; Petia Radeva |
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Utilización de la Estructura de los Campos Vectoriales para la Detección de la Adventicia en Imágenes de Ecografía Intracoronaria |
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2004 |
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Revista Internacional de Enfermedades Cardiovasculares Revista Española de Cardiología |
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57 |
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2 |
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100 |
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IAM @ iam @ RMF2004 |
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