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Author |
Debora Gil; Jaume Garcia; Mariano Vazquez; Ruth Aris; Guilleaume Houzeaux |
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Title |
Patient-Sensitive Anatomic and Functional 3D Model of the Left Ventricle Function |
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Conference Article |
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2008 |
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8th World Congress on Computational Mechanichs (WCCM8) |
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Left Ventricle, Electromechanical Models, Image Processing, Magnetic Resonance. |
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Early diagnosis and accurate treatment of Left Ventricle (LV) dysfunction significantly increases the patient survival. Impairment of LV contractility due to cardiovascular diseases is reflected in its motion patterns. Recent advances in medical imaging, such as Magnetic Resonance (MR), have encouraged research on 3D simulation and modelling of the LV dynamics. Most of the existing 3D models [1] consider just the gross anatomy of the LV and restore a truncated ellipse which deforms along the cardiac cycle. The contraction mechanics of any muscle strongly depends on the spatial orientation of its muscular fibers since the motion that the muscle undergoes mainly takes place along the fibers. It follows that such simplified models do not allow evaluation of the heart electro-mechanical function and coupling, which has recently risen as the key point for understanding the LV functionality [2]. In order to thoroughly understand the LV mechanics it is necessary to consider the complete anatomy of the LV given by the orientation of the myocardial fibres in 3D space as described by Torrent Guasp [3].
We propose developing a 3D patient-sensitive model of the LV integrating, for the first time, the ven- tricular band anatomy (fibers orientation), the LV gross anatomy and its functionality. Such model will represent the LV function as a natural consequence of its own ventricular band anatomy. This might be decisive in restoring a proper LV contraction in patients undergoing pace marker treatment.
The LV function is defined as soon as the propagation of the contractile electromechanical pulse has been modelled. In our experiments we have used the wave equation for the propagation of the electric pulse. The electromechanical wave moves on the myocardial surface and should have a conductivity tensor oriented along the muscular fibers. Thus, whatever mathematical model for electric pulse propa- gation [4] we consider, the complete anatomy of the LV should be extracted.
The LV gross anatomy is obtained by processing multi slice MR images recorded for each patient. Information about the myocardial fibers distribution can only be extracted by Diffusion Tensor Imag- ing (DTI), which can not provide in vivo information for each patient. As a first approach, we have
Figure 1: Scheme for the Left Ventricle Patient-Sensitive Model.
computed an average model of fibers from several DTI studies of canine hearts. This rough anatomy is the input for our electro-mechanical propagation model simulating LV dynamics. The average fiber orientation is updated until the simulated LV motion agrees with the experimental evidence provided by the LV motion observed in tagged MR (TMR) sequences. Experimental LV motion is recovered by applying image processing, differential geometry and interpolation techniques to 2D TMR slices [5]. The pipeline in figure 1 outlines the interaction between simulations and experimental data leading to our patient-tailored model. |
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Venice; Italy |
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9788496736559 |
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IAM; |
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IAM @ iam @ GGV2008b |
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993 |
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Agata Lapedriza; Jaume Garcia; Ernest Valveny; Robert Benavente; Miquel Ferrer; Gemma Sanchez |
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Una experiencia de aprenentatge basada en projectes en el ambit de la informatica |
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Miscellaneous |
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2008 |
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V Jornades d’Innovacio Docent (UAB) |
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63 |
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Bellaterra (Spain) |
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OR; IAM; DAG; CIC; MV |
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BCNPCL @ bcnpcl @ LGV2008 |
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1030 |
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Robert Benavente; Ernest Valveny; Jaume Garcia; Agata Lapedriza; Miquel Ferrer; Gemma Sanchez |
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Una experiencia de adaptacion al EEES de las asignaturas de programacion en Ingenieria Informatica |
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Miscellaneous |
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2008 |
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V Congreso Iberoamericano de Docencia Universitaria, pp. 213–216 |
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Valencia |
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OR;DAG;CIC;MV |
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BCNPCL @ bcnpcl @ BVG2008 |
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1031 |
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Author |
C. Santa-Marta; Jaume Garcia; A. Bajo; J.J. Vaquero; M. Ledesma-Carbayo; Debora Gil |
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Title |
Influence of the Temporal Resolution on the Quantification of Displacement Fields in Cardiac Magnetic Resonance Tagged Images |
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Conference Article |
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2008 |
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XXVI Congreso Anual de la Sociedad Española de Ingenieria Biomedica |
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352–353 |
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It is difficult to acquire tagged cardiac MR images with a high temporal and spatial resolution using clinical MR scanners. However, if such images are used for quantifying scores based on motion, it is essential a resolution as high as possibl e. This paper explores the influence of the temporal resolution of a tagged series on the quantification of myocardial dynamic parameters. To such purpose we have designed a SPAMM (Spatial Modulation of Magnetization) sequence allowing acquisition of sequences at simple and double temporal resolution. Sequences are processed to compute myocardial motion by an automatic technique based on the tracking of the harmonic phase of tagged images (the Harmonic Phase Flow, HPF). The results have been compared to manual tracking of myocardial tags. The error in displacement fields for double resolution sequences reduces 17%. |
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Valladolid |
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Roberto hornero, Saniel Abasolo |
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CASEIB |
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IAM @ iam @ SGB2008 |
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1033 |
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Author |
Mariano Vazquez; Ruth Aris; Guillaume Hozeaux; R.Aubry; P.Villar;Jaume Garcia ; Debora Gil; Francesc Carreras |
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A massively parallel computational electrophysiology model of the heart |
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Journal Article |
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Year |
2011 |
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International Journal for Numerical Methods in Biomedical Engineering |
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IJNMBE |
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27 |
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1911-1929 |
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computational electrophysiology; parallelization; finite element methods |
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This paper presents a patient-sensitive simulation strategy capable of using the most efficient way the high-performance computational resources. The proposed strategy directly involves three different players: Computational Mechanics Scientists (CMS), Image Processing Scientists and Cardiologists, each one mastering its own expertise area within the project. This paper describes the general integrative scheme but focusing on the CMS side presents a massively parallel implementation of computational electrophysiology applied to cardiac tissue simulation. The paper covers different angles of the computational problem: equations, numerical issues, the algorithm and parallel implementation. The proposed methodology is illustrated with numerical simulations testing all the different possibilities, ranging from small domains up to very large ones. A key issue is the almost ideal scalability not only for large and complex problems but also for medium-size meshes. The explicit formulation is particularly well suited for solving this highly transient problems, with very short time-scale. |
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Swansea (UK) |
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John Wiley & Sons, Ltd. |
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John Wiley & Sons, Ltd. |
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IAM @ iam @ VAH2011 |
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1198 |
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Author |
Albert Andaluz; Francesc Carreras; Debora Gil; Jaume Garcia |
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Title |
Una aplicació amigable pel càlcul de indicadors clínics del ventricle esquerre |
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Miscellaneous |
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2010 |
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Forum Biocat 2010 |
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Lonja de Mar,Barcelona (Spain) |
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CVC |
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Biocat |
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Barcelona |
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Catalan |
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IAM @ iam @ ACG2010 |
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1483 |
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Joel Barajas; Jaume Garcia; Karla Lizbeth Caballero; Francesc Carreras; Sandra Pujades; Petia Radeva |
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Title |
Correction of Misalignment Artifacts Among 2-D Cardiac MR Images in 3-D Space |
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2006 |
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1st International Wokshop on Computer Vision for Intravascular and Intracardiac Imaging (CVII’06) |
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3217 |
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114-121 |
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Cardiac Magnetic Resonance images offer the opportunity to study the heart in detail. One of the main issues in its modelling is to create an accurate 3-D reconstruction of the left ventricle from 2-D views. A first step to achieve this goal is the correct registration among the different image planes due to patient movements. In this article, we present an accurate method to correct displacement artifacts using the Normalized Mutual Information. Here, the image views are treated as planes in order to diminish the approximation error caused by the association of a certain thickness, and moved simultaneously to avoid any kind of bias in the alignment process. This method has been validated using real and syntectic plane displacements, yielding promising results. |
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Copenhagen (Denmark) |
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978-3-540-22977-3 |
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IAM @ iam @ BGC2006 |
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1485 |
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Author |
Jaume Garcia; Petia Radeva; Francesc Carreras |
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Title |
Combining Spectral and Active Shape methods to Track Tagged MRI |
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2004 |
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Recent Advances in Artificial Intelligence Research and Development |
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37-44 |
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MR; tagged MR; ASM; LV segmentation; motion estimation. |
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Tagged magnetic resonance is a very usefull and unique tool that provides a complete local and global knowledge of the left ventricle (LV) motion. In this article we introduce a method capable of tracking and segmenting the LV. Spectral methods are applied in order to obtain the so called HARP images which encode information about movement and are the base for LV point-tracking. For segmentation we use Active Shapes (ASM) that model LV shape variation in order to overcome possible local misplacements of the boundary. We finally show experiments on both synthetic and real data which appear to be very promising. |
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IOS Press |
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CCIA |
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IAM @ iam @ GRC2004 |
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1488 |
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Author |
Jaume Garcia |
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Title |
Statistical Models of the Architecture and Function of the Left Ventricle |
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2009 |
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PhD Thesis, Universitat Autonoma de Barcelona-CVC |
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Cardiovascular Diseases, specially those affecting the Left Ventricle (LV), are the leading cause of death in developed countries with approximately a 30% of all global deaths. In order to address this public health concern, physicians focus on diagnosis and therapy planning. On one hand, early and accurate detection of Regional Wall Motion Abnormalities (RWMA) significantly contributes to a quick diagnosis and prevents the patient to reach more severe stages. On the other hand, a thouroughly knowledge of the normal gross anatomy of the LV, as well as, the distribution of its muscular fibers is crucial for designing specific interventions and therapies (such as pacemaker implanction). Statistical models obtained from the analysis of different imaging modalities allow the computation of the normal ranges of variation within a given population. Normality models are a valuable tool for the definition of objective criterions quantifying the degree of (anomalous) deviation of the LV function and anatomy for a given subject. The creation of statistical models involve addressing three main issues: extraction of data from images, definition of a common domain for comparison of data across patients and designing appropriate statistical analysis schemes. In this PhD thesis we present generic image processing tools for the creation of statistical models of the LV anatomy and function. On one hand, we use differential geometry concepts to define a computational framework (the Normalized Parametric Domain, NPD) suitable for the comparison and fusion of several clinical scores obtained over the LV. On the other hand, we present a variational approach (the Harmonic Phase Flow, HPF) for the estimation of myocardial motion that provides dense and continuous vector fields without overestimating motion at injured areas. These tools are used for the creation of statistical models. Regarding anatomy, we obtain an atlas jointly modelling, both, LV gross anatomy and fiber architecture. Regarding function, we compute normality patterns of scores characterizing the (global and local) LV function and explore, for the first time, the configuration of local scores better suited for RWMA detection. |
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Ph.D. thesis |
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Ediciones Graficas Rey |
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Debora Gil |
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IAM @ iam @ Gar2009a |
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1499 |
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Author |
Jaume Garcia; Debora Gil; Francesc Carreras; Sandra Pujades; R.Leta; Xavier Alomar; Guillem Pons-LLados |
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Title |
Patrons de Normalitat Regional per la Valoració de la Funció del Ventricle Esquerre |
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Conference Article |
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2008 |
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XX Congrés de la Societat Catalana de Cardiologia |
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60 |
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Les malalties cardiovasculars afecten les propietats contràctils de la banda ventricular i provoquen una variació de la funció del Ventricle Esquerre (VE) . Només els indicadors locals (strains, la deformació del teixit) són capaços de detectar anomalies en territoris específics del VE . Patrons de normalitat regionals d’aquests paràmetres serien d’utilitat a l’hora de valorar-ne la funció .
Presentem un Domini Paramètric Normalitzat (DPN) que permet comparar dades de diferents pacients i definir Patrons de Normalitat Regional (PNR) |
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Barcelona |
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catalan |
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catalan |
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IAM @ iam @ GGC2008b |
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