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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mechanistic analysis of the function of agonists and allosteric modulators: Reconciling two-state and operational models |
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Journal Article |
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Year |
2013 |
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British Journal of Pharmacology |
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BJP |
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Volume |
169 |
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6 |
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1189-202 |
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Two-state and operational models of both agonism and allosterism are compared to identify and characterize common pharmacological parameters. To account for the receptor-dependent basal response, constitutive receptor activity is considered in the operational models. By arranging two-state models as the fraction of active receptors and operational models as the fractional response relative to the maximum effect of the system, a one-by-one correspondence between parameters is found. The comparative analysis allows a better understanding of complex allosteric interactions. In particular, the inclusion of constitutive receptor activity in the operational model of allosterism allows the characterization of modulators able to lower the basal response of the system; that is, allosteric modulators with negative intrinsic efficacy. Theoretical simulations and overall goodness of fit of the models to simulated data suggest that it is feasible to apply the models to experimental data and constitute one step forward in receptor theory formalism. |
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IAM; 600.044; 605.203 |
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IAM @ iam @ RGG2013b |
Serial |
2195 |
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Author |
Joan M. Nuñez; Debora Gil; Fernando Vilariño |
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Title |
Finger joint characterization from X-ray images for rheymatoid arthritis assessment |
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Conference Article |
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Year |
2013 |
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6th International Conference on Biomedical Electronics and Devices |
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288-292 |
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Rheumatoid Arthritis; X-Ray; Hand Joint; Sclerosis; Sharp Van der Heijde |
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In this study we propose amodular systemfor automatic rheumatoid arthritis assessment which provides a joint space width measure. A hand joint model is proposed based on the accurate analysis of a X-ray finger joint image sample set. This model shows that the sclerosis and the lower bone are the main necessary features in order to perform a proper finger joint characterization. We propose sclerosis and lower bone detection methods as well as the experimental setup necessary for its performance assessment. Our characterization is used to propose and compute a joint space width score which is shown to be related to the different degrees of arthritis. This assertion is verified by comparing our proposed score with Sharp Van der Heijde score, confirming that the lower our score is the more advanced is the patient affection. |
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Barcelona; February 2013 |
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SciTePress |
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800 |
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BIODEVICES |
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IAM;MV; 600.057; 600.054;SIAI |
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Call Number |
IAM @ iam @ NGV2013 |
Serial |
2196 |
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Author |
David Roche; Debora Gil; Jesus Giraldo |
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Title |
Mathematical modeling of G protein-coupled receptor function: What can we learn from empirical and mechanistic models? |
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Book Chapter |
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Year |
2014 |
Publication |
G Protein-Coupled Receptors – Modeling and Simulation Advances in Experimental Medicine and Biology |
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796 |
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3 |
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159-181 |
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β-arrestin; biased agonism; curve fitting; empirical modeling; evolutionary algorithm; functional selectivity; G protein; GPCR; Hill coefficient; intrinsic efficacy; inverse agonism; mathematical modeling; mechanistic modeling; operational model; parameter optimization; receptor dimer; receptor oligomerization; receptor constitutive activity; signal transduction; two-state model |
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Empirical and mechanistic models differ in their approaches to the analysis of pharmacological effect. Whereas the parameters of the former are not physical constants those of the latter embody the nature, often complex, of biology. Empirical models are exclusively used for curve fitting, merely to characterize the shape of the E/[A] curves. Mechanistic models, on the contrary, enable the examination of mechanistic hypotheses by parameter simulation. Regretfully, the many parameters that mechanistic models may include can represent a great difficulty for curve fitting, representing, thus, a challenge for computational method development. In the present study some empirical and mechanistic models are shown and the connections, which may appear in a number of cases between them, are analyzed from the curves they yield. It may be concluded that systematic and careful curve shape analysis can be extremely useful for the understanding of receptor function, ligand classification and drug discovery, thus providing a common language for the communication between pharmacologists and medicinal chemists. |
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Springer Netherlands |
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0065-2598 |
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978-94-007-7422-3 |
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IAM; 600.075 |
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IAM @ iam @ RGG2014 |
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2197 |
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Author |
Patricia Marquez; Debora Gil; R.Mester; Aura Hernandez-Sabate |
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Title |
Local Analysis of Confidence Measures for Optical Flow Quality Evaluation |
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Conference Article |
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Year |
2014 |
Publication |
9th International Conference on Computer Vision Theory and Applications |
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3 |
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450-457 |
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Optical Flow; Confidence Measure; Performance Evaluation. |
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Optical Flow (OF) techniques facing the complexity of real sequences have been developed in the last years. Even using the most appropriate technique for our specific problem, at some points the output flow might fail to achieve the minimum error required for the system. Confidence measures computed from either input data or OF output should discard those points where OF is not accurate enough for its further use. It follows that evaluating the capabilities of a confidence measure for bounding OF error is as important as the definition
itself. In this paper we analyze different confidence measures and point out their advantages and limitations for their use in real world settings. We also explore the agreement with current tools for their evaluation of confidence measures performance. |
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Lisboa; January 2014 |
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VISAPP |
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IAM; ADAS; 600.044; 600.060; 600.057; 601.145; 600.076; 600.075 |
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Admin @ si @ MGM2014 |
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2432 |
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Author |
Sergio Vera; Debora Gil; Miguel Angel Gonzalez Ballester |
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Title |
Anatomical parameterization for volumetric meshing of the liver |
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Conference Article |
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Year |
2014 |
Publication |
SPIE – Medical Imaging |
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9036 |
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Coordinate System; Anatomy Modeling; Parameterization |
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A coordinate system describing the interior of organs is a powerful tool for a systematic localization of injured tissue. If the same coordinate values are assigned to specific anatomical landmarks, the coordinate system allows integration of data across different medical image modalities. Harmonic mappings have been used to produce parametric coordinate systems over the surface of anatomical shapes, given their flexibility to set values
at specific locations through boundary conditions. However, most of the existing implementations in medical imaging restrict to either anatomical surfaces, or the depth coordinate with boundary conditions is given at sites
of limited geometric diversity. In this paper we present a method for anatomical volumetric parameterization that extends current harmonic parameterizations to the interior anatomy using information provided by the
volume medial surface. We have applied the methodology to define a common reference system for the liver shape and functional anatomy. This reference system sets a solid base for creating anatomical models of the patient’s liver, and allows comparing livers from several patients in a common framework of reference. |
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Amsterdam; September 2014 |
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SPIE-MI |
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IAM; 600.075 |
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Admin @ si @ VGG2014 |
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2456 |
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Author |
Enric Marti; Antoni Gurgui; Debora Gil; Aura Hernandez-Sabate; Jaume Rocarias; Ferran Poveda |
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Title |
ABP on line: Seguimiento, estregas y evaluación en aprendizaje basado en proyectos |
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Miscellaneous |
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2014 |
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8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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CIDUI |
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IAM; ADAS; 600.076; 600.063; 600.075 |
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Admin @ si @ MGG2014 |
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2457 |
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Author |
Carles Sanchez; Oriol Ramos Terrades; Patricia Marquez; Enric Marti; Jaume Rocarias; Debora Gil |
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Evaluación automática de prácticas en Moodle para el aprendizaje autónomo en Ingenierías |
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Miscellaneous |
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2014 |
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8th International Congress on University Teaching and Innovation |
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Tarragona; juliol 2014 |
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CIDUI |
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IAM; 600.075;DAG |
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Admin @ si @ SRM2014 |
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2458 |
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Author |
Debora Gil; David Roche; Agnes Borras; Jesus Giraldo |
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Title |
Terminating Evolutionary Algorithms at their Steady State |
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Journal Article |
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2015 |
Publication |
Computational Optimization and Applications |
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COA |
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61 |
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2 |
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489-515 |
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Evolutionary algorithms; Termination condition; Steady state; Differential evolution |
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Assessing the reliability of termination conditions for evolutionary algorithms (EAs) is of prime importance. An erroneous or weak stop criterion can negatively affect both the computational effort and the final result. We introduce a statistical framework for assessing whether a termination condition is able to stop an EA at its steady state, so that its results can not be improved anymore. We use a regression model in order to determine the requirements ensuring that a measure derived from EA evolving population is related to the distance to the optimum in decision variable space. Our framework is analyzed across 24 benchmark test functions and two standard termination criteria based on function fitness value in objective function space and EA population decision variable space distribution for the differential evolution (DE) paradigm. Results validate our framework as a powerful tool for determining the capability of a measure for terminating EA and the results also identify the decision variable space distribution as the best-suited for accurately terminating DE in real-world applications. |
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Springer US |
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0926-6003 |
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IAM; 600.044; 605.203; 600.060; 600.075 |
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Admin @ si @ GRB2015 |
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2560 |
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Enric Marti; J.Roncaries; Debora Gil; Aura Hernandez-Sabate; Antoni Gurgui; Ferran Poveda |
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Title |
PBL On Line: A proposal for the organization, part-time monitoring and assessment of PBL group activities |
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2015 |
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Journal of Technology and Science Education |
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JOTSE |
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5 |
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2 |
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87-96 |
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IAM; ADAS; 600.076; 600.075 |
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Admin @ si @ MRG2015 |
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2608 |
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Author |
Jorge Bernal; F. Javier Sanchez; Gloria Fernandez Esparrach; Debora Gil; Cristina Rodriguez de Miguel; Fernando Vilariño |
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Title |
WM-DOVA Maps for Accurate Polyp Highlighting in Colonoscopy: Validation vs. Saliency Maps from Physicians |
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Journal Article |
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2015 |
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Computerized Medical Imaging and Graphics |
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CMIG |
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43 |
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99-111 |
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Polyp localization; Energy Maps; Colonoscopy; Saliency; Valley detection |
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We introduce in this paper a novel polyp localization method for colonoscopy videos. Our method is based on a model of appearance for polyps which defines polyp boundaries in terms of valley information. We propose the integration of valley information in a robust way fostering complete, concave and continuous boundaries typically associated to polyps. This integration is done by using a window of radial sectors which accumulate valley information to create WMDOVA1 energy maps related with the likelihood of polyp presence. We perform a double validation of our maps, which include the introduction of two new databases, including the first, up to our knowledge, fully annotated database with clinical metadata associated. First we assess that the highest value corresponds with the location of the polyp in the image. Second, we show that WM-DOVA energy maps can be comparable with saliency maps obtained from physicians' fixations obtained via an eye-tracker. Finally, we prove that our method outperforms state-of-the-art computational saliency results. Our method shows good performance, particularly for small polyps which are reported to be the main sources of polyp miss-rate, which indicates the potential applicability of our method in clinical practice. |
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0895-6111 |
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MV; IAM; 600.047; 600.060; 600.075;SIAI |
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Admin @ si @ BSF2015 |
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2609 |
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